CM-Path Network Development

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What is CM-Path?

• Severe decline in the number of clinical academic pathologists over the past 15 years compared with other

clinical academic specialties

• Increasing need for molecular testing within the NHS

- New technologies

- New skills required

- Pathology capacity

• Disconnect between pathology research, clinical practice and industry

What is CM-Path?

CM-Path Executive Group

Skills and capacity

Clinical trials DiscoveryTechnology and

information

Input from

trial

designers

and funders

Input from

patients and

public

Supporting

Trainees

Engaging

with wider

initiatives

Patient and

Public

Engagement

Biosample

Consent

Cross-cutting themes

Louise Jones Abeer Shaaban Gareth Thomas Clare Verrill

Karin Oien (Chair), Andy Hall (Deputy Chair)

CM-Path Vision: Working Together

Cancer Research UK Stratified Medicine Programme

CRUK Accelerator Awards

MRC/EPSRC Molecular Pathology Nodes

Genomics England and related

Exemplar trials e.g. SMP2/Matrix

Supporting clinical trials and

tissue-based research

Coordinating new approaches

to diagnosis

Pathology

research across

NHS, academia and industry

MRC Nodes

CRUK Accelerators

NCRI

CSGsGenomics England

CRUK Strat Med

CM-Path

Clinical Trials

Academic training

Biobanking

Biomarker Research

Technology &

innovation

CCB/UKCRC

Sanger Institute

PathSoc

RCPath

NC3RMolecular pathology

CM-Path Vision: Working Together

The ambition:

A UK-wide network of CM-Path ‘badged’ pathology centres

The purpose/objectives:

• Help establish UK-wide best practice for molecular

testing across the UK

• Support pathology centres to engage in research-based

activities: biobanking, clinical trials, tissue-based

research

• Support academic training and development

CM-Path NetworkNetwork

Anatomical clinical-molecular dimension of pathology

Salto-Tellez M. Clinical Chemistry 2007 Jul;53(7):1188-90

Clinical Medicine

Traditional Pathology

Molecular

Pathology

(Molecular

Diagnostics)

1. The future of modern medicine will be dictated by technical advancement, management advancements, and

advancements in molecular medicine – stratified medicine

2. Molecular Diagnostics in the fastest growing area in modern medicine

Changing the way we handle human tissues

• Optimal fixation for immunohistochemistry

• Routine handling of fresh tissue

• Optimal tissue selection for molecular analysis

• Better regional/ national standardisation

• Biobanking – a focus on tissue quality

• Engagement with industrial partners

100,000 Genomes Project

Transformational project

• Rare genetic diseases

• Cancer samples

• Fresh samples 5 x 5 x 5mm

• Cellularity score (EQA)

• Consent by Genomic staff

• HRA/HTA statement April 2017

Handling the tissues

• WGS - formalin fragments the DNA

• Eliminating formalin from theatres

• Small diagnostic biopsies best in 10% NBF

• Training staff to sample fresh tissue

• Fresh tissue can be stored at 4oC for ? *

• Maintenance at 4oC during transport

• Recording time of removal and arrival

* Currently under discussion

CM-Path Network: An Inclusive NetworkNetwork

CM-Path Network Requirements

• Named CM-Path representative in each department

• Best practice guidelines for molecular testing

• SOPs for tissue processing re genomics (fixation times etc.)

• Judging tumour content/quality

• Pathway for frozen tissue analysis/collection

CM-Path Network Aspirations

• Research/ training activities

• SOP for releasing tissues for research

• Accessing diagnostic archives for research – creating research biobanks

• Training/research opportunities – workshops, meetings, grants, directory

What will you get for signing up to the CM-Path NetworkNetwork

• Add your name to the pathology directory – become involved in research

• contact departments/fellow pathologists for advice

• Advice on obtaining research funding

• Check out information on training courses, workshops, funding opportunities and

more

• See case studies from fellow pathologists

• Check out our academic roadmap and advice on training

• Download and utilise our SOPs for best practice guidelines for molecular testing,

tissue processing re genomics (fixation times etc.), judging tumour content/quality,

pathway for frozen tissue analysis/collection

• Routinely updated SOPs based on changes in pathology practice

• Quarterly newsletter – linking you to CM-Path activity, opinion pieces, workshops,

training, opportunities to input into calls for information

• Opportunity to advertise specific projects

CM-Pathologists (The Pathology Directory)Network

I'm a pathologist, what will I get out of being on the directory

• Tell us your name, email, area of interest, what you might be interested in getting involved in an we can match

you up to various opportunities/you may be contacted by various people to get involved with projects or

scientific review committees

• Easily link up with fellow pathologists interested in research or trainees looking for projects to get involved in

I'm a research funding organisation what will I get out of using the directory:

• CM-Path encourages funding organisations that award research grants to incorporate a pathology review

• The pathology directory will help you to identify pathologists across the country that might be interested in

joining a funding committee. You will be able to see their speciality and any previous experience they might

have

I'm part of an industrial organisation or a researcher what will I get out of using the directory:

• Want to involve a pathologist in your work or need help developing a research proposal, use the directory to

more easily link yourself up to pathologists who want to be involved in research.

CM-Path Network – More ideas?Network

In the future what you will be able to access through the Network

• Cost recovery tool for tissue

• Contracts

• Business cases

• Links to CCB and CM-Path biobank network

• Case studies from pathologists involved in research

Do you have any other ideas you would like to see on the CM-Path Network – please get in touch by emailing

helen.pitman@ncri.org.uk

The Alternative

https://goo.gl/images/wh434K https://goo.gl/images/bRlhmX

Find out more about what CM-Path is doing…

cmpath.ncri.org.uk

Pathology collaborations

Pathology advice

Further information

Email

cmpath@ncri.org.uk

for…