CLP Common Lymphoid Progenitor - WORK-FLOW · 2020. 2. 11. · CLP Common Lymphoid Progenitor CMP...
Transcript of CLP Common Lymphoid Progenitor - WORK-FLOW · 2020. 2. 11. · CLP Common Lymphoid Progenitor CMP...
B cell p15 CD4 T cell p16 CD8 T cell p17 NK/ILC p18 NKT/γδ T cell p19 Macrophage / Monocyte p20 Dendritic cell p21 Granulocyte p22 Megakaryocyte / Platelet p23 Stem cell p24 Other cell types p25
B cell p4 CD4 T cell p5 CD8 T cell p6 NK/ILC p7 NKT/γδ T cell p8 Macrophage / Monocyte p9 Dendritic cell p10Granulocyte p11Megakaryocyte / Platelet p12Stem cell p13Other cell types p14
CLP Common Lymphoid ProgenitorCMP Common Myeloid Progenitor HSC Hematopoietic Stem Cell ILC Innate Lymphoid Cell LTi Lymphoid Tissue inducer M1 classically activatedM2 alternatively activatedNK Natural Killer Tfh Follicular Helper T cell Th1 T Helper Type 1 cell Th2 T Helper Type 2 cell Treg Regulatory T cell
3
B cell markers
Human
Follicular
SurfaceCD20CD21CD22CD27CD23h�CD24CD40hCD45R (B220)CD69hCD80hCD81CD86hCD137 (4-1BB)hCD275 (B7-H2)CD279 (PD-1)CD360 (IL-2 receptor)HLA-DRIgDhigh�
IgMlow/int
Intracellular/transcription factorBcl-6EBF1FoxO1IkarosPax5
Marginal zone
SurfaceCD1dCD9CD21�CD45R (B220)CD81CD103CD180 (RP105)CD268 (BAFF receptor)�CD307d (FcRL4)IgM
Intracellular/transcription factorEBF1Notch2Pax5
Memory
SurfaceCD27IgGTLR1, 2, 6, 7, 10
Intracellular/transcription factorCBF1Pax5Spi-B
Germinal center
SecretedIgAIgEIgG
SurfaceCD45R (B220)CD81
Intracellular/transcription factorAIDBach2Bcl-6�IRF8NF-kappaBPax5
Plasma cell
SecretedIgAIgEIgG
SurfaceCD9CD19low/neg
CD20low/neg
CD27CD31CD38CD81CD138�CD184 (CXCR4)CD252 (OX40 ligand)CD269 (BCMA)
Intracellular/transcription factorBLIMP1IRF4XBP-1
Pan markers
CD19 CD20 CD22CD70hCD79α/β Igκ/λ
4
Tfh
SecretedIL-21
SurfaceCD183 (CXCR3) CD185 (CXCR5)� CD278 (ICOS)� CD279 (PD-1)�
Intracellular/transcription factorBATFBcl-6c-MafIRF4STAT3
Treg
SecretedIL-10TGFβ
SurfaceCD25�CD39CD73CD101CD121aCD121b CD137 (4-1BB)CD152 (CTLA-4)CD357 (GITR/AITR)GARPhLAPhTIGIT
Intracellular/transcription factorc-RelEosFoxp3�HeliosSTAT5
Th1
SecretedIFNγIL-2 TNFαTNFβ (LTα)
SurfaceCD94CD119 (IFNγR1)CD183 (CXCR3)�CD186 (CXCR6)CD191 (CCR1)CD195 (CCR5)CD212 (IL-12Rβ1)CD218a (IL-18Rα)CD254 (RANKL)CD366 (TIM3)
Intracellular/transcription factorSTAT1STAT4T-bet�
Th17
SecretedGM-CSFIL-17AIL-17AFIL-17FIL-21IL-22
SurfaceCD121aCD161CD194 (CCR4)CD196 (CCR6)� CD360 (IL-21R)CD212 (IL-12β1)IL-23R
Intracellular/transcription factorAHRBATFc-MafIκBζ IRF4RORαRORγt�STAT3
Th2
SecretedAmphiregulin IL-4IL-5 IL-13
SurfaceCD184 (CXCR4)CD194 (CCR4)CD198 (CCR8)CD294 (CRTH2)�CD365 (TIM1)IL-25R (IL-17RB)IL-33R (ST2)
Intracellular/transcription factorBATF GATA-3�IRF4STAT6
Pan markers
CD2CD3CD4CD5CD7CD25hCD27CD28CD45RA (naïve)CD45RO (memory)CD62L (naïve: high, effector: low, memory: high)CD69hCD127 (IL7Rα)CD134 (OX40)hCD137 (4-1BB)hCD152 (CTLA-4)hCD154 (CD40L)hCD272 (BTLA)hCD279 (PD-1)h
CD4 T cell markers
Human
5
CD8 T cell markers
Human
Central memory
SecretedIFNγint
IL-2int
TNFα int
SurfaceCCR7low
CD27CD28CD45ROCD62L�CD62Llow
CD127 (IL7Rα)high
CD197 (CCR7)low�
Intracellular/transcription factorEomesT-betint
Effector memory
SecretedGranzyme BIFNγhigh
IL-2low
PerforinTNFαhigh
SurfaceCD44CD45RO�CD62Llow
CD127 (IL7Rα)high
CD197 (CCR7)low
KLRG1�KRG1high
Intracellular/transcription factorEomesint
T-betint
Effector
SecretedCCL3 (MIP-1α)CCL4 (MIP-1β)CCL5 (RANTES)Granzyme AGranzyme BGranzyme KIFNγIL-2PerforinTNFα
SurfaceCD25hCD69hCD30CD122h�CD137 (4-1BB)CD134 (OX40)CD223 (LAG-3)CD272 (BTLA)CD278 (ICOS)CD279 (PD-1)CD366 (TIM3)KLRG1�
Intracellular/transcription factorT-bet
Naïve
SurfaceCD27CD45RACD62LCD127 (IL7Rα)CD197 (CCR7)
Pan markers
CD2CD3CD5CD7CD8
CD25hCD27CD28
6
ILC3
SecretedIL-17AIL-17AFIL-17FIL-22
SurfaceCD56CD117�CD127 (IL-7Rα)�CD335 (NKp46)CD336 (NKp44)CD337 (NKp30)IL-23R Linneg
Intracellular/transcription factorAHRId2RORγtT-betTCF1
LTi
SecretedIL-17IL-22LTβTNFβ (LTα)
SurfaceCD7CD25CD117�CD127 (IL-7Rα)CD161CD196 (CCR6)CD252 (OX40L)IL-23RMHCII
Intracellular/transcription factorAHRId2RORγtRunx1TOX
ILC2
SecretedIL-4IL-5IL-9IL-13Amphiregulin
SurfaceCD25CD45CD117�CD127 (IL-7Rα)CD161CD184 (CXCR4)CD186 (CXCR6)CD199 (CCR9) CD278 (ICOS) CD294 (CRTH2)IL-25R (IL-17RB)IL-33R (ST2)Linneg
TSLP receptor
Intracellular/transcription factorArginase-1GATA-3Gfi1Id2RORαTCF1
ILC1
SecretedCCL3 (MIP-1α)IFNγ
SurfaceCD56CD103CD183 (CXCR3)CD335 (NKp46)CD336 (NKp44)CD337 (NKp30)Linneg
Intracellular/transcription factorId2Tbet
NK
SecretedGranulysinGranzyme AGranzyme BGranzyme KGranzyme M
IFNγIL-10PerforinTNFα
SurfaceCD11bCD16CD56�CD69hCD94CD122CD161CD244�CD226 CD314 (NKG2D)CD335 (NKp46)CD336 (NKp44) CD337 (NKp30)CD158 family KLRG1TIGIT
Intracellular/transcription factorE4BP4EomesGATA-3Id2Runx1T-betTOX
NK/ILC markers
Human
7
Human
γδ T cell
SecretedGM-CSFGranzyme BIFNγIL-4IL-5IL-17APerforinTNFα
SurfaceCD5CD16CD27CD28CD45RACD56CD57CD62LCD69CD70hCD107aCD314 (NKG2D)TCR γδ�TCR Vδ1TCR Vδ2TCR Vδ3
NKT
SecretedIL-4hIL-10hIL-13hIFNγhTNFαh
SurfaceCD4CD8CD16CD56CD69CD160TCR Vα24�
Intracellular/transcription factorPLZFId2
Pan markers
CD3
NKT/γδ T cell markers
8
Human
Macrophage/monocyte markers
Human
M2 macrophage
SecretedIDOIL-10TGFβ
SurfaceCD115CD204CD163CD206 (MMR)CD209 (DC-SIGN)FcεR1VSIG4
Intracellular/transcription factorIRF4STAT6
M1 macrophage
SecretedIFNγIL-1αIL-1βIL-6IL-12IL-23TNFα
SurfaceCD16CD16/CD32CD32CD64CD68CD80CD86CD369 (Dectin-1) Mer (MerTK)MHCII
Intracellular/transcription factorIRF5STAT1
Monocyte
SurfaceCD14�CD33CD172a (SIRPα)
Tissue associated macrophage
SurfaceAxlCD192 (CCR2)CD14CD68CD115CD163CD206CD369 (Dectin-1)HLA-DRCD273 (PD-L2)
IntracellularNOS2
Pan markers
CD11bCD15CD33CD40CD63CD68 (mature)CD80hCD85CD86hCD105hCD115CD169CD195 (CCR5)CD282 (TLR2)CD284 (TLR4)CD354 (Trem-1)CXCL10CXCL11CXCL9GPNMBMature macrophage markerMIP-2α (CXCL2)
9
Dendritic cell markers
Human
Conventional dendritic cell
SecretedIDOIL-1βIL-6IL-8IL-12IL-15IL-23
SurfaceCD1bCD1c (BDCA-1)CD11c�CD14iCD40hCD49dCD141 (BDCA-3)CD172a (SIRPa)CD197 (CCR7)CD205 (DEC-205)CD207 (Langerin)CD206CD273 (B7-DC)CD282 (TLR2)CD284 (TLR4)CD369 (Dectin-1)CD370 (CLEC9A)
Intracellular/transcription factorCD135CD289 (TLR9)Fit3
Plasmacytoid dendritic cell
SecretedIFNαIFNβ
SurfaceCD85g (ILT7)CD123�CD283 (TLR3)CD303 (BDCA-2)�CD304 (BDCA-4)�CD370 (CLEC9A)
Intracellular/transcription factorCD287 (TLR7)CD289 (TLR9)E2-2IRF8
Pan markers
CD11bCD13CD33CD80hCD83CD86hMHCIIh
10
Granulocyte markersMast
SecretedCathepsinsHistamineTNFαIL-4TGFßNGF
SurfaceCD9CD15CD24CD35CD43CD64CD116CD117 (c-kit)�CD123CD125CD126FcεR1�IL-33R (ST-2)
Neutrophil
SecretedElastaseLactoferrinIL-6IL-12TNFαIL-1 α/ß
SurfaceCD10CD15CD17CD24CD35CD43CD66aCD66b�CD66cCD66dCD89CD93CD112 CD114CD116CD157
CD177CD181 (CXCR1)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)Calprotectin (S100A8/A9)
Intracellular/transcription factorCD281 (TLR1)CD289 (TLR9)
Basophil
SecretedIL-4IL-13HistamineCCL3 (MIP-1α)
SurfaceBasophil MarkerCD9CD11aCD13CD16CD25CD33CD38CD43CD88CD123�CD125CD154CD192CD203cCD218 (IL-18R)CD282 (TLR2)
CD284 (TLR4)CD286 (TLR6)CD294FcεR1�
Intracellular/transcription factorC/EBPαCD281 (TLR1)CD289 (TLR9)GATA2
Eosinophil
SecretedMBPsEDNEPX
SurfaceCD9CD15CD24CD35CD43CD64CD116CD123CD125�CD126CD193 (CCR3)�CD244FcεR1
Pan markers
CD11bCD13CD15CD32CD33
Human
11
Megakaryocyte/platelet markers
Human
Platelet
SurfaceCD9CD23CD31CD36CD41CD42a�CD42b�CD42cCD42dCD49fCD51CD60aCD61CD84CD92
CD107ah
CD107bhCD110CD147CD151CD173CD226GARPLAP
Megakaryocyte
SurfaceCD41�CD42aCD42b�CD42cCD42dCD49fCD51CD61CD110CD112CD123
12
HumanHuman
Stem cell markersHSC
SurfaceCD38low/neg
CD59CD133�CD135 (Flt3)CD338Linneg
Intracellular/transcription factorGATA-3TdT
CMP
SurfaceCD33�CD45RACD123low
CD131CD135 (Flt3)CD173CD174Linneg
Intracellular/transcription factorIkarosPU.1
CLP
SurfaceCD7CD38CD45RACD90low
CD110CD117 (c-kit)low
CD127 (IL-7Rα)�HLA-DRLinneg
Intracellular/transcription factorAiolosc-mybGATA-3PU.1TdT
Pan markers
CD34CD117 (c-kit)CD164
13
Human
CD24 CD49f CD66a CD75 CD104 CD121a CD133 CD167a CD326 (EpCAM) CytokeratinMHCII pos
Erythrocytes
CD45neg
CD51 CD61 CD235a/glycophorin
Fibroblasts
CD10CD29CD47CD81CD91CD121aCD140a/PDGFRaCD140b/PDGFRbVimentin
Neurons
CD6 CD24 CD90 CD143CD166 CD171 CD200 CD230 (prion protein) CD271 (NGFR) CD304 (neuropilin) Nestin
Stromal cells
CD10 CD34 CD157 Podoplanin/p38 Stro-1
Other cell type markers
Human
Epithelial cells
Endothelial cells
SurfaceCD31CD34CD54 (ICAM-1)CD61 (Integrinβ3)CD62E (E-selectin)CD105 (Endoglin)CD106 (VCAM-1)CD144 (VE-cadherin)CD146CD202b (Tie2)CD309 (FLK1)Podoplanin
14
h = Upregulated i = Downregulated � = Key marker = Subset
Follicular
SurfaceCD20CD21/CD35low/neg
CD22CD23�CD24 (HSA)low
CD25hCD36hCD40hCD69hCD80hCD81CD86hCD180 (RP105)CD252 (OX40 ligand)hIgDhigh�
IgMlow/int
Intracellular/transcription factorBcl-6EBF1FoxO1IkarosPax5
Marginal zone
SurfaceCD1dCD5low
CD9CD21/CD35high�
CD23low/neg
CD24 (HSA)low
CD36CD81CD180 (RP105)CD363 (S1PR1)FcRL3IgDlow/neg
IgMhigh�
Intracellular/transcription factorEBF1Notch2
Germinal center
SurfaceCD19CD81CD95GL7�IgG
Intracellular/transcription factorAIDBach2Bcl-6IRF8NF-кBPax5
Plasma cell
SurfaceCD9CD16/32CD19low
CD81CD138�IgG
Intracellular/transcription factorBLIMP1IRF4XBP-1
Pan markers
CD20CD21/CD35low/neg
CD22CD23CD24 (HSA)low
CD25hCD36hCD40hCD69hCD80hCD81CD86hCD180 (RP105)
CD252 (OX40 ligand)hIgDhigh
IgMlow/int
Mouse
Memory
SurfaceCD38�CD45R (B220)low
CD267 (TACI)CD269 (BCMA)IgG
Intracellular/transcription factorCBF1Spi-B
15
B cell markers
Tfh
SecretedIL-21
SurfaceCD185 (CXCR5)� CD278 (ICOS)� CD279 (PD-1)�
Intra/TxnBATFBcl-6c-MafIRF4STAT3
Treg
SecretedIL-10TGFβ
SurfaceCD25 CD137 (4-1BB)CD39CD73CD101CD121aCD121bCD152 (CTLA-4)CD304 (Neuropilin-1)�CD357 (GITR)FR4GARPhLAPhTIGIT
Intracellular/transcription factorc-RelEosFoxp3�HeliosSTAT5
Th1
SecretedIFNγIL-2 TNFαTNFβ (LTα)
SurfaceCD94CD119 (IFNγR1)CD183 (CXCR3)�CD186 (CXCR6)CD191 (CCR1)CD195 (CCR5)CD212 (IL-12Rβ1)CD218a (IL-18Rα)CD254 (RANKL)CD366 (TIM3)
Intracellular/transcription factorSTAT1STAT4T-bet�
Th17
SecretedGM-CSFIL-17AIL-17AFIL-17FIL-21IL-22
SurfaceCD194 (CCR4)CD196 (CCR6)�CD121a CD212 (IL-12β1)CD360 (IL-21R)IL-23R
Intracellular/transcription factorAHRBATFc-MafIκBζ IRF4RORαRORγt�STAT3
Th2
SecretedAmphiregulin IL-4IL-5IL-10 IL-13
SurfaceCD184 (CXCR4)CD194 (CCR4)CD198 (CCR8)CD294 (CRTH2)CD365 (TIM1)IL-25R (IL-17RB)IL-33R (ST2)�
Intracellular/transcription factorBATF GATA-3�IRF4STAT6
Pan markers
CD3
CD4
CD5
CD7
CD25h
CD27
CD28
CD44h
CD62L (naïve: high, effector: low, memory: high)
CD69h
CD127 (IL7Rα)
CD134 (OX40)h
CD137 (4-1BB)h
CD152 (CTLA-4)h
CD154 (CD40L)h
CD272 (BTLA)h
CD278 (ICOS)h
CD279 (PD-1)h
Mouse
h = Upregulated i = Downregulated � = Key marker = Subset
16
CD4 T cell markers
Central memory
SecretedIL-4low
IFNγlow
SurfaceCD44CD62L�CD127 (IL-7Rα) CD197 (CCR7)high�
Intracellular/transcription factorbcl-6 Eomesint
T-betint
Effector memory
SecretedGranzyme BIFNγIL-2PerforinTNFα
SurfaceCD44CD57KLRG1�
Intracellular/transcription factorEomesint
T-betint
BLIMP1
Effector
SecretedCCL3 (MIP-1α)CCL4 (MIP-1β)CCL5 (RANTES)Granzyme AGranzyme BIFNγIL-2PerforinTNFα
SurfaceCD25hCD30CD44CD69hCD122hCD134 (OX40)CD137 (4-1BB)CD223 (LAG-3)CD272 (BTLA-4)CD278 (ICOS)CD279 (PD-1)CD366 (TIM3)KLRG1
Intracellular/transcription factorBLIMP1Id2T-bet
Naïve
SurfaceCD62LCD127 (IL-7Rα)CD197 (CCR7)CD183 (CXCR3)
Pan markers
CD3CD5CD8CD27CD28
Mouse
17 h = Upregulated i = Downregulated � = Key marker = Subset
CD8 T cell markers
Mouse
ILC3
SecretedIL-17AIL-17AFIL-17FIL-22
SurfaceCD117CD127 (IL-7Rα)CD196 (CCR6)�CD335 (NKp46)IL-23RLinneg
Intracellular/transcription factorAHR�Id2RORγtT-betTCF1
LTi
SecretedIL-17LTβTNFβ (LTα)
SurfaceCD4CD25CD117CD127 (IL-7Rα)�CD185 (CXCR5)CD186 (CXCR6)CD196 (CCR6)IL-23RMHCII
Intracellular/transcription factorAHRId2RORγt�Runx1TOX
ILC2
SecretedAmphiregulinIL-4IL-5IL-9IL-13
SurfaceCD25CD117CD127 (IL-7Rα)CD184 (CXCR4)CD186 (CXCR6)CD199 (CCR9)CD278 (ICOS)CD294 (CRTH2)�IL-25R (IL-17RB)�LinnegLy-6A/E (Sca-1)IL-33R (ST2)TSLP receptor
Intracellular/transcription factorArginase-1GATA-3Gfi1Id2RORα�TCF1
ILC1
SecretedIFNγCCL3 (MIP-1α)
SurfaceCD103CD183 (CXCR3)CD335 (NKp46)�Linneg
Ly-6A/E (Sca-1)
Intracellular/transcription factorId2Tbet
NK
SecretedGranzyme A Granzyme BGranzyme KIFNγ
IL-10PerforinTNFα
SurfaceCD11bCD16CD25CD49b (DX5)�CD94CD122CD161c (NK1.1)CD226CD314 (NKG2D)CD335 (NKp46)�Ly-49 familyTIGIT
Intracellular/transcription factorE4BP4EomesGATA-3Id2Runx1T-betTOX
NK/ILC markers
18 h = Upregulated i = Downregulated � = Key marker = Subset
Mouse
γδ T cell
SecretedGranzyme BIFNγIL-4IL-5IL-17APerforinTNFα
SurfaceCD25hCD27CD28CD44CD45R (B220)hCD45RBCD62LCD69hCD71hCD103CD122CD127 (IL-7Rα)CD150CD196 (CCR6)TCR γδ �
IL-1R1NK1.1 (on C57BL/6)TCR Vγ1TCR Vγ4TCR Vγ5TCR Vγ6TCR Vγ7
Intracellular/transcription factorEomes RORγtT-bet
NKT
SecretedIFNγhIL-4hIL-10hIL-13hIL-17hIL-21hIL-22hTNFαh
SurfaceCD4CD8CD44hCD49bCD94CD160CD183 (CXCR3)CD184 (CXCR4)CD186 (CXCR6)CD314 (NKG2D)DX5Ly-49NK1.1 (on C57BL/6)TCR Vα14�
Intracellular/transcription factorPLZFEgr2HEBHobit
Pan markers
CD3
19 h = Upregulated i = Downregulated � = Key marker = Subset
NKT/γδ T cell markers
M2 macrophage
SecretedArginaseIDOIL-10TGFβYM1
SurfaceCD14CD115CD163CD204CD206 (MMR)CD209 (DC-SIGN)CSF1RFcεR1Ly-6C
Intracellular/transcription factorIRF4RELMα STAT6
M1 macrophage
SecretedIFNγIL-1IL-6IL-12IL-23TNFα
SurfaceCD14 CD16/CD32CD32CD64CD68CD80CD86CD204CD369 (Dectin-1)Ly-6CMer (MerTK)MHCII
Intracellular/transcription factorIRF5NOS2STAT1
Monocyte
SurfaceLy6cCSF1R
Pan markers
AxlCD11bCD16/CD32CD40CD64CD68CD107 (Mac3)CD115CD282 (TLR2)CD284 (TLR4)F4/80Galectin-3 (Mac2)GITRLGPNMBLy6G (Gr-1)MHC Class IIh
Mouse
Tissue associated macrophage
SurfaceAxlCD192 (CCR2)CD14CD68CD115CD163CD206CD369 (Dectin-1)HLA-DRCD273 (PD-L2)
IntracellularNOS2
20 h = Upregulated i = Downregulated � = Key marker = Subset
Macrophage/monocyte markers
Conventional dendritic cell
SecretedIDOIL-1βIL-6IL-8IL-12IL-15IL-23
SurfaceCD4CD8 CD11blow
CD40hCD83CD197 (CCR7)CD205 (DEC-205)�CD207 (Langerin)CD209 (DC-SIGN)CD273 (B7-DC)CD369 (Dectin-1)CD370 (CLEC9A)DCIR2
Intracellular/transcription factorCD135 (Flt3)CD183 (TLR3)CD289 (TLR9)
Plasmacytoid dendritic cell
SecretedIFNαIFNβ
SurfaceCD45R (B220)CD317 (BST2, PDCA-1)�Siglec-H�
Intracellular/transcription factorCD287 (TLR7)CD289 (TLR9)E2-2IRF8
Pan markers
CD11cCD80hCD86hMHCIIh
Mouse
21 h = Upregulated i = Downregulated � = Key marker = Subset
Dendritic cell markers
Mouse
Mast
SecretedCathepsinsHistamineTNFαIL-4TGFßNGF
SurfaceCD9CD15CD24CD35CD43CD64CD116CD117 (c-kit)�CD123CD125CD126FcεR1�IL-33R (ST2)
Neutrophil
SecretedElastaseLactoferrinIL-6IL-12TNFαIL-1 α/ß
SurfaceCD10CD15CD17CD24CD35CD43CD66a�CD66bCD66dCD89CD93 CD112 (Nectin-2)CD114 (G-CSFR)CD116CD157CD177CD181 (CXCR1)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)Ly-6G (Gr-1)�
Intracellular/transcription factorCD281 (TLR1)CD289 (TLR9)
Basophil
SecretedIL-4IL-13HistamineCCL3 (MIP-1α)
SurfaceCD9CD11aCD13CD25CD33CD38CD43CD88 (C5a receptor)CD123CD125CD154 (CD40 ligand)CD192 (CCR2)CD218 (IL-18 receptor)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)CD294 (CRTH2)FcεR1�
Intracellular/transcription factorCD281 (TLR1)CD289 (TLR9)C/EBPαGATA-2
Eosinophil
Secreted EPXMBPs
SurfaceCD9CD15CD24CD35 CD43 CD64CD116CD123CD125CD126CD170 (SiglecF)�CD193 (CCR3)�CD244FcεR1
Pan markers
CD11bCD16/CD32
22 h = Upregulated i = Downregulated � = Key marker = Subset
Granulocyte markers
Platelet
SurfaceCD9CD23 CD41CD42a, b, and cCD43CD44CD47CD49bCD49fCD51 CD61CD63CD69CD93 CD62PhCD107ah CD107bhCD110CD147CD151GARPLAP
Megakaryocyte
SurfaceCD9 CD31 CD41� CD42b CD51 CD61 CD62PhCD93CD147CD151CD154GARPLAP
Mouse
23 h = Upregulated i = Downregulated � = Key marker = Subset
Megakaryocyte/platelet markers
Mouse
HSC
SurfaceCD34CD38low/neg
CD59CD117 (c-kit)�CD133 (prominin-1)CD135 (Flt3)CD150 (SLAM)�Linneg
Ly-6A/E (Sca-1)�
Intracellular/transcription factorGATA-2TdT
CMP
SurfaceCD34CD123 (IL-3R)�Linneg
Intracellular/transcription factorIkarosPU.1
CLP
SurfaceCD34CD43CD135 (Flt3)CD127 (IL-7Rα)�Linneg
Intracellular/transcription factorAiolosc-mybGATA-3PU.1TdT
24 h = Upregulated i = Downregulated � = Key marker = Subset
Stem cell markers
Mouse
Epithelial cells
CD24 CD49f CD66a CD75 CD104 CD121a CD133 CD167a CD326 (EpCAM) CytokeratinMHCII pos
Erythrocytes
CD24CD45neg
CD51 CD61 Ter119
Fibroblasts
CD10CD29CD47CD81CD91CD121aCD140a/PDGFRaCD140b/PDGFRbVimentin
Neurons
CD6 CD24 CD90 CD143CD166 CD171 CD200 CD230 (prion protein) CD271 (NGFR) CD304 (neuropilin) Nestin
Stromal cells
CD10 CD34 CD157 Podoplanin/p38 Stro-1
SurfaceCD31 (PECAM-1)CD34CD54 (ICAM-1)CD61 (Integrinβ3)CD62E (E-selectin)CD105 (Endoglin)CD106 (VCAM-1)CD144 (VE-cadherin)CD146CD202b (Tie2)CD309 (FLK1)PodoplaninVEGF receptor 3
Endothelial cells
25 h = Upregulated i = Downregulated � = Key marker = Subset
Other cell type markers