Clinical Pharmacy in Malaysia: Past ,Present and Future
Transcript of Clinical Pharmacy in Malaysia: Past ,Present and Future
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Clinical Pharmacy in Malaysia: Past ,Present and Future
Noraini bt Mohamad
Senior Principal Assistant Director
Pharmaceutical Services Division
Ministry of Health, Malaysia
11.10.2014
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VISION, MISSION & OBJECTIVE
Vision
To provide the best pharmacy service for the health and well being of the nation
Mission
To lead a dynamic pharmacy service emphasizing on the highest level of integrity, professionalism,
and excellence, that meets the application and challenges of the nation
Objective
To ensure quality, safe efficacy, and affordable pharmaceutical and healthcare products are
available and accessible to the public
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Optimising utilisation of manpower for pharmaceutical services in Malaysia
Providing dynamic pharmaceutical services & progresses with current global development Formulating policies
on drugs & pharmaceuticals
Ensuring drug expenditure is at economic level & quality medicines are available at point of need
Generating
consumer awareness
on issues of rational
use of medicines &
adverse events
through consumer
education
Optimising drug therapy through effective pharmaceutical control & up-to-date clinical & professional services
MAIN OBJECTIVES
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Clinical pharmacy is an area of pharmacy concerned with
the science and practice of rational use of medicine.
- with specialized therapeutic knowledge
- with experience and judgment to ensure optimal
patient outcomes
A health science discipline where pharmacist provides
patient care by:
- optimizing the use of medication
- promotes health, wellness, and disease prevention
Definition: Clinical pharmacy
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Patient Care
Pharmacist
Doctors
Nurses
Dietitian
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ROLE 1: Prepare, obtain, store, secure, distribute, administer, dispense and dispose of medical products
ROLE 2: Provide effective medication therapy management
ROLE 3: Maintain and improve professional performance
ROLE 4: Contribute to improve effectiveness of the health-care system and public health
ROLES OF PHARMACISTS
Joint FIP / WHO Guidelines on GPP :
Standards for Quality of Pharmacy Services
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In 1980’s, there was a change from product oriented service to patient focused service.
Concept of Clinical Pharmacy was
introduced in 90’s
Total Parenteral Nutrition
Therapeutic Drug
Monitoring
Cytotoxic Drug Reconstitution
Drug Information
Services
Clinical Pharmacy in Malaysia
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The next major step in the drug distribution system
Introduction of an individualised drug supply system on the ward by Unit Dose or Unit of Use systems.
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These two systems allow the distribution
of drugs to wards to be done in an
efficient and cost-effective manner. It
also minimises medication errors and
wastage.
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12 2004 onwards
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1. WARD PHARMACY
2. MEDICATION THERAPY ADHERENCE CLINIC (MTAC)
3. DRUG SURVEILLANCE
4. HOME MEDICATION REVIEW (HMR)
5. HARM REDUCTION PROGRAM – METHADONE MAINTENANCE THERAPY
6. QUALITY INITIATIVES
EXPANSION OF CLINICAL PHARMACY SERVICES
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Part of medical team in assisting pharmacotherapy decision-making
Activities;
ward rounds
patient assessment
pharmaceutical care plan
bedside counseling
Identify drug-related problems
1 - WARD PHARMACY
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Patient assessment
• Past medication history
• Patient’s disease & medication knowledge
• Patient’s medication adherence
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Documentation
Patient’s progress note
Lab results
Drug monitoring
Pharmaceutical care issues
Intervention
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Documentation
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WARD PHARMACY ACTIVITIES
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Pharmacist
Surgical round Medical round
Medication History Taking
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Bedside Counseling
Bedside Dispensing
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Pharmacist
GERIATRIC WARDS
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Routine Daily Rounds at Medical Wards
Cardiology Round
Pharmacotherapy Round
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Ward Pharmacy Statistics (Jan – Dis 2013)
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Placement of Full Time Pharmacists in the Wards (Major Hospitals)
ICU Medical
Wards
Number of
ICU/Ward 56 236
Number of
pharmacists
(full time)
47 186
% ICU/Ward with full
time pharmacists 83.9% 78.8
Documentation
No. of medication
history taking 213,692
No. of cases clerked 209,441
No. of cases reviewed 258,610
28%
54%
18%
Interventions Done by Inpatient Pharmacists in the Year 2013
Incomplete prescription (27.6%)
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1. WARD PHARMACY
2. MEDICATION THERAPY ADHERENCE CLINIC (MTAC)
3. DRUG SURVEILLANCE
4. HOME MEDICATION REVIEW (HMR)
5. HARM REDUCTION PROGRAM – METHADONE MAINTENANCE THERAPY
6. QUALITY INITIATIVES
EXPANSION OF CLINICAL PHARMACY SERVICES
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• In 2004 , Medication Therapy Adherence Clinics (MTAC) were initiated by the Pharmaceutical Services Division, Ministry of Health Malaysia in ambulatory settings.
• The primary objectives:
• to optimise drug therapy,
• to improve medication adherence and
• to reduce or prevent the occurrence of adverse events and complications due to the drug regimen.
2.0 Medication Therapy Adherence Clinic (MTAC)
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Until year 2013, there are 13 types of MTAC offered in MOH, with established protocol published by the Pharmaceutical Services Division:
Types of MTAC
13 MTACs with Established Protocols
Diabetes Stroke
Warfarin Psychiatry
Retrovirus Disease (RVD)
Rheumatology
Respiratory Hemophilia
Nephrology -Chronic Kidney Disease -Post renal transplant -Dialysis
Psoriasis
Geriatric
2014
Hepatitis MTAC Protocol
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The 1st MTAC in Malaysia, Post-Renal Transplant MTAC, was started in year 2004
1 5 10 27
98
187
390
561
662 660
0
100
200
300
400
500
600
700
800
2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
Nu
mb
er
of
Fa
cili
tie
s
Number of MOH Facilities Offering MTAC Services (2004-2013)
13 MTAC
Development of MTAC Services
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Ambulatory Care Services : MTAC
Diabetes - MTAC
Warfarin – MTAC
Teaching & Consultation
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1. WARD PHARMACY
2. MEDICATION THERAPY ADHERENCE CLINIC (MTAC)
3. HOME MEDICATION REVIEW (HMR)
4. HARM REDUCTION PROGRAM – METHADONE MAINTENANCE THERAPY
5. DRUG SURVEILLANCE
6. QUALITY INITIATIVES
EXPANSION OF CLINICAL PHARMACY SERVICES
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Increase in medication expenditure but many patients fail to achieve the targeted goals of treatment:
RM 206m medicine expenditure (1995) vs. RM 1.5b (2008) in Ministry of Health Malaysia (MOH)
Only ~26.3% patients who received antihypertensive treatment were able to reach the targeted blood pressure (National Health and Morbidity
Survey 2006)
High value of returned medications (RM 200k in 2008 and RM 700k in 2009)(Pharmaceutical Services Division, MOH).
MOH Strategic Plan (2011-2015) Mid-Term Review – bringing care closer to home with a focus on domiciliary care.
Why HMR?
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Current Focus for HMR
Psychiatric
Stroke Geriatrics
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Responsibilities of Pharmacist in HMR team
Discussion with patient’s caregiver
Counselling to improve patients’ adherence toward medication
Proper storage and disposal of unused
medication
Involving Pharmacists in the implementation of HMR services will ensure better therapeutic outcomes in the overall management of the
patient.
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Total (93)
Hospital 38
Health Clinic 55
Number of facilities offering Home Medication Review (Jan – June 2014)
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1. WARD PHARMACY
2. MEDICATION THERAPY ADHERENCE CLINIC (MTAC)
3. HOME MEDICATION REVIEW (HMR)
4. HARM REDUCTION PROGRAM – METHADONE DISPENSING PROGRAM
5. DRUG SURVEILLANCE
6. QUALITY INITIATIVES
EXPANSION OF CLINICAL PHARMACY SERVICES
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4. Methadone Dispensing Program
Initiated and collaborated with MOH Disease Control Division in 2005
Objective: To support the success of MOH Methadone Maintenance Therapy program via DOT
Develop strong pharmacist-patient relationships, collaborate with the physician and promote other health care providers to create seamless care and to achieve better retention rate
As June 2014, there are 412 MOH methadone center 58 hospitals, 286 health clinic, 21 GP, 50 National Anti-Drugs
Agency
Service available everyday (365 days/year)
33,000 patient with retention rate at 75%
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Methadone Dispensing Process
Patient verification & assessment Dose preparation
Direct Observed
Therapy (DOT)
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1. WARD PHARMACY
2. MEDICATION THERAPY ADHERENCE CLINIC (MTAC)
3. HOME MEDICATION REVIEW (HMR)
4. HARM REDUCTION PROGRAM – METHADONE MAINTENANCE THERAPY
5. DRUG SURVEILLANCE
6. QUALITY INITIATIVES
EXPANSION OF SERVICES
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5. Drug Surveillance
National antibiotic usage: DDD (twice a year)
26 types of antibiotics
43 facilities
National Antiretroviral drug usage (yearly)
Surgical Prophylaxis Audit (2014)
Antibiotic Point Prevalence Survey (2015)
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National Surveillance on Antibiotics Utilisation in Malaysia 2009-2013
38
2009 2010 2011 2012 2013
Mean
DDD/1000 PD797.19 910.21 939.5 1010.781195.28
No. of
Contributors67 81 72 66 64
No. of
Antibiotics18 20 20 22 26
0
20
40
60
80
100
120
0
200
400
600
800
1000
1200
1400
Me
an
DD
D/1
00
0 P
D
2010 2011 2012 2013
No. of
DDD/1000 Pt
Days
1507.14 1677.11 1701.04 2868.87
No. of
Contributors41 41 41 47
No. of
Antibiotics20 20 22 26
0
10
20
30
40
50
60
70
80
0
500
1000
1500
2000
2500
3000
3500
Me
an
DD
D/1
00
0 P
D
↑ 18.25%
↑ 68.65% All wards ICU
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Antiretroviral Drug Surveillance - 38 Items monitored
Lamivudine 100 mg (Tab/Cap)
Lamivudine 150 mg (Tab/Cap)
Zidovudine 300 mg/Lamivudine 150 mg (Tab/Cap)
Efavirenz 20 0mg (Tab/Cap)
Efavirenz 600 mg (Tab/Cap)
Indinavir 400 mg (Tab/Cap)
Ritonavir 100 mg (Tab/Cap)
Lopinavir/Ritonavir 200/50 mg- Kaletra®
Stavudine/Lamivudine/Nevirapine - SLN 30 mg (Tab/Cap)
Tenofovir 300 mg (Tab/Cap)
Tenofovir 300 mg/Emtricitabine 200 mg (Tab/Cap)
Didanosine 100 mg (Tab/Cap)
Didanosine 2 g Oral Solution (Bot)
Didanosine 25 mg (Tab/Cap)
Didanosine 250 mg (Tab/Cap)
Didanosine 400 mg (Tab/Cap)
Zidovudine 1 % Inj. (Vial)
Zidovudine 10 mg/ml Syrup (Bot)
Zidovudine 300 mg (Tab/Cap)
Zidovudine 100 mg (Tab/Cap)
Lamivudine 10 mg/ml Oral Solution (Bot)
Raltegravir 400 mg (Tab/Cap)
Stavudine 1 mg/ml Oral Solution (Bot)
Stavudine 30 mg (Tab/Cap)
Stavudine 40 mg (Tab/Cap)
Efavirenz 50 mg (Tab/Cap)
Efavirenz 100mg (Tab/Cap)
Nevirapine 200 mg (Tab/Cap)
Ritonavir 80 mg/ml Oral Solution (Bot)
Lopinavir/ Ritonavir Oral Solution 533/13.3 mg -Kaletra® (Bot)
Abacavir 20 mg/ml (Bot)
Abacavir 300 mg (Tab/Cap)
Abacavir 600 mg + Lamivudine
300 mg (Tab)
Atazanavir 300 mg (Tab/Cap)
Darunavir 300 mg (Tab/Cap)
Nevirapine 50 mg/5 ml Oral
Suspension (Bot)
Lopinavir/ Ritonavir 100/25mg –
Kaletra®
Tenofovir DF 300 mg +
Lamivudine 300mg (Tab)
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Antiretroviral Drug Surveillance
No State Hospital Health Clinics
2011 2012 2013 2011 2012 2013
1 Perlis 94 105 109 12 12 15
2 Kedah 540 594 642 75 78 90
3 Pulau Pinang 1,378 1,706 1,441 30 53 59
4 Perak 806 956 1,057 48 52 70
5 Selangor 4,280 5,548 3,893 210 350 452
6 HKL 306 251 94 NA NA 0
7 Negeri
Sembilan 397 371 236 102 193 154
8 Melaka 270 224 569 82 103 116
9 Johor 1,425 1,241 1,313 247 302 423
10 Pahang 451 509 518 89 118 153
11 Terengganu 349 459 470 60 92 104
12 Kelantan 1,358 451 322 97 167 247
13 Sabah 712 669 691 82 98 88
14 Sarawak 465 519 608 3 9 7
15 WP Labuan 5 7 10 0 0 0
16 WPKL 17 0 7 12 296 449
Total 12,853 13,610 11,980 1,149 1,923 2427
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1. WARD PHARMACY
2. MEDICATION THERAPY ADHERENCE CLINIC (MTAC)
3. HOME MEDICATION REVIEW (HMR)
4. HARM REDUCTION PROGRAM – METHADONE MAINTENANCE THERAPY
5. DRUG SURVEILLANCE
6. QUALITY INITIATIVES
EXPANSION OF CLINICAL PHARMACY SERVICES
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Pharmacist as part of the team in Hospital Clinical Research Centre
Part time or fulltime
As preceptor for PRP research projects
Involvement in clinical trials
Involvement in QA studies
Quality Initiatives – R & D
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National R & D Conference (organized every 2 years) as a platform to present findings..
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How it happened?
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1. Strengthen Services Establishment of Clinical Working Committees
International partnership
Development of training module and teaching material
Establish training centers
Appointment of dedicated preceptors
2. Standardization of Practices Development of guidelines & protocols
3. Quality Assurance –Clinical & Pharmacy Practice Audit (ADAF)
Approaches to Success
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CARDIOLOGY
CRITICAL CARE
RESPIRATORY
PSYCHIATRIC
DIABETES
PHARMACOKINETICS
NUCLEAR PHARMACY
PARENTERAL NUTRITION
ONCOLOGY
NEPHROLOGY
METHADONE
RETROVIRAL DISEASE
GERIATRICS
ANTIBIOTICS
PSORIASIS
HEPATITIS
EMERGENCY
RHEUMATOLOGY
Clinical Pharmacy Working Committees / Task Forces, MOH
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For more information, please visit MOH website:
www.pharmacy.gov.my
Protocols
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Fully Registered Pharmacist : Peer review for ensuring everyone have the same
knowledge and skill
Provisionally Registered Pharmacist Validation Counseling Technique : Must
pass at least 80% types of counseling within 2 months of report duty
Counseling Guidelines
Minimum counseling
target was set for every
health facility
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MTAC RESPIRATORY
MTAC DIABETES
Training Modules
MTAC WARFARIN
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Pharmacists with postgraduate degrees in MOH, Malaysia
Master 372 Clinical Pharmacy : 190
PHD 19 Pharmacotherapy /Clinical : 6
Developing Expertise…. Short courses/attachment
-Abroad or local
Postgraduate study : Master & PhD
* Fully/Partially sponsored by the government
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Numbers of
Pharmacist
Area or Fields Country
40 Oncology (including
palliative care)
Pediatric
Rheumatology
Cardiology (Warfarin /Heart
Failure)
Critical care
Emergency
Neurology (Stroke)
Geriatric
Nuclear
Psoriasis
Pharmacogenomics
USA
Australia
Korea
UK
Singapore
Canada
etc…
Short Course Attachment / International Partnership in Clinical Pharmacy
2006 -2014
Sharing and gaining knowledge
Develop expertise in specialized area
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QUALITY ASSURANCE - AUDIT ON CLINICAL ACTIVITES
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Objectives
To ensure compliance towards the protocols and guidelines
To ensure the monthly data reported in line with the activities carried out
To find out problems or obstacles faced by pharmacists
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Challenges
Restricted budget
Attachments (local or overseas)
Training @ excellence centers
Short courses
Manpower:
Multitasking and variation in job distribution ( types of facilities)
High turnover rate of pharmacists (transfer, resign)
Reluctant to expand job scope
No Key Performances Indicator –ward Pharmacy, HMR
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THE FUTURE OF CLINICAL PHARMACY SERVICES
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CREDENTIALING & PRIVILEGING
1. Ward Pharmacy Service:
• Critical Care
• Pediatrics
• Medical
2. MTAC:
• Diabetes
• Respiratory
• Warfarin
• Retroviral Disease
• Nephrology (Chronic Kidney Disease, Renal Transplant, Dialysis)
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BCPS certification
Pharmacotherapy
Ambulatory
Nuclear Pharmacy
Oncology Pharmacy
Psychiatry
Emergency Medicine
Antibiotic Stewardship Program
Development of ASP Protocol for pharmacy
WAYS AND MEANS..
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1st BCPS Examination in Malaysia..2012 UITM Puncak Alam
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2012 Specialties :
Pharmacotherapy, Ambulatory, Psychiatry & Oncology
18 BCPS certified (MOH)
59
2013
• Specialties : Pharmacotherapy, Ambulatory
• 10 BCPS certified
BPS 2012-2013
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SPECIALIZATION
Generalist
Paraspecialist
Specialist
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Infectious Disease
Nephrology
Cardiology
Oncology
Critical Care Pharmacy
Carrier Pathway Pharmacist as Specialist
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PHARMACY PRACTICE &
MANAGEMENT
CLINICAL PHARMACY
RESEARCH Regulatory Pharmacy
PHARMACY ENFORCEMENT
Pharmacy Practice Manager
Clinical Pharmacist Director/ Consultant
Research Pharmacist Manager
Regulatory Pharmacist Director/ Consultant
Enforcement Pharmacist Director/ Consultant
Senior Principal Pharmacist
Senior Principal Clinical Pharmacist
Senior Principal Research Pharmacist
Senior Principal Regulatory Pharmacist
Senior Principal Enforcement Pharmacist
Principal Pharmacist
Principal Clinical Pharmacist
Principal Research Pharmacist
Principal Regulatory Pharmacist
Principal Enforcement Pharmacist
Senior Pharmacist Senior Clinical Pharmacist
Senior Research Pharmacist
Senior Regulatory Pharmacist
Senior Enforcement Pharmacist
Pharmacist Clinical Pharmacist
Research Pharmacist
Regulatory Pharmacist
Enforcement Pharmacist
PROPOSAL FOR PHARMACIST CAREER PATHWAYS
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CLINICAL PHARMACY/ PHARMACOTHERAPY SPECIALIST
Pre-requisites
Post graduate degree – master in clinical pharmacy
Board Certification – Board of Pharmacy Specialty (optional)
2 year post graduate residency program in field of specialization
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WHAT NEEDS TO BE DONE
Framework for specialisation program
Identify priority areas for recognition of specialisation
Needs and acceptance by doctors
Number of pharmacists already involved
Grandfather pharmacists who can be accredited
2 year Residency Program
Areas and assessment mechanism
Preceptors – pharmacists and doctors
Training hospitals
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Proposed Residency Program
R1 6/12
R2 6/12
R3 6/12
R4 6/12
This Residency Program is proposed as a duration of 2 years, and divided into 4 semester, 6 months each.
Participants will be assessed in the forms of written examinations, research in specialized area, viva, presentation and etc.
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Endless
opportunity for
clinical
pharmacist
to grow…..
66
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Hopefully, in two years time, pharmacists can be recognized
as specialist in Malaysia
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