Clinical Cancer Research Table of Contents · Md Abu Shufean, Ann M. Bailey, Nora S. Sanchez,...
Transcript of Clinical Cancer Research Table of Contents · Md Abu Shufean, Ann M. Bailey, Nora S. Sanchez,...
SPECIAL FEATURES
Highlights of This Issue 2711
CCR Translations
2713 Sequencing Pancreatic Juice: Squeezing the MostOut of SurveillanceMatthew B. Lipner and Jen Jen YehSee related article, p. 2963
2716 Revisiting Interleukin-12 as a CancerImmunotherapy AgentPedro Berraondo, I~naki Etxeberria, Mariano Ponz-Sarvise,and Ignacio MeleroSee related article, p. 2920
Review
2719 Precision Oncology Decision Support: CurrentApproaches and Strategies for the FutureKatherine C. Kurnit, Ecaterina E. Ileana Dumbrava,Beate Litzenburger, Yekaterina B. Khotskaya,Amber M. Johnson, Timothy A. Yap, Jordi Rodon, Jia Zeng,Md Abu Shufean, Ann M. Bailey, Nora S. S�anchez,Vijaykumar Holla, John Mendelsohn, Kenna Mills Shaw,Elmer V. Bernstam, Gordon B. Mills, andFunda Meric-Bernstam
CLINICAL TRIAL BRIEF REPORT
2732 Anaplastic Lymphoma Kinase Mutation (ALKF1174C) in Small Cell Carcinoma of the Prostateand Molecular Response to AlectinibBenedito A. Carneiro, Sahithi Pamarthy, Ami N. Shah,Vinay Sagar, Kenji Unno, HuiYing Han, Ximing J. Yang,Rubens B. Costa, Rebecca J. Nagy, Richard B. Lanman,Timothy M. Kuzel, Jeffrey S. Ross, Laurie Gay, Julia A. Elvin,Siraj M. Ali, Massimo Cristofanilli, Young K. Chae,Francis J. Giles, and Sarki A. Abdulkadir
CLINICAL TRIALS: TARGETED THERAPY
2740 A Phase I Clinical Trial of AZD1775 inCombination with Neoadjuvant Weekly Docetaxeland Cisplatin before Definitive Therapy in Headand Neck Squamous Cell CarcinomaEduardo M�endez, Cristina P. Rodriguez, Michael C. Kao,Sharat Raju, Ahmed Diab, R. Alex Harbison,Eric Q. Konnick, Ganesh M. Mugundu,Rafael Santana-Davila, Renato Martins, Neal D. Futran, andLaura Q.M. Chow
2749 Phase I Study of MEDI3617, a SelectiveAngiopoietin-2 Inhibitor Alone and Combinedwith Carboplatin/Paclitaxel, Paclitaxel, orBevacizumab for Advanced Solid TumorsDavid M. Hyman, Naiyer Rizvi, Ronald Natale,Deborah K. Armstrong, Michael Birrer, Lawrence Recht,Efrat Dotan, Vicky Makker, Thomas Kaley,Denison Kuruvilla, Matthew Gribbin, Jennifer McDevitt,Dominic W. Lai, and Mohammed Dar
2758 Clinical Utility of Cell-Free DNA for the Detectionof ALK Fusions and Genomic Mechanisms of ALKInhibitor Resistance in Non–Small Cell LungCancerCaroline E. McCoach, Collin M. Blakely,Kimberly C. Banks, Benjamin Levy, Ben M. Chue,Victoria M. Raymond, Anh T. Le, Christine E. Lee,Joseph Diaz, Saiama N. Waqar, William T. Purcell,Dara L. Aisner, Kurtis D. Davies, Richard B. Lanman,Alice T. Shaw, and Robert C. Doebele
2771 Ensartinib (X-396) in ALK-Positive Non–SmallCell Lung Cancer: Results from a First-in-HumanPhase I/II, Multicenter StudyLeora Horn, Jeffrey R. Infante, Karen L. Reckamp,George R. Blumenschein, Ticiana A. Leal, Saiama N.Waqar,Barbara J. Gitlitz, Rachel E. Sanborn, Jennifer G.Whisenant,Liping Du, Joel W. Neal, Jon P. Gockerman, Gary Dukart,Kimberly Harrow, Chris Liang, James J. Gibbons,Allison Holzhausen, Christine M. Lovly, andHeather A. Wakelee
CLINICAL TRIALS: IMMUNOTHERAPY
2780 A Novel TGFb Trap Blocks Chemotherapeutics-Induced TGFb1 Signaling and Enhances TheirAnticancer Activity in Gynecologic CancersHaiyan Zhu, Xiang Gu, Lu Xia, You Zhou, Hakim Bouamar,Junhua Yang, Xiaofei Ding, Christian Zwieb, Jianan Zhang,Andrew P. Hinck, Lu-Zhe Sun, and Xueqiong Zhu
2794 Impact of Donor Type in Patients with AML GivenAllogeneic Hematopoietic Cell TransplantationAfter Low-Dose TBI-Based RegimenFr�ed�eric Baron, Myriam Labopin, Annalisa Ruggeri,Jan J. Cornelissen, Ellen Meijer, Henrik Sengeloev,Dietger Niederwieser, Marco R. De Groot,Harry C. Schouten, Noel Milpied, Didier Blaise,Bipin N. Savani, Eliane Gluckman, Mohamad Mohty, andArnon Nagler
June 15, 2018 � Volume 24 � Number 12
Clinical Cancer Research
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2804 Safety and Antitumor Activity of Pembrolizumabin Patients with Estrogen Receptor–Positive/Human Epidermal Growth FactorReceptor 2–Negative Advanced Breast CancerHope S. Rugo, Jean-Pierre Delord, Seock-Ah Im,Patrick A. Ott, Sarina A. Piha-Paul, Philippe L. Bedard,Jasgit Sachdev, Christophe Le Tourneau,Emilie M.J. van Brummelen, Andrea Varga,Roberto Salgado, Sherene Loi, Sanatan Saraf,Dina Pietrangelo, Vassiliki Karantza, and Antoinette R. Tan
PRECISION MEDICINE AND IMAGING
2812 Molecular Diagnosis of Diffuse Gliomas throughSequencing of Cell-Free Circulating TumorDNA from Cerebrospinal FluidFrancisco Martínez-Ricarte, Regina Mayor,Elena Martínez-S�aez, Carlota Rubio-P�erez, Estela Pineda,Esteban Cordero, Marta Cicu�endez, Maria A. Poca,Nuria L�opez-Bigas, Santiago Ramon y Cajal, María Vieito,Joan Carles, Josep Tabernero, Ana Vivancos,Soledad Gallego, Francesc Graus, Juan Sahuquillo, andJoan Seoane
2820 TFAP2E Methylation and Expression Status DoesNot Predict Response to 5-FU-basedChemotherapy in Colorectal CancerOscar Murcia, Rodrigo Jover, Cecilia Egoavil,Lucia Perez-Carbonell, Miriam Ju�arez,Eva Hern�andez-Ill�an, Estefania Rojas, Cristina Alenda,Francesc Balaguer, Montserrat Andreu, Xavier Llor,Antoni Castells, C. Richard Boland, and Ajay Goel
2828 Functional Precision Medicine Identifies NovelDruggable Targets and Therapeutic Options inHead and Neck CancerChang Xu, Olga Nikolova, Ryan S. Basom,Ryan M. Mitchell, Reid Shaw, Russell D. Moser,Heuijoon Park, Kay E. Gurley, Michael C. Kao,Carlos L. Green, Franz X. Schaub, Robert L. Diaz,Hallie A. Swan, In S. Jang, Justin Guinney,Vijayakrishna K. Gadi, AdamA.Margolin, Carla Grandori,Christopher J. Kemp, and Eduardo M�endez
2844 Improved Risk Stratification by CirculatingTumor Cell Counts in Pancreatic CancerKatharina E. Effenberger, Cornelia Schroeder,Annkathrin Hanssen, Stefan Wolter, Christine Eulenburg,Michael Tachezy, Florian Gebauer, Jacob R. Izbicki,Klaus Pantel, and Maximilian Bockhorn
2851 Higher Absolute Lymphocyte Counts PredictLower Mortality from Early-Stage Triple-NegativeBreast CancerAnosheh Afghahi, Natasha Purington, Summer S. Han,Manisha Desai, Emma Pierson, Maya B. Mathur,Tina Seto, Caroline A. Thompson, Joseph Rigdon,Melinda L. Telli, Sunil S. Badve, Christina N. Curtis,Robert B. West, Kathleen Horst, Scarlett L. Gomez,James M. Ford, George W. Sledge, and Allison W. Kurian
TRANSLATIONAL CANCER MECHANISMSAND THERAPY
2859 Tumor-Derived GM-CSF Promotes GranulocyteImmunosuppression in Mesothelioma PatientsSwati Khanna, Suzanne Graef, Francis Mussai,Anish Thomas, Neha Wali, Bahar Guliz Yenidunya,Constance Yuan, Betsy Morrow, Jingli Zhang,Firouzeh Korangy, Tim F. Greten, Seth M. Steinberg,Maryalice Stetler-Stevenson, Gary Middleton,Carmela De Santo, and Raffit Hassan
2873 Dual Inhibition of IGF-1R and ErbB3 Enhancesthe Activity of Gemcitabine and Nab-Paclitaxel inPreclinical Models of Pancreatic CancerAdam J. Camblin, Emily A. Pace, Sharlene Adams,Michael D. Curley, Victoria Rimkunas, Lin Nie, Gege Tan,Troy Bloom, Sergio Iadevaia, Jason Baum, CharleneMinx,Akos Czibere, Chrystal U. Louis, Daryl C. Drummond,Ulrik B. Nielsen, Birgit Schoeberl, J. Marc Pipas,Robert M. Straubinger, Vasileios Askoxylakis, andAlexey A. Lugovskoy
2886 RIP1–HAT1–SIRT Complex Identification andTargeting in Treatment and Prevention of CancerVincenzo Carafa, Angela Nebbioso, Francesca Cuomo,Dante Rotili, Gilda Cobellis, Paola Bontempo,Alfonso Baldi, Enrico P. Spugnini, Gennaro Citro,Angela Chambery, Rosita Russo, Menotti Ruvo,Paolo Ciana, Luca Maravigna, Jani Shaik, Enrico Radaelli,Pasquale De Antonellis, Domenico Tarantino,Adele Pirolli, Rino Ragno, Massimo Zollo,Hendrik G. Stunnenberg, Antonello Mai, andLucia Altucci
2901 Endogenous Replication Stress MarksMelanomas Sensitive to CHEK1 Inhibitors In VivoZay Yar Oo, Alexander J. Stevenson, Martina Proctor,Sheena M. Daignault, Sebastian Walpole,
Catherine Lanagan, James Chen, Dubravka �Skalamera,Loredana Spoerri, Stephen A. Ainger, Richard A. Sturm,Nikolas K. Haass, and Brian Gabrielli
2913 The Pattern of Mesenchymal Stem CellExpression Is an IndependentMarker of Outcomein Multiple MyelomaCarolina Schinke, Pingping Qu, Syed J. Mehdi,Antje Hoering, Joshua Epstein, Sarah K. Johnson,Frits van Rhee, Maurizio Zangari,Sharmilan Thanendrarajan, Bart Barlogie, Faith E. Davies,Shmuel Yaccoby, and Gareth J. Morgan
2920 T-cell Homing Therapy for Reducing RegulatoryT Cells and Preserving Effector T-cell Functionin Large Solid TumorsJiemiao Hu, Chuang Sun, Chantale Bernatchez,Xueqing Xia, Patrick Hwu, Gianpietro Dotti, andShulin LiSee related commentary, p. 2716
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2935 Salivary Gland Cancer Patient-DerivedXenografts Enable Characterization of CancerStem Cells and New Gene Events Associatedwith Tumor ProgressionStephen B. Keysar, Justin R. Eagles, Bettina Miller,Brian C. Jackson, Farshad N. Chowdhury, Julie Reisinger,Tugs-Saikhan Chimed, Phuong N. Le, John J. Morton,Hilary L. Somerset, Marileila Varella-Garcia,Aik-Choon Tan, John I. Song, Daniel W. Bowles,Mary E. Reyland, and Antonio Jimeno
2944 Exosome-Based Detection of EGFR T790M inPlasma from Non–Small Cell Lung CancerPatientsElena Castellanos-Rizaldos, Dominik G. Grimm,Vasisht Tadigotla, James Hurley, John Healy,Patricia L. Neal, Mia Sher, Raajdeep Venkatesan,Chris Karlovich, Mitch Raponi, Anne Krug,Mikkel Noerholm, Jihane Tannous, Bakhos A. Tannous,Luis E. Raez, and Johan K. Skog
2951 Identification of CRKII, CFL1, CNTN1, NME2,and TKT as Novel and Frequent T-Cell Targets inHuman IDH-Mutant GliomaSteffen Dettling, Slava Stamova, Rolf Warta,Martina Schn€olzer, Carmen Rapp, Anchana Rathinasamy,David Reuss, Kolja Pocha, Saskia Roesch, Christine Jungk,Uwe Warnken, Volker Eckstein, Niels Grabe,Christoph Schramm, Markus A. Weigand,Andreas von Deimling, Andreas Unterberg,Philipp Beckhove, and Christel Herold-Mende
2963 Pancreatic Juice Mutation Concentrations CanHelp Predict the Grade of Dysplasia in PatientsUndergoing Pancreatic SurveillanceMasaya Suenaga, Jun Yu, Koji Shindo, Koji Tamura,Jose Alejandro Almario, Christopher Zaykoski,P. Dane Witmer, Shahriar Fesharakizadeh,Michael Borges, Anne-Marie Lennon, Eun-Ji Shin,Marcia Irene Canto, and Michael GogginsSee related commentary, p. 2713
OBITUARY
2975 Eduardo ''Eddie'' M�endez: In Memoriam(1972–2018)Christopher J. Kemp
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ABOUT THE COVER
The cover shows a section of a human cervical tumor from a patient treated withchemotherapy. Immunohistochemical staining shows cytoplasmic and nuclear localizationof Smad2. For details, see the article by Zhu and colleagues on page 2780 of this issue.
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2018;24:2711-2976. Clin Cancer Res 24 (12)
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