Clinical Aspects of Veterinary ListeriosisListeriosis cases 2000-2007 ISU Veterinary Diagnostic Lab...
Transcript of Clinical Aspects of Veterinary ListeriosisListeriosis cases 2000-2007 ISU Veterinary Diagnostic Lab...
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Clinical Aspects of Veterinary Listeriosis
Dr. David Larson, DVM, MSIowa State Veterinary Diagnostic Laboratory
Dr. Arach Wilson, DVM, MSUSDA-APHIS-VS, National Center for Animal Health, Pathobiology Laboratory, Special Pathology Services
Irene V. Wesley, DrPHUSDA-ARS-National Animal Disease Center
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ListeriaListeria monocytogenesmonocytogenes• All livestock species
• Cattle, sheep, goats
• Three clinical manifestations
Encephalitis
Abortion
Septicemia
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Listeriosis cases 2000-2007 ISU Veterinary Diagnostic Lab
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Bovine Ovine Camelid Caprine
AbortionBacterial IsoEncephalitisSepticemia
Num
ber o
f Cas
es
Courtesy of Randy Berghefer, ISU
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Seasonal Distribution
Wesley et al. 2002. J Vet Diagn Invest.14: 314-321
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Diagnostic flow chart
Wesley et al. 2002. Microbial Food Safety In Animal Agriculture pp.233-241
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Encephalitis: Clinical Symptoms
• Depressed/disoriented• Head pressing• Circling• Ataxia• Head tilt• Facial paralysis• Facial hypoalgesia• Paresis of jaw muscles
Copyright NADIS 2004
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Differential Diagnosis
ListeriosisRabiesThromboembolic meningoencephalitis(TEME) PolioencephalomalaciaTransmissible Spongiform Encephalopathies(TSE)etc.
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Methods ComparisonBact Isol Gram (+) IHC (+)
YES 17/25 17 9/17 16/17
NO 8/25 8 3/8 5/8
NO ATTEMPT
13/38 13 6/13 10/13
TOTAL 17/25(68%)
13/38 (34.2%)
31/38 (81.5%)
Johnson et al. 1995. J Vet Diagn Invest 7:223-228
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Immunohistochemistry (IHC)Listeria in brain micro-abscess
Johnson et al. 1995. J Vet Diagn Invest 7:223-228
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Gram stain of ovine brainstem
Johnson et al. 1995. J Vet Diagn Invest 7:223-228
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IHC of Listeria in bovine brainstem
Loeb 2004. J. Vet Med 51: 453-455.
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Case Histories
• Clinically healthy carriers!
• Bovine• Sheep• Alpaca
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Encephalitis
• No gross lesions in brain• Perviascular cuffing of vessels in brain stem• Microabscesses in the neuropil• Leptomeningitis may be present• Ocular iritis and keratoconjunctivitis RARE
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IHC of Listeria in ovine brainstem
Wesley et al. 2002. J. Vet Diagn Invest. 14: 314-321
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Septicemia (generalized listeriosis)
Most common in neonatesFeverDepressionEmaciationDiarrheaNystagmusOpisthotonos
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Courtesy of Deb Hoyt, ISU
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Abortion
•Sporadic or up to 15% of herd
•Usually in last trimester without clinical signs (~280 day gestation-bovine)
•Fetus dies in utero, stillbirths, neonatal deaths
•Dystocia, retained placenta
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Conclusion
• Progress since 1926!• Molecular methods complement
diagnostic assays
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Acknowledgements
James Fosse, Visual ServicesRandy Berghefer, Computer
SpecialistDeb Hoyt, Medical Technologist
Dr. Amir Hamir, Pathologist
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