Class I Class II Class Figures.pdf · PDF file • Galactose • Fructose SLC2A12/...

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    21-May-2020
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Transcript of Class I Class II Class Figures.pdf · PDF file • Galactose • Fructose SLC2A12/...

  • Class I

    Class II

    Class III

  • NH2 COOH

    N

    1 2 3 4 5 7 8 6 12 11 10 9

    Extracellular

    Intracellular

    LL LL

    QLS

  • p m

    o l/

    o o

    cy te

    /m in

    0

    10

    20

    30

    40

    50

    60

    70

    NI

    GLUT12

    Na + buffer Na

    + - free

    ree

    buffer

  • A. Glucose 100 mM B. Glucose 100 mM

  • Related diseases

    • Obesity ? • Type II diabetes? • Cancer Physiological

    role

    Breast and Prostate Cancer

    Location

    Physiological role

    Adipose Tissue

    Skeletal Muscle

    Small intestine

    Unknown

    • Glucose • Galactose • Fructose

    Glucose SLC2A12/ GLUT12 Functional characteristics

    Equilibrative Concentrative

    Glucose H+

    or Na+ ?

    or

    Extracellular

    Intracellular Substrates

    Cytoplasmic Vesicles Translocation

    IRS-1

    PI3K PDKI

    GLUT4

    GLUT12

    Insulin response Glucose Insulin IR

    GLUT12 GLUT4

    Glucose Glycolytic metabolism

    Mitochondrion

    Pyruvate

    Lactate

    GLUT1 GLUT12 MCT1

    LDH-A Glycolysis

    H+

    Oxidative metabolism

    Glucose