Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · •...

5
Class I Class II Class III

Transcript of Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · •...

Page 1: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative

Class I

Class II

Class III

Page 2: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative

NH2 COOH

N

1 2 3 4 5 7 8 6 12 11 10 9

Extracellular

Intracellular

LL LL

QLS

Page 3: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative

pm

ol/

oo

cyte

/min

0

10

20

30

40

50

60

70

NI

GLUT12

Na+ buffer Na

+- free

ree

buffer

Page 4: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative

A. Glucose 100 mM B. Glucose 100 mM

Page 5: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative

Related diseases

• Obesity ? • Type II diabetes? • Cancer Physiological

role

Breast and Prostate Cancer

Location

Physiological role

Adipose Tissue

Skeletal Muscle

Small intestine

Unknown

• Glucose • Galactose • Fructose

Glucose SLC2A12/ GLUT12 Functional characteristics

Equilibrative Concentrative

Glucose H+

or Na+ ?

or

Extracellular

Intracellular Substrates

Cytoplasmic Vesicles Translocation

IRS-1

PI3K PDKI

GLUT4

GLUT12

Insulin response Glucose Insulin

IR GLUT12 GLUT4

Glucose Glycolytic metabolism

Mitochondrion

Pyruvate

Lactate

GLUT1 GLUT12 MCT1

LDH-A Glycolysis

H+

Oxidative metabolism

Glucose


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