Kaposi Sarcoma in Immune Reconstitution Inflammatory Syndrome
Chronic immune activation Inflammatory response
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Washington D.C., USA, 22-27 July 2012 www.aids2012.org Cytokine storm in Leishmania/HIV-1 co-infected patients can be caused by LPS and Leishmania infection Chronic immune activation Inflammatory response Immunoactivation Inflammatory response LPS Visceral leishmaniasis HIV-1/AIDS Brenchley et al. 2006 Aim: investigate whether LPS from microbial translocation is implicated in the pathogenesis of this co-infection Immunodeficiency Parasite-specific immunosuppression 600,000 people infected (Brazil) 3,500 anual/cases (Brazil) Santos-Oliveira et al. 2011
description
Cytokine storm in Leishmania /HIV-1 co-infected patients can be caused by LPS and Leishmania infection. HIV-1 / AIDS. Visceral leishmaniasis. 600,000 people infected ( Brazil ). Immunodeficiency. Parasite-specific immunosuppression. 3,500 anual/cases ( Brazil ). - PowerPoint PPT Presentation
Transcript of Chronic immune activation Inflammatory response
Washington D.C., USA, 22-27 July 2012www.aids2012.org
Cytokine storm in Leishmania/HIV-1 co-infected patients can be caused by LPS
and Leishmania infection
Chronic immune activationInflammatory response
ImmunoactivationInflammatory response
LPS
Visceralleishmaniasis
HIV-1/AIDS
Brenchley et al. 2006
Aim: investigate whether LPS from microbial translocation is implicated in the pathogenesis of this co-infection
Immunodeficiency Parasite-specific immunosuppression
600,000 people infected (Brazil) 3,500 anual/cases (Brazil)
Santos-Oliveira et al. 2011
Washington D.C., USA, 22-27 July 2012www.aids2012.org
Under HAART
Which factors contribute to cellular activation and cytokine storm in co-infected patients?
Washington D.C., USA, 22-27 July 2012www.aids2012.org
LPS plays an important role in the immunopathogenesis of visceral leishmaniasis-HIV-1 co-infection, acting as a co-factor to enhance the cellular activation and inflammatory cytokine response.
Conclusions
Acknowledgements
Dr. Carmem Giacoia-Gripp, Eduardo Regis,
Dr. Mariza Morgado and Dr. Alda Da-Cruz – IOC, Fiocruz
Dr. Manoel Oliveira-Neto, Dr. Beatriz Grinzstejn – IPEC, Fiocruz
Dr. Valdir Amato, Dr. Hiro Goto, Dr. José Angelo Lindoso - USP
Dr. Jorge Guerra – FMT
Dr. Priscilla Alexandrino-de-Oliveira – UFMS
Brazilian Ministry of Health - PN/DST-AIDS
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