CURRICULUM VITAE

Christopher M.J. Cain, MBBS, MD (Adel), FRACS (Orth), FAOrthA

Personal History:

Current Position: Associate Professor University of Colorado at Denver Mail Stop B202 12631 East 17th Avenue, Room 4611 Aurora, CO 80045 Office: 303-724-8936 Fax: 303-724-1593 Cell: 303-727-0529 Email: Christopher.cain@ucdenver.edu

Citizenship: Australia

Residency: USA - Resident Green Card: 210-204-274 Expiration: 01/06/2022

Education:

Undergraduate: University of Adelaide North Terrace Adelaide SA 5005 AUSTRALIA Bachelor of Medicine, Bachelor of Surgery 1985 (equivalent to MD in US)

Post Graduate: University of Adelaide North Terrace Adelaide SA 5005 AUSTRALIA Doctor of Medicine 1993 (equivalent to PhD in US)

Internship: Queen Elizabeth Hospital 28 Woodville Road Woodville South SA 5011 AUSTRALIA Jan 1985 – Jan 1986

Basic Surgical Training: Queen Elizabeth Hospital 28 Woodville Road Woodville South SA 5011 AUSTRALIA Feb 1986 – Feb 1987

Neurosurgical Residency: Queen Elizabeth Hospital 28 Woodville Road Woodville South SA 5011 AUSTRALIA Feb 1987 – Feb 1988 (Also worked at Women’s & Children’s Hospital as the Neurosurgical Resident and undertook research into cervical injuries in motor vehicle accidents with the National Health & Medical Research Council Road Accident Research Unit during this period)

Clinical Research Fellow: Royal Adelaide Hospital Spine Unit Department of Orthopedics & Trauma Level 4, Bice Building North Terrace Adelaide SA 5000 AUSTRALIA Feb 1988 – Feb 1989

Orthopedic Residency: Feb 1989 – Jan 1994 Supervised by: Australian Orthopedic Association Level 12 45 Clarence Street Sydney NSW 2000 AUSTRALIA Office: +61 2 8071 8000 Fax: +61 2 8071 8002 Email: admin@aoa.org.au Accredited by: Royal Australasian College of Surgeons College of Surgeons’ Gardens 250-290 Spring Street East Melbourne VIC 3002 AUSTRALIA Office: +61 3 9249 1200 Fax: +61 3 9249 1219 Email: college.sec@surgeons.org

Clinical rotations in 6-month blocks between the 4 hospitals listed below.

Royal Adelaide Hospital Department of Orthopedics & Trauma Level 4, Bice Building North Terrace Adelaide SA 5000 AUSTRALIA

Flinders Medical Centre Department of Orthopedics & Trauma Bedford Park SA 5042 AUSTRALIA

Queen Elizabeth Hospital 28 Woodville Road Woodville South SA 5011 AUSTRALIA

Women’s & Children’s Hospital 72 King William Road North Adelaide SA 5006 AUSTRALIA

Fellowship Training:

Sept 1993 - Aug 1994 Supervisor: Mr John K. Webb University Hospital Queens Medical Centre Derby Road Nottingham NG7 2UH UNITED KINGDOM

Aug 1994 - Sept 1994 AO Spine Fellow Dr Fritz Margerl & Dr Bernard Jeanneret Kantonsspital St Gallen SWITZERLAND

Academic Appointments:

Jan 1999 - Jun 2010 Clinical Lecturer Faculty of Health Sciences University of Adelaide North Terrace Adelaide SA 5005 AUSTRALIA Phone: +61 8 8303 5277 Fax: +61 8 8303 4360 Email: enquiries@eleceng.adelaide.edu.au

Oct 2010 - Current Associate Professor Department of Orthopedics University of Colorado Denver 12631 E. 17th Avenue, Mail Stop B202 Academic Office 1, Room 4611 Aurora CO 80045 Phone: +1 303 724 2958 Fax: + 303 724 2977 Email: Christopher.Cain@ucdenver.edu

Professional Appointments:

Oct 1994 - Jun 1997 Visiting Medical Specialist Department of Orthopaedics Flinders Medical Centre Bedford Park South Australia

Oct 1994 - Feb 1998 Visiting Medical Specialist Department of Orthopaedic Surgery & Trauma Royal Adelaide Hospital North Terrace, Adelaide South Australia

Oct 1994 - Jun 2010 Visiting Orthopaedic Specialist Wakefield Private Hospital 300 Wakefield Street Adelaide 5000 South Australia

Oct 1994 - June 2010 Visiting Orthopaedic Specialist Memorial Private Hospital Sir Edwin Smith Avenue North Adelaide 5006 South Australia

Jul 1997 - Jun 1999 Honorary Visiting Medical Specialist (Unpaid) Women’s & Children’s Hospital 72 King William Road North Adelaide 5006 South Australia

Jun 1997- Dec1999 Senior Visiting Medical Specialist Department of Orthopaedics Flinders Medical Centre Bedford Park South Australia

Nov 1997 - June 2010 Visiting Orthopaedic Specialist St Andrews Private Hospital 350 South Terrace Adelaide 5000 South Australia

Feb 1998 - Jun 2010 Senior Visiting Medical Specialist Department of Orthopaedic Surgery & Trauma Royal Adelaide Hospital North Terrace, Adelaide South Australia

Jul 1999 - Jun 2010 Senior Visiting Medical Specialist Women’s & Children’s Hospital 72 King William Road North Adelaide 5006 South Australia

Oct 2010 - Current Associate Professor Department of Orthopedics University of Colorado Denver 12631 E. 17th Avenue, Mail Stop B202 Academic Office 1, Room 4611 Aurora CO 80045 Phone: +1 303 724 8936 Fax: +1 303 724 1593 Email: Christopher.Cain@ucdenver.edu

Awards and Honors:

1990 Rob Johnston Award Best Paper, Annual Scientific Meeting of the Spine Society of Australia, July 1990, Sydney

1990 Censor-in-Chief's Prize Best Paper: Australian Orthopaedic Registrars Association Conference

1991 Censor-in-Chief's Prize Second Place: Australian Orthopaedic Registrars Association Conference

1993 Smith & Nephew Richards Academic Prize Awarded by the Australian Orthopaedic Association

2003 President’s Award, Australian Medical Association

2007 Marquis Who’s Who in the World 24th Edition

2011 AOSpine “Oscar” – Educational Excellence Award (Asia Pacific)

Membership in Professional Organizations:

1985 - Current Australian Medical Association

1986 - 2003 Royal Australian Army Medical Corps Reserve (Promoted to rank of Major)

1990 - Current Spine Society of Australia

1993 - Current AO Alumni

1994 - Current Australian Orthopaedic Association

1994 - Current Royal Australasian College of Surgeons

1994 - 2010 Australian Society of Orthopaedic Surgeons

1996 - Current AOSpine International Faculty Member

2011 - Current North American Spine Society

2011 - Current The International Society of Orthopedic Surgery and Traumatology

Committee and Service Responsibilities:

Local Committees and Service Activities:

Nov 1997- Jul 1999 Executive member Association for the Advancement of Private Health

May 2005 - May 2007 Member Credentialing Committee St Andrews Private Hospital

June 2015 - Current Promotions Committee Department of Orthopaedics, University of Colorado, Denver

June 2015 - Current Finance Committee, Department of Orthopaedics, University of Colorado, Denver

May 2016 - Current University of Colorado Hospital, Strategic Sourcing Committee

State Committees and Service Activities:

Aug 1996 - Aug 1998 Secretary Treasurer Australian Society of Orthopaedic Surgeons, South Australia Branch

Aug 1998 - Aug 2002 Chairman Australian Society of Orthopaedic Surgeons South Australia Branch

Jun 2001 - Jun 2003 Seconded Member of Royal Australasian College of Surgeons Council, South Australian Regional Board

May 2001 - May 2003 Australian Medical Association, (AMA) South Australian Branch Surgical Craft Group Representative

Jun 2003 - May 2005 Vice President Australian Medical Association, South Australia

May 2005 - May 2007 President Australian Medical Association, South Australia

Mar 2007 - Jun 2010 South Australian Department of Health Clinical Network Chairman – Orthopaedics

Jun 2007 - Jun 2010 Member Clinical Senate – Department of Health

Jul 2007 - Jun 2010 Specialist Medical Advisor – Chief Executive Department of Health & Minister of Health, South Australian Government

Apr 2008 - June 2010 Chair Physician Assistant Implementation and Evaluation Trail Oversight Committee, South Australian Department of Health

National Committees and Service Activities

Aug 1996- Aug 1999 Treasurer Australian Society of Orthopaedic Surgeons

Jun 2002 - May 2004 South Australian Branch representative on Australian Medical Association Federal Council & Director AMA Ltd.

Aug 2003 - May 2005 Director AMA Commercial Ltd.

Apr 2004 - Aug 2007 Australian Medical Association Representative and Chair National Risk Management Working Party (Council Professional Medical Colleges, Medical Indemnity Industry & Australian Medical Association)

Jun 2004 - Aug 2007 South Australian/Northern Territory Area Representative Australian Medical Association Federal Council & Director AMA Ltd.

Apr 2005 - Aug 2007 Royal Australasian College of Surgeons nominee to Federal Government Spine Prosthesis Clinical Consultative Group

Jun 2005 - May 2007 Executive Council of Australian Medical Association

Apr 2005 - Jun 2007 Royal Australasian College of Surgeons Nominee - Spinal Clinical Advisory Group - Prostheses and Devices Committee

May 2006 - Aug 2007 Director Australian Medical Publishing Co.

Jul 2006 - Aug 2007 Director AMA Commercial Ltd.

International Committees and Service Activities

Oct 2003 - Dec 2005 Chairman AOSpine Australia/New Zealand

Dec 2003 - Dec 2005 Educational Director and Board Member AOSpine Asia Pacific

Dec 2003 - Dec 2005 Member AOSpine Education Commission

Aug 2010 – July 2013 Educational Director, and Board Member AOSpine Asia Pacific

Aug 2010 – July 2013 Member AOSpine Education Commission

Licensures and Certifications:

Certifications:

Australian Orthopaedic Association Affiliate 1990 - 1993 Associate member 1993 - 1997 Full Member 1997 - Current

Fellow Royal Australasian College of Surgeons Feb 1994 - Current

Licensures:

Medical Boards Australia Registration Number: MED0001403352 Provisional Registration Jan 1985 - Jan 1986 (Internship) General Medical Registration Feb 1986 - Jan 1994 Specialist Medical Registration - Orthopaedic Surgery Feb 1994 - Current

Colorado Medical Board Foreign Teaching Physician - TDP-1025 Initial issue date: 8/18/2010

Federal DEA License No: FC2267739

Inventions and Patents:

US 7,232,464 B2 “Intervertebral Implant” Date of Patent: Jun. 19, 2007

US 7,618,456 B2 “Intervertebral Implant” Date of Patent: Nov. 17, 2009

US 7,875,076 B2 “Intervertebral Implant” Date of Patent: Jan. 25, 2011

US 8,709,085 B2 “Intervertebral Implant Date of Patent: April 29, 2014

US 8,715,354 B2 “Intervertebral Implant” Date of Patent: May 6, 2014

US 8,936,641 B2 “Expandable Intervertebral Implant” Date of Patent: Jan. 20, 2015

US 9,155,564 B2 “Spine Stabilization System and Method” Date of Patent: Oct. 13, 2015

Provisional Patents:

Patent Pending - “Intervertebral Implant” US Patent Application Number: US 2011/0118843 A1 US Publication Date: May 19, 2011

Patent Pending - “Intervertebral Implant” US Patent Application Number: US 2012/0101581 A1 US Publication Date: Apr. 12, 2012

Patent Pending - “Intervertebral Implant” US Patent Application Number: US 2012/0109309 A1 US Publication Date: May 3, 2012

Patent Pending - “Intervertebral Implant” US Patent Application Number: US 2012/0109310 A1 US Publication Date: May 3, 2012

Patent Pending - “Intervertebral Implant” US Patent Application Number: US 2012/0109311 A1 US Publication Date: May 3, 2012

Patent Pending - “Intervertebral Implant” US Patent Application Number: US 2012/0109312 A1 US Publication Date: May 3,2012

Patent Pending - “Intervertebral Implant” US Patent Application Number: US 2012/0109313 A1 US Publication Date: May 3,2012

Patent Pending - “Intervertebral Implant” US Patent Application Number: US 2014/0243985 A1 US Publication Date: Aug. 28, 2014

Patent Pending - “Vertebral Body Replacement or Fusion Device” US Patent Application Number: US 2014/0330383 A1 US Publication Date: Nov. 6, 2014

Patent Pending - “Expandable Intervertebral Implant” US Patent Application Number: US 2015/0094812 A1 US Publication Date: Apr. 2, 2015

Patent Pending - “Expandable Intervertebral Implant” US Patent Application Number: US 2015/0173916 A1 US Publication Date: Jun. 25, 2015

Patent Pending - “Expandable Intervertebral Implant” US Patent Application Number: US 2015/0216671 A1 US Publication Date: Aug. 6, 2015

Patent Pending - “Expandable Intervertebral Implant” US Patent Application Number: US 2015/0216672 A1 US Publication Date: Aug. 6, 2015

Patent Pending - “Expandable Intervertebral Implant” US Patent Application Number: US 2015/0320571 A1 US Publication Date: Nov. 12, 2015

Review and Referee Work:

Sept 1994 - Current Editorial Review Board of “Spine”

Feb 2011 - Current Editorial Review Board the “Journal of Orthopedics”

April 2011 - Current Editorial Review Board “Global Spine Journal”

July 2012 - 2014 Editorial Review Board “Evidence Based Spine Journal”

Invited Lectures and Presentations:

• Instructor AO Spine Course, Nottingham 1994

• Instructor AO Spine Course, Davos 1995

• Lecturer 10th International Spinal Workshop, Cleveland 1997

• Instructor AO Spine Course, Davos 1997

• Faculty Western Pacific Orthopaedic Association Operative Spine Course, Bangkok, May 1998

• Faculty 7th Congress of the Military Orthopaedic Society of China and International Orthopaedic Symposium, Guang Zhou, China November 1998

• Instructor / Lecturer AO Spine Course, Davos Switzerland, December 1999

• Faculty Y2K Orthopaedic Symposium, Xian, China, October 25th – 28th 2000

• “Ready for the Spine in the New Millennium” Mathys China Lectures & Workshop, Xian China October 2000

• International Chairman AO Spine Seminar Kobe Japan March 2001

• Co Convener Stryker Spine Symposium, “Controversies and Challenges in Spine Surgery” Noosa Heads QLD Australia, May 2001

• Faculty AO/ASIF Comprehensive Spine Course, Tri-Service General Hospital Taipei, Taiwan June 2001

• Faculty AO/ASIF Comprehensive Spine Course, Davos Switzerland, December 2001

• Chairman International Spine Specialty Seminar “The Future of Arthrodesis in Degenerative Disc Disease” March 13th - 14th Meiringen Switzerland 2003

• Convener Australian Orthopaedic Association National Annual Scientific Meeting, Adelaide, October 2003

• International Chairman AO Spine Masters Course - Complex pathologies and managing complications, Barossa Valley, South Australia, October 2003

• Faculty AO/ASIF Comprehensive Spine Course, Davos Switzerland, December 2003

• Faculty AO/ASIF Comprehensive Spine Course, Davos Switzerland, December 2004

• Chairman AOSpine “Teach the Teachers” Course, Canberra, Australia, March 2005

• Faculty AOSpine Basic Course, Singapore April 2005

• International Chairman AOSpine Operative Course Guangzhou & Hang Zou China, July 2005

• Chairman AOSpine Masters Course – Degenerative spine, Perth, Australia, October 2005

• Faculty Australian Orthopaedic Association Annual Scientific Meeting – Spine Section, Perth, Australia, October 2005

• Faculty AOSpine Interactive & Masters course, Davos, Switzerland, December 2005

• Lumbar Degenerative Disease Seminar, International Meeting of Advanced Spine Technologies, Athens, Greece, July 2006

• International Chairman AOSpine Interactive Course Tokyo, Japan, October 2006

• 13th Asia Pacific Orthopaedic Association Operative Spine Course, Coimbatore, India, March 2007 - Faculty & live surgery demonstration.

• Poster presentation, International Society for the Study of the Lumbar Spine Meeting, Bergen, Norway, June 2006. "Clinical and Radiological outcomes of a Stand-Alone Anterior Fusion Cage with Integrated Screw Fixation: One year results" Bernard LaRue, Russell Morcom, David Hall, Christopher Cain

• Faculty AOSpine North America Meeting Niagara on the lake, Ontario Canada, August 2007

• International Chairman Anterior Lumbar Access Course, Hong Kong, September 2007

• Lumbar Degenerative Disease Seminar, North American Spine Society Meeting, Austin, Texas, October 2007.

• Presentation, Global Spine Congress, San Francisco, June 2008. "Clinical and Radiological outcomes of Stand-Alone Anterior Lumbar Interbody Fusion: Two year results" Christopher Cain, David Ardern,, Martin Wilby, Simon Tizzard, Bernard Larue, Russell Morcom, David Hall

• Poster presentation, North American Spine Society Meeting, Toronto, Canada, October 2008. "Clinical and Radiological outcomes of Stand-Alone Anterior Lumbar Interbody Fusion: Two year results" Christopher Cain, David Ardern,, Martin Wilby, Simon Tizzard, Bernard Larue, Russell Morcom, David Hall

• International Faculty, AOSpine Regional Seminar "Surgical Treatment of Deformity" Tokyo, Japan, June 2010

• Presidential Guest, Chilian Orthopaedic Association Annual Meeting La Serena, Chile, November 2010

• Faculty and presenter, AOSpine Global Spine Congress, Barcelona, Spain March 2011

• International Chairman, AOSpine “Teach the Teachers” Course, Shanghai, China, May 2011

• International Chairman, AOSpine “Teach the Teachers” Course, Seoul, Korea, June 2011

• Chairman, “Degenerative Lumbar Spine Module” AOSpine Advanced Courses, Davos, Switzerland, December 2011

• Chairman, AOSpine Educational Advisors Course, Asia Pacific Faculty, Hong Kong, May 2012

• Chairman, AOSpine Training for Chairpersons course, Asia Pacific Faculty, Kuala Lumpur, Malaysia, September 2012

• International Chaiman and Convenor, AOSpine Aisa Pacific Regional Interactive Courses, Kuala Lumpur, Malaysia, September 2012

• Education Advisor, AOSpine Principles Course, Kuala Lumpur, Malaysia, September 2012

• Faculty, AOSpine Advances Course (Kyphosis and Spondylolisthesis), Kuala Lumpur, Malaysia, September 2012

• International Faculty, AOSpine “Challenging Cases” Symposium, Chinese Orthopedic Association Meeting, Beijing, China, November 2012

• Education Advisor, “Degenerative Lumbar Spine Module” AOSpine Advanced Courses, Davos, Switzerland, December 2012

• Faculty, AOSpine Anatomical Specimen Workshop, Lucern, Switzerland, December 2012

• International Faculty Global Spine Congress, Hong Kong, April 2013

• Chairman, AOSpine Training for Chairpersons & Education Advisors, Shanghai, April 2013

• Chairman, AOSpine Training for Chairpersons, Asia Pacific Faculty, Hong Kong, May 2013

• Chairman, AOSpine Training for Faculty & Chairpersons, Asia Pacific Faculty, Hong Kong, October 2013

• International Facutly “Degenerative Lumbar & Cervical Spine Modules” AOSpine Advanced Courses, Davos, Switzerland, December 2013

• Chairman & Principle Faculty, AOSpine Principles and Masters Courses, Nepal, Kathmandu, February 2014

• Chairman, AOSpine Training for Faculty, Asia Pacific Faculty, Hong Kong, June 2014

• International Faculty, AOSpine Cadaver Course, Melbourne, Australia, August 2014

• International Faculty, AOSpine Advances Course, Yokohama, Japan, September 2014

• Chairman, AOSpine Traning for Chairpersons, Asia Pacific Faculty, Hong Kong, October 2014

• Preoperative Coagulation Profile Testing to Predict Blood Loss in Complex Spine Surgery: Identifying the Patient at Risk. 29th Annual Meeting of the North American Spine Society. San Francisco, California, November 2014.

• Patient-specific templating for ADR identifies factors that influence clinical outcomes. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery. San Diego, California, April 15-17, 2015

• Education Advisor, AOSpine Masters Course, Hong Kong, September 2015

• A Surgeons Experience with Product Development, Asia Pacific Spine Symposium, Hong Kong, September 2015

TEACHING ACTIVITES:

1. Since the completion of my postgraduate and fellowship training in October 1994, I have maintained university appointments and involvement in both undergraduate and postgraduate teaching as a Lecturer at Flinders University, South Australia from October 1994 until December 1999 and at the University of Adelaide, South Australia from October 1994 until June 2010. My teaching responsibilities varied throughout this time and involved lectures, tutoring, mentorship and clinical supervision.

2. I served as an examiner for undergraduate medical students in surgical specialties from January 2006 until December 2009.

3. Through my involvement with AOSpine, a not-for-profit educational body linked to the AO Foundation, I have maintained a role in the education of spine surgeons internationally since 1994. Following my election as Chairman of AOSpine Australia and New Zealand in October 2003 and my appointment to the Asia Pacific Board, I took on the role of Education Committee Chairman for the Asia Pacific region. This involved the coordination of educational activities, faculty support and training for Asia Pacific, with activities undertaken in 14 countries including India, China, Japan, Taiwan, Korea, Singapore, Hong Kong, Australia and New Zealand. I also served on the International Education Commission during this time. I stepped down from this role in December 2005 when I was elected President of the Australian Medical Association (SA), after which my focus for the term of this appointment was to represent the Medical Profession in South Australia in both the political and professional arena.

4. In January 2010, I was approached to stand again as the Education Committee Chairman for the Asia Pacific region. This was an open election with candidates nominated from five different countries. My focus since returning to this role has been faculty development, standardization of course content, and syllabus design for both faculty training activities and course content throughout the region. Through involvement in AOSpine in this capacity, I have assisted in training and mentoring over 100 surgeons in the Asia Pacific region. I have also participated in training activities to increase my own understanding of educational principles. These principles include the identifying knowledge gaps and the learning needs of course and program participants and then applying this to course design, faculty selection and content. This process is commonly referred to as “backwards planning”. I have also been involved in the formulation of a comprehensive AOSpine curriculum for lifelong learning, and developed an international syllabus for AOSpine Principles Courses, targeted at the level of knowledge required for residents and fellows.

The skills and knowledge I have obtained through these activities has had a marked effect on my understanding of educational processes, the effectiveness of various forms of educational activities. I have also become more skilled in relation to the provision of constructive feedback to medical students, residents, fellows, training course participants and faculty.

These skills, knowledge and experience have great relevance to my role and practice in my University practice and educational activities.

Undergraduate:

I have been involved in the supervision and mentorship of medical students since my appointment to both Flinders University and the University of Adelaide in 1994.

While practicing in Australia, I delivered lectures relating to the practice of spine surgery to medical students two or three times per year.

Since my appointment as Associate Professor, University of Colorado I have acted as mentor preceptor for the medical students MSK III orthopedic program. This involves regular, usually weekly, preceptor interaction with students in my clinics and intermittent lecturing relating to core curriculum topics their observation of my activities in the operating room.

I am also involved in the redesign of the Core Curriculum as it relates to spine pathology and the development of an online resource to students to access to undertake self-directed leaning in spinal disease and disorders.

Postgraduate:

I have been involved in postgraduate training in the field of orthopedics and spine throughout my career and continue to be involved in this activity through my appointment to the University of Colorado and working with residents in the UCDHSC Residency program.

Since July 2012 I have taken on responsibility for the University of Colorado Orthopedic Resident Core Curriculum program in spine. I have discussed the needs of the residents with the resident group and our Spine Fellows, to develop a program over 2 years that addresses their learning needs and knowledge gaps. There are a total of 13 lectures covering a wide range of spine disorders and their management, two bio-skills sessions to learn approaches and practice surgical techniques and spinal instrumentation. There is also an annual quiz session to assess their knowledge and knowledge gaps to enable modification of the program content and focus for the coming year.

I coordinate the Spine Service Journal Club, held the first Monday of the month. There are usually 11 such journal club meetings through the year that cover a wide range of spinal pathologies, research topics and techniques.

I have also been involved in the supervision of post-residency Fellows since 1994. Two clinical/research Fellows were appointed to the spine service of the Royal Adelaide Hospital annually, and one of these Fellows would spend two days per week under my direct supervision.

The Spine Unit at the Royal Adelaide Hospital, and Adelaide Spine Clinic were recognize as the first AOSpine Centre outside of Europe and the USA in 1996 and we hosted and supervised short term AOSpine Fellows from Asia and the Middle East on a regular basis.

My involvement in the supervision of Fellows continues having moved to Colorado, with one ACGME accredited Fellow appointed to the Spine Service annually. This program recently underwent review and has been accredited through 01/01/2018.

Lectures Topics Delivered Internationally:

ALIF Indications and Techniques AO Classification of Fractures Thoraco-Lumbar spine Classification of Cervical Fractures C1-C7 Classification of Upper Cervical Injuries Indications for Surgery Thoraco-Lumbar Fractures IDET: A Prospective Randomised Trial Spinal Canal Stenosis: Indications for Fusion Central Cord Syndrome: Case for Intervention Choosing Levels in Scoliosis Surgery for Kyphotic Deformities Surgical Management of Ankylosing Spondylitis & Kyphosis Management of Neoplastic Disease of the Spine Cervical Laminectomy vs Laminoplasty Osteoporotic Fractures: Short vs Long Fixation Postero-Lateral Fusion Indications and Technique USS Concept and Technique Degenerative Scoliosis Short Segment Fixation Thoraco-Lumbar Fractures Without Fusion Controversies in the Management of Cervical Spine Trauma Anterior Lumbar Cage Design and Development “Stand Alone” Lumbar Fusion: Technique and Results Anterior Lumbar Fusion: Historical Perspective Motion Preservation: Myth or Magic? Anterior Lumbar Fusion: Indication and Results Bracing is Out-dated Treatment for Scoliosis Management of Adult Spinal Deformity Universal Spine System Concept and Technique

Adjacent Segment: Avoiding Problems

Axial Back Pain: Non-Operative Management

Backs, Necks and Pain: A Primer for Non-surgeons

Management of the Degenerative Lumbar Spine: Past, Present & Future

Discitis and Spinal Infection

Disorders of the Spine

Iatrogenic Spinal Cord Injury

Principles and Practice of Spine Surgery

Imaging of the Spine in the Spine Surgeons Assessment of Back Pain

Debate: TDR or Fusion – The Case for Fusion

Debate: New Technologies Produce Better Outcomes in the Treatment of Low Back Pain; The Case Against

Management of High Grade Spondylolisthesis

Cervical Cages: Stand Alone Results

Posterior Approaches to the Degenerate Cervical Spine

IDET & Nucleoplasty: The Evidence

Historical Review: Lumbar Interbody Fusion

Laparoscopic Anterior Interbody Fusion

360o Fusion: Implants, Techniques and Results, Can you Believe What you Read?

Sagittal and Coronal Balance

Laminectomy vs. Laminoplasty

Postero-Lateral Fusion: Inductions and Results

Spondylolisthesis, Is there a Need for PLIF or ALIF?

Thoraco-Lumbar Fractures: Anterior vs. Posterior?

Dealing with Complications in Spine Surgery

“Gaines Procedure” in High Grade Spondylolisthesis

Sagittal Balance and Pelvic Parameters

Management of Congenital Kypho-scoliosis

Considerations in the Management of Severe Adult Spinal Deformity

CLINICAL ACTIVITIES:

Up until June 2010, when I ceased practice in Australia to take up the post as Associate Professor, University of Colorado Denver in the Department of Orthopedics, my clinical activities were divided between my private practice and a Government hospital/University practice.

Approximately half of my clinical time was spent working as a Senior Visiting Medical Specialist in the South Australian Government hospital system. I held two appointments, one at the Royal Adelaide Hospital, a Level 1 trauma hospital, and the Women’s and Children’s Hospital. At the Royal Adelaide Hospital my involvement over in the 5 years prior to my move to the US was principally in the management of spine trauma as a member of the Spinal Injuries Unit. At the Women’s and Children’s Hospital, I was the senior spine surgeon involved in the assessment and treatment of pediatric spine disorders and deformity.

Since taking up my appointment at the University of Colorado in October 2010 I have built up a comprehensive spine practice focusing on the assessment and management of adult deformity and degenerative conditions of the cervical, thoracic and lumbar spine. A large proportion of my cases are more complex deformity or revision cases. Another significant area of my practice involves anterior exposure and instrumentation of the spine, and I am also taking on an increasing amount of access work for my colleagues.

RESEARCH AND SCHOLARSHIP:

1. Doctorial Thesis:

"Assessment of spinal cord blood flow and function in sheep following antero-lateral cervical interbody fusion in animals with and without spinal cord injuries" This research was conducted through the University of Adelaide in South Australia. Supervisors: Professor Robert D Fraser Professor Donald Howie Degree: Doctor of Medicine (Equivalent to PhD in USA) awarded October 1993

2. While working as a member of the Spine Unit of the Royal Adelaide Hospital, affiliated with University of Adelaide, the Institute for Medical and Veterinary Science and The Adelaide Centre for Spine Research, I collaborated and acted as co-investigator in a number of research projects resulting in the publications listed below.

3. Clinical Research

Clinical and research activities as Principle Investigator: I am the principle investigator for a research project in collaboration with the

Biomechanical Engineering Department of the University of Denver, who have expertise in the field of Finite Element Analysis. The aim of the project is to identify and evaluate the biomechanical parameters contributing to the success, or failure, of lumbar total disc replacement. Title: Pre-op Templating For TDR Alignment: Is It Clinically Relevant? COMIRB Protocol 12-1049 Effective Date: 28-Sep-2012 The interim results of this work have been presented at multiple international meetings since 2012. Clinical and research activities as Co-Investigator: Title: A Prospective, Multi-Center, Randomized Study Comparing the Vertiflex Superion Interspinous Spacer (ISS) to the X-Stop Interspinous Process Decompression (IPD) System in Patients with Moderate Lumbar Spinal Stenosis COMIRB Protocol 08-0743

Title: Prospective Analysis of Cell Saver Transfusion Related to Morbidity and Coagulopathy in Spine Surgery COMIRB Protocol 11-0270 Title: Prospective Study of Pedicle Screw Placement Using the O-Arm and Navigated Instrumentation COMIRB Protocol 11-0990 Title: The Relationship Between Sagittal Plane Correction and Quality of Life in Adult Deformity Patients Treated with Posterior Instrumentation COMIRB Protocol 12-0483 Title: INSITE- Investigation of Sacroiliac Fusion Treatment COMIRB Protocol 12-1137

Title: Denver SI-Joint Questionnaire Validation Study COMIRB Protocol 13-0091 Title: Vitamin D Deficiency in Rats IACUC 74711(06)1D

4. I continue to be involved in both undergraduate and post medical training and

mentorship in clinics, operating rooms and through lectures. My involvement in AOSpine has enhanced my skills to identify, address, and develop the educational needs of medical students, residents, fellows and seminar and instructional course attendees.

PODIUM/POSTER PRESENTATIONS: (National or International 2015-2016)

Oral Presentations

1. Cain CMJ, Noshchenko A, Lindley EM, Burger EL, Patel VV. What is the Clinical Relevance of Nonunion after Lumbar Arthrodesis? A Meta-Analysis of the YODA Project Database. Annual Meeting of the International Society for the Advanacment of Spine Surgery (ISASS). Las Vegas, Nevada, April 6-8, 2016.

2. Cain CMJ, Kleck CJ, Illing D, Lindley EM, Patel VV, Barton C, Baldini T, Burger EL. A Comparative Analysis of Lumbo-sacral Fixation Strengths: What is Best in a Long Fusion? Annual Meeting of the International Society for the Advanacment of Spine Surgery (ISASS). Las Vegas, Nevada, April 6-8, 2016.

3. Cain CMJ, Barton C, Noshchenko A, Patel VV, Kleck CJ, Burger EL. Risk Factors Associated with Rod Fracture After Osteotomy for Adult Spinal Deformity. Annual Meeting of the International Society for the Advanacment of Spine Surgery (ISASS). Las Vegas, Nevada, April 6-8, 2016.

4. Cain CMJ, Hollenbeck JFM, Fattor JA, Patel VV, Burger EL, Rullkoetter PJ. Patient-specific ROM Predicted by Pre-operative Templating after Total Disc Replacement Surgery. Annual Meeting of the International Society for the Advanacment of Spine Surgery (ISASS). Las Vegas, Nevada, April 6-8, 2016.

5. Hollenbeck JFM, Cain CMJ, Fattor JA, Patel VV, Burger EL, Rullkoetter PJ. Pre-operative Templating for TDR Predicts Post-operative ROM and Could Improve Clinical Outcomes. Annual Meeting of the Orthopeadic Research Society (ORS). Orlando, Florida, March 5-8, 2016

6. Barton C, Noshchenko A, Patel V, Cain CMJ, Kleck CJ, Burger E. Risk Factors Associated with Rod Fracture After Osteotomy for Adult Spinal Deformity. Annual Meeting of the International Society of Orthopaedic Surgery and Traumatology (SICOT). Guangzhou, China, September 17-19, 2015.

7. Noshchenko N, Lindley EM, Burger EL, Cain CMJ, Patel VV. What is the Clinical Relevance of Nonunion after Lumbar Arthrodesis? A Meta-Analysis of the YODA Project Database. Annual Meeting of the International Society of Orthopaedic Surgery and Traumatology (SICOT). Guangzhou, China, September 17-19, 2015.

8. Burger EL, Barton C, Noshchenko A, Patel VV, Cain CMJ, Kleck CJ. Risk Factors Associated with Rod Fracture After Osteotomy for Adult Spinal Deformity. Annual Meeting of Eurospine. Copenhagen, Denmark, September 2-4, 2015.

9. Burger EL, Barton C, Noshchenko A, Patel VV, Cain CMJ, Kleck CJ. Risk Factors Associated with Mechanical Complications Including Proximal Junctional Failure after Osteotomy for Adult Spinal Deformity. Annual Meeting of Eurospine. Copenhagen, Denmark, September 2-4, 2015.

10. Cain CMJ, Burger EL, Illing D, Razavi-Shearer D, Weitzel NS, Lindley EM, Kleck CJ, , Jameson LC, Patel VV. Preoperative Coagulation Profile Testing to Predict Blood Loss in Complex Spine Surgery: Identifying the Patient at Risk. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

11. Kleck CJ, Perry J, Burger EL, Cain C, Patel VV. Minimally Invasive Technique for Placement of Sacroiliac Arthrodesis Implants using O-Arm and Stealth Navigation. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

12. Lindley EM, Razavi-Shearer D, Patel VV, Burger EL, Cain CMJ, Finn MA. Medical Marijuana Use Characteristics in Patients With Chronic Spine Pain Disorders. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

13. Noshchenko A, Lindley EM, Burger EL, Cain CMJ, Patel VV. Rates of Complications and Required Additional Surgical Interventions after Spinal Arthrodesis versus Alternative Treatment in Lumbar Spondylosis: A Systematic Review with Meta Analysis. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

14. Noshchenko A, Lindley EM, Burger EL, Cain CMJ, Patel VV. Long Term Patient-Centered Clinical Outcomes of Lumbar Arthrodeses in Degenerative Disc Disease: A Systematic Review with Meta Analysis. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

15. Cain C, Hollenbeck JFM, Fattor JA, Patel VV, Burger EL, Laz PJ, Rullkoetter PJ. Patient-specific templating for ADR identifies factors that influence clinical outcomes. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

Poster Presentations 2015 1. Barton C, Noshchenko A, Patel VV, Cain CMJ, Kleck CJ, Burger EL. Risk Factors

Associated with Mechanical Complications Including Proximal Junctional Failure after Osteotomy for Adult Spinal Deformity. Annual Meeting of the International Society of Orthopaedic Surgery and Traumatology (SICOT). Guangzhou, China, September 17-19, 2015.

2. Martyn R, Zaghloul K, Lindley EM, Kleck CJ, Cain CMJ, Burger EL, Patel VV. Pedicle

Screw Placement in Spine Surgery: A retrospective review of O-arm/Stealth vs Non-Computerized Navigation Techniques. Annual Meeting of the International Society of Orthopaedic Surgery and Traumatology (SICOT). Guangzhou, China, September 17-19, 2015.

3. Kleck CJ, Illing D, Lindley EM, Patel VV, Barton C, Baldini T, Cain CMJ, Burger EL. A

Comparative Analysis of Lumbo-sacral Fixation Strengths: What is Best in a Long Fusion? 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

4. Illing D, Perry J, Lindley EM, Patel VV, Cain CMJ, Kleck CJ, Burger EL. The Effect of

Electronic Medical Record System Implementation on Complication Rates in Adult Spine Deformity Surgery. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

5. Lindley EM, Barton C, Blount T, Seim H, Turner AS, Burger EL, Cain CMJ, Patel VV. An

Analysis of Fusion Rates Among Control Groups in Sheep Fusion Models. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

6. Kleck CJ, Illing D, Lindley EM, Ryaby J, Hahn R, Ladiwalla S, Cain CMJ, Burger EL, Patel VV. Post-Market Analysis of Pulsed Electromagnetic Field (PEMF) Stimulation Use for Cervical Fusion. 15th Annual Meeting of The International Society for the Advancement of Spine Surgery (ISASS). San Diego, California, April 15-17, 2015.

7. Kleck CJ, Illing D, Lindley EM, Patel VV, Barton C, Baldini T, Razavi-Shearer D, Cain CMJ,

Burger EL. A Comparative Analysis of Lumbo-sacral Fixation Strengths: What is Best in a Long Fusion? 28th Annual Conference of Association of Spine Surgeons of India (ASSICON). Pune, India, January 23-25 2015.

8. Illing D, Perry J, Lindley EM, Patel VV, Cain CMJ, Kleck CJ, Burger EL. The Effect Of

Electronic Medical Record System Implementation On Complication Rates In Adult Spine Deformity Surgery. 28th Annual Conference of Association of Spine Surgeons of India (ASSICON). Pune, India, January 23-25 2015.

9. Kleck CJ, LaFleur M, Lindley EM, Clark M, Burger EL, Cain CMJ, Rentschler ME, Razavi-

Shearer D, Patel VV. Pedicle Screw Precision With 3-Dimensional Imaging, Navigation, And Measurement. 28th Annual Conference of Association of Spine Surgeons of India (ASSICON). Pune, India, January 23-25 2015.

PUBLICATIONS/SCHOLARSHIP:

Number of original articles in Peer-reviewed journals (Total): First Author 8 Senior Author 3 Other co-author 19 Book chapters: 2

1. McLean AJ, Simpson DA, Cain CMJ, McKaul K, Freund J; Head and Neck Injuries

in Passenger Cars; A review of the literature. Department of Transport and

Communications Federal Office for Road Safety, Report CR59, Sept. 1987

2. Cain CMJ, Simpson DA, Fraser RD, McLean AJ, Potter GR, McKaul K; Cervical

Spine Injuries in Road Traffic Crashes in South Australia, 1981-86. Aust. N.Z. J.

Surg., 1989;56,15-19

3. Cain CMJ, Simpson DA, Ryan GA, Manock CH, James RA; Road Crash Cervical

Injuries: A Radiological Study of Fatalities. Am. J. Forensic Med. & Pathol., 1989;

10(3):193-195

4. Howie DW, Cain CMJ, Cornish BL; Pseudo-Abscess of the Psoas Bursa in Failed

Double-Cup Arthroplasty of the Hip: J Bone Joint Surg, [B], 1991; 73B:29-32

5. Pohl AP Cain CMJ, Latham JM; Vibrational Resonance Analysis of Bones:

Orthopaedic Proceedings Supplement I; J Bone Joint Surg, [B], 1991;73B:5

6. Cain CMJ, Fraser RD; The effect of stabilization of the cervical spine on spinal cord

blood flow and function: Orthopaedic Proceedings Supplement II; J Bone Joint

Surg, [B], 1991;73B:152

7. Cain CMJ; Assessment of spinal cord blood flow and function in sheep following

antero-lateral cervical interbody fusion in animals with and without spinal cord

injuries: Thesis for the degree Doctor of Medicine, University of Adelaide, June

1993

8. Cain CMJ, Langston PG, Weston PF, Fraser RD; Assessment of spinal cord blood

flow and function in sheep after antero-lateral cervical interbody fusion in the

presence of cord damage: Spine 1994;19(5):511-519

9. Cain CMJ, Fraser RD; Bony and vascular anatomy of the normal cervical spine in

the sheep: Spine 1995;20(7):759-765

10. Cain CMJ, Langston PG, Weston PF, Fraser RD; Assessment of spinal cord blood

flow and function in sheep following antero-lateral cervical interbody fusion. Neuro

Orthopaedics 1995; 17/18:131-141

11. Newey ML, Cain CMJ; Delayed focal neurological deficit secondary to a cervico-

thoracic spinal cord epidural haematoma. Eur Spine J 1999; 8:332 – 333

12. Sanderson PL, Fraser RD, Hall DJ, Cain CMJ, Osti OL, Potter GR; Short segment

fixation of thoracolumbar burst fractures without fusion. Eur Spine J 1999;8(6):495-

500

13. Fagan AB, Cain CMJ, Hall DJ, Fraser RD; Carbon fiber cages for anterior lumbar

interbody fusion: A prospective study. (Book Chapter) Lumbar Segmental

Instability; Edited M Szpalski, R Gunzberg, & M Pope, Lippincott Williams &

Wilkins, Philadelphia 1999.

14. Kamat AS, Freeman BJ, Cain CMJ, Hall DJ; Laminated multi-segment graft in

anterior column reconstruction. Eur Spine J 2001;11 465-466

15. Freeman B, Fraser RD, Cain CMJ, Hall DJ, Chapple DC; A Randomized, Double-

Blind, Controlled Trial: Intradiscal Electrothermal Therapy versus Placebo for the

Treatment of Chronic Discogenic Low Back Pain. Spine. 30(21):2369-2377,

November 1, 2005

16. Cain CMJ, Schleicher P, Gerlach R, Pflugmacher R, Scholz M, Kandziora F; A

New Stand-Alone Anterior Lumbar Interbody Fusion Device: Biomechanical

Comparison with Established Fixation Techniques. Spine. 30(23):2631-2636,

December 1, 2005.

17. Schleicher P, Gerlach R, Schar B, Cain CMJ, Achatz W, Pflugmacher R, Hass NP,

Kandziora F; A Biomechanical Comparison of two different concepts for stand

alone anterior lumbar interbody fusion. Eur Spine J. 17(12):1757-1765, December,

2008.

18. Lindley EM, McBeth ZL, Henry SE, Cooley R, Burger EL, Cain CMJ, Patel VV.

Retrograde ejaculation following anterior lumbar spine surgery. Spine.

37(20):1785-1789. September 15, 2012

19. Golembeski S, Lindley EM, McBeth ZL, Sophacles A, Burger EL, Cain CMJ, Patel

VV. Translating versus non-translating cervical plates. Curr Orth Prac. 2013;

24(2):165-170

20. Noshchenko A; Hoffecker L, Lindley EM, Burger EL, Cain CM, Patel VV.

Perioperative and Long Term Clinical Outcomes for Bone Morphogenetic Protein

versus Iliac Crest Bone Graft for Lumbar Fusion in Degenerative Disc Disease.

Systematic Review with Meta-analysis. J Spinal Discord Tech. 2014; 27(3):117-35

21. Lindley EM, Levy BJ, Burger EL, Cain CMJ, Patel VV. Failure of the Fernstrom ball

in contemporary spine surgery: A case of history repeating itself. Curr Orth Prac.

2014; 25(1):87-91

22. Noshchenko A, Hoffecker L, Lindley EM, Buger EL, Cain CM, Patel VV. Long term

treatment effects of lumbar arthrodesis in degenerative disk disease: a systematic review

with meta-analysis. J Spinal Disord Tech. 2014 May;27(3):117-35

22. “Spine Surgery Basics”; Chapter 1 “Anatomy”, Editors, Patel VV, Patel A, Harrop J,

Burger E; Springer-Verlag, Copyright Springer-Verlag Berlin Heidelberg, 2014

23. Noshchenko A, Lindley EM, Burger EL, Cain CM, Patel VV. Perioperative and long-term

clinical outcomes for bone morphogenic protein versus iliac crest bone graft for lumbar

fusion in degenerative disk disease: systematic review with meta-analysis. J Spinal Disord

Tech. 2014 May;27(3):117-35

24. Noshchenko A, Hoffecker L, Lindley EM, Burger EL, Cain CMJ, Patel VV, Bradford AP.

Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic

review with meta-analysis. World J Orthop. 2015 Aug 18;6(7):537-58

25. Barton C, Noshchenko A, Patel V, Cain C, Kleck C, Burger E. Risk factors for rod fracture

after posterior correction of adult spinal deformity with osteotomy: a retrospective case-

series: Scoliosis, 2015 Nov 4; 10:30 13013-015 e-Collection

26. Noshchenko A, Lindley EM, Burger EL, Cain CM, Patel VV. What is the Clinical Relevance

of Radiographic Non union After Single-Level Lumbar Interbody Arthrodesis in

Degenerative Disc Disease?: A Meta-Analysis of the YODA Project Database. Spine

(Phila Pa 1976). 2016 Jan;41(1):9-17

27. Kleck CJ, MD; Perry JM, Burger EL, Cain CMJ, Milligan K, Patel VV. Sacroiliac Joint

Treatment - Personalized to Individual Patient Anatomy Using 3-Dimensional Navigation:

Orthopedics March/April 2016 - Volume 39 Issue 2: 89-94

28. Fattor JA, Hollenbeck JFM, Laz PJ, Rullkoetter PJ, Burger EL, Patel VV, Cain CMJ:

Patient-Specific Templating of Lumbar Total Disk Replacement to Restore Normal

Anatomy and Function. Orthopedics March/April 2016 - Volume 39 Issue 2: 97-102

29. Kleck CJ, Cullilmore I, LaFleur M, Lindley E, Rentschler ME, Burger EL, Cain CM, Patel

VV. A new 3-dimensional method for measuring precision in surgical navigation and

methods to optimize navigation accuracy. Eur Spine J. 2016 Jun;25(6):1764-74

30. Lindley EM, Barton C, Blount T, Burger EL, Cain CM, Seim HB 3rd, Turner AS, Patel VV.

An analysis of spine fusion outcomes in sheep pre-clinical models. Eur Spine J. 2016 May

10.

31. Zaghloul K, Matoian B, Denardin N, Cain CMJ, Burger EL, Patel VV. Surgical Technique:

Preventing Proximal Adjacent Level Kyphosis with Strap Stabilization. Orthopedics. In

Press

32. Christopher J. Kleck, Damian Illing, Emily M. Lindley, Andriy Noshchenko, Vikas V. Patel,

Cameron Barton, Todd Baldini, Christopher M.J. Cain, Evalina L. Burger. Strain in

Posterior Instrumentation Resulted in Different Combinations of Posterior and Anterior

Devices for Long Spine Fusion Constructs. Spine Deformity. Volume 5, Issue 1, Jan 2017:

27-36