Childhood Leukemia 소아백혈병의 치료
31
Childhood Leukemia 소아백혈병의 치료
Transcript of Childhood Leukemia 소아백혈병의 치료
4. 23
. 100
130~140, , ,
, , ,
.
.
77% ,
11% , 2~3%
, 1~2% .
7~9%
. 1999 2007
55.4%,
27.5%, 5.3%
.
2)
95% ,
(acute lymphoblastic leukemia,
ALL) (acute myelogenous
leukemia, AML) .
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.
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,
.
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.
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.
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( 1 ).
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10, 17 ( 2, 3)
. T
. t(9;22) t(4;11)
44
.
: 1 , 10
: 50,000/uL
0 1 2 3 4 5 6 7 8 9 10 12 14 16 18 ()
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,
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.
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,
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)
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.
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, 7
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6-
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5~6
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2
.
.
6)
. 4
,
12
. 6-
.
3, 2 .
1
.
7)
60%
.
(Blood-Brain
Barrier;BBB)
.
.
5%
.
.
.
3.
.
, ,
.
(7&3 5&3). BH-AC(), 6-
. (FAB M3 )
(ATRA)
.
20%
.
(FAB M3 )
. HLA
60~70%
.
BH-AC
HLA
,
.
t(8;21) M2
.
(M3 )
(ATRA) .
4.
.
.
,
. ,
.
.
70%
. (2
) ,
.
HLA . HLA
. HLA
.
HLA ,
(KONOS) . HLA
.
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.
,
.
.
,
500/uL 38.3
.
.
.
,
. ,
,
.
3~7
.
. (Pneumocystis jiroveci)
,
.
.
(Pentamidine) .
,
.
-
(varicella-zoster virus, VZV),
(cytomegalovirus, CMV), Epstein-Barr (EBV),
.
.
.
,
( )
, ,
. 20,000/uL
.
*
.
, ,
* : ‘ ’
** :
, , , ,
.
.
.
· .
02-766-7671
www.kclf.org
. 100
130~140, , ,
, , ,
.
.
77% ,
11% , 2~3%
, 1~2% .
7~9%
. 1999 2007
55.4%,
27.5%, 5.3%
.
2)
95% ,
(acute lymphoblastic leukemia,
ALL) (acute myelogenous
leukemia, AML) .
,
.
.
.
,
,
.
,
. ,
.
.
.
.
.
,
.
,
. ,
.
.
.
.
, (3,000mL/
/) ,
(pH 7 ) ,
.
.
.
2.
. 1950
,
.
,
1
.
, 10
,
.
7
3, 2 ‘ 3,
2’ .
.
2)
,
.
( 1 ).
1~9
50,000/uL ,
( 1 ).
DNA 1.16 () 4,
10, 17 ( 2, 3)
. T
. t(9;22) t(4;11)
44
.
: 1 , 10
: 50,000/uL
0 1 2 3 4 5 6 7 8 9 10 12 14 16 18 ()
70%
.
(2 ) ,
.
3)
,
5%
.
.
4
,
95%
.
.
: 40~60mg//, 1 3 ,
28, 2
: 25mg//, (3, 4
, ),
( , , ,
)
. L-
.
.
. ()
.
,
.
, .
7
, 7
14
.
.
4)
,
.
.
,
.
5)
6-
, .
. - ,
5~6
,
. 1
2
.
.
6)
. 4
,
12
. 6-
.
3, 2 .
1
.
7)
60%
.
(Blood-Brain
Barrier;BBB)
.
.
5%
.
.
.
3.
.
, ,
.
(7&3 5&3). BH-AC(), 6-
. (FAB M3 )
(ATRA)
.
20%
.
(FAB M3 )
. HLA
60~70%
.
BH-AC
HLA
,
.
t(8;21) M2
.
(M3 )
(ATRA) .
4.
.
.
,
. ,
.
.
70%
. (2
) ,
.
HLA . HLA
. HLA
.
HLA ,
(KONOS) . HLA
.
.
.
,
.
.
,
.
.
,
500/uL 38.3
.
.
.
,
. ,
,
.
3~7
.
. (Pneumocystis jiroveci)
,
.
.
(Pentamidine) .
,
.
-
(varicella-zoster virus, VZV),
(cytomegalovirus, CMV), Epstein-Barr (EBV),
.
.
.
,
( )
, ,
. 20,000/uL
.
*
.
, ,
* : ‘ ’
** :
, , , ,
.
.
.
· .
02-766-7671
www.kclf.org