Chicory root fiber inspires innovation

to target globesity

Elaine E. Vaughan, PhDSensus (Royal Cosun), the Netherlands

17th Nov 2019, Food Matters Live, London

Agro-industrial cooperative - established ~110 years ago by Dutch sugar beet growers

Sensus, in Royal Cosun Cooperative – plants powering people

Sensus: introduction

• Sensus established in 1995

R&D with Cosun Innovation Centre

We believe in inulin to contribute to consumer health

Because consumers will increasingly adopt healthier lifestyles and make

better food choices with ingredients from natural origin. These healthier food

products will be even more successful if they taste great.

Sensus product portfolio

Overweight, obesity, a global challenge

SUGAR: Reinventing Sweetness

SUGAR is the new dietary baddie !

TOO MUCH

SUGAR

../Video/Habit Pioneers Personalized Nutrition Category.mp4

Frutafit® inulin & Frutalose® FOS as sugar replacer

• Low caloric value (2 kcal / gram)

• Sweetness, up to 50% possible

• Low caloric bulking agent

• Combines well with High Intensity Sweeteners

Mask off and after taste

Synergistic effect

• Different types for each application, easy to use

• Low glycemic response - EC authorized health claim

SUGAR

SUGAR Reinventing Sweetness Strategies

Albert Heijn, NL

30% sugar reduction Marshmallow

Reduce the Sugar

Make it Natural

Pure Indulgence

Sugar for energy

Milkybar Wowsomes, UK

30% less sugar

Fever-Tree, UK

Light tonic with 4-5g

per 100ml fructose

W.K. Kellogg, UK

plant-based, no-added-sugar cereal

Deliciously Ella, US

energy balls

DiamondPure, MY

milk with Manuka honey Fruitella, UK

30% sugar

Inulin fermentation by gut microbiota - bifidobacteria - to SCFAs

Inulin → Short Chain Fatty Acids

Acetate 82%

Propionate 12%

Butyrate 6%

Bifidobacteria produce acetate

Inulin & SCFAs beneficial for human metabolism & weight...

SCFAs, notably acetate, may play central role in inulin effect on metabolic health

Project ENOF: chicory FOS for body weight ?

Treatment:

p=0.67

oligofructosecontrol

• FOS 16 g/d for 12 wk versus isoenergetic control

➢ Body weight, fat mass & body fat%, waist circumference

➢ Energy intake

➢ Appetite/satiety †Decreased HUNGER for FOS (p=0.04)

(microbiota effects? )

*FOS sign difference vs control (p

Systematic review – Inulin Fructans & Weight Parameters (preliminary)

Inclusion Criteria

✓ randomised controlled trials

✓ only active

✓ satiety, energy intake, body weight

✓ human (≧2 yr)✓ single or repeated exposures

✓ quality (amount, type, timing defined)

❖ Huge variation studies (doses, matrices) → comparison difficult

❖ ½ show significant effect on satiety & body weight

What are the key mechanisms?

Satiety

12 studies

Effect, n=6

No effect, n=6

Body weightPrimary parameter 12 wk; Dose: ~10-30g/d

Effect, n=3

No effect, n=3

6 studies

SCFA acetate in distal colon improved weight-related parameters

Can inulins increase SCFA/ acetate in the human distal colon

to improve metabolic parameters - in a pleasant manner ☺ ?

(Na)acetate anal infusion with catheter

Van der Beek & Canfora, et al. (2016) Clinical Science; Canfora et al. (2017) Scientific

Reports; Canfora & Van der Beek, et al. (2017) Gastroenterology

Does inulin produce SCFAs/acetate in distal colon?

Hypothesis:

Microbiota ferment resistant starch (RS) first, so

Frutafit® inulin will be fermented in the distal colon

TIM Human Colon Model

Inulin + RS (single shot) increases acetate in in vitro distal colon of lean subjects

Human study with inulin+RS

➢ Does inulin+RS improve metabolism in humans?

➢ Is there a difference between lean and obese insulin-resistant men?

❖ Randomised double blind, n=12 men

❖ ‘lean healthy’ versus ‘overweight pre-diabetic’

❖ +/- high fat meal

❖ Acute intake one day before measurements:

I = Frutafit® inulin 12 g

I+RS = Frutafit® inulin 12 g + resistant starch 7.5 g

C = control (maltodextrin)

C

Day -7 Day 0 washout Day 14 washout Day 28

I+RSI+RS I+RS

I

C

I

C

I

C

Inulin+RS acute intake improves numerous metabolic parameters in lean men

Fat oxidation

Values: means SEM, *p

Inulin+RS increases breadth H2 → fermentation in lean men

* *_______

Bifidobacteria

Inulin-type fructans …increase

bifidobacteria in overweight/obese adults –

12 week trial(Reimer et al 2017 AmJClinNut)

Longer term intervention required to modify microbiota of obese subjects

Bifidobacteria → acetate

Before & after

high fat mixed meal

Chicory Inulin & FOS are Prebiotic

Prebiotic: A substrate that is selectively utilized by host microorganisms conferring a health benefit

Inulin selectively enhances bifidobacteria

Perspectives: Chicory root fibers – supporting human health

Mental

health

Digestive health

Prebiotic

Immunity

Body

weight

Insulin

resistance

Calcium

absorption

Anti-Inflammation

• Dietary fiber

• Low caloric value, sugar replacement

• Low glycemic response (EC authorized claim)

• Prebiotic

• Inulin fibre fermentation - gut microbiota -

metabolites SCFAs - increasing evidence for

supporting weight management, besides other

benefits

Emanuel Canfora

Ellen Blaak

Koen Venema

Mattea Müller

Monica Mars

Korrie Pol

Cees de Graaf

James Dower

Sabita Soedamah-Muthu

Els Siebelink

Acknowledgements

Diederick Meyer

All study volunteers

Gerben D.A. Hermes

Erwin G. Zoetendal

Thank you!

Sensus at Food Matters LiveDiscover the benefits of inulin chicory root fibers

Visit us at Booth #E20