Chemistry Newsletter Vol. I - Chemie Brunschwig · We have the pleasure to submit you our 1 st...

Chemie Brunschwig, Auf dem Wolf 10, PO Box, CH 4023 Basel

Tel: 061 308 91 11, Fax: 061 308 91 19 E-mail: [email protected] Web: www.brunschwig-ch.com 1

Dear Chemist,

We have the pleasure to submit you our 1st edition of the Chemistry Newsletter.

This „Chemistry News“ will be edited 2-3 time each year.

Our objective is to keep you updated with the latest infirmation from our chemistry products portfolio.

For any further information, our Marketing and Sales Team will be more than happy to support you.

Your sincerely

Chemie Brunschwig Team

CONTENTS

• Solvents for GC Headspace from Fisher Chemicals

• J&K: Get 15% discount on your order until the 31.03.2017!

• LINK: Best pricing on the best products

• Boronate Esters and Boronic Acids for Suzuki Coupling from Strem

• High purity metals and materials from Alfa Aesar

• Discover 4 new scavengers from Silicycle and get 25% off!

• New Partner: SwissGas AG

• Hepatochem: EvoluchemTM Chemistry screening kits

• Spirochem: Focus on Cubanes

• Cobetter: special promotion on syringe Filters until 31.03.2017

Chemistry Newsletter Vol. I

For more information on these products contact us,

by email: [email protected] or web: www.brunschwig-ch.com



Fisher Chemical solvents for GC Headspace

The determination of residual solvents (organic volatile impurities) by GC headspace is an important

quality control procedure in the pharmaceutical industry. Residual solvent testing is defined in

accordance with the ICH1 and required by USP and Ph. Eur. The technique requires extraction of

residual solvents from the sample using a high purity solvent free of contaminants that could interfere

with GC analysis by co-eluting with the peaks of interest.

Key Features of Fisher Chemical GC Headspace Solvents

• Processed to high purity for accurate and repeatable determination of trace levels of Class

1, Class 2, and Class 3 residual solvents in pharmaceuticals

• Tested by UV absorbance to ensure low organic contamination

• Processed for low water content to facilitate the extraction of organic volatile impurities

• Packaged in an inert atmosphere to maximize shelf life in unopened containers

Benefit from our special Promotion

Product Description Size Cat. No Promo Price

(CHF)*

Water, GC Headspace 1L W10-1 41.50

DMSO, Dimethyl Sulfoxide, GC Headspace 1L D139-1 141.70

DMF, N,N-Dimethylformamide, GC Headspace 1L D133-1 129.00

DMAC, N,N-Dimethylacetamide, GC Headspace 1L D160-1 144.80

NMP, N-Methyl-2-Pyrrolidone, GC Headspace 1L N140-1 459.90

Product flyer and white paper available for more details.

*Prices are net, ex works, excl. V.A.T. and not cumulative with other discounts. Valid until 31.03.2017.



J&K Scientific offers a wide range of chemicals, lab supplies and packaging and take great pride in

the safe and efficient delivery of only the finest quality products, with expert consultation.

J&K Scientific is an Integrated Scientific & Industrial Resource Platform, ready to meet all of your

research, manufacturing and commercial requirements. J&K offers a team of scientific and business

professionals who are relentless in the mission to find new ways to contribute significantly to hu-

manity, both today and in the years to come.

Try and get 15% discount* on all the products from J&K until 31.03.2017!

*Not cumulative with other discounts

LINK manufactures reagents for oligonucleotide synthesis and modification to an unrivalled level

of quality. They control and check the whole manufacturing process, repeatedly, at every stage.

They put 25 years' experience in nucleotide chemistry at your disposal, and whether you want 1g or

1kg, we're with you all the way.

Reduce your modified oligo costs with lower pricing on HEX, TET, dSpacer, Biotin-TEG CPG and Da-

bcyl CPG.

Best pricing on the best products

Product Description Cat No List Price*

( CHF)

6-FAM 2134 164.75

HEX 2136 373.60

TET 2137 319.90

3‘-Biotin-TEG CPG 2353 101.00

dSpacer-CE Phosphoramidite 2146 254.70

3'-Dabcyl-CPG 2374 80.70

Packaging

250mg

250mg

250mg

100mg

250mg

100mg

*Prices are ex works, excl. V.A.T and subject to change.

Ask us if you want to receive the complete catalog

Ask us if you want to receive the complete catalog





Boronate Esters and Boronic Acids for Suzuki Coupling

Cat. No Product description

05-0020 Bis(hexyleneglycolato)diboron, 99% , CAS 230299-21-5

05-0025 Bis(neopentylglycolato)diboron, min. 97% , CAS 201733-56-4

05-0030 Bis(pinacolato)diboron, 99% , CAS 73183-34-3

05-0360 t-Butyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate, min. 97%,

CAS 330793-01-6

05-0370 t-Butyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl carbonate, min. 97%,CAS 480424-71-3

05-0380 t-Butyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl carbonate, min. 97%,CAS 480438-74-2

05-0760 2,6-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, min. 97% , CAS 269410-25-5

05-0765 Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, min. 97% , CAS 195062-62-5



05-0950 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, min. 97% , CAS 269410-22-2

05-1015 Tetrahydroxydiboron, min. 95% , CAS 13675-18-8

05-1032 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide, min. 97% , CAS 214360-60-8

05-1034 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, min. 97% , CAS 214360-73-3

05-1036 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97% , CAS 269409-73-6

05-1037 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97% , CAS 180516-87-4

05-1039 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)furan, min. 97% , CAS 248924-59-6

05-1042 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, min. 97% , CAS 269409-97-4



05-1045 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl acetate, min. 97% , CAS 480424-68-8

05-1047 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl acetate, min. 97% , CAS 480424-70-2

Boronate Esters

Available in 1g and 5g units (except 06-0090 available in 500mg, 2g, 10g and 50g and 05-1015 available in 1g,

5g and 25g)

05-1048 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, min. 97% , CAS 269410-08-4

05-1037 05-0030 05-0148 05-0770



Ask us if you want to receive the complete catalog or the application note

Cat. No Product description

Boronic acids

05-0399 3-Carboxyphenylboronic acid, min. 97% , CAS 25487-66-5

05-0400 4-Carboxyphenylboronic acid, min. 97% , CAS 14047-29-1

05-0430 4-Chlorophenylboronic acid, min. 97% , CAS 1679-18-1

05-0800 4-Fluorophenylboronic acid, min. 97% , CAS 1765-93-1

05-0780 Hexylboronic acid, min. 97% , CAS 16343-08-1

05-0878 2-Methoxyphenylboronic acid, min. 97% , CAS 09.06.5720

05-0880 4-Methoxyphenylboronic acid, min. 97% , CAS 5720-07-0

05-1010 4-(Methylthiophenyl)boronic acid, min. 97% , CAS 98546-51-1

05-1030 1-Naphthylboronic acid, min. 97% , CAS 13922-41-3

05-1040 2-Thiopheneboronic acid, min. 97% , CAS 6165-68-0

05-1049 m-Tolylboronic acid, min. 97% , CAS 17933-03-8

05-1050 o-Tolylboronic acid, min. 97% , CAS 16419-60-6

05-1051 p-Tolylboronic acid, min. 97% , CAS 08-05-5720

93-0570 Phenylboronic acid, min. 97% , CAS 98-80-6

05-0399 05-0430 05-0780 05-0880

05-1030 05-1049 05-1051





High purity metals and materials

Pure elements

Our broad range of pure elements, from Aluminum to Zirconium, are designed to meet a wide

variety of high technology applications. Different purities and forms are provided to correspond

to the demands of many different uses and applications. Representative physical properties and

additional facts pertaining to each element are available. Our range of pure elements contains

over 1400 products.

A selection of our pure elements can be found in the table below.

Full product listing and pack sizes available online www.alfa.com/pure-elements

Alloys

We offer a wide variety of alloys in several compositions and forms. Our range of alloys contains

over 250 products.

Aluminum alloys for use in many industries such as equipment, machinery, vehicles and various

specialized applications. Copper alloys are the less expensive option than gold and platinum and

provide incomparable heat and thermal performance. Nickel and

stainless steel alloys are available and are used widely within the

chemical industry.

Evaporation materials

Our product line consists of a compiled broad representation of the

more commonly used materials for evaporating and

crystal growing applications. All purities are based on total metallic impurities unless otherwise

specified.

All products designated as Puratronic® or REacton® grade are automatically supplied with a

Certificate of Analysis (COA).

This certificate details elements sought, detection limits and total metallic impurity levels in

parts per million. Purities are based on Total Metallic Impurities (TMI). Tolerances for metal are

normally +/- 10% of listed value unless specifically identified.



Fuel cell grade products

Our extensive product line is a great fit for all of your needs. We offer a full range of

membrane electrode assemblies,

Toray carbon papers, Nafion® membranes, anodes for hydrogen and reformate fuel cells,

cathodes for hydrogen and reformate fuel cells, cathodes and anodes for direct methanol

fuel cells and fuel cell catalysts.

Carbon, graphite and ceramics

Our portfolio includes a wide selection of carbon products in a variety of forms, including

powder, diamond, fullerene, glassy carbon and graphite. This product range includes over

350 products.

Labware

Our Labware includes precious metal, non-precious metal, PTFE Labware, quartz, glassy

carbon, and ceramic labware. From crucibles to plates, we offer labware in many different

forms. We offer over 750 products in our labware and equipment portfolio.

If your need is for precious metal labware, then trust the precious metal experts the next

time you need the tolerance of platinum or other precious metal labware. Alfa Aesar lab-

ware is competitively priced on a daily basis and standard items are in stock for immediate

shipment.

Only a few metals are required to produce a wide array of durable labware. The basic nob-

le metals group consists of platinum, rhodium, ruthenium, osmium, palladium, iridium,

gold and silver. Ruthenium and osmium, however, are unworkable in their pure form and

are only offered under special circumstances.

Contact us if you would like to receive the complete product list.





PURITY AFTER IMPURITY: 4 new scavengers

Discover our 4 new scavengers:

Organic Scavengers Metal Scavengers

Functionnal Group

Guanidine 1 DEAM AMPA DOTA

Product Number R68230B R54430B R85130B R591030B

Structure

Minimal Loading 0.80 mmol/g 0.85 mmol/g 0.80 mmol/g 0.38 mmol/g

Approx. Density (g/mL)

0.732 0.691 0.707 0.681

Storage Keep dry Keep cool (≤ 8°C) and dry Keep dry Keep dry

Typical Metals Scavenged 2

Known to be efficient to-ward some heavy metals

Ag, Fe, Sn, Ti & Zn

Al, Ce, Dy, Er, Eu, Gd, Ho, La, Lu, Mn, Nd, Ni, Pm, Pr,

Sb, Sm, Tb, Tm, V & Yb Co, Cu, Fe, Mg & Zn

Ca, Cu, Gd, La, Ni & Zn Co, Fe, Mg, Pd, Pt & Rh

1 Also a strong “superbase” for organic synthesis: useful for alkylation / etherification reactions, Micheal additions, as an organoca-talyst, an exchange membrane transporter, and as a peptide / peptide mimic. Sufficiently basic to deprotonate moderately acidic hydrogens 2 Metals metal: Best Scavengered Metals metal: Scavengered Metals

SiliaBond Guanidine (R68230B) at CHF 258.70/50gr*

SiliaMetS DEAM (R54430B) at CHF 220.50/50gr*

SiliaMetS AMPA (R85130B) at CHF 191.10/50gr*

SiliaMetS DOTA (R91030B) at CHF 198.50/50gr*

and our Novel Scavengers Kit (K34530B) at CHF 1017.45/Kit*

More sizes available! Just ask!

*Prices are net, ex works, excl. V.A.T. and not cumula1ve with other discounts. Valid un1l 31.03.2017.

Application notes, catalog and posters are available. (List prices available on our website)

Benefit from our special promotion on our new scavengers



Your supplier for:

Hydrogen, zero air, and nitrogen generators for GC and LC-MS applications

Why should you go for in-situ gas generation?

• Costs reduction

• Availability: Main sources for nitrogen, hydrogen and pure air are free and available everywhere

• The move from Helium to Hydrogen :Helium is relatively rare on earth, cannot be produced,

and prices have risen steadily in the last decade. An available alternative exist for gas

chromatography with high purity hydrogen.

• Safety improvement : minimal storage of hydrogen and nitrogen, gas on demand,

Self-monitoring and automatic shutdown and no transport.

• Ergonomics and convenience improvement

• Space recovering: The footprint of a modern gas generator is many times less than a rack

of cylinders

• Carbon footprint reduction of your lab

High Purity Nitrogen generator (HP-N2 Evo) GC zero air generator compact H2 generator

Contact us if you would like to receive product flyer or user manual.

Interested in a Demonstration? Please ask us to organise a meeting.





Discover the

Product overview:

The EvoluChem™ kits are chemistry screening kits. They are the ideal tools for the investigation of

chemical reaction conditions. It enables you to conveniently screen multiple reaction conditions si-

multaneously using pre-weighed catalysts and reagents.

Easy Protocol

Available kits

Benefits Features

Facilitates screen of reaction conditions 0.3 ml crimped vial with stirring bar

No glove-box needed to manipulate air or moisture sensitive reagents Specifically designed reaction block

Enables up to 32 reaction conditions simultaneously Pre-weighed reagents and catalysts

Save substrate using low scale reaction conditions Temperature from 0°C to 120°C

Save time on optimization Pre-designed or custom arrays available

⇒ Cross Coupling Chemistry

>Suzuki

>Palladium Precatalysts

>Palladium catalyzed amination

⇒ Amide Coupling

⇒ Weak base kit ⇒ C-H activation chemistry

>Direct fluorination, methoxylation, acetoxylation, hydroxylation

⇒ Biomimetic Oxidation chemistry

>BMO Kit

⇒ Glucuronidation Chemistry group

>Glucuronidation kit

Ask us if you want to receive the complete booklet.



Why Cubanes?

Cubanes have recently been highlighted in the scientific literature as useful chemical tools

for bioisosteric replacement of aromatic groups. Cubanes are rigid scaffolds. Our range of cuba-

nes have one or two exit vectors positioned in a linear manner (1,4-substitution), thereby

mimicking the para substitution pattern on arenes.

Cubanes are three-dimensional fragments and were shown to display equivalent or improved

physico-chemical and pharmaco-kinetic properties compared to the arene groups they are

replacing. Therefore, when the arene group is serving as a spacer/scaffold and is not involved in Pi

interactions with the biological target, switching to the corresponding cubane is strongly

recommended.

We also postulate that mono-substituted cubanes can also serve as lipophilic group replacement and

can be considered as bioisosteres of tert-butyl groups. Cubanes are now standard components of our

LipoSwitch kits and services.

Why SpiroChem?

SpiroChem is a world-leading player in the design, synthesis and manufacturing of Cubanes. Most of

the Cubanes can be offered on multi-gram scale and up to kilogram scale, in a short lead time and

are affordable to support your drug discovery programs and beyond.

SpiroChem can provide these advanced building blocks containing Cubanes from our comprehensi-

ve catalog, but also design synthetic routes to new series that are fit for your applications and that

will facilitate their introduction in your molecules of interest, thereby reducing the amount of synthetic

work that needs to be done and allowing you to focus on high-value- added transformations.

Get Inspired with our Building Blocks to Create the Drugs of Tomorrow.

Some cubanes available:

...and many more!

ASK US!

Cubanes





YOUR PARTNER FOR FILTRATION!

Product Description Cat. No Packaging Promo Price

(CHF)*

Hydrophilic PTFE syringe filters

Nonsterile Hydrophilic PTFE syringe filters , 0.22um,13mm SFM13PTH0022 100 59.90




Hydrophobic PTFE syringe filters

Nonsterile Hydrophilic PTFE syringe filters , 0.22um,13mm SFM13PT0022 100 56.10




Hydrophilic PVDF syringe filters

Nonsterile hydrophilic PVDF syringe filters, 0.22um, 13mm SFM13PVH0022 100 65.10




Non Sterile PES syringe filters

Nonsterile PES syringe filters, 0.22um, 13mm




SFM13PE0022 100 52.70

SFM13PE0045 100 52.70

SFM25PE0022 100 57.20

SFM25PE0045 100 57.20

Hydrophilic PTFE syringe filters :

• maximal chemical and pH resistance

• optically clear when wet with water

• Filtration of aqueous and aggressive organic

solvent-based solutions, HPLC operation

Hydrophobic PTFE syringe filters:

• Broad chemical compatibility

• Strong chemical stability and inertia

• Filtration of organic solvent with strong chemical

causticity, strong acid solvent and alkali solvent.

Hydrophilic PVDF syringe filters:

• Ultra low protein binding

• Very low extractables

• Broad chemical compatibility

• HPLC and UHPLC operation

PES syringe filters:

• Lowest protein binding

• Low extractables

• Filtration of buffers and culture media

Free Samples are available, simply ask.

Benefit from our special offer!

*Prices are net, ex works, excl. V.A.T. and not cumulative with other discounts. Valid until 31.03.2017.

Chemistry Newsletter Vol. I - Chemie Brunschwig · We have the pleasure to submit you our 1 st...

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Transcript of Chemistry Newsletter Vol. I - Chemie Brunschwig · We have the pleasure to submit you our 1 st...