Chemistry 501 Handout 10 Lipids Chapter 10
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Chemistry 501 Handout 10 Lipids Chapter 10 Dep. of Chemistry & Biochemistry Prof. Indig Lehninger. Principles of Biochemistry. by Nelson and Cox, 5 th Edition; W.H. Freeman and Company
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Dep. of Chemistry & Biochemistry Prof. Indig. Chemistry 501 Handout 10 Lipids Chapter 10. Lehninger. Principles of Biochemistry. by Nelson and Cox, 5 th Edition; W.H. Freeman and Company. Two conventions for naming fatty acids. Fatty Acids. Stearic acid. Oleic acid. - PowerPoint PPT Presentation
Transcript of Chemistry 501 Handout 10 Lipids Chapter 10
Chemistry 501 Handout 10
LipidsChapter 10
Dep. of Chemistry & BiochemistryProf. Indig
Lehninger. Principles of Biochemistry.by Nelson and Cox, 5th Edition; W.H. Freeman and Company
Two conventions for naming fatty acids.
Fatty Acids
Stearic acid Oleic acid
The packing of fatty acids into stable aggregates
Glycerol and a triacylglycerol
Triacylglycerols provide stored energy and insulation
Fatty stores in cells
Guinea pig adipocytes Cotyledon cell from a seed of Arabidopsis
Fatty acid composition of three food fats
Many foods contain triacylglycerols
Waxes serve as energy stores and water repellents
Triacontanoylpalmitate
The major component of beeswax
Some common types of storage and membrane lipids
Glycerophospholipids
The backbone ofphospholipids
Some phospholipids have ether-linked fatty acids
Three glycolipids of chloroplast membranes
Galactolipids and
sulfolipids
Archaebacteria contain unique membrane lipids
Sphingolipids are derivatives of sphingosine
Sphingolipids at cell surfaces are sites of biological recognition
Glycosphingolipids as determinants of blood groups
Phospholipids and sphingolipids are degraded in lysosomes
The specificities of phospholipases
Abnormal ganglioside deposits in lysosomes (brain cell)
Tay-Sachs
Inherited human diseases resulting from abnormal accumulations of membrane lipids
Sterols have four fused carbon rings
Cholesterol
Arachidonic acid and some eicosanoid derivatives
Steroids derived from cholesterol
Vitamin D3 production and metabolism
a hormone that regulates Ca+2 uptake in the intestines and calcium levels in kidney and bones
Rickets
Gene SLC24A5Two variants
Difference: just one amino acid
Vitamin A1 and its precursor and derivatives
Isoprene structural unit
Some other biologically active isoprenoid compounds
involved in the formation ofactive prothrombin
fibrinogen fibrin
Wisconsin Alumni Research Foundation + arin
inhibits the formation of active prothrombin
Lipids as pigments in plants and bird feathers
Working with Lipids
Determination of the structure of a fatty acid by mass spectrometry
