ChemInform Abstract: Towards the Total Synthesis of FD-838: Modular Enantioselective Assembly of the...

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2008 Antibiotics U 1200 Towards the Total Synthesis of FD-838: Modular Enantioselective Assembly of the Core. — The spirobicyclic core of FD-838 is synthesized via a catalytic Stetter reaction as key transformation. Under optimized conditions using an aminoindanol derived pre- catalyst high yields and enantioselectivities could be obtained. — (ORELLANA, A.; ROVIS*, T.; Chem. Commun. (Cambridge) 2008, 6, 730-732; Dep. Chem., Colo. State Univ., Fort Collins, CO 80523, USA; Eng.) — M. Paetzel 25- 207

Transcript of ChemInform Abstract: Towards the Total Synthesis of FD-838: Modular Enantioselective Assembly of the...

2008

AntibioticsU 1200 Towards the Total Synthesis of FD-838: Modular Enantioselective Assembly of the

Core. — The spirobicyclic core of FD-838 is synthesized via a catalytic Stetter reaction as key transformation. Under optimized conditions using an aminoindanol derived pre-catalyst high yields and enantioselectivities could be obtained. — (ORELLANA, A.; ROVIS*, T.; Chem. Commun. (Cambridge) 2008, 6, 730-732; Dep. Chem., Colo. State Univ., Fort Collins, CO 80523, USA; Eng.) — M. Paetzel

25- 207