ChemInform Abstract: Stereoselective Synthesis of Non Symmetric Dihydroxyethylene Dipeptide...
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2000 furan derivatives furan derivatives R 0060 07 - 094 Stereoselective Synthesis of Non Symmetric Dihydroxyethylene Dipeptide Isosteres via Epoxyalcohols Derived from α-Amino Acids. — A novel approach to dihydroxyethylene isosteres potentially useful for new HIV-protease inhibitors is developed. Key step in the synthesis is a regio- and stereoselective reaction of the epoxyalcohol (I) with diethyl aluminum cyanide (II). — (BENEDETTI, FABIO; MAGNAN, MONICA; MIERTUS, STANISLAV; NORBEDO, STEFANO; PARAT, DJIANA; TOSSI, ALESSAN- DRO; Bioorg. Med. Chem. Lett. 9 (1999) 20, 3027-3030; Dip. Sci. Chim., Univ. Trieste, I-34127 Trieste, Italy; EN) 1
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Transcript of ChemInform Abstract: Stereoselective Synthesis of Non Symmetric Dihydroxyethylene Dipeptide...
![Page 1: ChemInform Abstract: Stereoselective Synthesis of Non Symmetric Dihydroxyethylene Dipeptide Isosteres via Epoxyalcohols Derived from α-Amino Acids.](https://reader030.fdocuments.net/reader030/viewer/2022020508/5750036f1a28ab11489922b0/html5/thumbnails/1.jpg)
2000 furan derivatives
furan derivativesR 0060
07 - 094Stereoselective Synthesis of Non Symmetric DihydroxyethyleneDipeptide Isosteres via Epoxyalcohols Derived from α-Amino Acids.— A novel approach to dihydroxyethylene isosteres potentially useful for newHIV-protease inhibitors is developed. Key step in the synthesis is a regio-and stereoselective reaction of the epoxyalcohol (I) with diethyl aluminumcyanide (II). — (BENEDETTI, FABIO; MAGNAN, MONICA; MIERTUS,STANISLAV; NORBEDO, STEFANO; PARAT, DJIANA; TOSSI, ALESSAN-DRO; Bioorg. Med. Chem. Lett. 9 (1999) 20, 3027-3030; Dip. Sci. Chim.,Univ. Trieste, I-34127 Trieste, Italy; EN)
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