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ChemInform Abstract: N-Aryltriazole Ribonucleosides with Potent Antiproliferative Activity Against...
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ChemInform 2010, 41, issue 40 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Nucleic acids U 0700 DOI: 10.1002/chin.201040209 N-Aryltriazole Ribonucleosides with Potent Antiproliferative Activity Against Drug-Resistant Pancreatic Cancer. — A variety of novel N-aryltriazole nucleosides is synthesized via Cu-mediated C—N cross-coupling of 3-aminotriazole ribonucleo- side and various aromatic boronic acids. Compounds (IVb) and (IVf) show increased apoptosis-related antiproliferative activity against the drug-resistant pancreatic cancer cell line MiaPaCa compared to the reference drug gemcitabine. — (LIU, Y.; XIA, Y.; FAN, Y.; MAGGIANI, A.; ROCCHI, P.; QU, F.; IOVANNA, J. L.; PENG*, L.; Bioorg. Med. Chem. Lett. 20 (2010) 8, 2503-2507, DOI:10.1016/j.bmcl.2010.02.104 ; Dep. Chem., CNRS, F-13288 Marseille, Fr.; Eng.) — H. Toeppel 40- 209
Transcript of ChemInform Abstract: N-Aryltriazole Ribonucleosides with Potent Antiproliferative Activity Against...
www.cheminform.wiley-vch.de
Nucleic acidsU 0700 DOI: 10.1002/chin.201040209
N-Aryltriazole Ribonucleosides with Potent Antiproliferative Activity Against Drug-Resistant Pancreatic Cancer. — A variety of novel N-aryltriazole nucleosides is synthesized via Cu-mediated C—N cross-coupling of 3-aminotriazole ribonucleo-side and various aromatic boronic acids. Compounds (IVb) and (IVf) show increased apoptosis-related antiproliferative activity against the drug-resistant pancreatic cancer cell line MiaPaCa compared to the reference drug gemcitabine. — (LIU, Y.; XIA, Y.; FAN, Y.; MAGGIANI, A.; ROCCHI, P.; QU, F.; IOVANNA, J. L.; PENG*, L.; Bioorg. Med. Chem. Lett. 20 (2010) 8, 2503-2507, DOI:10.1016/j.bmcl.2010.02.104 ; Dep. Chem., CNRS, F-13288 Marseille, Fr.; Eng.) — H. Toeppel
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ChemInform 2010, 41, issue 40 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
