ChemInform Abstract: Efficient Mono- and Bis-Functionalization of 3,6-Dichloropyridazine Using...
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ChemInform 2009, 40, issue 17 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Pyridazine derivatives R 0500 Efficient Mono- and Bis-Functionalization of 3,6-Dichloropyridazine Using (tmp) 2 Zn·2MgCl 2 ·2LiCl. — Dichloropyridazine (I) undergoes metalation using a neu- tral mixed-Zn complex base. The resulting bis-organozinc species reacts with various electrophiles, such as (III) and (V). Subsequent functionalization via a second metala- tion process can also be achieved. — (WUNDERLICH, S.; KNOCHEL*, P.; Chem. Commun. (Cambridge) 2008, 47, 6387-6389; Fachbereich Chem., Ludwig-Maximilians-Univ., D-81377 Muenchen, Germany; Eng.) — M. Paetzel 17- 157
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Transcript of ChemInform Abstract: Efficient Mono- and Bis-Functionalization of 3,6-Dichloropyridazine Using...
www.cheminform.wiley-vch.de
Pyridazine derivativesR 0500 Efficient Mono- and Bis-Functionalization of 3,6-Dichloropyridazine Using
(tmp)2Zn·2MgCl2·2LiCl. — Dichloropyridazine (I) undergoes metalation using a neu-tral mixed-Zn complex base. The resulting bis-organozinc species reacts with various electrophiles, such as (III) and (V). Subsequent functionalization via a second metala-tion process can also be achieved. — (WUNDERLICH, S.; KNOCHEL*, P.; Chem. Commun. (Cambridge) 2008, 47, 6387-6389; Fachbereich Chem., Ludwig-Maximilians-Univ., D-81377 Muenchen, Germany; Eng.) — M. Paetzel
17- 157
ChemInform 2009, 40, issue 17 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
