Chem 509 Signal Transduction Winter 2012
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Transcript of Chem 509 Signal Transduction Winter 2012
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Chem 509Signal Transduction
Winter 2012
Lecture 1
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6 general classes of receptors
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Ligand, agonist, antagonist
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Autocrine, paracrine, endocrine: three mechanisms of signaling cells
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Fight or Flight Response
http://monmouthfamilywellness.com/yahoo_site_admin/assets/images/fight-or-flight.107165735_std.jpg
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Cholera
Vibrio cholerae
http://geo.arc.nasa.gov/sge/health/sensor/diseases/cholera.html
http://blackminis.wordpress.com/2008/12/12/winter-brings-infection/
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AKAP: A kinaseanchoring protein
Protein Kinase A
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Termination of beta adrenergic signaling pathway:
1. Epinepherine concentration is lowered.2. GAP activity of Gs alpha (GTP converted to GDP)3. cAMP phosphodiesterase4. Phosphorylation of beta-adrenergic receptor
-kinase is beta-adrenergic receptor kinase(BARK)-also known as G protein-coupled receptor kinase 2
5. Association of phosphorylated beta-adrenergic receptor with arrestin. This is followed by receptor endocytosis.
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End of Lecture 1
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