Science and Innovation for FMD control & Response

Characteristics of Recent Foot-and-

Mouth Disease Outbreak in Korea

GFRA Scientific Meeting

Incheon, Korea / Oct. 25, 2017.

Hyunil Kim1, Won Hyung Lee2, Sang Chul Kang1, Sungho Shin1

1Optipharm Inc., Cheongju, Korea, 2XP Bio Inc., Anseong, Gyeonggi, Korea

History of FMD outbreak in Korea (2000-2010)

2000 2002 2010 (J) 2010(A)

Duration of Outbreak

23 Days 56 Days 28 Days 29 Days

2017-11-17 2

0

500000

1000000

1500000

2000000

2500000

3000000

3500000

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010JAN

2010APR

2010NOV

2011 2012 2013 2014JUL

2014DEC

2015 2016 2017

MAX : 56 Days

Strong and rapid preventive Stamping out

2017-11-17 3

History of FMD outbreak in Korea (2010-2011)

2000 2002 2010 (J) 2010(A) 2010(N)

Duration of Outbreak

23 Days 56 Days 28 Days 29 Days 145 Days

2017-11-17 4

0

500000

1000000

1500000

2000000

2500000

3000000

3500000

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010JAN

2010APR

2010NOV

2011 2012 2013 2014JUL

2014DEC

2015 2016 2017

Mistakes in early diagnosis

5

1

29

2

5

19

26

30

8

17

3

6

0

31

3

0

5

10

15

20

25

30

35

10.11.29.Level YELLOW

FMDConfirmed(2010.11.29.)

Suckling Piglets Death regarded as cupric toxicity

FMDV jumped over 200km!

Manuer Veihicle visited North Gyeongsang area

-. 2010.11.17. -. 2010.11.25.

Decided to vaccinate all over the country

8

1

29

2

5

19

26

30

8

17

3

6

0

31

3

0

5

10

15

20

25

30

35

10.11.29.Level YELLOW

FMDConfirmed(2010.11.29.)

10.12.15.Level ORANGE

VaccineIn Six

premises

VaccineOver the Country

10.12.29.Level RED

1st

Vaccinationcomplete

2nd

Vaccination complete

FMDV spreads to near premises rapidly

2017-11-17 9

0.0%

10.0%

20.0%

30.0%

40.0%

50.0%

60.0%

70.0%

80.0%

90.0%

100.0%

경기도 경상북도 경상남도 강원도 충청북도 충청남도 전라북도 한국양돈전체

Kyounggy

Kangwon

Chungbuk

KyoungbukChungnam

The farmer who travelled Vietnam was suspected

2017-11-17 10

2010. 11. 23 – First suspected report (FMD Ab test : Negative) 2010. 11. 25 : Manuer vehicle visted2010. 11. 26 – Second suspected report from different farm. 2010. 11. 28. – Confirmed FMD outbreak

2010. November

2010. 11. 02. Travel to Northern Vietnam

2010. 11. 07. Came back to Korea

Nov. 1

Nov. 8

Nov. 15.

Nov. 22.

Nov. 29.

2010.11.17. : Manuer vehicle visited

Korean FMDV showed closer homology with HKN Virus

2017-11-17 11

Korean Gov. suspected International travelers and Overseas workers

12

(Emerging infectious disease 20(12):2014 )

Disinfection for Korean Travelers (since Jul. 25. 2011)

13

Since Travellers disinfection….

2017-11-17 14

2010 2011 2012 2013 2014 2015 2016 2017

2017-11-17 15

Investigated over 37 times FMD outbreak in 14 European countries ‘85~’06.

The cause of 59.5% (22/37) cases were not clarified yet.

History of FMD outbreak in Korea

2000 2002 2010 (J) 2010(A) 2010(N)

Duration of Outbreak

23 Days 56 Days 28 Days 29 Days 145 Days

2017-11-17 16

0

500000

1000000

1500000

2000000

2500000

3000000

3500000

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010JAN

2010APR

2010NOV

2011 2012 2013 2014JUL

2014DEC

2015 2016 2017

FMD vaccination

FMD outbreak from 2014 to 2015

2017-11-17 17

33 Cities (7 Province)

185 Cases (Cattle 5, Pigs 180)

Poor vaccine matching

2017-11-17 18

Summary of FMD Outbreak in 2017

2017-11-17 19

1 Boeun (2.5)

2 Jeongeup (2.6)

3 Yeoncheon (2.8)

1 Daily Cow (2.5) 8 KNC (2.13)

9 KNC (2.13)

7 KNC (2.12)

6 KNC (2.12)

5 KNC (2.11) 4 KNC (2.9)

O/MESA/Ind2001

O/MESA/Ind2001

A/Asia/Sea-97

VIT/20/2016

What were the routes of FMD infection?

2017-11-17 20

VIT/14/2016VIT/16/2016

RUS/Zabaikalsky/3/2016RUS/Zabaikalsky/4/2016

We can suspect, but cannot confirm where they come from.

FMD ELISA S/P ratio

2017-11-17 21

5%

20%

52%

38%

76%

87% 86%

100%

23%30%

63.20% 65.20%

92.80%

0%

20%

40%

60%

80%

100%

120%

2/5/2017 2/6/2017 2/7/2017 2/8/2017 2/9/2017 2/10/2017 2/11/2017 2/12/2017 2/13/2017

SP ELISA Premise Avg.

Abnormal Meat occurrence after FMD vaccination

2017-11-17 22

Abnormal Meat detection rate in Slaughterhouse

2017-11-17 23

66%63%

44%

25%

0%

10%

20%

30%

40%

50%

60%

70%

Group 1 Group 2 Group 3 Group 4

USD 10.9 loss per pig (By Dr. HG Jeoung)

Summary

2017-11-17 24

0

500000

1000000

1500000

2000000

2500000

3000000

3500000

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010JAN

2010APR

2010NOV

2011 2012 2013 2014JUL

2014DEC

2015 2016 2017

MAX : 56 Days FMD vaccination

Vaccine matching

Thank you for attention!

2017-11-17 25