Chapter 3: Molecules of Life - Goodhue€¦ · with up to four atoms. structural formula for...
Transcript of Chapter 3: Molecules of Life - Goodhue€¦ · with up to four atoms. structural formula for...
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Chapter 3: Molecules of Life
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Organic Compounds
Hydrogen and other elements covalently
bonded to carbon
• Carbohydrates
• Lipids
• Proteins
• Nucleic Acids
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Carbon’s Bonding Behavior
Chemistry of Carbon
• Outer shell of carbon has 4 electrons; can hold 8
• Each carbon atom can form covalent bonds with up to four atoms
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structural formula
for methane
ball-and-stick model space-filling model
p.34b
Organic Compounds
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Bonding Arrangements
• Carbon atoms can form chains or rings
• Other atoms project from the carbon backbone
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Fig. 3-2, p.35
Organic Compounds
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Examples of Functional Groups
Hydroxyl group - OH
Amino group - NH3+
Carboxyl group - COOH
Phosphate group - PO3-
Sulfhydryl group - SH
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Functional Groups
• Atoms or clusters of atoms that are covalently bonded to carbon backbone
• Give organic compounds their different properties
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Fig. 3-4, p.36
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Condensation
Fig. 3-6a, p.38
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Hydrolysis
Fig. 3-6b, p.38
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Carbohydrates
Monosaccharides(simple sugars)
Oligosaccharides(short-chain carbohydrates)
Polysaccharides(complex carbohydrates)
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Monosaccharides
• Simplest carbohydrates
• Most are sweet tasting,
water soluble
• Most have 5- or 6-carbon
backbone
– Glucose (6 C)
– Fructose (6 C)
– Ribose (5 C)
– Deoxyribose (5 C)glucose fructose
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Disaccharides
• Type of oligosaccharide
• Two monosaccharidescovalently bonded
• Formed by condensation reaction + H2O
glucose fructose
sucrose
Fig. 3-7b, p.38
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Polysaccharides
• Straight or branched chains of many sugar
monomers
• Most common are composed entirely of
glucose
– Cellulose
– Starch (such as amylose)
– Glycogen
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Cellulose & Starch
• Differ in bonding patterns between monomers
• Cellulose - tough, indigestible, structural material in plants
• Starch - easily digested, storage form in plants
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Glycogen
• Sugar storage form in animals
• Large stores in muscle and liver cells
• When blood sugar decreases, liver cells degrade glycogen, release glucose
Fig. 3-9, p.38
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Lipids
• Most include fatty acids
– Fats
– Phospholipids
– Waxes
• Sterols (steriods) and their derivatives have no fatty acids
• Tend to be insoluble in water
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Fats
• Fatty acid(s) attached to glycerol
• Triglycerides are the most common fat
Fig. 3-12, p.40
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Three Fatty Acids
Fig. 3-11, p.40
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Fig. 3-12a, p.40
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Phospholipids
• Main components of cell membranes
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Sterols and Derivatives
• No fatty acids
• Rigid backbone of four
fused-together carbon
rings
• Cholesterol, estrogen,
testosterone - most
common type in
animals
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Amino Acid Structure
amino
group
carboxyl
group
R group
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Properties of Amino Acids
• Determined by the “R group”
• Amino acids may be:
– Non-polar
– Uncharged, polar
– Positively charged, polar
– Negatively charged, polar
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Protein Synthesis
• Protein is a chain of amino acids linked by
peptide bonds
• Peptide bond
– Type of covalent bond
– Links amino group of one amino acid with
carboxyl group of next
– Forms through condensation reaction
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Fig. 3-15c, p.42
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Fig. 3-15e, p.42
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Primary Structure
• Sequence of amino acids
• Unique for each protein
• Two linked amino acids = dipeptide
• Three or more = polypeptide
• Backbone of polypeptide has N atoms:
-N-C-C-N-C-C-N-C-C-N-
one
peptide
group
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Primary Structure
• Primary structure influences shape in two
main ways:
– Allows hydrogen bonds to form between
different amino acids along length of chain
– Puts R groups in positions that allow them to
interact
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Secondary Structure
• Hydrogen bonds form between different parts of polypeptide chain
• These bonds give rise to coiled or extended pattern
• Helix or pleated sheet
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Tertiary Structure
• Folding as a result of interactions between R groups
heme group
coiled and twisted
polypeptide chain of one
globin molecule
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Quaternary Structure
• Some proteins are made up of more than one polypeptide chain
Hemoglobin
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Nucleotide Structure
• Sugar
– Ribose or deoxyribose
• At least one phosphate group
• Base
– Nitrogen-containing
– Single or double ring structure
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Nucleotide Functions
• Energy carriers
• Coenzymes
• Chemical messengers
• Building blocks for nucleic acids
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DNA
• Double-stranded
• Consists of four types of nucleotides
• A bound to T
• C bound to G
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RNA
• Usually single strands
• Four types of nucleotides
• Unlike DNA, contains the base uracil in place
of thymine
• Three types are key players in protein
synthesis