Chapter 11 Polyprotic Acid and Bases. 2 Diprotic Acids Compounds with two acid/base groups Can be...
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Transcript of Chapter 11 Polyprotic Acid and Bases. 2 Diprotic Acids Compounds with two acid/base groups Can be...
Chapter 11
Polyprotic Acid and Bases
2
Diprotic Acids
Compounds with two acid/base groups
Can be two acids groups Oxalic Acid
Can be two basic groups Cadaverine
Or and acid and base group Amino acids
3
Oxalic Acid
HO
OH
O
O
4
Cadaverine
H2N NH2
5
Generic Amino Acid
H2N
OH
O
R
6
7
8
Amino Acids
H2L+ = HL = L2-
Glycine.HCl CAS 6000-43-7
Glycine CAS 56-40-6
Sodium Glycinate CAS 6000-44-8
9
Ionic Structures
Glycine HCl
+H3N
OH
O
Cl-
10
Sodium Glycinate
H2N
O-
O
Na+
11
Intermediate Form
+H3N
O-
O
H2N
OH
O
Zwitterion form
12
Constants
H2L+ = HL = L-
Ka1 Ka2
Kb2 Kb1
Ka1 * Kb2 = Kw
or Ka2 * Kb1 = Kw
13
How do we then calculate the pH’s
Acid Form H2L+
Treat was a weak monoprotic acid.
Base Form L-
Treat as a weak monoprotic base
14
Intermediate Form pH
These compounds can either gain a proton (work as a base) or they can donate a proton (work as an acid).
The magnitude of the K values will determine the pH.
The following equation can be derived …
15
Intermediate Form
][
][][
1
121
HLK
KKHLKKH w
16
Approximations
In many cases the K1Kw term will be much smaller than the other term in the numerator so the equation becomes:
Then often K1 will be much smaller than [HL] so we end up with:
21][ KKH
][
][][
1
121
HLK
KKHLKKH w
][
][][
1
21
HLK
HLKKH
17
Intermediate Form
Which when taken to the log form gives us.
pH = (pKa1 + pKa2)/2
18
Diprotic Buffer Systems
Same treatment as with monoprotic systems but we use the pKa that is between the two major forms that are in the solution.
19
Buffers
Phosphoric acid system H3PO4 and H2PO4
- use pKa1
H2PO4- and HPO4
2- use pKa2
HPO42- and PO4
3- use pKa3
20
Principle Species
Monoprotic
21
Principle Species
Diprotic Fumaric acid
22
Principle Species