Chapter 20 Viruses and Bacteria Section 1: Viruses Section 2: Bacteria.
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CHAPTER 10
Regulation of Gene Expression in Bacteria and Their Viruses
CHAPTER 10
Regulation of Gene Expression in Bacteria and Their Viruses
Copyright 2008 © W H Freeman and Company
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CHAPTER OUTLINE10.1 Gene regulation
10.2 Discovery of the lac system: negative control
10.3 Catabolite repression of the lac operon: positive control
10.4 Dual positive and negative control: the arabinose operon
10.5 Metabolic pathways and additional levels of regulation: attenuation
10.6 Bacteriophage life cycles: more regulators, complex operons
10.7 Alternative sigma factors regulate large sets of genes
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Regulatory proteins control transcription
Figure 10-2
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Allosteric effectors bind to regulatory proteins
Figure 10-3
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Repressor protein controls the lac operon
Figure 10-4
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Lactose is broken down into two sugars
Figure 10-5
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The lac operon is transcribed only in the presence of lactose
Figure 10-6a
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The lac operon is transcribed only in the presence of lactose
Figure 10-6b
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Structure of IPTG
Figure 10-7
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Table 10-1
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Operators are cis-acting
Figure 10-8
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Table 10-2
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Repressors are trans-acting
Figure 10-9
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Table 10-3
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The repressor contains a lactose-binding site
Figure 10-10
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RNA polymerase contacts the promoter at specific sequences
Figure 10-11
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The operator is a specific DNA sequence
Figure 10-12
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Glucose levels control the lac operon
Figure 10-13
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Glucose levels control the lac operon
Figure 10-13a
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Glucose levels control the lac operon
Figure 10-13b
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Many DNA binding sites are symmetrical
Figure 10-14
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Binding of CAP bends DNA
Figure 10-15
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CAP and RNA polymerase bind next to each other
Figure 10-16
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Negative and positive control of the lac operon
Figure 10-17
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Negative and positive control of the lac operon
Figure 10-17a
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Negative and positive control of the lac operon
Figure 10-17b
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Negative and positive control of the lac operon
Figure 10-17c
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Repression and activation compared
Figure 10-18
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Repression and activation compared
Figure 10-18a
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Repression and activation compared
Figure 10-18b
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Map of the ara operon
Figure 10-19
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AraC serves as an activator and as a repressor
Figure 10-20
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Gene order in the trp operon corresponds to reaction order in
the biosynthetic pathway
Figure 10-21
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The trp mRNA leader sequence contains an attenuator region
and two tryptophan codons
Figure 10-22
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Abundant tryptophan attenuates transcription of the trp operon
Figure 10-23
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Leader peptides of amino acid biosynthesis operons
Figure 10-24
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The life cycle of bacteriophage
Figure 10-25
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Phage genome is organized for coordinate control
Figure 10-26
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Figure 10-27
The lysogenic-versus-lytic cycle is determined by repressoroccupancy on the OR operators
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Helix-turn-helix is a common DNA-binding motif
Figure 10-28
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Amino acid side chains determine the specificity of DNA binding
Figure 10-29
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factors control clusters of unlinked genes
Figure 10-30a
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factors control clusters of unlinked genes
Figure 10-30b