Chap44 Diabetes insipidus and aquaporin (ADH, aldosterone and ACTH)
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Transcript of Chap44 Diabetes insipidus and aquaporin (ADH, aldosterone and ACTH)
B9902036 洪健睿B9902045 許仲皓
Frequency: uncommon, with a prevalence of 1 case per 25,000 population (as in the United States).
Signs and symptoms: polydipsia : extreme thirst (especially for cold or ice water)
polyuria : excretion of large amounts of severely diluted urine
Central (neurogenic) DI: decreased secretion of antidiuretic hormone (ADH) in the brain.
Nephrogenic DI: inability of the kidney to respond normally to ADH.
arginine vasopressin V2 receptor(AVPR2)
aquaporin-2 water channel (AQP2)
Acquired (most common)
Hereditary:Type Gene Locus
NDI 1 AVPR2
(a) X-linked genetic defect.(b) causes the arginine vasopressin receptor V2 receptor in the kidney to not function correctly.
NDI 2(rare)
AQP2
(a) Gene map locus : 12q13(b) mutation in the aquaporin 2 gene
impede the normal function of the kidney water channel
AQP2
The mutation of AQP2 gene causes: 1. misfolding of mutant aquaporin-2 water channels 2. unsuccessful AQP2 transition in the ER
transcription factor
intracellularreceptor
(steroid ligand)
epithelial sodium channel
sodium-potassium pump
ADH RAAS (aldosterone)
Secretionhypothalamus
ADHadrenal cortex aldosterone
Homeostasis blood osmolarityblood pressure, blood volume
Function
increases permeability
H2O reabsorption
Prevents furthur dehydration
increases Na+ reabsorption
passively reabsorbs H2O
Adrenal gland
Kidney
ex.Aldosterone
Anterior Pituitary Hormone Tropic Hormone: targets endocrine
glands adrenal cortex Adrenal Cortex: secretes corticosteroids glucocorticoids mineralocorticoids Severe stress rises the blood ACTH level
Campbell N. A., Reece J. B., and Mitchell L.G. Biology 8th ed. Benjamin/Cummings. 2008.
Campbell N. A and Reece J. B. 生物學第六版 (下冊 ), 偉明圖書有限公司 , 2007 http://emedicine.medscape.com/article/117648-overview http://www.bhp-gc.tw/index.php?
mo=DiseasePaper&action=paper1_show&cate=Set1&csn=72&sn=250 http://en.wikipedia.org/wiki/Nephrogenic_diabetes_insipidus#Hereditary http://www.ncbi.nlm.nih.gov/omim/304800 http://www.ndif.org/public/pages/1-Introduction http://zh.wikipedia.org/wiki/尿崩症 http://g.wanfangdata.com.hk/Service/File/File.ashx?
fileid=Periodical_zhszb98201004011&pay=True&sign=0A8EAE9400DDAA5203A42726CBDD22E85B7575C6103822BCD877A758592162722AC491A1DB9B07123F5CD4D5A7A5782BE6858C0B0B6968D94FF44170C015FDEE65ECAB4BDCC7B6C5B3E3B857B8315E20D21DD5F6E74EC8B3D3868FD9F27AE42B64A889ABCE3EEB8A2D878D765F72098D7A6DBEC837B3E53042DA4E6C7655B292&Type=
http://www.differencebetween.net/science/health/difference-between-adh-and-aldosterone/
http://en.wikipedia.org/wiki/Aldosterone http://hyper.ahajournals.org/content/vol52/issue4/cover.shtml