1st ALCW Abstracts/ Lung Cancer 10 (1994) 386-394 381

The clinical meaning of general survey for lung cancer

Yurun L, Zhenghui L

In Beijing General Hospital of the Railway Mini&y from 1975 to 1984, staffand workers with their families (4,000 - 5000, persons) were included in a general survey using X-ray and indirect film to investigate tuberculosis each year.

The results were as follows: abnormal shadow in the lungs represented, in descending order of incidence: (1) transient inflam- mations; (2) tuberculosis; (3) malignant tumor.

During the succeeding ten years, among 40,000-50,000 per- sons surveyed by histological methods, only two cases were found with confirmed squamous cell carcinoma and adenocarcinoma. respectively,

Therefore, it is concluded that such a general survey is not called for. Instead, we should survey those who are high-risk smokers, or have related symptoms, or suffer from tuberculosis or occupational diseases, such as silicosis.

An observation and study on the incidence and causes of NSCLC and XC.

Yurun L, Zhenghui L.

This report investigated the results in LYR clinic from 1985 to 1989. Among 244 patients with carcinomas, there were 2 12 cases (86.9%) of lung cancer and 32 cases (13.1%) of non-lung cancer. Among the 212 cases of lung cancer were 189 cases (89.2%) of NSCLC, and among the 189 NSCLC were 166 cases (87.6%) of xc. The distribution of SCC was as follows: 1) sex: male 148 cases (89.2%)

female 18 cases (10.8%) 2) occupation: drivers 89 cases (53.6%)

white collar 39 cases (23.5%) others 18 cases (22.9%)

3) living habit: smoking for over 20 years 123 cases (74.1%)

others 43 cases (25.9%) among them non-smoking persons II cases (6.6%)

The internal and external causes of SCC are genetic factors and smoking habit. Both are vital ones. Those whose family had a case history of cancer must give up smoking, especially drivers who must thoroughly drop this bad habit.

If so. the incidence of NSCLC can be controlled and. in particular, the incidence of SCC can be reduced.

Changes in cell populkionandtumor necrosis factor, interleukin- 6, andinterleuldn-8 inmalignant pleural effusions after treatment with intrapleural tetracycline.

Lin CC, Lin CY. Chest Division. Mackay Memorial Hospital. Taipei, Taiwan, R. 0. C.

To evaluate the changes in cellular components and cytokine levels (tumor necrosis factor, interleukin-6 (IL-6) and -8) before and after

intrapleural tetracycliie (TC) injection we evaluated 10 patient with malignant pleural effusion. Differential cell counts in the pleural fluid were obtained using cytocentrifuge preparations. Mononuclear cells from pleural fluid, collected before intmpleural injection of TC and on day 4, and days lo-14 after TC injection, were stimulated either with phytohaemagglutinin (PHA) or PI-IA plus phorbol m_yristic acetate. The production of tumor necrosis factor (TNF) and IL-8 was measured. In addition, IL-6 IL-S, and TNF from serial collections of pleural fluid in these patients were measured by RIAor ELISA. The main inflammatory cells in pleural ef&sions before therapy were lymphocytes and mononuclear cells, but neutrophils predominated after TC injection. IL-6, IL-8 and TNF were markedly increased on the 4th day afkr TC intrapleural injection and then decreased to baseline levels on the 14th day. The results suggest that TC intrapleural injection induces cytokine (IL- 6 and TNF) release, which are markers ofan inflammatory response and releases IL-8 which attracts neutrophils into the pleural space, which may be the mechanism of the sclerosing effect of TC.

Surgery for N, non-small cell lung cancer

Huang M-H, Shyu H-L, Huang M-S, Wang L-S, Huang B-S, Chien K-Y. Division of Thoracic Surgery, Department of Surgery, National Yang-Ming Medical College, Veterans General Hospi- tal-Taipei, Taipei, Taiwan. ROC.

A total of 175 N, patients between 1980 to 1992 in VGH-Taipei were reviewed in a retrospective manner. The most effective form oftreatment for lung cancer is surgical. The surgical intervention in the 175 patients studiedconsistedofpneumonectomy 74, bilobectomy 26, and lobectomy 75. Age distribution from 19 to 78-year-old with male predominance was noted. We found no difference of cell type for survival rate in N, disease. Surgical modalities were related to the survival. Lobectomy had less complications than bilobectomy and penumorectomy. In analyzing, no significant difference in survival between T,, T., and TX tumor was noted.

We detail our experience with the different surgical modalities of N, -non small cell lung cancer and the results achieved to date.

Is bilobectomy superior to lobectomy in treating non-small cell lung cancer (NSCLC) of the right lower lung field?

Cheng C-Y, Huang B-S. Huang M-S, Wang L-S, Huang M-H, Chien K-Y. Division ofrhoranc Surgery, Department ofsurgery. Veterans General Hospital-Taipei, Taiwan. ROC.

Lung cancer is a common cause of death in human beiigs and sur- gical intervention remains the treatment ofchoice for NSCLC. Cur- rently, radical lobectomy is the most frequently performed proce- dure. Under the concept of radical lymph nodes dissection and lymphatic sump of Bonie, bilobectomy for cancer of either middle or lower lobe was generally accepted.

From June 1980 to June 1992. 192 consecutive patients with right middle or lower lobe lung cancer underwent surgical treatment at Veterans General Hospital. Taipei, ROC. One hundred and thirty-five patients underwent bilobectomy or lobectomy. The numbers of patients receiving lobectomy were as follows: 50 stage I: 9 stage II: 10 stage III, and 5 stage N. Oftbe 6 1 patients receiving