Consensual gene co-expression network inference with multiple samples
CH.10 Statistical Inference for Two Samples · 2014-04-16 · CH.10 Statistical Inference for Two...
Transcript of CH.10 Statistical Inference for Two Samples · 2014-04-16 · CH.10 Statistical Inference for Two...
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CH.10 Statistical Inferencefor Two Samples
• Inference on the difference in means of twonormal distributions, variances known
• Inference on the difference in means of twonormal distributions, variances unknown
• Paired t-test• Inference on the variances of two normal
distributions• Inference on two population proportions
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10-1 Introduction
Two independent populations.
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
Assumptions
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known10-1.1 Hypothesis Tests for a Difference in Means, Variances Known
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
Example 10-1
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
Example 10-1
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
Example 10-1
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
10-1.2 Type II Error and Choice of Sample SizeUse of Operating Characteristic Curves
Two-sided orone-sided alternative:
Choose equal sample sizes, n=n1=n2If not possible: n1≠n2, compute equivalent value of n as follows
2 21 2
2 21 1 2 2
nn nσ σ
σ σ+
=+
make adjustment to n1 and n2 untilthe specified β is reached.
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
10-1.2 Type II Error and Choice of Sample SizeSample Size Formulas
Two-sided alternative:
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
10-1.2 Type II Error and Choice of Sample SizeSample Size Formulas
One-sided alternative:
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances KnownExample 10-3
1 2
2 2 2 21 2
0 10 0.888 8
dµ µ
σ σ
− −= = =
+ +
ALSO,with β=0.1, d=0.88, α=0.05from Appendix Chart VIIcn=n1=n2≈11
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known10-1.3 Confidence Interval on a Difference in Means, Variances KnownDefinition
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
Example 10-4
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
Example 10-4
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances Known
Choice of Sample Size
The required sample size so that the error in estimating µ1- µ2 bywill be less than E at 100(1-α)% confidence.1 2x x−
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10-1 Inference for a Difference in Means of Two Normal Distributions, Variances KnownOne-Sided Confidence Bounds
Upper Confidence Bound
Lower Confidence Bound
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown10-2.1 Hypotheses Tests for a Difference in Means, Variances Unknown
Case 1: 22
221 σ=σ=σ
We wish to test:
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown10-2.1 Hypotheses Tests for a Difference in Means, Variances Unknown
combine and to form an estimator of σ2
The pooled estimator of σ2:
Case 1: 222
21 σ=σ=σ
21S 2
2S
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown10-2.1 Hypotheses Tests for a Difference in Means, Variances Unknown
Case 1: 222
21 σ=σ=σ
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances UnknownDefinition: The Two-Sample or Pooled t-Test
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
Example 10-5
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
Example 10-5
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
Example 10-5
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
Example 10-5
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
Minitab Output for Example 10-5
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Normal probability plot: 1) normality assumption can be made.2) similar slopes indicate assumption of equal variances
Comparative box plot: no obvious difference in the two catalysts. However, catalyst 2 has slightly greater sample variability.
10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown10-2.1 Hypotheses Tests for a Difference in Means, Variances Unknown
22
21 σ≠σCase 2:
is distributed approximately as t distribution with degrees of freedom ν given by
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown10-2.1 Hypotheses Tests for a Difference in Means, Variances Unknown
22
21 σ≠σCase 2:
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances UnknownExample 10-6
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances UnknownExample 10-6 (Continued)
Figure 10-2 Normalprobability plot of the arsenic concentration data from Example 10-6.
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances UnknownExample 10-6 (Continued)
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances UnknownExample 10-6 (Continued)
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances UnknownExample 10-6 (Continued)
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
10-2.2 Type II Error and Choice of Sample Size
Case 1: 222
21 σ=σ=σ
Use operating characteristic curves in Appendix Charts VIIe, VIIf, VIIg, VIIh.
0
*
22 1
d
n nσ
∆ −∆=
= −
22
21 σ≠σCase 2:
No operating characteristic curves are available.
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
10-2.2 Type II Error and Choice of Sample Size
Example 10-7
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances UnknownMinitab Output for Example 10-7
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown10-2.3 Confidence Interval on the Difference in Means, Variance Unknown
Case 1: 222
21 σ=σ=σ
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
Case 1: 222
21 σ=σ=σ
Example 10-8
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
Case 1: 222
21 σ=σ=σ
Example 10-8 (Continued)
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
Case 1: 222
21 σ=σ=σ
Example 10-8 (Continued)
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown
Case 1: 222
21 σ=σ=σ
Example 10-8 (Continued)
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10-2 Inference for a Difference in Means of Two Normal Distributions, Variances Unknown10-2.3 Confidence Interval on the Difference in Means, Variance Unknown
Case 2: 22
21 σ≠σ
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10-4 Paired t-Test
• A special case of the two-sample t-tests of Section 10-2 occurs when the observations on the two populations of interest are collected in pairs.
• Each pair of observations, say (X1j , X2j ), is taken under homogeneous conditions, but these conditions may change from one pair to another.
• The test procedure consists of analyzing the differences on each pair.
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10-4 Paired t-Test
The Paired t-Test
1 2j j j
D
D X X
DS
= −
==
sample average of Djsample standard dev. of Dj
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10-4 Paired t-TestExample 10-9
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10-4 Paired t-TestExample 10-9
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10-4 Paired t-TestExample 10-9
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10-4 Paired t-Test
Paired Versus Unpaired Comparisons
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10-4 Paired t-Test
A Confidence Interval for µD
Definition
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Example 10-10
10-4 Paired t-Test
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10-4 Paired t-Test
Example 10-10
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10-5 Inferences on the Variances of Two Normal Populations
10-5.1 The F DistributionWe wish to test the hypotheses:
• The development of a test procedure for these hypotheses requires a new probability distribution, the F distribution.
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10-5 Inferences on the Variances of Two Normal Populations
10-5.1 The F Distribution
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10-5 Inferences on the Variances of Two Normal Populations
10-5.1 The F Distribution
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10-5 Inferences on the Variances of Two Normal Populations
10-5.1 The F Distribution
The lower-tail percentage points f1-α,u,ν can be found as follows.
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10-5 Inferences on the Variances of Two Normal Populations
10-5.2 Hypothesis Tests on the Ratio of Two Variances
2 21 1 1 1
2 22 2 2 2
( 1) ( 1)( 1) ( 1)
n S nFn S n
σσ
− −=
− −
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10-5 Inferences on the Variances of Two Normal Populations
10-5.2 Hypothesis Tests on the Ratio of Two Variances
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10-5 Inferences on the Variances of Two Normal Populations
Example 10-11
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10-5 Inferences on the Variances of Two Normal Populations
Example 10-11
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10-5 Inferences on the Variances of Two Normal Populations
Example 10-11
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10-5 Inferences on the Variances of Two Normal Populations
10-5.3 Type II Error and Choice of Sample Size
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10-5 Inferences on the Variances of Two Normal Populations
Example 10-12
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10-5 Inferences on the Variances of Two Normal Populations
10-5.4 Confidence Interval on the Ratio of Two Variances
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10-5 Inferences on the Variances of Two Normal Populations
Example 10-13
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10-5 Inferences on the Variances of Two Normal Populations
Example 10-13
n1=11n2=16
1
2
0.678 1.832σσ
≤ ≤ [it includes 1, so cannot claimthat the two standard deviationsare different at 90% confidence.]
0.95,15,100.05,10,15
1 1where 0.392.54f f= = =
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10-6 Inference on Two Population Proportions
10-6.1 Large-Sample Test on the Difference in Population Proportions
We wish to test the hypotheses:
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10-6 Inference on Two Population Proportions
10-6.1 Large-Sample Test on the Difference in Population Proportions
The following test statistic is distributed approximately as standard normal and is the basis of the test:
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10-6 Inference on Two Population Proportions
10-6.1 Large-Sample Test on the Difference in Population Proportions
1 2
1 2
ˆwhere X XPn n+
=+
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10-6 Inference on Two Population Proportions
Example 10-14
Placebo: yalancı ilaçSt. John’s wort: sarı kantaron
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10-6 Inference on Two Population Proportions
Example 10-14
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10-6 Inference on Two Population Proportions
Example 10-14
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10-6 Inference on Two Population Proportions
Minitab Output for Example 10-14
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10-6 Inference on Two Population Proportions
10-6.2 Type II Error and Choice of Sample Size
1 2
1 1 2 2ˆ ˆ
1 2
1 1 2 2 1 1 2 2
1 2 1 2
(1 ) (1 )
(1 ) (1 ) and
P P
p p p pn n
n p n p n p n pp qn n n n
σ−
− −= +
+ − + −= =
+ +
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10-6 Inference on Two Population Proportions
10-6.2 Type II Error and Choice of Sample Size
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10-6 Inference on Two Population Proportions
10-6.2 Type II Error and Choice of Sample Size
1 2n n n= =
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10-6 Inference on Two Population Proportions
10-6.3 Confidence Interval on the Difference in the Population Proportions
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10-6 Inference on Two Population Proportions
Example 10-15
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10-6 Inference on Two Population Proportions
Example 10-15