第二节 糖和苷的分类 糖类物质根据其能否水解和分子量的大小分为 单糖、低聚糖和多糖 一、单糖类( monosaccharide )
疾患にリンクした 膜タンパク質の 糖ペプチド抗原 …ECL2の糖鎖修飾部位数...
Transcript of 疾患にリンクした 膜タンパク質の 糖ペプチド抗原 …ECL2の糖鎖修飾部位数...
GlyPAdoc™リスト
1. GPCR編_1.0.
疾患にリンクした膜タンパク質の
糖ペプチド抗原ラインアップ
GlyPAdoc™は、さまざまな疾患とリンクする膜タンパク質の細胞外糖鎖修飾部位情報をもとに、抗原糖ペプチドをデザインしラインアップしたものです。本リストは、疾患、ターゲット膜タンパク質、糖鎖修飾部位に関する情報をリストアップいたしました。
凡例GlyPAdoc™シリーズ第1弾として、G-タンパク質共役受容体 (GPCR) 編リスト-PDF版 をお届けします。
Reference no.GA- : GPCR Class AGB- : GPCR Class BGC- : GPCR Class CGD- : adhesion GPCR
ターゲット分子 : GPCR
Nの次ぎ数字はN末端の糖鎖修飾部位数を表します。
Lの次の数字はECLの糖鎖修飾部位数を表します。
( )内の数字は、ECL1の糖鎖修飾部位数 例(12)はECL1に2部位ECL2の糖鎖修飾部位数 例(23)はECL2に3部位ECL3の糖鎖修飾部位数 例(31)はECL3に1部位
PDFの検索機能で、疾患領域、対象疾患、ターゲット分子、および糖鎖修飾の単語からご自由に検索することができます。
GPRC
疾患領域
CV GIIDInfKMNsObOncOp OtoR Ur Mis
循環器消化器免疫・皮膚感染腎臓代謝ニューロサイエンス産科オンコロジー眼科耳鼻咽喉科呼吸器泌尿器その他
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遺伝子名 名称 リガンド 糖鎖修飾
CV アテローム血栓症 PAR4 Protease-activated receptor-4
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L0 GA- 0072
CV アテローム性動脈硬化症 LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
CV アテローム性動脈硬化症 EDG5/S1P2Sphingosine-1-phosphate receptor
2
Lysosphingolipid sphingosine 1-
phosphateN1-L0 GA- 0029
CV アテローム性動脈硬化症BLT1/GPR16/P2
RY7
Leukotriene B4 receptor 1
Chemoattractant receptor-like 1
P2Y7
Leukotriene B4, extracellular ATP
> UTP and ADPN1-L1(21) GA- 0033
CV アテローム性動脈硬化症 GPR176G-protein coupled receptor 176
HB-954
Orphan, involved in normal
circadian rhythm behaviorN4-L0 GA- 0042
CV アテローム性動脈硬化症 GPR132/GA-2Probable G-protein coupled
receptor 132Proton N2-L0 GA- 0194
CVアテローム性動脈硬化症に
よる炎症
GPER1/CEPR/
CMKRL2/DRY12/
GPER/GPR30
G-protein coupled estrogen
receptor 1
G-protein coupled receptor 30
17-beta-estradiol (E2) N3-L0 GA- 0010
CV 虚血, 脳卒中 GPR39 G-protein coupled receptor 39 Orphan, Zn2+ acts as an agonist N0-L3(23) GA- 0066
CV 虚血性心疾患 GPR68/OGR1Ovarian cancer G-protein coupled
receptor 1Proton N2-L0 GA- 0196
CV 血圧, 脳卒中 AVPR1AVasopressin V1a receptor
Antidiuretic hormone receptor 1aArginine vasopressin N2-L0 GA- 0051
CV遺伝性血管浮腫, 虚血時の
組織保護BDKRB2
B2 bradykinin receptor
BK-2 receptorBradykinin N2-L1(21) GA- 0074
CV 血栓塞栓症 BAI3/ADGRB3
Adhesion G protein-coupled
receptor B3
Brain-specific angiogenesis
inhibitor 3
Orphan N13-L11(11) GD- 0144
疾患領域 対象疾患ターゲット分子 Reference
no.
1
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
CV 高血圧症ADRA1A/ADRA1
C
Alpha-1A adrenergic receptor
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Catecholamine N3-L0 GA- 0094
CV 高血圧症ADRB2/ADRB2R
/ B2AR
Beta-2 adrenergic receptor
Beta-2 adrenoreceptorCatecholamine N2-L1(21) GA- 0097
CV 高血圧症
AGTR1/AGTR1A/
AGTR1B/AT2R1/
AT2R1B
Type-1 angiotensin II receptor,
AT1Angiotensin II N1-L2(22) GA- 0099
CV 循環器疾患
GPER1/CEPR/
CMKRL2/DRY12/
GPER/GPR30
G-protein coupled estrogen
receptor 1
G-protein coupled receptor 30
17-beta-estradiol (E2) N3-L0 GA- 0010
CV 循環器疾患 GPR22Probable G-protein coupled
receptor 22Orphan N1-L1(21) GA- 0107
CV 心筋症, 心筋炎ADRB1/ADRB1R
/ B1AR
Beta-1 adrenergic receptor
Beta-1 adrenoreceptorCatecholamine N1-L0 GA- 0096
CV 心肥大GPR37L1 (ETBR-
LP-2)
Prosaposin receptor GPR37L1
Endothelin B receptor-like protein
2
The neuroprotective and
glioprotective factor prosaposinN6(N1O5)-L0 GA- 0076
CV 心肥大 GPR132/GA-2Probable G-protein coupled
receptor 132Proton N2-L0 GA- 0194
CV 心不全ADRB1/ADRB1R
/ B1AR
Beta-1 adrenergic receptor
Beta-1 adrenoreceptorCatecholamine N1-L0 GA- 0096
CV 心不全
AGTR1/AGTR1A/
AGTR1B/AT2R1/
AT2R1B
Type-1 angiotensin II receptor,
AT1Angiotensin II N1-L2(22) GA- 0099
CV 心弁膜症 HTR2B 5-hydroxytryptamine receptor 2B 5-hydroxytryptamine (serotonin) N1-L2(21-31) GA- 0058
CV低ナトリウム血症を伴う心
不全AVPR2 Vasopressin V2 receptor Arginine vasopressin N1-L0 GA- 0053
2
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
CV 脳卒中 LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
CV 脳卒中 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
CV 脳卒中 PAR1 Protease-activated receptor-1
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L1(21) GA- 0069
CV 敗血症 EDG3/S1P3Sphingosine-1-phosphate receptor
3
Lysosphingolipid sphingosine 1-
phosphateN1-L0 GA- 0030
CV 敗血症 AVPR1AVasopressin V1a receptor
Antidiuretic hormone receptor 1aArginine vasopressin N2-L0 GA- 0051
CV 敗血症,全身性炎症 ADGRE2/EMR2
Adhesion G protein-coupled
receptor E2
EGF-like module receptor 2
Chondroitin sulfate N8-L0 GD- 0155
CV 肺高血圧症EDNRA/ETA/ETR
A
Endothelin-1 receptor
Endothelin receptor type A, ETA-REndothelin-1 N2-L1(21) GA- 0101
CV 不整脈ADRB1/ADRB1R
/ B1AR
Beta-1 adrenergic receptor
Beta-1 adrenoreceptorCatecholamine N1-L0 GA- 0096
GI 肝疾患, 肝硬変 AVPR2 Vasopressin V2 receptor Arginine vasopressin N1-L0 GA- 0053
GI 肝虚血による再かん流障害 GPR3112-(S)-hydroxy-5,8,10,14-
eicosatetraenoic acid receptor
12-(S)-hydroxy-5,8,10,14-
eicosatetraenoic acid (12HETE)N1-L1(21) GA- 0011
GI 肝硬変 ADGRE2/EMR2
Adhesion G protein-coupled
receptor E2
EGF-like module receptor 2
Chondroitin sulfate N8-L0 GD- 0155
GI 肝硬変ADGRF1/GPR110
/ PGR19
Adhesion G-protein coupled
receptor F1
G protein-coupled receptor 110
Orphan N17-L2(22) GD- 0170
3
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
GI 肝疾患 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
GI 肝疾患BLT1/GPR16/P2
RY7
Leukotriene B4 receptor 1
P2Y7
Leukotriene B4, extracellular ATP
> UTP and ADPN1-L1(21) GA- 0033
GI肝疾患
肝硬変
GPCR19/TGR5/G
PBAR
G-protein coupled bile acid
receptor 1
G-protein coupled receptor
GPCR19
Bile acid N1-L2(11-21) GA- 0009
ID アジソン病 GPR174Probable G-protein coupled
receptor 174Prines N1-L1(21) GA- 0025
ID 炎症 GPR32Probable G-protein coupled
receptor 32Orphan N1-L1(21) GA- 0137
ID クローン病 LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
ID クローン病 PAR2 Protease-activated receptor-2
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L1(21) GA- 0070
ID クローン病 MAS1/MAS Proto-oncogene Mas Angiotensin 1-7 N3-L0 GA- 0131
ID クローン病 CCR9/GPR28C-C chemokine receptor type 9
G-protein coupled receptor 28Chemokine SCYA25/TECK N1-L0 GA- 0084
ID シェーングレン症候群 CHRM3Muscarinic acetylcholine receptor
M3Muscarine, acetylcholine N5-L0 GA- 0046
ID 自己免疫疾患GPR83/GPR72/
KIAA1540
Probable G-protein coupled
receptor 83
G-protein coupled receptor 72
Orphan N2-L1(11) GA- 0138
ID バセドウ病 GPR174Probable G-protein coupled
receptor 174Prines N1-L1(21) GA- 0025
ID バセドウ病 CHRM2Muscarinic acetylcholine receptor
M2Muscarine, acetylcholine N4-L0 GA- 0045
4
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
IDバセドウ病 (甲状腺眼
症)TSHR
Thyroid stimulating hormone
receptor
Thyrotropin receptor
Thyroid-stimulating hormone
(TSH) or thyrotropin.N6-L0 GB- 0068
ID リウマチ様関節炎 LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
ID リウマチ様関節炎 EDG2/LPA1Lysophosphatidic acid receptor 1
LPA-1Lysophosphatidic acid (LPA) N2-L1(21) GA- 0037
ID リウマチ様関節炎 PAR2 Protease-activated receptor-2
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L1(21) GA- 0070
ID リウマチ様関節炎 PAR4 Protease-activated receptor-4
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L0 GA- 0072
ID リウマチ様関節炎C5AR1/C5AR/C5
R1
C5a anaphylatoxin chemotactic
receptor 1, C5a-RC5a N1-L0 GA- 0087
ID リウマチ様関節炎 CCRL2 C-C chemokine receptor-like 2 CCL19 and chemerin/RARRES2 N1-L0 GA- 0139
ID 炎症性疾患CNR2/CB2A/CB2
B
Cannabinoid receptor 2
CB2
Endocannabinoid 2-
arachidonoylglycerolN1-L0 GA- 0027
ID 炎症性腸疾患 LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
ID 炎症性腸疾患 GPR35G-protein coupled receptor 35
kynurenic acid receptorKynurenic acid N1-L0 GA- 0012
ID 炎症性腸疾患 EDG1/S1P1Sphingosine-1-phosphate receptor
1
Lysosphingolipid sphingosine 1-
phosphateN2-L0 GA- 0028
ID 炎症性腸疾患 GPR39 G-protein coupled receptor 39Orphan, Zn2+ acts as an agonist,
obestatinN0-L3(23) GA- 0066
ID 炎症性腸疾患 PAR2 Protease-activated receptor-2
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L1(21) GA- 0070
ID 炎症性腸疾患 CCR9/GPR28C-C chemokine receptor type 9
G-protein coupled receptor 28Chemokine SCYA25/TECK N1-L0 GA- 0084
5
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
ID 炎症性腸疾患 MAS1/MAS Proto-oncogene Mas Angiotensin 1-7 N3-L0 GA- 0131
ID 炎症性腸疾患 GPR68/OGR1Ovarian cancer G-protein coupled
receptor 1Proton N2-L0 GA- 0196
ID 乾癬 EDG1/S1P1Sphingosine-1-phosphate receptor
1
Lysosphingolipid sphingosine 1-
phosphateN2-L0 GA- 0028
ID 乾癬 EDG2/LPA1Lysophosphatidic acid receptor 1
LPA-1Lysophosphatidic acid (LPA) N2-L1(21) GA- 0037
ID 関節炎 EDG1/S1P1Sphingosine-1-phosphate receptor
1
Lysosphingolipid sphingosine 1-
phosphateN2-L0 GA- 0028
ID 関節炎BLT1/GPR16/P2
RY7
Leukotriene B4 receptor 1
Chemoattractant receptor-like 1
P2Y7
Leukotriene B4, extracellular ATP
> UTP and ADPN1-L1(21) GA- 0033
ID 関節炎 BLT2 Leukotriene B4 receptor 2 Leukotriene B4 N1-L0 GA- 0034
ID 関節炎 CD97 CD97 antigen Orphan N9-L0 GD- 0153
ID自己免疫性多腺性内分泌不
全症
CASR/GPRC2A/P
CAR1
Extracellular calcium-sensing
receptor, CaR, CaSR
Parathyroid cell calcium-sensing
receptor 1, PCaR1
Calcium N11-L0 GC- 0185
ID 線維症 MAS1/MAS Proto-oncogene Mas Angiotensin 1-7 N3-L0 GA- 0131
ID 全身性エリテマトーデス HTR45-hydroxytryptamine receptor 4,
5-HT4, Serotonin receptor 45-hydroxytryptamine (serotonin) N1-L1(21) GA- 0102
ID 全身性エリテマトーデスCXCR5/BLR1/MD
R15C-X-C chemokine receptor type 5 B-lymphocyte chemoattractant N1-L1(21) GA- 0086
ID 潰瘍性大腸炎 GPR39 G-protein coupled receptor 39Orphan, Zn2+ acts as an agonist,
obestatinN0-L3(23) GA- 0066
ID 潰瘍性大腸炎 MAS1/MAS Proto-oncogene Mas Angiotensin 1-7 N3-L0 GA- 0131
ID潰瘍性大腸炎, 炎症性腸疾
患CCR5/CMKBR5 C-C chemokine receptor type 5 CC-chemokines N4(O4)L1(31) GA- 0083
6
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Inf EBウイルス感染症 GPR183/EBI2
G-protein coupled receptor 183
Epstein-Barr virus-induced G-
protein coupled receptor 2
Oxysterol 7-alpha,25-
dihydroxycholesterol (7-alpha,25-
OHC)
N1-L0 GA- 0008
Inf HIV, 移植片対宿主病 CCR5/CMKBR5 C-C chemokine receptor type 5 CC-chemokines N4(O4)L1(31) GA- 0083
K 腎線維症 EDG2/LPA1Lysophosphatidic acid receptor 1
LPA-1Lysophosphatidic acid (LPA) N2-L1(21) GA- 0037
K糸球体腎炎
慢性腎疾患PAR1 Protease-activated receptor-1
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N3-L2(22) GA- 0069
K 腎疾患 EDG1/S1P1Sphingosine-1-phosphate receptor
1
Lysosphingolipid sphingosine 1-
phosphateN2-L0 GA- 0028
K腎疾患
腸管内菌叢GPR43/FFA2 Free fatty acid receptor-2 Short chain fatty acids N0-L2(22) GA- 0016
K 糖尿病性腎症 AVPR2 Vasopressin V2 receptor Arginine vasopressin N1-L0 GA- 0053
K 慢性腎疾患 EDG5/S1P2Sphingosine-1-phosphate receptor
2
Lysosphingolipid sphingosine 1-
phosphateN1-L0 GA- 0029
K 慢性腎疾患 EDG2/LPA1Lysophosphatidic acid receptor 1
LPA-1Lysophosphatidic acid (LPA) N2-L1(21) GA- 0037
K 慢性腎疾患 AVPR2 Vasopressin V2 receptor Arginine vasopressin N2-L0 GA- 0053
K 慢性腎疾患 EDNRB/ETRB
Endothelin receptor type B, ETB-R
Endothelin receptor non-selective
type
Endothelin N1-L0 GA- 0141
K 慢性腎疾患CASR/GPRC2A/P
CAR1
Extracellular calcium-sensing
receptor, CaR, CaSR
Parathyroid cell calcium-sensing
receptor 1, PCaR1
Calcium N11-L0 GC- 0185
K慢性腎疾患
(慢性アシドーシス)GPR4
G-protein coupled receptor 4
G-protein coupled receptor 19Proton N1-L1(21) GA- 0043
7
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
M 2型糖尿病 GPR18 N-arachidonyl glycine receptorEndocannabinoid, N-arachidonyl
glycineN1-L0 GA- 0007
M 2型糖尿病 EDG5/S1P2Sphingosine-1-phosphate receptor
2
Lysosphingolipid sphingosine 1-
phosphateN1-L0 GA- 0029
M 2型糖尿病 GHSRGrowth hormone secretagogue
receptor type 1
Ghrelin, a small peptide with 28
amino acidsN3-L0 GA- 0065
M 2型糖尿病 T1R3 Taste receptor type 1 member 3 Umami taste stimulus N8-L0 GC- 0067
M 2型糖尿病 PAR4 Protease-activated receptor-4
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L0 GA- 0072
M 2型糖尿病 GPR146Probable G-protein coupled
receptor 146Orphan N1-L0 GA- 0077
M 2型糖尿病 GC-GR Glucagon receptor, GL-R Glucagon N4-L0 GB- 0091
M 2型糖尿病 GLP1R Glucagon-like peptide 1 receptor Glucagon-like peptide 1 (GLP-1) N3-L0 GB- 0092
M 2型糖尿病 GIPR
Gastric inhibitory polypeptide
receptor
Glucose-dependent insulinotropic
polypeptide receptor
Gastric inhibitory polypeptide (GIP) N2-L0 GB- 0093
M 2型糖尿病ADRA1A/ADRA1
C
Alpha-1A adrenergic receptor
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Catecholamine N3-L0 GA- 0094
M 2型糖尿病 GPR21Probable G-protein coupled
receptor 21Orphan N2-L0 GA- 0106
M 2型糖尿病 SSTR1Somatostatin receptor type 1
SRIF-2Somatostatin N3-L0 GA- 0186
M 2型糖尿病 SSTR2Somatostatin receptor type 2
SRIF-1Somatostatin-14 and -28 N4-L0 GA- 0187
8
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
M 2型糖尿病GPCR19/TGR5/G
PBAR
G-protein coupled bile acid
receptor 1
G-protein coupled receptor
GPCR19
Bile acid N1-L2(11-21) GA- 0009
M 2型糖尿病 GPR55 G-protein coupled receptor 55 L-a-lysophosphatidylinositol N1-L1(21) GA- 0013
M 2型糖尿病 GPR40/FFA1 Free fatty acid receptor-1Saturated and unsaturated fatty
acidsN0-L1(21) GA- 0015
M 2型糖尿病 GPR43/FFA2 Free fatty acid receptor-2 Short chain fatty acids N0-L2(22) GA- 0016
M 2型糖尿病 PAR1 Protease-activated receptor-1
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N3-L2(22) GA- 0069
M 2型糖尿病 PAR2 Protease-activated receptor-2
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L1(21) GA- 0070
M 2型糖尿病 GPR56/ADGRG1Adhesion G-protein coupled
receptor G1Collagen III/COL3A1 N7-L0 GD- 0145
M 2型糖尿病 GPRC6AG-protein coupled receptor family
C group 6 member A, GPRC33
Basic amino acids, osteocalcin,
testosteroneN3-L1(21) GC- 0184
M2型糖尿病
肥満, 食欲障害GPR120/FFR4 Free fatty acid receptor-4
Saturated and unsaturated fatty
acidsN1-L0 GA- 0018
M 2型糖尿病に関連した肥満 GPR39 G-protein coupled receptor 39Orphan, Zn2+ acts as an agonist,
obestatinN0-L3(23) GA- 0066
M 糖尿病CASR/GPRC2A/P
CAR1
Extracellular calcium-sensing
receptor, CaR, CaSR
Parathyroid cell calcium-sensing
receptor 1, PCaR1
Calcium N11-L0 GC- 0185
M メタボリック症候群 GPRC6AG-protein coupled receptor family
C group 6 member A, GPRC33
Basic amino acids, osteocalcin,
testosteroneN3-L1(21) GC- 0184
M 高脂血症 T1R3 Taste receptor type 1 member 3 Umami taste stimulus N8-L0 GC- 0067
9
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
M食欲障害
肥満T1R3 Taste receptor type 1 member 3 Umami taste stimulus N8-L0 GC- 0067
M 糖尿病 GPR27/SREB1
Probable G-protein coupled
receptor 27
Super conserved receptor
expressed in brain 1
Orphan N1-L0 GA- 0116
M 肥満 GPR3/ACCA G-protein coupled receptor 3 Orphan N1-L0 GA- 0006
M 肥満 GPR18 N-arachidonyl glycine receptorEndocannabinoid, N-arachidonyl
glycineN1-L0 GA- 0007
M 肥満 GPR12 G-protein coupled receptor 12 Orphan N2-L0 GA- 0021
M 肥満 GPR24/MCHR1Melanin-concentrating hormone
receptor 1Melanin-concentrating hormone N3-L0 GA- 0054
M 肥満 HTR2C 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine (serotonin) N1-L2(22) GA- 0056
M 肥満 GPR7
Neuropeptides B/W receptor type
1
G-protein coupled receptor 7
Neuropeptides B and W
Interacts specifically with a
number of opioid ligands
N3-L0 GA- 0059
M 肥満 GHSRGrowth hormone secretagogue
receptor type 1
Ghrelin, a small peptide with 28
amino acidsN3-L0 GA- 0065
M 肥満 TSHR
Thyroid stimulating hormone
receptor
Thyrotropin receptor
Thyroid-stimulating hormone
(TSH) or thyrotropin.N6-L0 GB- 0068
M 肥満 PAR4 Protease-activated receptor-4
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L0 GA- 0072
M 肥満 GLP1R Glucagon-like peptide 1 receptor Glucagon-like peptide 1 (GLP-1) N3-L0 GB- 0092
M 肥満 GIPR
Gastric inhibitory polypeptide
receptor
Glucose-dependent insulinotropic
polypeptide receptor
Gastric inhibitory polypeptide (GIP) N2-L0 GB- 0093
10
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
M 肥満ADRB3/ADRB3R
/B3AR
Beta-3 adrenergic receptor
Beta-3 adrenoreceptorCatecholamine N2L0 GA- 0098
M 肥満 GPR82Probable G-protein coupled
receptor 82Orphan N2-L0 GA- 0112
M 肥満 GPR97/PGR26
Adhesion G protein-coupled
receptor G3
G-protein coupled receptor 97
Orphan N3-L1(21) GD- 0146
M 肥満GPCR19/TGR5/G
PBAR
G-protein coupled bile acid
receptor 1
G-protein coupled receptor
GPCR19
Bile acid N1-L2(11-21) GA- 0009
M 肥満 GPR55 G-protein coupled receptor 55 L-a-lysophosphatidylinositol N1-L1(21) GA- 0013
M 肥満 GPR43/FFA2 Free fatty acid receptor-2 Short chain fatty acids N0-L2(22) GA- 0016
M 肥満 GPR41/FFR3 Free fatty acid receptor-3 Short chain fatty acids N0-L1(21) GA- 0017
M 肥満 GPR23/LPAR4 Lysophosphatidic acid receptor 4 Lysophosphatidic acid (LPA) N3-L1(21) GA- 0022
M 肥満 GPR92/LPAR5 Lysophosphatidic acid receptor 5 Lysophosphatidic acid (LPA) N2-L0 GA- 0023
M 肥満 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
M 肥満 PAR1 Protease-activated receptor-1
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N3-L2(22) GA- 0069
Mis woolly hair/ 減毛症 LPA6/P2Y5Lysophosphatidic acid receptor 6
P2Y5
Lysophosphatidic acid (LPA)
oleoyl-L-alpha-LPAN1-L0 GA- 0005
Mis 好酸球性疾患ADGRE1/EMR1/T
M7LN3
Adhesion G protein-coupled receptor
E1 EGF-like module-containing mucin-
like hormone receptor-like 1
Orphan N12-L0 GD- 0154
11
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Mis ホットフラッシュ CALCRL/CGRPR
Calcitonin gene-related peptide
type 1 receptor, CGRP type 1
receptor
Calcitonin receptor-like receptor
Calcitonin-gene-related peptide
(CGRP), Adrenomedullin together
with RAMP3
N3-L0 GB- 0089
Mis 骨粗しょう症 LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
Mis 骨粗しょう症 GPR183/EBI2
G-protein coupled receptor 183
Epstein-Barr virus-induced G-
protein coupled receptor 2
Oxysterol 7-alpha,25-
dihydroxycholesterol (7-alpha,25-
OHC)
N1-L0 GA- 0008
Mis 骨粗しょう症
GPER1/CEPR/
CMKRL2/DRY12/
GPER/GPR30
G-protein coupled estrogen
receptor 1
G-protein coupled receptor 30
17-beta-estradiol (E2) N3-L0 GA- 0010
Mis 骨粗しょう症 GPR55 G-protein coupled receptor 55 L-a-lysophosphatidylinositol N1-L1(21) GA- 0013
Mis 骨粗しょう症 GPR40/FFA1 Free fatty acid receptor-1Saturated and unsaturated fatty
acidsN0-L1(21) GA- 0015
Mis 骨粗しょう症 GPR120/FFR4 Free fatty acid receptor-4Saturated and unsaturated fatty
acidsN1-L0 GA- 0018
Mis 骨粗しょう症 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
Mis 骨粗しょう症CNR2/CB2A/CB2
B
Cannabinoid receptor 2
CB2
Endocannabinoid 2-
arachidonoylglycerolN1-L0 GA- 0027
Mis 骨粗しょう症 EDG1/S1P1Sphingosine-1-phosphate receptor
1
Lysosphingolipid sphingosine 1-
phosphateN2-L0 GA- 0028
Mis 骨粗しょう症 BLT2 Leukotriene B4 receptor 2 Leukotriene B4 N1-L0 GA- 0034
Mis 骨粗しょう症 TSHR
Thyroid stimulating hormone
receptor
Thyrotropin receptor
Thyroid-stimulating hormone
(TSH) or thyrotropin.N6-L0 GB- 0068
Mis 骨粗しょう症 CALCR Calcitonin receptor Calcitonin N4-L0 GB- 0088
12
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Mis 骨粗しょう症 GPR65/TDAG8
Psychosine receptor
G-protein coupled receptor 65
T-cell death-associated gene 8
protein
Psychosine N1-L2(11-21) GA- 0195
Mis 骨粗しょう症 PTHR/PTHR1
Parathyroid hormone/parathyroid
hormone-related peptide receptor
PTH/PTHrP type I receptor
PTH1 receptor
Parathyroid hormone and
parathyroid hormone-related
peptide
N4-L0 GB- 0198
Mis 骨粗しょう症,骨疾患 LGR4/GPR48
Leucine-rich repeat-containing G-
protein coupled receptor 4
G-protein coupled receptor 48
R-spondins N5-L0 GA- 0121
Mis 歯周炎ADRB1/ADRB1R
/ B1AR
Beta-1 adrenergic receptor
Beta-1 adrenoreceptorCatecholamine N1-L0 GA- 0096
Mis 歯周炎 GPR126
Adhesion G-protein coupled
receptor G6
G-protein coupled receptor 126
Orphan, activated by type IV
collagenN23-L0 GD- 0149
Mis 線維症, 脂肪変性 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
Mis 線維症,脂肪変性BLT1/GPR16/P2
RY7
Leukotriene B4 receptor 1
P2Y7
Leukotriene B4, extracellular ATP
> UTP and ADPN1-L1(21) GA- 0033
Mis 創傷 GPR23/LPAR4 Lysophosphatidic acid receptor 4 Lysophosphatidic acid (LPA) N3-L1(21) GA- 0022
Mis 創傷 GPR92/LPAR5 Lysophosphatidic acid receptor 5 Lysophosphatidic acid (LPA) N2-L0 GA- 0023
Mis 椎間板変性 GPR68/OGR1Ovarian cancer G-protein coupled
receptor 1Proton N2-L0 GA- 0196
Mis 特発性脊柱側彎症 GPR126
Adhesion G-protein coupled
receptor G6
G-protein coupled receptor 126
Orphan, activated by type IV
collagenN23-L0 GD- 0149
13
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns アルコール使用障害GRM2/GPRC1B/
MGLUR2Metabotropic glutamate receptor 2 Glutamate N5-L0 GC- 0176
Ns アルコール乱用GRM1/GPRC1A/
MGLUR1Metabotropic glutamate receptor 1 Glutamate N4-L0 GC- 0175
Ns アルツハイマー病 GPR3/ACCA G-protein coupled receptor 3 Orphan N1-L0 GA- 0006
Ns アルツハイマー病 GPR17
Uracil nucleotide/cysteinyl
leukotriene receptor, G-protein
coupled receptor 17
Uracil nucleotides and cysteinyl
leukotrienes (CysLTs)N1-L2(21-31) GA- 0014
Ns アルツハイマー病 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
Ns アルツハイマー病 CHRM1Muscarinic acetylcholine receptor
M1Muscarine, acetylcholine N2-L0 GA- 0044
Ns アルツハイマー病 GPR39 G-protein coupled receptor 39Orphan, Zn2+ acts as an agonist,
obestatinN0-L3(23) GA- 0066
Ns アルツハイマー病GPR103
QRFPR
Pyroglutamylated RFamide peptide
receptor
G-protein coupled receptor 103
Orexigenic neuropeptide QRFP N1-L0 GA- 0080
Ns アルツハイマー病ADRA1A/ADRA1
C
Alpha-1A adrenergic receptor
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Catecholamine N3-L0 GA- 0094
Ns アルツハイマー病ADRB2/ADRB2R
/ B2AR
Beta-2 adrenergic receptor
Beta-2 adrenoreceptorCatecholamine N2-L1(21) GA- 0097
Ns アルツハイマー病GRM5/GPRC1E/
MGLUR5Metabotropic glutamate receptor 5 Glutamate N5-L1(21) GC- 0179
Nsアルツハイマー病
認知疾患GPR84
G-protein coupled receptor 84
Inflammation-related G-protein
coupled receptor EX33
Medium-chain free fatty acid N2-L0 GA- 0041
14
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns 運藤失調GRM3/GPRC1C/
MGLUR3Metabotropic glutamate receptor 3 Glutamate N4-L0 GC- 0177
Ns 運動障害 GPR12 G-protein coupled receptor 12 Orphan N2-L0 GA- 0021
Ns 学習記憶障害 Oprd1/Opioid δ Delta-type opioid receptorEndogenous opioids such as beta-
endorphin and endomorphinN2-L0 GA- 0063
Ns 下垂体茎断裂症候群 GPR161 G-protein coupled receptor 161 Orphan N2-L0 GA- 0120
Ns 急性疼痛 BDKRB2B2 bradykinin receptor
BK-2 receptorBradykinin N2-L1(21) GA- 0074
Ns コカイン依存症GRM2/GPRC1B/
MGLUR2Metabotropic glutamate receptor 2 Glutamate N5-L0 GC- 0176
Ns コカイン依存症GRM7/GPRC1G/
MGLUR7Metabotropic glutamate receptor 7 Glutamate N4-L0 GC- 0181
Ns神経因性疼痛, 炎症性疼
痛PAR4 Protease-activated receptor-4
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L0 GA- 0072
Ns神経変性疾患
アルツハイマー病BAI1/ADGRB1
Adhesion G protein-coupled
receptor B1
Brain-specific angiogenesis
inhibitor 1
Phosphatidylserine N7-L0 GD- 0142
Ns 神経精神疾患GRM1/GPRC1A/
MGLUR1Metabotropic glutamate receptor 1 Glutamate N4-L0 GC- 0175
Ns 神経精神疾患GRM7/GPRC1G/
MGLUR7Metabotropic glutamate receptor 7 Glutamate N4-L0 GC- 0181
Ns 脊髄外傷 GPR17
Uracil nucleotide/cysteinyl
leukotriene receptor, G-protein
coupled receptor 17
Uracil nucleotides and cysteinyl
leukotrienes (CysLTs)N1-L2(21-31) GA- 0014
Ns先天性小脳性運動失調, 摂
食障害LGR4/GPR48
Leucine-rich repeat-containing G-
protein coupled receptor 4
G-protein coupled receptor 48
R-spondins N5-L0 GA- 0121
15
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns てんかん CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
Ns てんかん GPR39 G-protein coupled receptor 39Orphan, Zn2+ acts as an agonist,
obestatinN0-L3(23) GA- 0066
Ns 疼痛GRM3/GPRC1C/
MGLUR3Metabotropic glutamate receptor 3 Glutamate N4-L0 GC- 0177
Ns糖尿病性疼痛, 神経障害,
炎症性疼痛BDKRB1
B1 bradykinin receptor
BK-1 receptorBradykinin N1-L1(21) GA- 0073
Ns 認知障害 GPR12 G-protein coupled receptor 12 Orphan N2-L0 GA- 0021
Ns 脳および脊髄の先天性異常 GPR161 G-protein coupled receptor 161 Orphan N2-L0 GA- 0120
Ns脳血管関門破壊による中枢
神経系の疾患
ADGRA2/GPR12
4/
KIAA1531/TEM5
Adhesion G protein-coupled
receptor A2
G-protein coupled receptor 124
Orphan N7-L0 GD- 0163
Ns パーキンソン病 GPR17
Uracil nucleotide/cysteinyl
leukotriene receptor, G-protein
coupled receptor 17
Uracil nucleotides and cysteinyl
leukotrienes (CysLTs)N1-L2(21-31) GA- 0014
Ns パーキンソン病 GPR6 G-protein coupled receptor 6 Orphan N3-L0 GA- 0020
Ns パーキンソン病 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
Ns パーキンソン病 HTR2C 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine (serotonin) N1-L2(22) GA- 0056
Ns パーキンソン病 HTR2A 5-hydroxytryptamine receptor 2A 5-hydroxytryptamine (serotonin) N5-L0 GA- 0057
Ns パーキンソン病 GPR37 Prosaposin receptor GPR37The neuroprotective and
glioprotective factor prosaposinN2-L1(21) GA- 0075
Ns パーキンソン病 GPR52 G-protein coupled receptor 52 Orphan N3-L0 GA- 0126
Ns パーキンソン病 GPR139 Probable G-protein coupled
receptor 139Orphan N1-L0 GA- 0128
16
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns パーキンソン病GRM3/GPRC1C/
MGLUR3Metabotropic glutamate receptor 3 Glutamate N4-L0 GC- 0177
Ns パーキンソン病GRM4/GPRC1D/
MGLUR4Metabotropic glutamate receptor 4 Glutamate N5-L0 GC- 0178
Ns パーキンソン病GRM8/GPRC1H/
MGLUR8Metabotropic glutamate receptor 8 Glutamate N5-L0 GC- 0182
Ns パーキンソン病 ADOA2A Adenosine receptor A2a Adenosine N0-L1(21) GA- 0190
Ns ハンチントン病 GPR17
Uracil nucleotide/cysteinyl
leukotriene receptor, G-protein
coupled receptor 17
Uracil nucleotides and cysteinyl
leukotrienes (CysLTs)N1-L2(21-31) GA- 0014
Ns ハンチントン病GRM5/GPRC1E/
MGLUR5Metabotropic glutamate receptor 5 Glutamate N5-L1(21) GC- 0179
Ns プラダー・ウィリー症候群 MCHR2/GPR145
G-protein coupled receptor 145
Melanin-concentrating hormone
receptor 2
Melanin-concentrating hormone N2-L0 GA- 0055
Ns 依存症 OPRK1/Opioid κ Kappa-type opioid receptorEndogenous opioids such as beta-
endorphin and endomorphinN2-L0 GA- 0062
Ns 運動失調GRM1/GPRC1A/
MGLUR1Metabotropic glutamate receptor 1 Glutamate N4-L0 GC- 0175
Ns 円形脱毛症 MCHR2/GPR145
G-protein coupled receptor 145
Melanin-concentrating hormone
receptor 2
Melanin-concentrating hormone N2-L0 GA- 0055
Ns 外傷性脳損傷 GPR17
Uracil nucleotide/cysteinyl
leukotriene receptor, G-protein
coupled receptor 17
Uracil nucleotides and cysteinyl
leukotrienes (CysLTs)N1-L2(21-31) GA- 0014
Ns 巨人症 GPR101Probable G-protein coupled
receptor 101Orphan N2-L0 GA- 0113
Ns 虚血脳損傷 CCRL2 C-C chemokine receptor-like 2 CCL19 and chemerin/RARRES2 N1-L0 GA- 0139
17
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns 強迫神経症 GPR63Probable G-protein coupled
receptor 63Orphan N3-LO GA- 0004
Ns 局所疼痛症候群ADRB2/ADRB2R
/ B2AR
Beta-2 adrenergic receptor
Beta-2 adrenoreceptorCatecholamine N2-L1(21) GA- 0097
Ns 自閉症 GPR63Probable G-protein coupled
receptor 63Orphan N3-LO GA- 0004
Ns 自閉症 AVPR2 Vasopressin V2 receptor Arginine vasopressin N1-L0 GA- 0053
Ns 自閉症 GPR37 Prosaposin receptor GPR37The neuroprotective and
glioprotective factor prosaposinN2-L1(21) GA- 0075
Ns 自閉症スペクトラム障害GRM5/GPRC1E/
MGLUR5Metabotropic glutamate receptor 5 Glutamate N5-L1(21) GC- 0179
Ns 心的外傷後ストレス障害GRM8/GPRC1H/
MGLUR8Metabotropic glutamate receptor 8 Glutamate N5-L0 GC- 0182
Ns 神経因性疼痛 LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
Ns 神経因性疼痛 GPR3/ACCA G-protein coupled receptor 3 Orphan N1-L0 GA- 0006
Ns 神経因性疼痛 GPR92/LPAR5 Lysophosphatidic acid receptor 5 Lysophosphatidic acid (LPA) N2-L0 GA- 0023
Ns 神経因性疼痛 EDG2/LPA1Lysophosphatidic acid receptor 1
LPA-1Lysophosphatidic acid (LPA) N2-L1(21) GA- 0037
Ns 神経因性疼痛 PAR2 Protease-activated receptor-2
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L1(21) GA- 0070
Ns神経変性疾患, アルツハイ
マー病
CNR2/CB2A/CB2
B
Cannabinoid receptor 2
CB2
Endocannabinoid 2-
arachidonoylglycerolN1-L0 GA- 0027
Ns 睡眠障害 GPR176G-protein coupled receptor 176
HB-954
Orphan, involved in normal
circadian rhythm behaviorN4-L0 GA- 0115
Ns 精神疾患 GPR6 G-protein coupled receptor 6 Orphan N3-L0 GA- 0020
Ns 精神疾患 HTR2A 5-hydroxytryptamine receptor 2A 5-hydroxytryptamine (serotonin) N5-L0 GA- 0057
Ns精神疾患,
統合失調症GPR151/PGR7
Probable G-protein coupled
receptor 151Orphan N2-L0 GA- 0129
18
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns 精神障害 GPR52 G-protein coupled receptor 52 Orphan N3-L0 GA- 0126
Ns 精神障害 BAI3/ADGRB3
Adhesion G protein-coupled
receptor B3
Brain-specific angiogenesis
inhibitor 3
Orphan N13-L11(11) GD- 0144
Ns 脆弱X症候群GRM5/GPRC1E/
MGLUR5Metabotropic glutamate receptor 5 Glutamate N5-L1(21) GC- 0179
Ns 摂食障害 GPR61Probable G-protein coupled
receptor 61Biogenic amine N1-L0 GA- 0111
Ns 摂食障害 GPR171Probable G-protein coupled
receptor 171Orphan N1-L0 GA- 0114
Ns 摂食障害GPR83/GPR72/
KIAA1540
Probable G-protein coupled
receptor 83
G-protein coupled receptor 72
Orphan N2-L1(11) GA- 0138
Ns 双極性気分障害 MCHR2/GPR145
G-protein coupled receptor 145
Melanin-concentrating hormone
receptor 2
Melanin-concentrating hormone N2-L0 GA- 0055
Ns 掻痒 OPRK1/Opioid κ Kappa-type opioid receptorEndogenous opioids such as beta-
endorphin and endomorphinN2-L0 GA- 0062
Ns 多発性硬化症
GPER1/CEPR/
CMKRL2/DRY12/
GPER/GPR30
G-protein coupled estrogen
receptor 1
G-protein coupled receptor 30
17-beta-estradiol (E2) N3-L0 GA- 0010
Ns 多発性硬化症 GPR55 G-protein coupled receptor 55 L-a-lysophosphatidylinositol N1-L1(21) GA- 0013
Ns 多発性硬化症 GPR17
Uracil nucleotide/cysteinyl
leukotriene receptor, G-protein
coupled receptor 17
Uracil nucleotides and cysteinyl
leukotrienes (CysLTs)N1-L2(21-31) GA- 0014
19
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns 多発性硬化症 GPR17
Uracil nucleotide/cysteinyl
leukotriene receptor, G-protein
coupled receptor 17
Uracil nucleotides and cysteinyl
leukotrienes (CysLTs)N1-L2(21-31) GA- 0014
Ns 多発性硬化症 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
Ns 多発性硬化症 EDG1/S1P1Sphingosine-1-phosphate receptor
1
Lysosphingolipid sphingosine 1-
phosphateN2-L0 GA- 0028
Ns 多発性硬化症GRM4/GPRC1D/
MGLUR4Metabotropic glutamate receptor 4 Glutamate N5-L0 GC- 0178
Ns 多発性硬化症 EDG3/S1P3Sphingosine-1-phosphate receptor
3
Lysosphingolipid sphingosine 1-
phosphateN1-L0 GA- 0030
Ns 多発性硬化症 EDG8/S1P5Sphingosine-1-phosphate receptor
5
Lysosphingolipid sphingosine 1-
phosphateN1-L0 GA- 0032
Ns 多発性硬化症GRM8/GPRC1H/
MGLUR8Metabotropic glutamate receptor 8 Glutamate N5-L0 GC- 0182
Ns 多発性硬化症 GPR132/GA-2Probable G-protein coupled
receptor 132Proton N2-L0 GA- 0194
Ns 注意欠陥多動障害 TSHR
Thyroid stimulating hormone
receptor
Thyrotropin receptor
Thyroid-stimulating hormone
(TSH) or thyrotropin.N6-L0 GB- 0068
Ns 統合失調症 HTR2C 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine (serotonin) N1-L2(22) GA- 0056
Ns 統合失調症 GPR52 G-protein coupled receptor 52 Orphan N3-L0 GA- 0126
Ns 統合失調症 GPR85/SREB2Probable G-protein coupled
receptor 85Orphan N1-L2(11-21) GA- 0134
Ns 統合失調症GRM2/GPRC1B/
MGLUR2Metabotropic glutamate receptor 2 Glutamate N5-L0 GC- 0176
20
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns認知障害 (加齢関連認知行
動低下)CNR1
Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
Ns 認知疾患GPR158/KIAA11
36
Probable G-protein coupled
receptor 158Orphan N5-L0 GC- 0079
Ns 発作GPR37L1 (ETBR-
LP-2)
Prosaposin receptor GPR37L1
Endothelin B receptor-like protein
2
The neuroprotective and
glioprotective factor prosaposinN6(N1O5)-L0 GA- 0076
Ns 不安神経症 GPR3112-(S)-hydroxy-5,8,10,14-
eicosatetraenoic acid receptor
12-(S)-hydroxy-5,8,10,14-
eicosatetraenoic acid (12HETE)N1-L1(21) GA- 0011
Ns 不安神経症 GPR24/MCHR1Melanin-concentrating hormone
receptor 1Melanin-concentrating hormone N3-L0 GA- 0054
Ns 不安神経症 HTR2C 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine (serotonin) N1-L2(22) GA- 0056
Ns 不安神経症 OPRK1/Opioid κ Kappa-type opioid receptorEndogenous opioids such as beta-
endorphin and endomorphinN2-L0 GA- 0062
Ns 不安神経症 GPR171Probable G-protein coupled
receptor 171Orphan N1-L0 GA- 0114
Ns 不安神経症GRM4/GPRC1D/
MGLUR4Metabotropic glutamate receptor 4 Glutamate N5-L0 GC- 0178
Ns 不安神経症GRM8/GPRC1H/
MGLUR8Metabotropic glutamate receptor 8 Glutamate N5-L0 GC- 0182
Ns 不眠症 HTR2A 5-hydroxytryptamine receptor 2A 5-hydroxytryptamine (serotonin) N5-L0 GA- 0057
Ns 片頭痛 CGRPR/CALCRL
Calcitonin gene-related peptide
type 1 receptor, CGRP type 1
receptor
Calcitonin-gene-related peptide
(CGRP), Adrenomedullin together
with RAMP3
N3-L0 GB- 0089
Ns傍腫瘍性辺縁系脳炎
seizures
GA-
BBR1/GPRC3A
Gamma-aminobutyric acid type B
receptor subunit 1, GA-BA-B
receptor 1
GABA N8-L0 GC- 0105
21
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns 勃起機能不全 HTR2C 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine (serotonin) N1-L2(22) GA- 0056
Ns 薬物依存症 HTR2C 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine (serotonin) N1-L2(22) GA- 0056
Ns 鬱病 GPR24/MCHR1Melanin-concentrating hormone
receptor 1Melanin-concentrating hormone N3-L0 GA- 0054
Ns 鬱病 Oprd1/Opioid δ Delta-type opioid receptorEndogenous opioids such as beta-
endorphin and endomorphinN2-L0 GA- 0063
Ns 鬱病 GPR39 G-protein coupled receptor 39Orphan, Zn2+ acts as an agonist,
obestatinN0-L3(23) GA- 0066
Ns 鬱病 BAI2/ADGRB2
Adhesion G protein-coupled
receptor B2
Brain-specific angiogenesis
inhibitor 2
Orphan N8-L0 GD- 0143
Ns 鬱病GRM2/GPRC1B/
MGLUR2Metabotropic glutamate receptor 2 Glutamate N5-L0 GC- 0176
Ns 鬱病GRM3/GPRC1C/
MGLUR3Metabotropic glutamate receptor 3 Glutamate N4-L0 GC- 0177
Ns 鬱病, 不安神経症, HTR2C 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine (serotonin) N1-L2(22) GA- 0056
Ns 疼痛 GPR35G-protein coupled receptor 35
kynurenic acid receptorKynurenic acid N1-L0 GA- 0012
Ns 疼痛 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
Ns 疼痛 OPRM1/Opioid μ Mu-type opioid receptorEndogenous opioids such as beta-
endorphin and endomorphinN5-L0 GA- 0061
Ns 疼痛 OPRK1/Opioid κ Kappa-type opioid receptorEndogenous opioids such as beta-
endorphin and endomorphinN2-L0 GA- 0062
Ns 疼痛 Oprd1/Opioid δ Delta-type opioid receptorEndogenous opioids such as beta-
endorphin and endomorphinN2-L0 GA- 0063
22
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Ns 疼痛 CALCRL/CGRPR
Calcitonin gene-related peptide
type 1 receptor, CGRP type 1
receptor
Calcitonin receptor-like receptor
Calcitonin-gene-related peptide
(CGRP), Adrenomedullin together
with RAMP3
N3-L0 GB- 0089
Ns 疼痛GRM1/GPRC1A/
MGLUR1Metabotropic glutamate receptor 1 Glutamate N4-L0 GC- 0175
Ns 疼痛GRM8/GPRC1H/
MGLUR8Metabotropic glutamate receptor 8 Glutamate N5-L0 GC- 0182
Ns 疼痛GA-
BBR1/GPRC3A
Gamma-aminobutyric acid type B
receptor subunit 1, GA-BA-B
receptor 1
GABA N8-L0 GC- 0105
Ob 不妊 EDG7/LPA3Lysophosphatidic acid receptor 3
LPA3Lysophosphatidic acid (LPA) N1-L1(21) GA- 0039
Ob 排卵機能不全 GPR173/SREB3Probable G-protein coupled
receptor 173Orphan N1-L1(21) GA- 0135
Onc
VEGF誘発腫瘍血管新生,
ゲフィチニブ抵抗性非小細
胞肺癌
ADGRA2/GPR12
4/
KIAA1531/TEM5
Adhesion G protein-coupled
receptor A2
G-protein coupled receptor 124
Orphan N7-L0 GD- 0163
Onc 癌骨由来疼痛 GPR65/TDAG8
Psychosine receptor
G-protein coupled receptor 65
T-cell death-associated gene 8
protein
Psychosine N1-L2(11-21) GA- 0195
Onc 固形癌 DRD2 (D2) Dopamine receptor Dopamine N3-L0 GA- 0193
Onc 脳腫瘍 BAI3/ADGRB3
Adhesion G protein-coupled
receptor B3
Brain-specific angiogenesis
inhibitor 3
Orphan N13-L11(11) GD- 0144
23
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Onc膀胱癌,肺癌,大腸癌,膵
癌GPR87/GPR95 G-protein coupled receptor 87 Lysophosphatidic acid (LPA) N3-L0 GA- 0024
Onc 胃癌 GPR132/GA-2Probable G-protein coupled
receptor 132Proton N2-L0 GA- 0194
Onc 胃癌, 肝細胞癌GPCR19/TGR5/G
PBAR
G-protein coupled bile acid
receptor 1
G-protein coupled receptor
GPCR19
Bile acid N1-L2(11-21) GA- 0009
Onc胃癌, 黒色腫, 癌幹細胞
(免疫療法)GPR4
G-protein coupled receptor 4
G-protein coupled receptor 19Proton N1-L1(21) GA- 0043
Onc 胃癌, 前立腺癌 GPR39 G-protein coupled receptor 39Orphan, Zn2+ acts as an agonist,
obestatinN0-L3(23) GA- 0066
Onc 胃癌, 大腸癌 GPR34Probable G-protein coupled
receptor 34Orphan N3-L2(21-31) GA- 0040
Onc 胃癌, 膵癌 GHSRGrowth hormone secretagogue
receptor type 1
Ghrelin, a small peptide with 28
amino acidsN3-L0 GA- 0065
Onc 肝細胞癌GPR99/GPR80/O
XGR1
2-oxoglutarate receptor 1
Alpha-ketoglutarate receptor 1
G-protein coupled receptor 80
G-protein coupled receptor 99
Alpha-ketoglutarate N2-L2(22) GA- 0064
Onc 肝細胞癌, 胃癌 GPR37 Prosaposin receptor GPR37The neuroprotective and
glioprotective factor prosaposinN2-L1(21) GA- 0075
Onc 肝細胞癌 LPA6/P2Y5Lysophosphatidic acid receptor 6
P2Y5
Lysophosphatidic acid (LPA)
oleoyl-L-alpha-LPAN1-L0 GA- 0005
Onc 肝細胞癌 EDG4/LPA4 Lysophosphatidic acid receptor 2 Lysophosphatidic acid (LPA) N2-L0 GA- 0038
Onc 肝細胞癌、 癌幹細胞 GPR87/GPR95 G-protein coupled receptor 87 Lysophosphatidic acid (LPA) N3-L0 GA- 0024
Onc 癌 EDG6/S1P4Sphingosine-1-phosphate receptor
4
Lysosphingolipid sphingosine 1-
phosphateN2-L0 GA- 0031
24
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Onc 癌 CCR9/GPR28C-C chemokine receptor type 9
G-protein coupled receptor 28Chemokine SCYA25/TECK N1-L0 GA- 0084
Onc 癌CXCR5/BLR1/MD
R15C-X-C chemokine receptor type 5 B-lymphocyte chemoattractant N1-L1(21) GA- 0086
Onc 癌C5AR1/C5AR/C5
R1
C5a anaphylatoxin chemotactic
receptor 1, C5a-RC5a N1-L0 GA- 0087
Onc 癌 CALCR Calcitonin receptor Calcitonin N4-L0 GB- 0088
Onc 癌ADRA1A/ADRA1
C
Alpha-1A adrenergic receptor
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Catecholamine N3-L0 GA- 0094
Onc 癌 EDNRB/ETRB
Endothelin receptor type B, ETB-R
Endothelin receptor non-selective
type
Endothelin N1-L0 GA- 0141
Onc 癌 CD97 CD97 antigen Orphan N9-L0 GD- 0153
Onc 癌GRM1/GPRC1A/
MGLUR1Metabotropic glutamate receptor 1 Glutamate N4-L0 GC- 0175
Onc 癌CASR/GPRC2A/P
CAR1
Extracellular calcium-sensing
receptor, CaR, CaSR
Parathyroid cell calcium-sensing
receptor 1, PCaR1
Calcium N11-L0 GC- 0185
Onc 癌, 白血病
ADGRG1/GPR56/
TM7LN4/TM7XN
1/
UNQ540/PRO10
83
Adhesion G-protein coupled
receptor G1
G-protein coupled receptor 56
Protein TM7XN1
Orphan N7-L0 GD- 0145
Onc 癌幹細胞 DRD2 (D2) Dopamine receptor Dopamine N3-L0 GA- 0193
25
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Onc癌幹細胞, 大腸癌, 肝細胞
癌, 食道腺癌
LGR5/GPR49/GP
R67
Leucine-rich repeat-containing G-
protein coupled receptor 5
G-protein coupled receptor 49
G-protein coupled receptor 67
G-protein coupled receptor HG38
R-spondins N4-L1(31) GA- 0122
Onc 黒色腫 GPR18 N-arachidonyl glycine receptorEndocannabinoid, N-arachidonyl
glycineN1-L0 GA- 0007
Onc 黒色腫 GPR92/LPAR5 Lysophosphatidic acid receptor 5 Lysophosphatidic acid (LPA) N2-L0 GA- 0023
Onc 黒色腫 GPR174Probable G-protein coupled
receptor 174Prines N1-L1(21) GA- 0025
Onc 黒色腫 GPR19Probable G-protein coupled
receptor 19Orphan N2-L0 GA- 0117
Onc 黒色腫 GPR65/TDAG8
Psychosine receptor
G-protein coupled receptor 65
T-cell death-associated gene 8
protein
Psychosine N1-L2(11-21) GA- 0195
Onc
骨髄腫
膠芽細胞腫
白血病
DRD2 (D2) Dopamine receptor Dopamine N3-L0 GA- 0193
Onc 神経芽細胞腫, 膠芽細胞腫 EDG5/S1P2Sphingosine-1-phosphate receptor
2
Lysosphingolipid sphingosine 1-
phosphateN1-L0 GA- 0029
Onc 神経膠腫
ADGRL4/ELTD1/
ETL/
UNQ202/PRO22
8
Adhesion G protein-coupled
receptor L4Orphan N9-L0 GD- 0158
Onc 神経膠腫ADGRF1/GPR110
/ PGR19
Adhesion G-protein coupled
receptor F1
G protein-coupled receptor 110
Orphan N17-L2(22) GD- 0170
26
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Onc成人T細胞白血病, 末梢T細
胞リンパ腫CCR4/CMKBR4 C-C chemokine receptor type 4 CC-chemokines N0-L2(22) GA- 0082
Onc 前立腺癌GPR158/KIAA11
36
Probable G-protein coupled
receptor 158Orphan N5-L0 GC- 0079
Onc 前立腺癌 GPRC6AG-protein coupled receptor family
C group 6 member A, GPRC33
Basic amino acids, osteocalcin,
testosteroneN3-L1(21) GC- 0184
Onc
前立腺癌
膵癌
卵巣
GPR68/OGR1Ovarian cancer G-protein coupled
receptor 1Proton N2-L0 GA- 0196
Onc前立腺癌,
大腸癌GPR31
12-(S)-hydroxy-5,8,10,14-
eicosatetraenoic acid receptor
12-(S)-hydroxy-5,8,10,14-
eicosatetraenoic acid (12HETE)N1-L1(21) GA- 0011
Onc 大腸癌, 前立腺癌, 皮膚 LGR4/GPR48
Leucine-rich repeat-containing G-
protein coupled receptor 4
G-protein coupled receptor 48
R-spondins N5-L0 GA- 0121
Onc大腸癌, 乳癌, 前立腺癌, 肺
癌CNR1
Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
Onc大腸癌, 卵巣癌, 癌幹細胞
(免疫療法)LGR6
Leucine-rich repeat-containing G-
protein coupled receptor 6
R-spondins that potentiates the
canonical Wnt signaling pathwayN2-L0 GA- 0140
Onc 大腸癌,上皮性悪性腫瘍ADGRF5/GPR116
/ KIAA0758
Adhesion G protein-coupled
receptor F5
G-protein coupled receptor 116
Orphan N21-L0 GD- 0174
Onc 乳癌 CCR5/CMKBR5 C-C chemokine receptor type 5 CC-chemokines N4(O4)L1(31) GA- 0083
Onc 乳癌 MAS1/MAS Proto-oncogene Mas Angiotensin 1-7 N3-L0 GA- 0131
Onc 乳癌ADGRF5/GPR116
/ KIAA0758
Adhesion G protein-coupled
receptor F5
G-protein coupled receptor 116
Orphan N21-L0 GD- 0174
27
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Onc 乳癌CXCR1/CMKAR1
/ IL8RA
C-X-C chemokine receptor type 1
IL-8 receptor type 1
CD_antigen: CD181
Interleukin-8 N2-L0 GA- 0189
Onc乳癌
膠芽細胞腫CCRL2 C-C chemokine receptor-like 2 CCL19 and chemerin/RARRES2 N1-L0 GA- 0139
Onc 乳癌, 前立腺癌
GPER1/CEPR/
CMKRL2/DRY12/
GPER/GPR30
G-protein coupled estrogen
receptor 1
G-protein coupled receptor 30
17-beta-estradiol (E2) N3-L0 GA- 0010
Onc 乳癌, 前立腺癌, 胃癌, 肺癌 EDG1/S1P1Sphingosine-1-phosphate receptor
1
Lysosphingolipid sphingosine 1-
phosphateN2-L0 GA- 0028
Onc乳癌, 大腸癌, 胃癌, 膵癌,
肺癌,LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
Onc乳癌, 大腸癌, 膵癌, 肺癌
EDG2/LPA1Lysophosphatidic acid receptor 1
LPA-1Lysophosphatidic acid (LPA) N2-L1(21) GA- 0037
Onc 乳癌, 肺癌 CXCR4 C-X-C chemokine receptor type 4 C-X-C chemokine CXCL12/SDF-1 N2-L1(21) GA- 0085
Onc乳癌, 肺癌, 膵癌, 大腸癌,
胃癌TSHR
Thyroid stimulating hormone
receptor
Thyrotropin receptor
Thyroid-stimulating hormone
(TSH) or thyrotropin.GPCR-A GB- 0068
Onc 乳癌,転移性上皮細胞 GPR161 G-protein coupled receptor 161 Orphan N2-L0 GA- 0120
Onc 乳癌,上皮性悪性腫瘍 ADGRE2/EMR2
Adhesion G protein-coupled
receptor E2
EGF-like module receptor 2
Chondroitin sulfate N8-L0 GD- 0155
Onc 乳癌,肺癌,胃癌 PAR1 Protease-activated receptor-1
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N3-L2(22) GA- 0069
Onc 肺癌 GPR171Probable G-protein coupled
receptor 171Orphan N1-L0 GA- 0114
28
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Onc 肺癌GPRC5A/GPCR5
A/ RAI3/RAIG1
Retinoic acid-induced protein 3
G-protein coupled receptor family
C group 5 member A
Retinoic acid-induced gene 1
protein, RAIG-1
Orphan N0-L1(21) GC- 0188
Onc肺癌 (免疫チェックポイ
ント療法 )ADOA2A Adenosine receptor A2a Adenosine N0-L1(21) GA- 0190
Onc 肺癌, 胃癌, 卵巣癌 GPR65/TDAG8
Psychosine receptor
G-protein coupled receptor 65
T-cell death-associated gene 8
protein
Psychosine N1-L2(11-21) GA- 0195
Onc 肺癌, 前立腺癌, 肝細胞癌ADGRF1/GPR110
/ PGR19
Adhesion G-protein coupled
receptor F1
G protein-coupled receptor 110
Orphan N17-L2(22) GD- 0170
Onc 肺癌, 前立腺癌, 乳癌, 胃癌 BDKRB2B2 bradykinin receptor
BK-2 receptorBradykinin N2-L1(21) GA- 0074
Onc 肺癌, 乳癌 GPR19Probable G-protein coupled
receptor 19Orphan N2-L0 GA- 0117
Onc肺癌, 乳癌, 前立腺癌, 大
腸癌, 胃癌, 膵癌CCR2
C-C chemokine receptor type 2
Monocyte Chemotactic Protein-
1(MCP-1)
CCL2, CCL7 and CCL13
chemokinesN1-L0 GA- 0081
Onc 肺癌, 乳癌, 卵巣癌, 脳腫瘍 BAI1/ADGRB1
Adhesion G protein-coupled
receptor B1
Brain-specific angiogenesis
inhibitor 1
Phosphatidylserine N7-L0 GD- 0142
Onc 白血病 P2RY8P2Y purinoceptor 8
P2Y8Orphan, purines N2-L0 GA- 0124
29
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Onc 白血病, 骨髄腫 CCR2
C-C chemokine receptor type 2
Monocyte Chemotactic Protein-
1(MCP-1)
CCL2, CCL7 and CCL13
chemokinesN1-L0 GA- 0081
Onc 白血病, 骨髄腫 CXCR4 C-X-C chemokine receptor type 4 C-X-C chemokine CXCL12/SDF-1 N2-L1(21) GA- 0085
Onc
皮膚癌, 乳癌, 前立腺癌, 卵
巣癌, 胆癌, 膵癌
膠芽細胞腫
GPR55 G-protein coupled receptor 55 L-a-lysophosphatidylinositol N1-L1(21) GA- 0013
Onc 卵巣癌 EDG7/LPA3Lysophosphatidic acid receptor 3
LPA3Lysophosphatidic acid (LPA) N1-L1(21) GA- 0039
Onc 膠芽細胞腫
ADGRE3/EMR3/
UNQ683/PRO15
62
Adhesion G protein-coupled
receptor E3Orphan N9-L0 GD- 0156
Onc 膵癌 GPR23/LPAR4 Lysophosphatidic acid receptor 4 Lysophosphatidic acid (LPA) N3-L1(21) GA- 0022
Onc 膵癌 GLP1R Glucagon-like peptide 1 receptor Glucagon-like peptide 1 (GLP-1) N3-L0 GB- 0092
Onc 膵癌 (免疫療法) GPR92/LPAR5 Lysophosphatidic acid receptor 5 Lysophosphatidic acid (LPA) N2-L0 GA- 0023
Op ドライアイ LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
Op ドライアイ CHRM3Muscarinic acetylcholine receptor
M3Muscarine, acetylcholine N5-L0 GA- 0046
Op ドライアイ CCR5/CMKBR5 C-C chemokine receptor type 5 CC-chemokines N4(O4)L1(31) GA- 0083
Op ドライアイ CXCR4 C-X-C chemokine receptor type 4 C-X-C chemokine CXCL12/SDF-1 N2-L1(21) GA- 0085
Op ドライアイ CGRPR/CALCRL
Calcitonin gene-related peptide
type 1 receptor, CGRP type 1
receptor
Calcitonin-gene-related peptide
(CGRP), Adrenomedullin together
with RAMP3
N3-L0 GB- 0089
Op 光酸化による網膜症 HTR1A/5-HT1A5-hydroxytryptamine receptor 1A
Serotonin receptor 1A, 5HT1A5-hydroxytryptamine (serotonin) N3-L0 GA- 0197
Op 虚血性網膜症 CysLT2 Cysteinyl leukotriene receptor 2 LTD4 N3-L1(21) GA- 0036
Op 先天白内障 GPR161 G-protein coupled receptor 161 Orphan N2-L0 GA- 0120
30
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
Op 白内障 LGR4/GPR48
Leucine-rich repeat-containing G-
protein coupled receptor 4
G-protein coupled receptor 48
R-spondins N5-L0 GA- 0121
Op 夜盲症GRM6/GPRC1F/
MGLUR6Metabotropic glutamate receptor 6 Glutamate N4-L0 GC- 0180
Op 緑内障 CHRM3Muscarinic acetylcholine receptor
M3Muscarine, acetylcholine N5-L0 GA- 0046
Op 緑内障 CHRM5Muscarinic acetylcholine receptor
M5Muscarine, acetylcholine N2-L0 GA- 0050
Op 緑内障 CCR5/CMKBR5 C-C chemokine receptor type 5 CC-chemokines N4(O4)L1(31) GA- 0083
Op 緑内障 CXCR4 C-X-C chemokine receptor type 4 C-X-C chemokine CXCL12/SDF-1 N2-L1(21) GA- 0085
Op 緑内障ADRB2/ADRB2R
/ B2AR
Beta-2 adrenergic receptor
Beta-2 adrenoreceptorCatecholamine N2-L1(21) GA- 0097
Op 緑内障 LGR4/GPR48
Leucine-rich repeat-containing G-
protein coupled receptor 4
G-protein coupled receptor 48
R-spondins N5-L0 GA- 0121
Op 緑内障 ADOA3 Adenosine receptor A3 Adenosine N3-L0 GA- 0191
Op緑内障
糖尿病性網膜症EDG1/S1P1
Sphingosine-1-phosphate receptor
1
Lysosphingolipid sphingosine 1-
phosphateN2-L0 GA- 0028
Oto 口渇, 疼痛 (細菌感染症) LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
R肺線維症
呼吸窮迫症候群
CELSR1/CDHF9/
FMI2
Cadherin EGF LAG seven-pass G-
type receptor 1
Cadherin family member 9
Flamingo homolog 2
Orphan N19L1(11) GD- 0165
R 急性呼吸窮迫症候群 T1R3 Taste receptor type 1 member 3 Umami taste stimulus N8-L0 GC- 0067
R 肺線維症 EDG3/S1P3Sphingosine-1-phosphate receptor
3
Lysosphingolipid sphingosine 1-
phosphateN1-L0 GA- 0030
31
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
R 肺線維症 EDG2/LPA1Lysophosphatidic acid receptor 1
LPA-1Lysophosphatidic acid (LPA) N2-L1(21) GA- 0037
R 肺線維症 EDG4/LPA2Lysophosphatidic acid receptor 2
LPA-2Lysophosphatidic acid (LPA) N2-L0 GA- 0038
R 慢性閉塞性肺疾患 LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
R 慢性閉塞性肺疾患 CysLT1 Cysteinyl leukotriene receptor 1 LTD4 N1-L2(21-31) GA- 0035
R 慢性閉塞性肺疾患 CHRM2Muscarinic acetylcholine receptor
M2Muscarine, acetylcholine N4-L0 GA- 0045
R 慢性閉塞性肺疾患 MAS1/MAS Proto-oncogene Mas Angiotensin 1-7 N3-L0 GA- 0131
R 喘息 LXA4/ALX/FPR2 N-formyl peptide receptor 2 Lipoxin A4, N-formyl peptide N1-L0 GA- 0003
R 喘息 GPR35G-protein coupled receptor 35
kynurenic acid receptorKynurenic acid N1-L0 GA- 0012
R 喘息 TG1019/OXEOxoeicosanoid receptor 1
G-protein coupled receptor 170
Eicosanoids
polyunsaturated fatty acidsN1-L0 GA- 0019
R 喘息 CNR1Cannabinoid receptor 1
CB1
Endocannabinoid, such as N-
arachidonoylethanolamide and 2-
arachidonoylglycerol
N3-L0 GA- 0026
R 喘息BLT1/GPR16/P2
RY7
Leukotriene B4 receptor 1
P2Y7
Leukotriene B4, extracellular ATP
> UTP and ADPN1-L1(21) GA- 0033
R 喘息 CysLT1 Cysteinyl leukotriene receptor 1 LTD4 N1-L3(22-31) GA- 0035
R 喘息 CHRM2Muscarinic acetylcholine receptor
M2Muscarine, acetylcholine N4-L0 GA- 0045
R 喘息NPSR1/GPR154/
GPRA/PGR14
Neuropeptide S receptor
G-protein coupled receptor 154Neuropeptide S (NPS) N1-L0 GA- 0078
R 喘息 CCR4/CMKBR4 C-C chemokine receptor type 4 CC-chemokines N0-L2(22) GA- 0082
R 喘息 MAS1/MAS Proto-oncogene Mas Angiotensin 1-7 N3-L0 GA- 0131
32
遺伝子名 名称 リガンド 糖鎖修飾疾患領域 対象疾患
ターゲット分子 Reference
no.
R 喘息 GPR97/PGR26
Adhesion G protein-coupled
receptor G3
G-protein coupled receptor 97
Orphan N3-L1(21) GD- 0146
R喘息
炎症GPR65/TDAG8
Psychosine receptor
G-protein coupled receptor 65
T-cell death-associated gene 8
protein
Psychosine N1-L2(11-21) GA- 0195
R喘息
慢性閉塞性肺疾患ADOA1 Adenosine receptor A1 Adenosine N0-L1(21) GA- 0192
R 喘息, 炎症性疾患 PAR2 Protease-activated receptor-2
Activated thrombin. A proteolytic
cleavage generates a new N-terminus
that functions as a tethered ligand.
N1-L1(21) GA- 0070
R 喘息, 慢性閉塞性肺疾患ADRB1/ADRB1R
/ B1AR
Beta-1 adrenergic receptor
Beta-1 adrenoreceptorCatecholamine N1-L0 GA- 0096
Ur 尿崩症 AVPR1b Vasopressin V1b receptor Arginine vasopressin N1-L0 GA- 0052
Ur 尿失禁 HTR2C 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine (serotonin) N1-L2(22) GA- 0056
Ur 過活動膀胱ADRB3/ADRB3R
/B3AR
Beta-3 adrenergic receptor
Beta-3 adrenoreceptorCatecholamine N2L0 GA- 0098
33