Cerebral Cortex Structure, Function, Dysfunction. Cortex Dental 2012.ppt.pdf · Limbic System (not...
Transcript of Cerebral Cortex Structure, Function, Dysfunction. Cortex Dental 2012.ppt.pdf · Limbic System (not...
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Cerebral CortexStructure, Function, Dysfunction
Reading Ch 10 WaxmanDental Neuroanatomy Lecture
Suzanne Stensaas, Ph.D.March 7, 2012
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Anatomy Review
• Lobes and layers• Brodmann’s areas• Vascular Supply• Major Neurological Findings
– Frontal, Parietal, Temporal, Occipital, Limbic• Quiz Questions?
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Types of Cortex
• Sensory (Primary)• Motor (Primary)• Unimodal association• Association and Multimodal necessary
for language, reason, plan, imagine,create
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Structure of neocortex (6 layers)
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The general pattern of primary, association and mulimodalassociation cortex (Mesulam)
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Brodmann, Lateral Left Hemisphere
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MCA left hemisphere from D.Haines
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ACA and PCA-Haines
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Issues of Functional Localization
• Earliest studies -Signs, symptoms and note location at autopsy• Electrical discharge (epilepsy) suggested function• Ablation - deficit suggest function• Reappearance of infant functions suggest loss of inhibition
(disinhibition), i.e. grasp, suck, Babinski• Linked networks of afferent and efferent neurons in several
regions working to accomplish a task (attention)• Functional imaging does not always equate with abnormal
function associated with location of lesion• fMRI activation of several cortical regions• Same sign from lesions in different areas – i.e.paraphasias• Notion of the right hemisphere as "emotional" in contrast to the
left one as "logical" has no basis in fact.
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Limbic System (not a true lobe) involves
• Cingulate gyrus - affect, pain, memory• Hippocampus- short term memory• Amygdala- fear, agression, mating• Fornix pathway to hypothalamus• Hypothalamus- ANS & endocr control• Prefrontal Cortex- appropriate behavior
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Schematic Diagram of principal limbic areas
From College of DuPage Biology 1152 Syllabus
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Amygdala and relationship to ventricle andhippocampus
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Classic Hippocampal Circuit
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Hippocampal Formation & Amygdala
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Hippocampus
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Hypothalamus
Interbrain, Springer Verlag ©
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Lateral view gross brain. Lefthemisphere Frontal Lobe
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Frontal Lobe Motor areas
• Contralateral weakness or paralysis (area 4)• Premotor planning of action (area 6)• Frontal eye fields for moving eyes to
opposite side (area 8) e.g. Epilepticdischarge
• Speech production (Broca’s area 44, 45)• Prefrontal areas
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Apraxia(Error in execution of learned movements without coexisting weakness)
• Damage to dominant parietal, premotor,and supplementary motor areas
• Dominant hemisphere associationareas
• Parietal - integrates motor sequenceswith vision and somatic sensory info
• Frontal lobe - execution of act
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Frontal Lobe prefrontal association cortex
• Bilateral prefrontal damage– distractible, apathetic– lack foresight, abstract reasoning, initiative– stubborn,– perseverate,– lack ambition, responsibility, judgment or
social graces
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Parietal Lobe
•Somatosensory Cortex-paresthesias•Dominant Parietal lobe-reading, writing,naming
• L. Angular gyrus• L. Supramarginal gyrus• L. Multimodal cortex
•Agraphia can be frontal or parietal
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Contralateral Neglect(asomatognosia)
• Right parietal• Right side is dominant for attention - do not attend to
opposite side, ie. Dressing apraxia• Severe - failure to recognize one’s opposite limb• Impaired visuospatial ability (drawing, copying, 3D,
manipulate objects in space• Fail to appreciate humor
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Temporal Lobe
• Association auditory cortex• Speech comprehension• Important in naming• Memory - bilateral medial temporal lobe
near hippocampus• Superior part of contralateral visual field
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Aphasias-Motor• Full Broca’s involves operculum, insula and subjacent
white matter with contralateral hemiparesis of face,arm
• Telegraphic speech• Agrammatism - syntax more affected than semantics• Usually agraphia too• Transcortical - interruption of inferred linkage paths
inward to Broca’s area
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Global aphasia
• Dominant hemisphere• Frontal• Temporal• Parietal• Head of caudate associated with
language disorders• Internal carotid or proximal MCA,
hemorrhage, or large tumor
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Aphasias-Sensory
• Wernicke’s• Dominant (left usually) hemisphere• Fluent, paraphasias, poor comprehension,• Naming, repetition, reading and writing impaired• Less aware and less frustrated than motor
aphasias
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Right hemisphere and aphasia
• Emotional tone modulation• Propositional prosody• Body language gestures
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Temporal Lobe Functions• Wernicke speech comprehension - dominant side• Verbal learning- dominant• Inferior temporal gyrus naming and faces - bilateral R or L• Superior homonymous quadrantanopia - (Meyers loop)• Hallucination incld gustatory, visual, auditory with emotion• Lyrics in dominant lobe• Harmony and melody is impaired by lesions of the
nondominant,• Visual learning- nondominant• Visual agnosia dominant, auditory agnosia nondominant
hemisphere• Bilateral: cortical deafness. Otherwise subtle• Bilateral: psychic blindness, Klüver-Bucy rarely full in
man.• Bilateral hippocampal formation : Amnesia
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Agnosia-impaired perception or recognition withOK vision, hearing, sensation , attention,intelligence• Visual: colors, faces, letters• Auditory: tunes, spoken words, pure word deafness• Somatosensory - stereognosis, graphesthesia• May not have other signs: aphasia, apraxia• Atrophy or metastatic disease• Disconnections of specific sensory association areas• Corpus callosum, deep white matter near main sensory areas
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Brodmann, Lateral
Occipital Lobe
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Ventral and dorsal Stream, MT
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Medial Gross Brain
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Visual Path
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Ventral,Gross Brain
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PCA ventral viewright hemisphere
from D.Haines
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Write the patient historyPosterior view, angiogram
FIRST ANGIO SECOND ANGIO next day
R R LL
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STROKE:Remember the 1stFour Letters...S.T.R.O.
If everyone can remember something this simple,we could save some folks.
Doctors say a bystander canrecognize a stroke by askingthree simple questions:
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Ask four simple questions: • S Ask the person to SMILE• T Ask the person to TALK and
SPEAK A SIMPLE SENTENCE(Coherently) (i.e. It is sunny outtoday)• R Ask them to RAISE BOTH ARMS.• O Ask them to open their mouth
and STICK OUT your tongue. (Doesit deviate to one side?)• K Kall 911• E Every minute counts (180 mins)
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End of Dental lecture