CENTER FOR PROCESS ANALYTICAL CHEMISTRYdepts.washington.edu/cpac/About/CPACOverview.pdf ·...
Transcript of CENTER FOR PROCESS ANALYTICAL CHEMISTRYdepts.washington.edu/cpac/About/CPACOverview.pdf ·...
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CENTER FOR PROCESS
ANALYTICAL CHEMISTRY UNIVERSITY OF WASHINGTON, SEATTLE
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Provides a Global Forum for Multi-disciplinary
and Multi-University Participation in
Developments in Process Analytical Technology
The Objective of the Center is to Address
Challenges in Real-Time Analysis and Process
Optimization
CPAC is a Consortium of Multi-Industry
Sponsors, and Government Agencies
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CPAC is Multidisciplinary
Chemistry
Electrical Engineering
Applied Physics
Forest Resources
Computer Sciences
Chemical Engineering
Food Sciences
Health Sciences
Biochemistry
With 30 industry sponsors,
CPAC presently supports 15
research projects at 3
Universities involving 15
Principal Investigators (Faculty
and Research Scientists) and
28 graduate students and post
docs
Since 1984, 150 PhD graduates
have been associated with CPAC
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CPAC Activities
• Semiannual Sponsor Meetings (May & Nov)
• Tutorials and Technical Workshops
• Summer Institute – Seattle (July)
• Satellite Workshop – Rome, Italy (March)
• Industry Driven Initiatives
• Graduate Education
• IFPAC, FACSS, AIChE, Pittcon, etc.
• FDA (PAT, QbD), USP
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Today’s Key Industrial Topics include:
Quality by Design - QbD
Process Analytical Technology - PAT
Food Quality and Safety
Bio-Processing
Green Chemistry
Nanotechnology
Micro-instrumentation
Process Control and Data Handling
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What CPAC is interested in:
The Development and Application
of New Technology Tools for
Enhancing:
Quality by Design (QbD), Process
Analytical Technology (PAT),
Process Intensification, and
Greener Processing
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What is Quality by Design?
Systematic approach to
development
• Begins with predefined
objectives
• Emphasizes product and
process understanding and
process control
• Based on sound science and
quality risk management
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PAT Tools
• PAT tools can be categorized as:
– Process analyzers
– Process control tools
– Multivariate tools for design, data
acquisition and analysis
– Continuous improvement and
knowledge management tools
• PAT is more than just an analyzer!
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Core Research Areas
Chemometrics
Sensors
Spectroscopy / Imaging
Chromatography
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CPAC RESEARCH PROJECTS
• SELF ASSEMLED SENSOR PLATFORMS BASED ON RFID
• ADAPTIVE OPTICS TO VISUALIZE DYNAMIC PROCESSES
• SMALL NMR SYSTEMS
• VAPO CHROMIC BASED SENSORS
• DIELECTRIC SPECTROSCOPY SENSORS
• DATA MINING AND DATA FUSION
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CPAC RESEARCH PROJECTS
• RAMAN SPECTROSCOPY
• GC / GC
• SMALL LC
• LIBS
• SURFACE PLASMON RESONANCE BASED BIO-SENSORS
• MEMBRANES FOR SEPARATION AND CONCENTRATION OF LIGNOCELLUOSES
• MICRO-REACTORS AND NeSSI
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CPAC INITIATIVES INCLUDE:
- BIO-PROCESSING IMPROVEMENTS
- MICRO-INSTRUMENTATION FOR HIGH THROUGHPUT EXPERIMENTATION AND PROCESS OPTIMIZATION
- NEW SAMPLING AND SENSOR INITIATIVE (NeSSI)
- CHEMOMETRICS ON-LINE INITIATIVE
- MEASUREMENT TOOLS FOR FOOD QUALITY AND SAFETY
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Some of the Current Initiatives at CPAC that
are Keys to the Future of Process Analytics
• Micro-instrumentation for high throughput,
development, and process optimization
(Micro-Analytical)
• New sampling system
approaches (NeSSI™)
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CPAC LEGACY
• CREATING FORUMS FOR PROMOTING ADVANCES IN PAT AND IN GLOBAL APPROACHES TO TECHNICAL COOPERATION IN PAT
• ACADEMIC PROGRAMS TO EDUCATE STUDENTS
• MULTI-DISCIPLINARY, MULTI-INDUSTRY
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CPAC Activities
IMTeC – June 2010
Summer Institute – July 2010
IFPAC Europa – September 2010
Corning / Oggi Chemist – October 2010
PPAR – October 2010
Members meeting – Nov. 2010
IFPAC – January 2011
Satellite Workshop - Rome – March 2011
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CPAC SUMMER INSTITUTES • THE DEVELOPMENT OF ENABLING
TECHNOLOGIES FOR THE PROCESSING INDUSTRIES
• MICRO-INSTRUMENTATION FOR HIGH THROUGHPUT EXPERIMENTATION AND PROCESS INTENSIFICATION
• A TOOL FOR PAT
• EMPHASIS ON BIO-PROCESSING
• JULY 20-22, 2011 SEATTLE
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CPAC SATELLITE WORKSHOP
(Winter Institute)
• MICRO-REACTORS AND
MICRO-ANALYTICAL
• PROCESS OPTIMIZATION
• UW ROME CENTER
• MARCH 2006 – 2010
• MARCH 22-24, 2011
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Global Approach to Create a Reference
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BENEFITS OF CONSORTIA
MEMBERSHIP
New Technology Peer Communication
Students
Deliverables
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PEER COMMUNICATION
BENCHMARKING
CLEARING HOUSE
FOCUS GROUPS
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CENTERS ENHANCE
ACADEMIC PROGRAMS
MULTIDISCIPLINARY
SHOWCASE EMERGING TECHNOLOGIES
PROVIDE PRACTICAL FOCUS
COMPETE WELL FOR SCARCE RESOURCES