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Center for Biological Physics Lori Goldner, Jenny Ross Adrian Parsegian Direct measurement of...
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Transcript of Center for Biological Physics Lori Goldner, Jenny Ross Adrian Parsegian Direct measurement of...
Center for Biological PhysicsLori Goldner, Jenny Ross
Adrian Parsegian
Direct measurement of intermolecular forces
to build a physics of molecular organization
Watching single molecules move through channels
Theory of intermolecular forces organizing soft materials, colloids and large bio-molecules
exploded virus and intact virus
Bacteriophage T2 Kleinschmidt et al. (1962)
DNA spooled inside a virusA. Evilevitch, (2006).
Viral DNA is under pressure that can drive infection:
QuickTime™ and a decompressor
are needed to see this picture.
QuickTime™ and a decompressor
are needed to see this picture.
Equation of State: Osmotic pressure vs. DNA density, function of salt, temperature, etc.
Building a physics of forces and energies for nanometer-to-micrometer - size particles
Unified equation of state for flexible polymers: Osmotic pressures of many sizes and concentrations fit with ONE parameter.
Joel Cohen (Univ Pacific), Rudi Podgornik (Slovenia)
To be part-time @UMass
25 µm
1 cm
_+
2 nm
70 µm
E(mV)
I(pA)
100 µm
10 ms
pA
Detection
10 ms
pA
Current through channel
0
Sergey Bezrukov, Philip Gurnev
Building an apparatus in Hasbrouck next month
Transport through single ionic channels Current detection of single-molecule transit
Theory of intermolecular forces
(electrostatics, electrodynamics, solvation, steric) example of single-walled carbon nanotubes
Rick Rajter, Rudi Podgornik, Roger French, Wai-Yim Ching, AP
Connection between dielectric spectra
and van der Waalstorques/forces.
Under study
DNA, Lipids (cell membranes), Proteins
Xiangyun Qiu, Rudi Podgornik, to be working @UMass
Jason DeRouchey, Don Rau, et al. at NIH (where I used to work)
Thanks