Cell-Cell Signaling
description
Transcript of Cell-Cell Signaling
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Cell-Cell Signaling
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Neurotransmitters
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Ligand-Gated Na+ Channel
Post-synaptic membrane
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Target Cell
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Signal Transduction Pathway of Target Cell
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Receptor Tyrosine Kinase-MAP Kinase Pathway
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Receptor Tyrosine Kinase (RTK) Activation
(RTK)
(GEF)
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RTKs Bound to Signal Molecule
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(GEF)
Activation of Ras Protein
Kinase Cascade
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Kinase Cascade
Target Proteins
(MKKK)
(MKK)
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TumorProgression
Pg. 729
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ColonizeNew Tissues
Pg. 727
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Tumor Growth
Pg. 736
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Normal Ras and Oncogenic Ras
Normal Ras Oncogenic Ras
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Post-Translational Modfication of Ras
Ras
FTase
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Therapy for “Ras-Positive” Tumors
Ras
FTaseFTase Inhibitors
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Pathways Disrupted in Cancer Cells
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Signal Transduction Pathways and Cell Differentiation
Specialized cell type(neuron, skin cell, red blood cell, etc.)
Stem Cell
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Blood Cell Formation
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Red Blood Cell Development
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EPO
Synthesis of proteins that stimulate Red Blood Cell development
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Negative Regulation of JAK/STAT Pathway
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Seven-Pass ReceptorsAdrenalineGlucogonTSH, LH
Cell TypesHeart muscleSkeletal muscleThyroidOvaryKidneyIntestinal epithelia
ContractionGlycogen breakdownHormone secretionWater retentionIon transportPg. 546
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Activation of Galpha Subunit
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Synthesis of cyclic AMP
ATP
cyclic AMP
Adenylyl Cyclase
Pg. 550
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TargetsIon ChannelsTranscription FactorsEnzymes
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Cholera Toxin
G.I. Tract
G∂ “ON”
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Actin Microtubules Intermediatefilaments
Cytoskeletal Structures
Chapter 17
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Tubulin Dimer
GTP
GTP
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GFP-Tagged Centrosomes
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Centrosome Structure
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TaxolColchicine
(Pacific Yew)
(Autumn crocus)
Microtubule “Poisons”
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Tubulin Dimer
GTP
GTP Taxol
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Microtubules
Vesicle Transport
Chromosome segregation(mitotic spindle)
Cilia/Flagella
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Microtubule “Motor” Proteins
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Microtubule “Motor” Proteins
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Actin Filaments
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Actin Monomer
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Arp2/3 (Actin Related Proteins)
Arp2
Arp3
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Gelsolin Protein
New minus end
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Myosin-II
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Muscle Cell
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Sarcomere
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Contraction of a Sarcomere
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Resting Muscle
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Ca2+
Binds Troponin C
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Tropomyosin blocksaccess to actin filament
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Muscle Cell
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Muscle Relaxants
Pancuronium Baclofen
Ligand for Seven-pass receptorInhibits Ligand-gated ion channels
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Muscle Cell
Pancuronium
Muscle cell membrane can not be de-polarized
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Muscle Relaxants
Pancuronium Baclofen
Ligand for Seven-pass receptorInhibits Ligand-gated ion channels
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Baclofin
Muscle CellMembrane
Muscle CellMembrane
Muscle cell membrane can not be de-polarized
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Cytokinesis
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Myosin II - GFP
Interphase Telophase Cytokinesis
CytokinesisCytokinesis G1
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“Contractile Unit” in Cytokinesis
Fig. 17-41
Plasma Membrane
Cytosol
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Mitotic Cell Cycle
DNAReplication
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G1 S G2
G1
M-Phase
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G1 S G2
G1
M-Phase
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Binding site forOrigin Recognition Complex (ORC)
(ORC)
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(G1 Phase)
(G2 Phase)
Semi-Conservative DNA Replication
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