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Celia P. Martinez-Jimenez

Cel ia .M ar t inez@ helmhol tz -muenchen .de o rc id .o rg /0000-0002-9534-6201

Cita t ions 1371 Publ ica t ions 20

EDUCATION AND EMPLOYMENT × Group Leader Helmoltz Pioneer Campus.HelmholtzZentrum München (DE) 2018-now × Post-doctoral Fellow (3rd) University of Cambridge / CRUK CI / Sanger Institute (UK) 2015 –2018 × Business Development Manager Applicacell Biotech, S. L. (Spin-off, ES) 2012 - 2014 × Master of Business Administration University San Pablo CEU. Business School (ES) 2012 × Post-doctoral Fellow (2nd) Biomedical Research Centre Príncipe Felipe (ES) 2010 - 2012 × Post-doctoral Fellow (1st) B.S.R.C. Alexander Fleming/FORTH Institute (GR) 2006 - 2010 × Pre-doctoral Fellow Health Research Institute Hospital La Fe (ES) 2001 - 2006 × MSc. Biochemistry/ MSc. Biology University of Valencia (ES) 1995 - 2003

HONORS, AWARDS AND PROFESIONAL DEVELOPMENT × 1st Re-entry Janet Thornton Fellowship Wellcome Trust Sanger Institute 2015-2018 × EMBO Lab. Management Course EMBO 2015 × Professional Development Course OTTO Walter International 2013 × 1st CEU Entrepreneurship Award University San Pablo CEU. Business School 2012 × Post-doctoral Long-Term FEBS Biomedical Research Centre Príncipe Felipe 2010-2012 × Post-doctoral Marie Curie (ITN) B.S.R.C. Alexander Fleming/FORTH Institute 2006-2008 × National Ph.D. Award University of Valencia (Spain) 2007 × Pre-doctoral fellowship ALIVE Foundation 2005 -2006 × Fellowships for international stays Spanish Central Government 2003 & 2004 × Pre-doctoral fellowship Spanish Central Government 2001-2005

FIVE SELECTED PUBLICATIONS × Martinez-Jimenez C.P.* Eling N.*, Vallejos C.A., Kolodziejczyk A.A., Chen H.C., Connor F., Stojic L., Rayner T.F.,

Stubbington M.J.T., Teichmann S.A., Roche M., Marioni J.C., Odom D.T. “Aging increases cell-to-cell transcriptional variability upon immune stimulation”. Science (2017) 1433

× Martinez-Jimenez C.P. and Odom D.T. “The mechanisms shaping the single-cell transcriptional landscape.” Current Opinion in Genetics & Development (2016) 27 × Martinez-Jimenez C.P., Kyrmizi I., Cardot P., Gonzalez F.J, Talianidis I. “HNF-4α coordinates the transcription factor

network regulating hepatic fatty acid metabolism. Molecular Cell Biology (2010) 565 × Martinez-Jimenez, C.P., Gómez-Lechón, M.J., Castell, J.V., Jover, R. “Under-expressed coactivators PGC1α and

SRC1 impair HNF4α function and cause dedifferentiation in human hepatoma cells”. JBC (2006) 29840

× Martinez-Jimenez, C.P., Gómez-Lechón, M.J., Castell, J.V., Jover, R. “Transcriptional regulation of the human hepatic CYP3A4: Identification of a new distal enhancer module in the human hepatic CYP3A4 responsive to CCAAT/enhancer binding protein beta isoforms (LAP and LIP)”. Molecular Pharmacology (2005) 2088

TEACHING EXPERIENCE Accredited as University Professor by the State National Agency of Quality Control and Accreditation (ANECA). Spain. × Assistant professor Hospital Universitary and

Polytechnic La Fe, Valencia. "Methodology in Biomedical Research” 2013-2014

× Associate professor

Catholic University of Valencia “Proteomics” 2012-2013

× Assistant professor University of Valencia. “Practices of Immunology” and “Practices of Biochemistry and Molecular Biology”

2001-2005

CP. Martinez-Jimenez - CV

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SELECTED INVITED TALKS × Instituto de Biomedicina de Valencia Valencia, ES “Single-cell sequencing” June-2017 × Leeds Beckett University Leeds, UK “Single-cell sequencing” May-2017 × 4th Annual Single Cell Analysis Congress London, UK “Single-cell sequencing” Nov-2016 × Biomedical Research Centre Príncipe Felipe Valencia, ES “Liver metabolism” Feb-2010 × University of Ioannina Ioannina, GR “Liver metabolism” Dec-2009

LEADERSHIP, COMUNNITY AND PEER REVIEWS × Cambridge Institute Scientists Society (CIS Soc) and Chair of the Career Pathways Talks (CRUK CI) × Senior Fellow at the Darwin College (Cambridge) × Society of Spanish Researchers in the United Kingdom (SRUK-CERU) × Spanish Association of Scientist Entrepreneurs (AEEC) × Federation of the Societies of Biochemistry and Molecular Biology (FEBS) × Society of Transplants of the Community of Valencia (STCV) × Peer reviews at Molecular Cell and Einstein Foundation Berlin

OUTREACH TRAINING AND ACTIVITIES × Rising Starts Public Engagement Training. University of Cambridge, UK. 2017 × Workshop for hospitalized children. Hospital Universitary and Polytechnic La Fe. Valencia, ES. 2013

CAREER BREAKS

ALL PUBLICATIONS

2. Ernst C.*, Eling N.*, Martinez-Jimenez C.P., Marioni J.C, Odom D.T. “Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis”. bioRxiv 350868 (2018). Nature Communications (under review).

3. Martinez-Jimenez C.P.* Eling N.*, Vallejos C.A., Kolodziejczyk A.A., Chen H.C., Connor F., Stojic L., Rayner T.F., Stubbington M.J.T., Teichmann S.A., Roche M., Marioni J.C., Odom D.T. (*equal contribution) “Aging increases cell-to-cell transcriptional variability upon immune stimulation”. Science (2017) 1433-1436

4. Le Guevel, R., Oger, F., Martinez-Jimenez, C. P., Bizot, M., Gheeraert, C., Firmin, F., Ploton, M., Kretova, M., Palierne, Staels, B., Barath, P., Talianidis, I., Lefebvre, P., Eeckhoute, J., Salbert, G. “Inactivation of the Nuclear Orphan Receptor COUP-TFII by Small Chemicals”. ACS Chem Biol (2017) 654-663

5. Calvo-Lerma, J., Martinez-Jimenez, C. P., Lazaro-Ramos, J. P., Andres, A., Crespo-Escobar, P., Stav, E., Schauber, C., Pannese, L., Hulst, J. M., Suarez, L., Colombo, C., Barreto, C., de Boeck, K., Ribes-Koninckx, C. “Innovative approach for self-management and social welfare of children with cystic fibrosis in Europe: development, validation and implementation of an mHealth tool (MyCyFAPP)”. BMJ Open (2017)

6. Martinez-Jimenez C.P. and Odom D.T. “The mechanisms shaping the single-cell transcriptional landscape”. (Review) Current Opinion in Genetics & Development (2016) 27-35.

7. Martinez-Jimenez C.P., and Sandoval-J. “Epigenetic crosstalk: a molecular language connecting transcription and metabolic disorders (Review)”. Frontiers in Bioscience (2015) 46-47

8. Vicente-Muñoz S, Romero P, Magraner-Pardo L, Martinez-Jimenez CP, Tordera V, Pamblanco M. “Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex”. FEBS Open Bio (2014) 996-1006.

9. Molina-Navarro MM*, Martinez-Jimenez C.P.*, Rodriguez-Navarro S. (*equal contribution). “Transcriptional elongation and mRNA export are co-regulated processes”. (Review) Genetics Research International (2011) 1-10.

⋅ I moved back and remain in Valencia due to personal reasons (2010). I returned with a long-term FEBS fellowship and after two years I moved to the private sector. I re-engaged in research in January 2015 with the inaugural Janet Thornton Fellowship. 35 months

1. Chen H-C., Eling N.*, Martinez-Jimenez C.P. *, O’Brien L.M., Marioni J.C., Odom D.T., and de la Roche M. Altered composition of the γδ T cell pool in lymph nodes during ageing enhances tumour growth. bioRxiv 480327 (2018). EMBO Medicine (under review).

CP. Martinez-Jimenez - CV

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10. Schmidt D., Wilson M.D., Ballester B., Schwalie P.C., Gordon D. Brown G.D., Marshall A., Kutter C., Watt S., Martinez-Jimenez C.P., MacKay S., Enright A. J., Talianidis I., Flicek P, Odom D. T. “Five vertebrate ChIP-seq reveals the genetic mechanisms of rapid transcription factor binding divergence”. Science (2010) 1036-40

11. Martinez-Jimenez C.P., Kyrmizi I., Cardot P., Gonzalez F.J, Talianidis I. “HNF-4α coordinates the transcription factor network regulating hepatic fatty acid metabolism”. Molecular Cell Biology (2010) 565-77

12. Tatarakis A., Thanasis M., Martinez-Jimenez CP., Kouskouti A., MohanII WS., Haroniti A., Kafetzopoulos D., Tora L., Talianidis I. “Dominant and redundant functions of TFIID envolved in the regulation of hepatic genes”. Molecular Cell (2008) 531-43

13. Martinez-Jimenez CP, Jover R, Donato MT, Castell JV, Gómez-Lechón MJ. “Transcriptional regulation and expression of CYP3A4 in hepatocytes”. Curr. Drug Metab. (2007) 185-94

14. Martinez-Jimenez, C.P., Castell, J.V., Gómez-Lechón, M.J., Jover, R. “Transcriptional activation of CYP2C9, CYP1A1 and CYP1A2 by HNF4α requires coactivators PGC1α and SRC1. Molecular Pharmacology (2006) 1681-1692

15. Martinez-Jimenez, C.P., Gómez-Lechón, M.J., Castell, J.V., Jover, R. “Under-expressed coactivators PGC1α and SRC1 impair HNF4α function and cause dedifferentiation in human hepatoma cells”. The Journal of Biological Chemistry (2006) 29840-29849

16. Castell, J.V., Jover, R., Martinez-Jimenez, C.P., Gómez-Lechón, M.J. “Hepatocyte cell lines: Their use, scope and limitations in drug metabolism studies”. Expert Opin. Drug Metab. Toxicol. (2006) 183-212

17. Martinez-Jimenez, C.P., Gómez-Lechón, M.J., Castell, J.V., Jover, R. “Engineering human hepatoma cells with key transcription factors to generate metabolically competent hepatic models”. ALTEX (2005) 435-440

18. Martinez-Jimenez, C.P., Gómez-Lechón, M.J., Castell, J.V., Jover, R. “Transcriptional regulation of the human hepatic CYP3A4: Identification of a new distal enhancer module in the human hepatic CYP3A4 responsive to CCAAT/enhancer binding protein beta isoforms (LAP and LIP)”. Molecular Pharmacology (2005) 2088-2101

19. Handschin, C., Gnerre, C., Fraser, D., Martinez-Jimenez, C.P., Jover, R., Meyer, U.A. “Species-specific mechanisms for cholesterol 7α-hidroxylase (CYP7A1) regulation by drugs and bile acids”. Archives of Biochemistry and Biophysics (2005) 75-85

20. Martinez-Jimenez, C.P., Jover, R., Gómez-Lechón, M.J., Castell, J.V. “Can hepatoma cell lines be re-differentiated to be used in drug metabolism studies?” ATLA (2004) 65-74