CDE innate response for targets webinar
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Transcript of CDE innate response for targets webinar
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Centre Defence Enterprise
for
Themed Competition Webinar
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© Crown copyright 2013 Dstl
20 May 2014
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The aim of CDE
Technology
Best providers
Barriers
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20 May 2014
Funding research
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Two routes to funding
Enduring
Themed
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Themed competition
Requirements
Bounded
Specific
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CDE themed competition
Innate response targets for therapy
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Enduring challenge competition
Perpetual
Radical
£3M per year
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Dstl is part of the Ministry of Defence
UNCLASSIFIED / For Public Release
Centre for Defence Enterprise www.science.mod.uk/enterprise [email protected]
Crown Copyright Dstl 2012
Enduring challenges
• protection • situational awareness • power • communications • data • lethality • mobility • human performance • lower cost of ownership • new capabilities
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Online bid submission
CDE Portal
Only route
Low overhead
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Dstl is part of the Ministry of Defence
UNCLASSIFIED / For Public Release
Centre for Defence Enterprise www.science.mod.uk/enterprise [email protected]
Crown Copyright Dstl 2012
Read available information
Start with –
Quick Start Guide
CDE Portal
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Intellectual property
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Dstl is part of the Ministry of Defence
UNCLASSIFIED / For Public Release
Centre for Defence Enterprise www.science.mod.uk/enterprise [email protected]
Crown Copyright Dstl 2012
Register now
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CDE Innovation Network
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Innate response targets for therapy
CDE themed competition March 25 - June 5 2014
20 May 2014
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Key dates
• Competition launches today • Presentation to follow • Opportunity for Q&A • Webinar Tuesday 1 April • Deadline for applications Thursday 5 June 2014 at 17:00 hrs via Centre for Defence Enterprise Portal • Funding decisions to be made July 2014 • Notifications end July
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20 May 2014
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Background: biothreat agents
• Pathogenic for man or animals
• Very low infectious dose
• Infectious via the inhalational route
• Cause endemic disease around world
• Usually are zoonotic diseases
• Lethal or incapacitating
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© Crown copyright 2014 Dstl
20 May 2014
Defence against biothreats
• Many potential biothreat agents • How to defend against them? • Impossible to make a vaccine/therapy for every potential agent • Require generic therapy
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Generic approach to therapy • By influencing the host response
• Requires an understanding of the host response to pathogen & safe ways to influence it
• Requires identification of relevant targets or pathways in the host
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Innate (host) response targets for therapy
• Objective of this competition is to look broadly across research and development to identify host cell targets and pathways
• Using data derived from diverse infection models
• Respondents to competition do not need to work directly with biothreat agents
• Ultimate aim is to apply the most innovative approaches to biothreat agents
20 May 2014
© Crown copyright 2014 Dstl
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CDE themed competition specifics • Seeking innovative proposals for short projects (<1year); £30-
80k guide; (£500k total budget)
• Show proof-of-concept for your proposal; there is funding allocated for follow-on work for successful projects
• Competition divided into 3 challenges
• Respondents need to address 1 of the challenges, may address >1, do not have to address all 3
• Challenges described fully in the competition document
• Bids must be ethical and compliant with UK government legislation
20 May 2014
© Crown copyright 2014 Dstl
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Challenge 1
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Identification of new cellular or host pathway targets
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Identification of new cellular or host pathway targets • In host-pathogen model of your choice
– Does not need to be a biodefence pathogen – Does not need to be in vivo
• Conditioning of cells ex vivo eg to profile responses or prior to adoptive transfer
• Targeting cells in situ eg – to refocus them – to activate them – to induce them to traffic – to redirect them
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Identification of new cellular or host pathway targets May involve the identification of eg • immuno stimulants • modulators • transfection factors • chemokines, cytokines or the induction (or blockade) of these • cytokine/chemokine/growth factor receptors and application of these to modulate host responses
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Identification of new cellular or host pathway targets
• Some of these may be
exogenous and some endogenous factors
• Some endogenous natural
regulators /regulatory pathways may be exploited
• to reduce inflammation and to restore homeostasis
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Normal
Overactive Underactive
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Possible outcomes Proposals for
– identification of new cellular targets /pathways – new applications of manipulating known cellular targets/pathways – demonstration that targets may be influenced beneficially, for
example to: • prevent cytotoxicity • prevent/reduce microbial invasion • reduce microbial load • restore normal cell function
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Challenge 2
Identification of new candidate therapies
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Identification of new candidate therapies Exploit appropriate cellular targets and pathways to identify new therapies by, for example:
• enhancing cell-mediated immunity • investigating novel combinations • identification and manipulation of significant
transcription factors • micro RNA-directed therapies or antagonists
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Possible outcomes • Candidate therapies should be druggable and generic • Proposals should show proof-of-concept
• Does not exclude the re-purposing or augmentation of existing
therapies
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Challenge 3
Identification of new platform technologies
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Identification of new platform technologies
For assessing therapeutic benefit • Novel technologies such as:
• non-invasive methods of in-vivo/ex-vivo analysis eg bio-imaging or tracking
• Transcriptomics including micro RNA analysis
• In-silico modelling of host responses
• Novel assays to monitor the host immune response
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Possible outcomes
• New technologies which may facilitate the identification and development of candidate therapies
• Proposals should demonstrate the impact of the technology on therapeutic development
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What we want • Highly innovative approaches that are significantly different from
existing technologies
• Generally technology readiness level (TRL) ≤ 3
• Generic approaches (not pathogen specific)
• Approaches applicable to intracellular pathogens where
appropriate
• Approaches that will lead to a feasible clinical product
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What we don’t want Proposals that concern: • high technology readiness level (TRL) capability • serological targets only (rather than cellular) • antibody-based therapies (but antibodies as a targeting
mechanism are acceptable) • existing solutions or technology already tested and found to
have limited utility • a paper study or review or similar • pre-exposure therapies or therapeutics • topical therapies for wounds
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Successful proposals
• Each will be assigned a Technical Partner
– Provides interface between project and defence community
– If project successful, potential routes to exploitation developed
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Summary
• Competition launches today • Webinar Tuesday 1 April • Closes on Thursday 5 June 2014 at 17:00 hrs • Short proof-of-concept proposals • If successful, potential for follow-on funding • May include additional research to develop technology for MOD • Competition information available on CDE website
www.science.mod.uk
© Crown copyright 2014 Dstl
20 May 2014
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Questions?
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20 May 2014
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Dstl is part of the Ministry of Defence
UNCLASSIFIED / For Public Release
Centre for Defence Enterprise www.science.mod.uk/enterprise [email protected]
Crown Copyright Dstl 2012
w: www.science.mod.uk
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