Catarina Duarte / Food and health @ IBET
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Transcript of Catarina Duarte / Food and health @ IBET
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Food and Health @ iBET
Catarina Duarte
Nutraceuticals and controlled Delivery Lab
IBET/ ITQB-UNL
Oeiras, Portugal
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To create value for our partners leveraging scientific & technological knowledge in Biology and Chemistry
To push for faster utilization of the new biotechnological tools in business activities;
To provide joint research advanced training – OPEN INSTITUTION - Research conducted through a close partnership with ITQB
To provide a support infrastructure for academia & companies in biotechnological processes and manufacturing in Portugal;
To support start up/spin off companies at the incubation stage of their activities
Mission :
www.ibet.pt
Oeiras, Lisbon
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BIAL │ IBERFAR │ JOSÉ de MELLO SAÚDE
GRUPO AZEVEDOS │ MEDINFAR │ TECNIMEDE
PHARMACEUTICALS AND HEALHCARE
AGROFOOD AND FORESTRY INDUSTRIES
AMORIM CORK INVESTIGAÇÃO E SERVIÇOS │ NUTRINVESTE
RAR│ SUMOL+COMPAL
ACADEMIC INSTITUTIONS
ESBUC – ESCOLA SUPERIOR DE BIOTECNOLOGIA (UCP)FCT-UNL – FACULDADE DE CIÊNCIAS E TECNOLOGIA (UNL)
ITQB – INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA (UNL)FACULDADE DE CIÊNCIAS MÉDICAS (UNL)
REITORIA DA UNIVERSIDADE NOVA DE LISBOA
FCT – FUNDAÇÃO PARA A CIÊNCIA E TECNOLOGIAFLAD – FUNDAÇÃO LUSO-AMERICANA PARA O DESENVOLVIMENTOIAPMEI – INSTITUTO DE APOIO ÀS PEQUENAS E MÉDIAS EMPRESAS
IICT – INSTITUTO DE INVESTIGAÇÃO CIENTÍFICA TROPICALINIAV – INST. NACIONAL DE INVESTIG. AGRÁRIA E VETERINÁRIA
FOUNDATIONS AND INSTITUTES
In total, iBET is 60% privately owned
Non-for-profit
Member of the LAO (ITQB, IGC, iBET, CEDOC)
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16 fully equipped
laboratories
Pilot Plant
cGMP Analytical Services Unit
cGMP CMO (GeniBET)
Human resources: 18 PhDs
4 Engineers 67 Researchers
14 Lab Technicians
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FLEXIBILITY & CONFIDENTIALITY
SPECIFIC NEEDS
• Contract Research Projects
• “Umbrella Research Contracts”
(plus per project based contracts)
• Satellite Laboratories
(Merck Serono and Bayer Healthcare)
• Joint Research for Advanced Training
(MSc, PhD, publications submitted after both parties approval)
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iBET is a certified Service Provider
Agro-forestry
Biopharmaceuticals and novel therapies
cGMP Analytical services and Bioassays
Food in Health
Food, Water and Energy Nexus
Protein stability, structure and drug design
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Bioactivity Chemical Characterization
and Metabolism
Process Tecnology
Analytical characterization:
Phytochemicals
Carbohydrates
Proteins
Sensory analysis
Metabolism:
• in vitro and in vivo digestion
and bioavailability
• metabolomic
Extraction and Fractionation (green and sustainable processes)
Fermentation
Formulation (development of bioactive and
bioavailable forms)
Scale-up (extraction, fermentation, drying)
Toxicity assessment
Health benefits (cell models, yeast models, …)
Preservative effects
Molecurar Structure - Bioactivy
Food and Health
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Chemical Characterization and Metabolism
Analytical characterization:
Phytochemicals
Carbohydrates
Proteins
Sensory analysis
Metabolism:
• in vitro and in vivo digestion
and bioavailability
• metabolomic
Molecurar Structure - Bioactivy
Food and Health
Spectrophotometric assays
Chromatographic techniques
• Total polyphenols content
• Total flavonoids content
• Total phenolic acids content
• Total procyanidin content
• Total anthocyanin content
• Total betalain content
• Analysis of carotenoids
• TLC
• UPLC
•HPLC-DAD-FD-ED
• GC-MS
• FTIR
• NMR
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Food and Health
Process Tecnology
• Conventional Extraction (with biocompatible solvents) • Pressurized Liquid Extraction • Supercritical Fluid Technology • Adsorption processes (molecular imprinted polymers)
Bioactive rich fractions (e.g. polyphenols, carotenoids, phytosterols, terpenes,...)
Natural colours
Natural flavours
Natural preservatives
Application in food, cosmetic or pharma industries
Extraction /Fraccionation of Natural Compounds
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Food and Health
Process Tecnology
Materials Processing – particle formation, encapsulation and impregnation
Fundamental studies
Design & optimization of Delivery Systems
DDS Characterization
(morphology, particle size, pharmacokinetics,…)
Nanotoxicity
Supercritical fluid Technology
Solid material processing with
ScCO2
Particle formation technologies
Impregnation by adsorption
Molecular Imprinting
Spray drying
Spray chilling
Fluidized-bed spray
“Conventional” Techniques
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Food and Health
Bioactivity
Characterization and pre-clinical Bioactivity evaluation of bioproducts
Enzymatic assays
Cell-based assays
Chemical assays
In vitro chemical and cell based assays for pre-clinical studies (antioxidant, anti-inflammatory, anti-proliferative,, neuroprotection, cardioprotective, anti-diabetes…)
Transport and permeability studies (in vitro)
Bioavailability evaluation after digestion (in vitro)
Molecurar Structure - Bioactivy
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Catarina Duarte
Contacts:
http://www.ibet.pt/services/food-health
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