Cat # PKI-TBB-050
1
Cat # PKI-TBB-050 TBB 4,5,6,7-Tetrabromobenzotriazole Size: 50 mg M.W.=434.71 Batch No.: 1A/20050309 15875 Gaither Drive Gaithersburg, MD 20877 FAX. 301-560-4919 TEL. 301-330-5966 Toll Free: 1-866-918-6812 Email: [email protected] Web: www.signagenlabs.com Description: A cell-permeable, selective inhibitor of casein kin ase-2 (CK2) (IC 50 = 0.9 and 1.6 µM for rat liver and human rec ombinant CK2 respectively). Exhibits modest discrim ination between CK2 subunits, with Ki values rangin g from 80 nM to 210 nM. Acts in an ATP/GTP-competi tive manner and displays one to two orders of magni tude selectivity over a panel of 33 protein kinases. Physical and Chemical Properties: Batch Molecular Formula: C6HBr4N3 Batch Molecular Weight: 434.71 CAS Number: [17374-26-4] Physical Appearance: White solid Batch Molecular Structure: Solubility: DMSO to 100 mM Ethanol to 15 mM Stability and Solubility Advice: Some solutions can be difficult to obtain and can b e encouraged by rapid stirring, sonication or gentle warming (in a 45-60°C water bath). Information concerning product stability, particula rly in solution, has rarely been reported and in most case s we can only offer a general guide. Our standard recommendations are: SOLIDS: Provided storage is as stated on the produc t label and the vial is kept tightly sealed, the product ca n be stored for up to 6 months from date of receipt. SOLUTIONS: We recommend that stock solutions, once This product is for laboratory research ONLY and not for diagnostic use 2006 SignaGen Laboratories References: 1. Sarno et al (2001) Selectivity of 4,5,6, 7-tetrabromobenzotriazole, an ATP site-dir ected inhibitor of protein kinase CK2 ('ca sein kinase-2'). FEBS Lett. 496 44. 2. Pagano et al (2004) Optimization of prote in kinase CK2 inhibitors derived from 4,5, 6,7-tetrabromobenzimidazole. J.Med.Chem. 4 7 6239. 3. Zien et al (2005) Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2. Biochim.Biophys.Acta. 1754 271. Storage: Upon arrival store this pro duct at 4 0 C. For long term, store t he product at -20 0 C. Product shipped at ambient temperature.
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TBB 4,5,6,7-Tetrabromobenzotriazole Size: 50 mg M.W.=434.71 Batch No.: 1A/20050309. 15875 Gaither Drive Gaithersburg, MD 20877 FAX. 301-560-4919 TEL. 301-330-5966 Toll Free: 1-866-918-6812 Email: [email protected] Web: www.signagenlabs.com. Cat # PKI-TBB-050. - PowerPoint PPT Presentation
Transcript of Cat # PKI-TBB-050
Cat
# P
KI-
TB
B-0
50 TBB
4,5,6,7-Tetrabromobenzotriazole
Size: 50 mgM.W.=434.71Batch No.: 1A/20050309
15875 Gaither Drive
Gaithersburg, MD 20877
FAX. 301-560-4919
TEL. 301-330-5966
Toll Free: 1-866-918-6812
Email: [email protected]
Web: www.signagenlabs.com
Description:A cell-permeable, selective inhibitor of casein kinase-2 (CK2)(IC 50 = 0.9 and 1.6 µM for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.
Physical and Chemical Properties:Batch Molecular Formula: C6HBr4N3Batch Molecular Weight: 434.71CAS Number: [17374-26-4]Physical Appearance: White solidBatch Molecular Structure:
Solubility: DMSO to 100 mM Ethanol to 15 mM
Stability and Solubility Advice:
Some solutions can be difficult to obtain and can beencouraged by rapid stirring, sonication or gentle warming(in a 45-60°C water bath).
Information concerning product stability, particularly insolution, has rarely been reported and in most cases wecan only offer a general guide. Our standardrecommendations are:
SOLIDS: Provided storage is as stated on the product labeland the vial is kept tightly sealed, the product can be storedfor up to 6 months from date of receipt.
SOLUTIONS: We recommend that stock solutions, onceprepared, are stored aliquoted in tightly sealed vials at -20 0C or below and used within 1 month. Wherever possiblesolutions should be made up and stored on the same day.
This product is for laboratory research ONLY and not for diagnostic use
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References:1. Sarno et al (2001) Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). FEBS Lett. 496 44. 2. Pagano et al (2004) Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J.Med.Chem. 476239.3. Zien et al (2005) Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2. Biochim.Biophys.Acta. 1754 271.
Storage: Upon arrival store this product at 4 0C.
For long term, store the product at -20 0C. Produc
t shipped at ambient temperature.
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