Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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Transcript of Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
http://slidepdf.com/reader/full/case-study-on-effectiveness-of-albendazole-emulsion-in-several-cases-of-echinococcosis 1/16
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
http://slidepdf.com/reader/full/case-study-on-effectiveness-of-albendazole-emulsion-in-several-cases-of-echinococcosis 2/16
CONTENTS:
SYNOPSIS
INTRODUCTION
MATERIALS AND METHOD
RESULT
CONCLUSION & DISCUSSION
REFERENCES
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
http://slidepdf.com/reader/full/case-study-on-effectiveness-of-albendazole-emulsion-in-several-cases-of-echinococcosis 3/16
SYNOPSIS
Benzimidazole Carbamates is used as anti-hydatidosis
drugs. And two common forms of it is
Albendazole(Abz) & Mebendazole(Mbz).
Abz is effective over Mbz as proven by clinical trials.
Hence Abz in tablet or emulsion form, is used to treat
cystic echinococcosis of liver in humans.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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The clinical efficacy of AbzE was studied in 264
cases of hepatic cystic echinococcosis on two
groups of patients with different doses:-10mg/kg/day
& 12.5mg/kg/day respectively. Higher doses was
found to be more effective in the study.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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INTRODUCTION
Benzimidazole carbamates are used as anti-
hydatidosis drug. And two commonly manufactured
forms of it are- Albendazole (Abz) & Mebendazole
(Mbz).
Clinical trials conducted in 1980s by WHO indicated
that Abz was better than Mbz.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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Abz is manufactured in two forms- as tablet (AbzT)
& as emulsion (AbzE). And AbzE was proved more
effective than AbzT.
Keeping in mind the above results, a novel
formulation of AbzE was developed in the Institute of
Parasitic Diseases of the Chinese Academy of
Preventive Medicine.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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MATERIALS & METHODS:
1. Selection of cases: Study subjects were patients of
cystic echinococcosis (CE) having mild symptoms
of epigastric pain, distention or abdominal mass.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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2. Drug & regimens: AbzE was prepared by emulsifying
Abz in 30% soybean oil (v/v). Two regimens of AbzE
were used in the study. Group A(71 cases); Abz
10mg/kg/day for adults weighing upto 70 kg. Group B
(193cases); Abz 12.5mg/kg/day for adults weighing upto
70kg. In both the above cases, the daily dosage was
divided into two & given – 1hr after breakfast & supper.
Treatment duration in both cases was one year.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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3. Clinical & laboratory examinations: History, signs &symptoms before & after chemotherapy as well as
responses & side-effects of patients after chemotherapy
were recorded. Ultrasonography & computed topography(CT) were used to examine patients at admission, every 3
months during treatment &every 3-6 months during follow-
up. Specific serological tests, examination of blood & urine
were also conducted during the treatment.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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4. Follow-up study: Patients in group A were
followed for 3-4 years & in group B for 2-4 years
post treatment.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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RESULT:
1. Evaluation of efficacy: Assessed by Ultrasonography at
the end of treatment, the overall effectiveness in group
A (71 cases, 10mg/kg/day) was found to be 97.2%.Whereas the overall effectiveness in group B (193
cases, 12.5mg/kg/day) was 97.9%. Improvement of
appetite & increase of body weight was observed in
most cases during the treatment.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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2. Side-effects: The common side-effects observed
were- 1) skin rashes 2)anorexia 3)nausea
4)vomiting 5) headache. These side-effects
gradually resolved over two weeks without any
treatment.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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CONCLUSION & DISCUSSION:
The efficacy was more prominent in case of higher
dosage.
Based on the preceding data, AbzE at a dose of
12.5m/kg/day for 9- 12 months was recommended
as the desirable regimen.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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A no. of factors like dosage, treatment duration, age,
sex, blood concentration of the drug etc may relate
to the efficacy of AbzE and needs to be considered.
The efficacy of Abz emulsion reported was muchhigher, surpassing all other anti-hydatidosis drugs or
formulations up-to-date. Hence Albendazole is the
best used medicine for treatment of hydatidosis
conditions.
7/30/2019 Case Study on effectiveness of Albendazole emulsion in several cases of Echinococcosis.
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REFERENCE:PARASITOLOGY INTERNATIONAL
VOLUME 53 (2004 EDITION) ISSUE- 1
PAGE NOS. 3-9