IV Practical Aspects of Lens Design October 2008 Rudi Rottenfusser – Carl Zeiss MicroImaging.
Carl Zeiss MicroImaging AIS Solutions for Digital Pathology Andrew Lesniak Director, Product...
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Transcript of Carl Zeiss MicroImaging AIS Solutions for Digital Pathology Andrew Lesniak Director, Product...
![Page 1: Carl Zeiss MicroImaging AIS Solutions for Digital Pathology Andrew Lesniak Director, Product Management.](https://reader031.fdocuments.net/reader031/viewer/2022020200/56649f305503460f94c4b497/html5/thumbnails/1.jpg)
Carl Zeiss MicroImaging AIS
Solutions for DigitalPathology
Andrew LesniakDirector, Product Management
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UpdateZeiss, Trestle, Clarient (ACIS)
The Device technology group was acquired from Clarient Inc., by Carl Zeiss in March 2007. Combined installation base of 600+ Units worldwide.
Full acquisition – including both the Trestle and the ACIS family of products
New entity formed under Carl Zeiss – Carl Zeiss MicroImaging AIS
Commitment to the technology portfolio, including:
- Integration into the Carl Zeiss Support structure (worldwide).
- Committed R&D investments for technology enhancement.
- Interoperability with the existing Zeiss product portfolio; including Image Acquisition, Mirax™ Platforms, and advanced technologies such as the PALM MicroBeam platform for Genomic and Phenotype applications.
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Light Microscopy
macro
Advanced Imaging Microscopy Digital Pathology Solutions
Classical Technologies Imaging Laser Digital Detection
cellular
molecular
Technology
Applications For Digital Pathology Information Management:
•Leading Computer Aided Diagnostics and Analysis
•AP Workflow and Educational Data Management
Leveraging a Leading Product Portfolio for a
Complete Pathology Imaging Solution
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Scalable Product Constellation
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• Small footprint
• 20x Plan-Apo objective with 0.8 NA
• Image capture from barcode area w/ barcode identification
• Optional 40x Plan-Apo objective with 0.95 NA
• Choice of different camera adaptors (1x or 0.63x)
• Optovar option (1.25x and 1.6x)
• Fluorescence option
Resolution range from 0.11 µm/pixel ... 0.52 µm/pixel
MIRAX Lab Automation Digital Pathology Solution
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• Zeiss Microscope Platform and Optics Configuration
• Full Robotic Telepathology functionality, including focal control, condenser settings
• Scalable to Digital Whole Slide Acquisition with user selectable Objective (4, 10, 20, 40, 60)
• Multi-focal plane imaging and robust focus technology ensures for robust imaging capability.
• Automated Slide Handling of 1, 4, 50 slides
• Fluorescence Multi-Channel Capable
MIRAX Micro Robotic Digital Pathology Solution
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Overlay Extended FocusReal-Time Acquisition of
image series from different focus positions
Unique Scanning Advancements: MicroField Acquisition
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Multi channel FluorescenceImage acquisition in several individual fluorescence channels
DAPI
Overlay
TexasRed
FITC
Scanning Advancements: Multi-channel
Fluorescence Acquisition
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Digital Pathology Analysis:
Innovations with Imaging
Tissue Scoring and Quantitative Analysis Membrane StainsNuclear stainsIntegrated Optical Density
Rare Event Detection Sentinel Lymph nodesBone marrow
Object Detection and CountingNuclear Cell Counting,Micro-Vessel Density, Ploidy
Tissue Micro Array Scoring
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Red blood cells
ICC-negative lymphoid cells
ICC-positive lymphoid cells
ICC-negative myeloid cells
ICC-positive myeloid cells
Size Blue Content Brown Contentsmall none/low medium/high
small high none/low
small high medium/high
large high none/low
large high medium/high
Digital Pathology Analysis:
Cellular Classification in Cytospin®
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Workflow, Educational and Reference Materials
Virtual Lab creation- organization ofDigital Images by context
Linking a slide to relevant accession,histological and pathological contextinformation
Linking areas of interest on a slideto relevant teaching or lesion specificinformation
Preservation of compound relatedeffects for future reference
Digital Pathology Workflow:
Enabling Scale
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