Cardiovascular and Pulmonary Research: A Year in Review

Combined Sections Meeting 2015

Indianapolis, Indiana, February 4-7, 2015

Paul Ricard, PT, DPT, CCSJohns Hopkins Hospital, Baltimore, MD

Lawrence Cahalin, PT, PhD, CCSUniversity of Miami, Miller School Of Medicine

Disclosures

• Paul Ricard has no disclosures regarding material presented in this course.

• Lawrence Cahalin has no disclosures regarding material presented in this course.

Speaker’s Note

• This year’s format will consist of each presenter speaking on a limited number of articles (bold/underlined in the following references) to allow for a more in depth presentation in areas that have been determined to be of most interest based on the literature review.

• Participants and authors are welcome to join in the conversation in the time allotted for each article.

• Please note that the following references are up to date as of December 2015. Articles from January, and February may be included in the final presentation and may supersede chosen articles to be discussed at the discretion of the presenters prior to the presentation.

Objectives

1. Report and interpret new literature surrounding the examination of or treatment for cardiovascular and pulmonary health conditions.

2. Compare their prior knowledge and practice to ideas and concept in current literature.

3. Discuss with peers the application and impact these studies may have on current and future practice.

General Health/Outcomes

1. Jette, Diane U., et al. "AM-PAC “6-Clicks” Functional Assessment Scores Predict Acute Hospital Discharge Destination." Physical therapy (2014).

2. Jette, Diane U., et al. "Validity of the AM-PAC “6-Clicks” Inpatient Daily Activity and Basic Mobility Short Forms." Physical therapy 94.3 (2014): 379-391.

3. Horoho, Patricia D. "Maintaining, Restoring, and Improving the Health of Our Nation." Journal of Orthopaedic & Sports Physical Therapy 44.5 (2014): 318-319.

4. Teyhen, Deydre S., et al. "Key Enablers to Facilitate Healthy Behavior Change: Workshop Summary." journal of orthopaedic & sports physical therapy 44.5 (2014): 378-387.

5. Albert, Michelle A., et al. "Early Results of Massachusetts Health Care Reform on Racial, Ethnic and Socioeconomic Disparities in Cardiovascular Care." Circulation. 2014;129:24 2528-2538.

6. Halpern, Scott D., et al. "An Official American Thoracic Society/American Association of Critical-Care Nurses/American College of Chest Physicians/Society of Critical Care Medicine Policy Statement: The Choosing Wisely® Top 5 List in Critical Care Medicine." American journal of respiratory and critical care medicine 190.7 (2014): 818-826.

Exercise Testing & Such1. Narang, Nikhil, et al. "Inaccuracy of

Estimated Resting Oxygen Uptake in the Clinical Setting.” 2014 Jan 14;129(2):203-10

2. McMurray, Robert G., et al. "Examining Variations of Resting Metabolic Rate of Adults: A Public Health Perspective." Med Sci Sports Exerc. 2014 Jul;46(7):1352-8.

3. Herda, Ashley A., et al. "Cross-Validation of the Recumbent Stepper SubmaximalExercise Test to Predict Peak Oxygen Uptake in Older Adults." Physical therapy94.5 (2014): 722-729.

4. Williams, Paul T. "Dose-response Relationship between Exercise and Respiratory Disease Mortality." Medicine and science in sports and exercise

46(4):711-717, April 2014.

5. Lawless, Christine E., et al. "Sports and Exercise Cardiology in the United States: Cardiovascular Specialists as Members of the Athlete Healthcare Team." Journal of the American College of Cardiology 63.15 (2014): 1461-1472.

6. Wen, Chi Pang, et al. "Minimal Amount of Exercise to Prolong Life: To Walk, to Run, or Just Mix It Up?." Journal of the American College of Cardiology 64.5 (2014): 482-484.

Exercise Testing & Such

1. Nes, BJARNE MARTENS, et al. "A Simple Nonexercise Model of CardiorespiratoryFitness Predicts Long-Term Mortality." Medicine and science in sports and exercise46(6):1159-1165, June 2014.

2. Levine, Benjamin D. "Can Intensive Exercise Harm the Heart? The Benefits of Competitive Endurance Training for Cardiovascular Structure and Function." Circulation 130.12 (2014): 987-991.

3. La Gerche, André, and Hein Heidbuchel. "Can Intensive Exercise Harm the Heart? You Can Get Too Much of a Good Thing." Circulation 130.12 (2014): 992-1002.

4. McDermott, Mary M., et al. "Six-minute walk is a better outcome measure than treadmill walking tests in therapeutic trials of patients with peripheral artery disease." Circulation 130.1 (2014): 61-68.

5. Hiatt, William R., R. Kevin Rogers, and Eric P. Brass. "The Treadmill Is a Better Functional Test Than the 6-Minute Walk Test in Therapeutic Trials of Patients With Peripheral Artery Disease." Circulation 130.1 (2014): 69-78.

6. Myers, Jonathan, et al. "Supervision of Exercise Testing by Nonphysicians A Scientific Statement From the American Heart Association." Circulation 130.12 (2014): 1014-1027.

Pulmonary Rehabilitation

1. de Sousa Pinto, Juliana M., et al. "Clinical Benefits of Home-Based Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary." J Cardiopulm Rehabil Prev. 2014 Sep-Oct;34(5):355-9

2. Collins, Eileen G., et al. "Clinical Competency Guidelines for Pulmonary Rehabilitation Professionals: POSITION STATEMENT OF THE AMERICAN ASSOCIATION OF CARDIOVASCULAR AND PULMONARY REHABILITATION." J Cardiopulm Rehabil Prev 34.5 (2014): 291-302.

3. Shoemaker, Michael J., et al. "Early ambulation predicts length of stay and discharge location following left ventricular assist device implantation." Cardiopulmonary Physical Therapy Journal 25.3 (2014): 75-85.

4. Robles, Priscila Games, et al. "Gender-Associated Differences in Pulmonary Rehabilitation Outcomes in People With Chronic Obstructive Pulmonary Disease: A SYSTEMATIC REVIEW." Journal of cardiopulmonary rehabilitation and prevention 34.2 (2014): 87-97.

Cystic Fibrosis

1. Sanders, Don B., et al. "Risk factors for the progression of cystic fibrosis lung disease throughout childhood." Annals of the American Thoracic Society 11.1 (2014): 63-72.

2. Hulzebos, E. H., et al. "Prediction of Mortality in Adolescents with Cystic Fibrosis." Med Sci Sports Exerc. 2014 Nov;46(11):2047-52

3. Jain, Manu, and Christopher H. Goss. "Update in cystic fibrosis 2013." American journal of respiratory and critical care medicine189.10 (2014): 1181-1186.

4. Dekerlegand RL, Hadjiliadis D, Myslinski MJ, Holsclar D, Ferrin M. Home-based Inspiratory Muscle Training in Adults With Cystic Fibrosis: A Case Series Report. Cardiopulmonary Physical Therapy Journal 25.3(2014): 85-91.

COPD

1. Nguyen, Huong Q., et al. "Associations between Physical Activity and 30-Day Readmission Risk in Chronic Obstructive Pulmonary Disease." Annals of the American Thoracic Society. 11.5(2014): 695-705.

2. Sharif, Roozbeh, et al. "Predictors of Early Readmission among Patients Aged 40 to 64 Years Hospitalized for Chronic Obstructive Pulmonary Disease." Annals of the American Thoracic Society. 11.5 (2014): 685-694.

3. Pohle-Krauza, Rachael J., et al. "Body Mass Index Moderates the Effects of Portable Oxygen Transport Modality on 6-Minute Walk Distance in Patients With COPD." Journal of cardiopulmonary rehabilitation and prevention 34.1 (2014): 62-68.

4. Van Remoortel, Hans, et al. "Risk factors and comorbidities in the preclinical stages of chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 189.1 (2014): 30-38.

5. Chawla, Harsh, et al. "Physical Activity as a Predictor of Thirty-Day Hospital Readmission after a Discharge for a Clinical Exacerbation of Chronic Obstructive Pulmonary Disease." Annals of the American Thoracic Society 11.8 (2014): 1203-1209.

6. Moy, Marilyn L., et al. "An Index of Daily Step Count and Systemic Inflammation Predicts Clinical Outcomes in Chronic Obstructive Pulmonary Disease." Annals of the American Thoracic Society11.2 (2014): 149-157.

COPD

1. Vestbo, Jørgen, et al. "Should We View Chronic Obstructive Pulmonary Disease Differently after ECLIPSE?. A Clinical Perspective from the Study Team." American journal of respiratory and critical care medicine 189.9 (2014): 1022-1030.

2. Feemster, Laura C., and David H. Au. "Penalizing hospitals for chronic obstructive pulmonary disease readmissions." American journal of respiratory and critical care medicine189.6 (2014): 634-639.

3. Shaikh, Zarrin F., et al. "Patent Foramen Ovale Is Not Associated with Hypoxemia in Severe Chronic Obstructive Pulmonary Disease and Does Not Impair Exercise Performance." American journal of respiratory and critical care medicine 189.5 (2014): 540-547.

Pulmonary Artery Hypertension

1. Batt, Jane, et al. "Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension." American journal of respiratory cell and molecular biology 50.1 (2014): 74-86.

2. Pullamsetti, Soni Savai, et al. "Novel and Emerging Therapies for Pulmonary Hypertension." American journal of respiratory and critical care medicine 189.4 (2014): 394-400.

Orthotopic Lung Transplant

1. Todd, Jamie L., et al. "Impact of Forced Vital Capacity Loss on Survival after the Onset of Chronic Lung Allograft Dysfunction." American journal of respiratory and critical care medicine 189.2 (2014): 159-166.

2. Todd JL, Christie JD, Palmer SM. "Update in Lung Transplantation 2013", American Journal of Respiratory and Critical Care Medicine 190. 1 (2014): 19-24.

Inspiratory Muscle Training

• Matsuo Y, Yanagisawa Y, Cahalin LP. Brief Research Report: The Feasibility of Expiratory Resistive Loading Using the Threshold Inspiratory Muscle Training Device. Cardiopulmonary Physical Therapy Journal 25.2(2014): 92-95.

• Dekerlegand RL, Hadjiliadis D, Myslinski MJ, Holsclar D, Ferrin M. Home-based InspiratoryMuscle Training in Adults With Cystic Fibrosis: A Case Series Report. Cardiopulmonary Physical Therapy Journal 25.3(2014): 85-91.

Pulmonary Potpourri

1. Hillegass E, Fick A, Pawlick A, Crouch R, Perme C, Chandrashekar R, McNamara SB, Cahalin LP. Supplemental Oxygen Utilization during Physical Therapy Interventions: Official Guidelines from the Cardiovascular and Pulmonary Section. Cardiopulmonary Physical Therapy Journal 25.2(2014): 38-49.

2. Bisca, Gianna Waldrich, et al. "Minimal Detectable Change of the London Chest Activity of Daily Living Scale in Patients With COPD." Journal of cardiopulmonary rehabilitation and prevention 34.3 (2014): 213-216.

3. Redlich, Carrie A., et al. "Official American Thoracic Society Technical Standards: Spirometry in the Occupational Setting." American journal of respiratory and critical care medicine 189.8 (2014): 983-993.

4. Benton, Melissa J., Jeffrey L. Alexander, and James D. Holland. "Relationship Between Strength, Function, and Quality of Life in Older Adults With Chronic Lung Disease: IS THERE AN INFLUENCE OF GENDER?." Journal of cardiopulmonary rehabilitation and prevention 34.2 (2014): 143-149.

5. Nisar, S., et al. "Impaired Functional Capacity Predicts Mortality In Patients With Obstructive Sleep Apnea." Am J Respir Crit Care Med 11.7 (2014): 1056-1063.

Heart Failure

1. Caldentey, Guillem, et al. "Prognostic value of the physical examination in patients with heart failure and atrial fibrillation: insights from the AF-CHF trial (Atrial Fibrillation and Chronic Heart Failure)." JACC: Heart Failure 2.1 (2014): 15-23.

2. Georgantas, Andreas, et al. "Beneficial Effects of Combined Exercise Training on Early Recovery Cardiopulmonary Exercise Testing Indices in Patients With Chronic Heart Failure." Journal of cardiopulmonary rehabilitation and prevention 34.6 (2014): 378-385.

3. Piña, Ileana L., et al. "Effects of Exercise Training on Outcomes in Women With Heart Failure: Analysis of HF-ACTION (Heart Failure–A Controlled Trial Investigating Outcomes of Exercise TraiNing) by Sex." JACC: Heart Failure 2.2 (2014): 180-186.

4. Perez-Moreno, Ana Cristina, et al. "Fatigue as a Predictor of Outcome in Patients With Heart Failure: Analysis of CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure)." JACC: Heart Failure 2.2 (2014): 187-197.

5. Choi, Eui-Young, et al. "Resting Heart Rate as Predictor for Left Ventricular Dysfunction and Heart Failure." Journal of the American College of Cardiology 63.12 (2014).

6. Basuray, Anupam, et al. "Heart Failure with Recovered Ejection Fraction: Clinical Description, Biomarkers, and Outcomes." Circulation (2014): 129:23 2380-2387.

7. Dracup, Kathleen, et al. "A Randomized Controlled Trial to Improve Self-Care in Patients with Heart Failure Living in Rural Areas." Circulation (2014): 130:3 256-264.

Heart Failure

1. Rengo, Jason L., et al. "Statin Therapy Does Not Attenuate Exercise Training Response in Cardiac Rehabilitation." Journal of the American College of Cardiology (2014). 20;63(19):2050-1.

2. Workgroup, Quality Initiative ADQI XI. "Proposal for a Functional Classification System of Heart Failure in Patients With End-Stage Renal Disease." Journal of the American College of Cardiology63.13 (2014).

3. Leifer, Eric S., et al. "Are there negative responders to exercise training among heart failure patients?." Medicine and science in sports and exercise 46.2 (2014): 219-224.

4. Thorvaldsen, Tonje, et al. "Triage of patients with moderate to severe heart failure: who should be referred to a heart failure center?." Journal of the American College of Cardiology 63.7 (2014): 661-671.

Cardiac Rehabilitation

1. Keteyian, Steven J., et al. "Greater Improvement in Cardiorespiratory Fitness Using Higher-Intensity Interval Training in the Standard Cardiac Rehabilitation Setting." Journal of cardiopulmonary rehabilitation and prevention 34.2 (2014): 98-105.

2. Gurovick AN, Flores OE, diaz RA. Comparison of the Observed Heart Rate During Lactate-based Exercise Intensity vs Three Heart Rate-based Methods in Cardiovascular Rehabilitation. Cardiopulmonary Physical Therapy Journal 25.2(2014): 50-54.

3. Hazelton, Garrett, et al. "Psychosocial Benefits of Cardiac Rehabilitation Among Women Compared With Men." Journal of cardiopulmonary rehabilitation and prevention 34.1 (2014): 21-28.

4. Gaalema, Diann E., et al. "State-by-State Variations in Cardiac Rehabilitation Participation Are Associated With Educational Attainment, Income, and Program Availability." Journal of cardiopulmonary rehabilitation and prevention (2014).

5. Keteyian, Steven J., et al. "Incorporating Patients With Chronic Heart Failure Into Outpatient Cardiac Rehabilitation." J Cardiopulm Rehabil Prev. 2014 Jul-Aug;34(4):223-32.

Cardiac Rehabilitation

1. Kerrigan, Dennis J., et al. "Cardiac Rehabilitation Improves Functional Capacity and Patient-Reported Health Status in Patients With Continuous-Flow Left Ventricular Assist Devices: The Rehab-VAD Randomized Controlled Trial." JACC: Heart Failure. JACC Heart Fail. 2014 Dec;2(6):653-9.

2. Ruivo, Jorge A. "Exergames and cardiac rehabilitation: a review." Journal of cardiopulmonary rehabilitation and prevention 34.1 (2014): 2-20.

3. Pack, Quinn R., et al. "The current and potential capacity for cardiac rehabilitation utilization in the United States." Journal of cardiopulmonary rehabilitation and prevention 34.5 (2014): 318-326.

4. Armstrong, Marni J., et al. "Patients with Diabetes in Cardiac Rehabilitation: Attendance and Exercise Capacity." Medicine and science in sports and exercise 2014 May;46(5):845-50

Ventricular Assist Devices

1. Kerrigan, Dennis J., et al. "Cardiac Rehabilitation Improves Functional Capacity and Patient-Reported Health Status in Patients With Continuous-Flow Left Ventricular Assist Devices: The Rehab-VAD Randomized Controlled Trial." JACC: Heart Failure. JACC Heart Fail. 2014 Dec;2(6):653-9.

2. Muthiah, Kavitha, et al. "Body position and activity, but not heart rate, affect pump flows in patients with continuous-flow left ventricular assist devices." JACC: Heart Failure 2.4 (2014): 323-330.

3. Alsara, Osama, et al. "Is Exercise Training Safe and Beneficial in Patients Receiving Left Ventricular Assist Device Therapy?." Journal of cardiopulmonary rehabilitation and prevention 34 (2014): 1-8.

4. Shoemaker MJ, Gaskell A, VanderBunte K, Sefton D, McLeod J, Karia DH, Dickenson MG, Khaghani A. Early Ambulation Predicts Length of Stay and Discharge Location Following Left Ventricular Assist Device Implantation. Cardiopulmonary Physical Therapy Journal 25.3(2014): 75-84.

5. Ottenberg, Abigale L., et al. "Choices for Patients “Without a Choice” Interviews With Patients Who Received a Left Ventricular Assist Device as Destination Therapy." Circulation: Cardiovascular Quality and Outcomes 7.3 (2014): 368-373.

6. McIlvennan, Colleen K., et al. "Decision Making for Destination Therapy Left Ventricular Assist Devices “There Was No Choice” Versus “I Thought About It an Awful Lot”." Circulation: Cardiovascular Quality and Outcomes 7.3 (2014): 374-380.

Cardiac Potpourri

1. Afilalo, Jonathan, et al. "Frailty assessment in the cardiovascular care of older adults." Journal of the American College of Cardiology 63.8 (2014): 747-762.

2. Fishbein, Daniel P., et al. "Use of the 6-Min Walk Distance to Identify Variations in Treatment Benefits From Implantable Cardioverter-Defibrillator and Amiodarone." Journal of the American College of Cardiology 63.23 (2014): 2560-2568.

3. Chen, Chun-An, et al. "Prognostic value of submaximal exercise data for cardiac morbidity in Fontan patients." Medicine and science in sports and exercise 46.1 (2014): 10-15.

4. Soares-Miranda, Luisa, et al. "Physical activity and heart rate variability in older adults: the Cardiovascular Health Study." Circulation (2014): May 27;129(21):2100-10.

5. Arefalk, Gabriel, et al. "Discontinuation of smokeless tobacco and mortality risk after myocardial infarction." Circulation (2014): Jul 22;130(4):325-32.

6. Walsh, Joseph A., Eric J. Topol, and Steven R. Steinhubl. "Novel wireless devices for cardiac monitoring." Circulation 130.7 (2014): 573-581.

7. Ahn B, et al. "Phrenic Nerve Stimulation Increases Human Diaphragm Fiber Force after Cardiothoracic Surgery." American journal of respiratory and critical care medicine 190.7 (2014): 837-839.

Critical Care

1. Bion, Julian, and Hans U. Rothen. "Models for Intensive Care Training. A European Perspective." American journal of respiratory and critical care medicine 189.3 (2014): 256-262.

2. Prescott HC, Langa KM, Liu V, Escobar GJ, Iwashyna TJ. "Increased 1-Year Healthcare Use in Survivors of Severe Sepsis", American Journal of Respiratory and Critical Care Medicine 190.1 (2014): 62-69.

3. Hodgson C, Stiller K, Needham DM, et.al. “Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults”. Crit. Care. 2014 Dec 4;18(6):658.

4. Baldwin, Claire E., and Andrew D. Bersten. "Alterations in respiratory and limb muscle strength and size in patients with sepsis who are mechanically ventilated." Physical therapy 94.1 (2014): 68-82.

5. Nordon-Craft, Amy, et al. "The Physical Function Intensive Care Test: Implementation in Survivors of Critical Illness." Phys Ther. 2014 Oct;94(10):1499-507.

6. Hua, May S., et al. "Estimates of the need for palliative care consultation across United States intensive care units using a trigger-based model." American journal of respiratory and critical care medicine 189.4 (2014): 428-436.

7. Patel, Shruti B., et al. "Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit." American journal of respiratory and critical care medicine 189.6 (2014): 658-665.

8. Page, Valerie J., et al. "Statin use and risk of delirium in the critically ill." American journal of respiratory and critical care medicine 189.6 (2014): 666-673.

Critical Care

1. Kiser, Tyree H., et al. "Outcomes associated with corticosteroid dosage in critically ill patients with acute exacerbations of chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 189.9 (2014): 1052-1064.

2. Yende, Sachin, et al. "Risk of Cardiovascular Events in Survivors of Severe Sepsis." American Journal of Respiratory and Critical Care Medicine 189.9 (2014): 1065-1074.

3. Needham, Dale M., et al. "Risk Factors for Physical Impairment after Acute Lung Injury in a National, Multicenter Study." American journal of respiratory and critical care medicine 189.10 (2014): 1214-1224.

4. Schmidt, Matthieu, et al. "Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure: The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score." American journal of respiratory and critical care medicine 189.11 (2014): 1374-1382.

5. Chao, Pei-wen, et al. "Association of postdischarge rehabilitation with mortality in intensive care unit survivors of sepsis." American journal of respiratory and critical care medicine 190.9 (2014): 1003-1011.

6. Cox, Christopher E., et al. "Development and preliminary evaluation of a telephone-based mindfulness training intervention for survivors of critical illness." Annals of the American Thoracic Society 11.2 (2014): 173-181.

7. Govindan, Sushant, et al. "Issues of Survivorship Are Rarely Addressed during Intensive Care Unit Stays. Baseline Results from a Statewide Quality Improvement Collaborative." Annals of the American Thoracic Society 11.4 (2014): 587-591.

Critical Care

1. Abrams, Darryl, Alain Combes, and Daniel Brodie. "Extracorporeal membrane oxygenation in cardiopulmonary disease in adults." Journal of the American College of Cardiology (2014).

2. Koch, Susanne, et al. "Long term Recovery in Critical Illness Myopathy is complete, contrary to Polyneuropathy." Muscle & nerve (2014).

3. Pruijsten R, et al. "Mobilization of patients on venovenousextracorporeal membrane oxygenation support using an ECMO helmet." Intensive care medicine 40.10 (2014): 1595-1597.

4. Ahasic A, et al. "Functional Status After Critical Illness: Agreement Between Patient and Proxy Assessments." Chest144.4_MeetingAbstracts (2013): 393A.