Cardiac Intervention in the Elderly. Cardiac Interventions Coronary Artery Bypass Grafting (CABG)...
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Transcript of Cardiac Intervention in the Elderly. Cardiac Interventions Coronary Artery Bypass Grafting (CABG)...
Cardiac Interventions
• Coronary Artery Bypass Grafting (CABG)
• Percutaneous Transluminal Coronary Angioplasty (PTCA) ± stenting
• Valve surgery• Radio-frequency Ablation• Automatic Implantable Cardiac
Defibrillators (AICDs)
Ischaemic Heart Disease
• Largest single cause of death in developed world
• Medical therapy
• CABG (Favaloro in 1969)
• PTCA (Gruentzig in 1977)
• Coronary stents (Sigwart in 1989)
CABG
• 600 000/year in the USA
Many trials selective/unrepresentative:– Males under 65 years old– Pre- Aspirin/Beta-blocker/ACE-I/Statin era– Saphenous vein grafts only
CABG - Mortality
Mortality (in-hospital) 1.3%
Predictors:» AGE» Co-morbidity» Pre-operative LV function» Surgical parameters» IABP requirement
CABG – MortalityNNECDSG SCORE
• Age + Gender
• LV Ejection Fraction
• Urgency of Surgery
• Previous CABG
• PVD, Diabetes, Renal Failure, COAD
• Body Habitus
NNECDSG scoreMortality score CVA score
Age 60-69 2 3.5
Age 70-79 3 5
Age 80 5 6
Renal dialysis 4 2
Each point = 0.2 – 2 % rise in mortality
CABG – 30 day Mortality
< 70 years > 70 years
All CABG 1.3 % 3.9 %
AVR + CABG 3 % 7.3 %
MVR + CABG 13 % 12.5 %
Emergency surgery
18.4 % 32 %
CABG – Neurological risks
CVA 3%
Prior neurological disease
IABP use
Diabetes
Hypertension
Unstable angina
Increased age
Prox. aortic atheroma
Drop in intellect 3%
Excess alcohol consumption
Arrhythmias
Hypertension
Previous CABG
Peripheral vascular disease
Congestive heart failure
Increased age
CABG – MorbidityRenal failure
• 8 % of all patients
• 1 % require dialysis (1.2 % of > 70 years)
Major predictor of mortality
• 18 % of patients die
• 66% of dialysis patients die
Risk factors
• Advanced age, CCF, re-do surgery, diabetes
CABG – MorbidityMediastinitis
• Deep sternal wound infection– 1% to 4% of patients– Mortality of 25%
• Predicted by:– Obesity– Re-do surgery– Use of both IMA’s at surgery– Diabetes mellitus
Survival after CABGCABG vs. Medical Rx
Mortality:@ 5 years: 10.2 % (CABG) vs. 15.8 % (medical)
@ 10 years: 26.4 % (CABG) vs. 30.5 % (medical)
Greatest benefit:– Left main stem or equivalent
– Proximal LAD involvement
Survival after CABGProximal LAD disease
• Relative risk reduction for CABG compared with medical treatment
– 42 % @ 5 years– 22 % @ 10 years
• Benefit increased if LV impaired
PTCA stent
• Most trials performed before:• Stents• Clopidogrel• IIb/IIIa platelet inhibitors
• 447 000 procedures/year in USA (1997)
PTCA stent
• Procedural success now 99.5% (76% in 1986)• Mortality
0.91% (UK values) 0 % (stents) 1.2% (stents in diabetic patients)
• Early repeat procedure (<7 months after 1st) 23.3 % with POBA 13.5 % with stents
PTCA (no stent)Mortality/morbidity
10 year follow-up:– Q-wave MI 3.9%– non Q-wave MI 11.3%– Death 23.1 %– CABG 32.7 %– Repeat procedure 38%– Recurrent angina 56.3 %
Risk factors:
• Extent of disease
• Diabetes
• Hypertension
• Previous MI
• Male
• Age >70 (mortality)
PTCA + stenting Mortality/morbidity
Follow – up data is over shorter period
Most data is pre - ticlopidine/clopidogrel
• Death rate @ 1 year 0.7 – 1.2%
• Target lesion re-intervention 15% (1yr)
• Cardiac event free survival 78% (1yr)
Outcomes similar for single vs. multivessel
PTCA + stenting Mortality/morbidity
Influence of ticlopidine
• MACE level dropped from:– 24.1% to 9.0 % (in hospital)– 47% to 33% (2 years)
PTCA stenting Influence of age
Study from 1980 –1996
< 50 70-79 >80
In-hospital mortality 0.28 % 2.1 % 3.45 %
Q-wave MI 1.6 % 1.0 % 2.54 %
CABG 4.94 % 3.5 % 2.7 %
5 year survival 94 % 76 % 65 %
PTCA stenting Influence of age
< 70 years
1yr 5yrs
70 years
1yr 5yrs
Non Q-wave MI 1.3 % 5.1 % 1.2 % 5.8 %
Severe angina 22.9 % 39.2 % 22.1 % 37.2 %
Repeat PTCA 11.0 % 22.9 % 9.3 % 18.6 %
CABG or PTCA?
• Data pre-stent / clopidogrel / IIb/IIIa inhibitors• BARI trial:Lower mortality with CABG vs. PTCA
– Diabetic patients do better with CABG– Non-diabetic patients – No difference
• QALY/activity/employment/costs equivalent at 5 years
• Recurrence of angina higher in PTCA– 21% vs 15% @ 5 years
Valve surgery in > 80 yrs age• High rate of co-morbidity
40-60% IHD 15-25% COAD 5-25% CVA 20-50% Hypertension
0
5
10
15
20
25
30
35
1 2 3 4 5 6 7 8
Risk score
Mor
tali
ty (
%)
Age > 80 years
AVR
MVR
Valve surgery in > 80 yrs ageRisk scoreEF: 30-50% +2 EF <30% +5Re-operation +2 Valve & CABG +2
0
5
10
15
20
25
30
35
1 2 3 4 5 6 7 8
Risk score
Mor
tali
ty (
%)
Age > 80 years
AVR
MVR
Valve surgery in > 80 yrs ageAppropriateness of surgery
• AVR for severe aortic stenosis +++• MVR for severe mitral regurgitation ++• AVR for moderate AS during CABG ++• MV repair for moderate MR at CABG +• Balloon valvuloplasty for MS +• MVR for moderate MR during CABG 0• AVR + MVR 0• Balloon valvuloplasty of aortic valve 0
Symtomatic Aortic Stenosis in the > 80 Year Old
00.10.20.30.40.50.60.70.80.9
1
1 2 3 4 5 6 7 8 9 10
Unselected 80 yearoldsAll patients afterAVR Unoperated patients> 80 Years oldPatients survivingafter AVR
Radio-frequency ablation
• Introduced in the 1980’s
• Treatment of choice in symptomatic SVT’s– AVNRT– AVRT (i.e. WPW)– Atrial flutter
• NO PROGNOSTIC ADVANTAGE
RFA Statistics
• Mortality 0.3%
• Major complication 3%
• Success 85 – 100% (95%)
• Recurrence 2 – 21%
RFA in the elderly
• Little data
• Most common procedure is AVJ (node) ablation for atrial fibrillation + PPM
• Age not a predictor of success/complication• Structural heart disease
• Multiple accessory pathways
• Heart disease
• Low ejection fraction
• AVJ ablation
Complications
Death
AICD’s
• Undoubted prognostic benefit
• Procedural mortality 0.5 – 0.8 %
• Primary prevention
• Secondary prevention
AICD’s –Primary Prevention
• Previous MI and all of the following:– Non-sustained VT on Holter (24 hour ECG)
– Inducible VT at EPS
– LV dysfunction • EF < 35%
• NYHA I – III
• Familial cardiac condition with risk of sudden death (long QT, HOCM etc.)
AICD’s – secondary prevention
• Patients who present, in the absence of a treatable cause, with:– Cardiac arrest due to VT or VF– Sustained VT causing syncope or significant
haemodynamic compromise– Sustained VT without haemodynamic
compromise + EF < 35% + NYHA I - III