CancerResearchOFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH

May 1, 1993Volume 53 •¿�Number 9PP. 1967-2198

ISSN 0008-5472 •¿�CNREA 8

An

84th Annual Meeting of theAMERICAN ASSOCIATION FOR CANCER RESEARCH

May 19-22.1993Orlando.FL

Outstaiiiliiif!Scientific Program Thai Integrates the Most Recen! Findings in Basic ami Clinical Cancer Research

Tucs. EveningMay IK

Wed. Mornini:May 19

Wed.AfternoonMay 19

Thurv MorningMay 20

Thurs. AlleninoliMay 20

Fri. MorningMay 21

Fri. AfternoonMay 21

SCIENTIFIC SESSIONSMinority Issues Committee Symposium: Careers andOpportunities in Cancer Research - Jerome Wilson, StiraliAntonia Li. Jacqueline Locklear. Eddie Reeü,Ücnny Jones. Jr.,Paideue S. (.¡ray.Rohen 11\'¡Unreal.

Kichurd und Hinda Kosenthal Foundation Award LectureWann Ki Hong.

Plenary Session: Predicting the Impact of Molecular Biologyon Cancer Therapy in the 21st Century (Joint AACR/ASCO)Su-plit-H H. F'nend. Front McCormick. CJtrísíoplwrWalsh. Judahr'olkmaii.

Svmposium: Cvlokines in the Inimunomodulation of CancerE'li.aheth A. Grimm. Waller Fiers. Bernd Gatisbacher. James J.

Mule. Jerome Kin.

Symposium: Molecular Mechanisms of Drug ResistanceJune L. Biedlei. George R. Stark. Peter W. Melera. Susan P.C.Cole. Igor B. Roninson.

Presidential Address - Lee W. Wattenherg

Plenary Session: From Bench to Clinic: Concepts in theDcsiu.it and Targeting of New Chemotherapeutic AgentsBruce A. Chahner. Susan E Bales. Beverly S. Mitt-hell. Rohen C

Jackxon. Yves G. Pommier. Anthony E. Pegg.

Symposium: I he Restoration of Normal DÌfíeren Iial ion and Sal. AHemoonGrowth hi Preneoplastic and Neoplastic Cells: Strategies for May 22Differentiation Therapy - Wann Kt Hont;. Lorraine ./. dudas.Anión M. Jenen. Scon M. Lippmaii. Raymond P. Warrell. Jr..Retihcn Lolan.

Sal. MornincMa\ 22

SKSSIONS OFPROFFEREDPAPERSSymposium: Nitric O\ide and Superoxide: Endogenous

Mediators of DNA Damage - Steven fi. Tannenbaum. Larr\ K.Keeffi: Michael A. Muriella. John M- Essigmann. Brute Dfmptt.

Symposium: Mesenchymal-Epithelial Interactions with Normaland Neoplastic Epithelial Cells - Gerald K. Cunha. Norbert E.Fusenig. Jeffrey S. Rnhin. Michael K. Skinner.

Bruce M. Cain Award Lecture - \'irt(»-Ling.

American Cancer Society Award Lecture -Joseph /•".Fraumeni.

Jr.

Methods Workshop: Clinical Research Methodology - Briniti(i. Leventhal. Steven Pianiamosi. Barry E. Storci . Stephen L.George. Jane E. Hennev. (Additional registration tec required.)

Plenary Session: Tumor Invasion. Angiogenesis, andMetastasis - Robert S. Kerbel. Isaiah ./. f-'iJIer. Judah Folkman.

Lance A. Liona.

Symposium: The Biology and Therapeutic Application ofNormal Hematopoietk Stem Cells - Muli nini A. S. Moore. AlanBernstein, Stephen G Emerson. Ronald Hoffman. Irving /..Welssmm,

Symposium: Strategies for I tili/ation of Antisense Moleculesor Ribo/vmes as Specific Anticancer Agents - Jack S. Cohen.Slanley f. Crooke. John ./. Rtm\i. Elie! Bavever. Jack A. Roth.Alan M. Gewirr:.

Symposium: The l-dl and H,l Receptor Superfamilics:Recent Ad\ anees in Ligands, Receptors, and SignalTransduction - Andrew Band. Michael Klagshrun. David C. Lee.Wallace L. McKeehan. Alan Rapraeger.

C. H. A. Clowes Memorial Award Lecture - Stuart H. Ynspa.

Plenary Session: Mechanisms of Action of Chemopre\entÕ\e FXHIBIT SHOWAgents: Basic Science and Clinical Applications - ManiaLipkin. Anita B Rohcrt\. Michael N. Gould. Malcolm C. Pike.

Svmposium: Biology and Treatment of Pediatrie Cancer POR YOtNC

Public Education Session - Speake

Symposium: Vitamin I) and Cancer - Michael B. Sporn. Hector/••'.DeLuca. John A. Eisman. Michael Holick. Thomas A. Brasiius.

Symposium: Advances in Molecular Epidemiology of HumanCancer - Curtis C. Harris. Rohen F. Murrav, Jr.. FredencaPeieitt. David Sidransky. Yusuke Nakamioa

Symposium: Molecular Basis for the Modulation of RadiationSensitivity - IV. allies McKenna. David A. Boothman. Michael B.Kastan. Ruth J. Muschel. Ralph R. Weichselhanm. Peter M. Manch.

Symposium: Protein Kinase C: Modulator of the CancerPhenot\pe and Target for Chemotherapy - Peter M Blumhcrg.RübenM. Bell. Michael Karin, l Reinard Weinstein. Smart HYHspa.

Symposium: Immunologie Approaches to Targeted TherapyIra Punían. Lee M. Nadlet: David M. Goldenherg. Peter D. Senter.

Symposium: Biology and Pathogenesis of Prostate CancerMaarten C. Kosland, William B Isaacs. Timothv C. Jhompson. JanTraprnan. Lelami W. K. Chung. Donald S. Coffey.

Symposium: (iene Rearrangements in Human Cancer - Stanlevj'. Korsmever. Anne Dejean. James \'. Hile, lian R. Kirsch. Thea D.

Methods Workshop: Embryonic Stem Cells and (iene knockouts - Thomas C. Doeischman. Kirk Thomas. Mark Moore. BcverlvKoller. (Additional registration lee required.)

Minisymposia, posier discussion sessions, and regular postersessions will he organi/ed from over 3.4(K) submitted papers in allareas of cancer research.

(¡ENERAL INFORMATION

Member RegistrationNonnieniber Registration

(includes Proceeding)Predocloral Student and

Associate Member RegistiWorkshop RegistrationProceedings of the AACR

SI 15*

$210*

$55**

SSO$35

*S25 discount for advance registration received bv March 29. 1993.*$KI discount tor advance registration received hv March 29. 1993.

Ktnplo>men( Register:

Candidates:AACR MembersNon members

Kmpio vers:AACR'Members

NtinmenibersCommercial Firnis

SU)S25

S75S125$250

p(:BI ¡CATIONS

EMPLOYAIENTREGISTER

INVESTIGATORSRichard J. O'Reilly. A. Thomas Look. Fatili M. (Jckiin. Irene

Newsham. Nat-Kong \ . Cheung.

Symposium: Protein Phosphatases in Carcinogenesis - ClaudeB. Klee. Marc Õ'. Mnmbv. Moiuko Nagao. David Harishorne. Nick

Tanks.

Symposium: Proteases in Carcinogenesis and TumorProgression - Lynn M. Matrisian. Ann R. Kennedy. Bonnie f-.Sloane. Keld Dane, William G. Stetler-Sievenson.

Plenary Session: Transgenic Mice as Models for CancerPathogenesis - Owen N. Witte. Terry A. Van Dyke. Cathy Finlay.Douglas Hanahan. Paul L. Stein.

Symposium: Human DNA and Protein Adduci Dosimetry DEADLINESR'egina M. Santella.John D. Groopman. Fred F. Kadltihar. David

H. Phillips. Paul L. Skipper.

Symposium: Biologv and (ienetics of Human Preneoplastic .... -i-RAVKILesions - Walter N. Hiitclrnan. Stanley R. Hamilton. HélèneS.

The Proceedings of the American Association for Cancer Researchetinl;iuis ;ihstr;iels ot all papers accepted for presenialion bv the ProgramCommittee and extended abstracts of symposium presentations andspecial lectures. The Proceedings is received by all members withpaid-up subscriptions to AACR journals, or it mav be purchased at thetime of registration tor $35.The Program ot the Annual Meeting ot" the American Association for

Cancer Research is included in the registration fee.

Detailed lisiings ol available positions and prospective candidates willbe available for consultation during the Annual Meeting and will bepublished in the Proceeding* and in two issues of the Association's

journal Cancer Research. Interviews will he scheduled in Orlando.

Displays by over 1(H) firms ottering the most up-to-date products,services, and publications for both basic and clinical cancer researchers.

Upjohn AwardsFor presenters of meritorious abstracts as selected by the ProgramCommittee. No formal application necessary. Predocloral students.[lostdoctoral fellows, and physicians in training are eligible. UpjohnCompany sponsors awards It) investigators in North America: UpjohnInternational. Inc. to investigators in other countries.

Comprehensive Minority Biomédical Program of (heNational Cancer InstituteFor predoctoral students, postdoctoral fellows, or physicians in trainingin ihe U.S. and Canada from minority groups that have beentraditional!) underrepresented in cancer research.

Women in Cancer Research will organi/e several sessions during theW1CR SESSIONS noting that will be of interest to all registrants.

Smith, filian J. Reid. A:ra Raía.Symposium: Latest Advances in Tumor Suppressor (ienes "_ —¿�TT"Edward E. Harlow. Tyiei Jacks. Daniel A. Hoher. Jon HuihreH- ' ' '

lese, Ann Bowcttck.

Ad%ance Registration (includes advance mailingot Program and Proceedings) March 29, 1993

Hotel Reservations April 16. IW3

Special fares available on Delta Air Lines ami Continental Airlinesthrough Uniglobe Travel. X(Kl-243-437() (from U.S. and Canada only)or 215-628-3322 (FAX).

Budget Rent a Car HW-772-3773 Account Number VAR3AACR

C. P. Rhoads Memorial Award Lecture Tom Cunan INFORMATIONAND FORMS

American Association for Cancer ResearchPublic Ledger Building620 Chestnut Street. Suite S16Philadelphia. PA 19106-3483215-440-9300FAX: 215-440-9313

AMERICAN ASSOCIATION FOR CANCER RESEARCHSCIENTIFIC CONFERENCES: 1993-1994

OCTOBER 17-21, 1993Cell Death and Cancer

Chairperson: Alan R. Eastman, Hanover, NHChatham Bars Inn, Chatham (Cape Cod), MA

NOVEMBER 7-11,1993Molecular Approaches to

Cancer ImmunotherapyChairperson: Ralph A. Reisfeld, San Diego, CAGrove Park Inn, Asheville, NC

NOVEMBER 9-13, 1993Interactions of Cancer Susceptibility

Genes and Environmental CarcinogensJoint Meeting with International Agency for

Research on Cancer (IARC)Chairpersons: Frederick P. Li, Boston, MA, and

Ruggero Montesano, Lyon, FranceIARC, Lyon, France

DECEMBER 5-9, 1993Cell Signalling and Cancer Treatment

Joint Meeting with British Association forCancer Research and EuropeanOrganisation for Research and Treatmentof Cancer (RAM Group)

Chairpersons: Garth Powis, Tucson, AZ;Paul Workman, Glasgow, Scotland

El San Juan Hotel,San Juan, PR

JANUARY 17-22, 1994Risk Assessment in Environmental

CarcinogenesisCo-Sponsored by the

Environmental Mutagen SocietyChairpersons: PhilipC. Hanawalt,Stanford,CA;

James A. Swenberg, Chapel Hill, NCWhistler Resort and Conference Center, Whistler,

B.C., Canada

JANUARY 31-FEBRUARY 5, 1994Molecular Genetics of Progression

and MetastasisChairperson: Lance A. Liotta, Bethesda, MDBig Sky Resort, Big Sky, MT

FEBRUARY 19-24, 1994Cancer: Perturbation in Cell Cycle

Control and Genomic IntegrityChairpersons: Thea D. Tlsty, Chapel Hill, NC;

Lawrence A. Loeb, Seattle, WABanff Springs Hotel, Banff, Alberta, Canada

MARCH 5-11, 1994Growth Factors, Development, and CancerJoint Meeting with Friedrich-Miescher InstitutChairpersons: Harold L. Moses, Nashville, TN;

Bernd Groner, Basel, SwitzerlandCongress Center, Interlaken, Switzerland

APRIL 10-13, 199485th Annual Meeting

Chairperson: Karen S. H. Antman, Boston, MAMoscone Convention Center, San Francisco, CA

OCTOBER 16-20, 1994Transcriptional Regulation in

Differentiation (Tentative Title)Chairpersons: Eric N. Olson, Houston, TX; Bruce

M. Spiegelman, Boston, MAChatham Bars Inn, Chatham (Cape Cod), MA

AACR members will receive brochures on theabove special conferences as soon as they areavailable. Nonmembers should call or write:

American Association for Cancer ResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483215-440-9300 •¿�215-440-9313 (FAX)

INTERACTIONS OFCANCER SUSCEPTIBILITY GENES

AND ENVIRONMENTAL CARCINOGENS

Joint Meeting Organized by theAmerican Association for Cancer Research (AACR)

and the International Agency for Research on Cancer (IARC)

November 9-13, 1993Lyon, France

CONFERENCE CHAIRPERSONSFrederickP.Li/ Boston,USA

RuggeroMontesano/ Lyon,France

SCIENTIFIC PROGRAM

IntroductoryLecturesCurtisC. Harris/ Bethesda,USALorenzoTomatis/ Lyon,FranceLeeW.Wattenberg/ Minneapolis,USAManfredF. Rajewsky/ Essen,Germany

GeneticInstabilityKariK.Alitalo/ Helsinki,FinlandT. Heidmann/ Paris,FranceTheaD.Tlsty/ ChapelHill,USA

ExperimentalModelsofGeneticSusceptibilityJ. CarlBarrett/ ResearchTrianglePark,USAHenryC.Pilot/ Madison,USABernardM.Mechler/ Heidelberg,Germany

DMADamageandRepairDirkBootsma/ Rotterdam,TheNetherlandsJohnM.Essigmann/ Cambridge,USAMutsuoSekiguchi/ Fukuoka,Japan

MechanismsofTransgenerationalCarcinogenesisCarmenSapienza/ LaJolla,USAUlrikeWintersberger/ Vienna,AustriaDavidMalkin/ Toronto,CanadaChristopherJ. Kemp/ Glasgow,Scotland

HumanCancersFrederickP. Li / Boston,USAValerieBeral/ Oxford,EnglandBruceA.J. Ponder/ Cambridge,EnglandNeilE.Caporaso/ Bethesda,USAGilbertM.Lenoir/ Lyon,France

Markersof IndividualExposureRuggeroMontesano/ Lyon,FrancePeterA.Cerutti/ Epalinges,Switzerland

OpportunitiesforPreventionI. BernardWeinstein/ NewYork,USA

InformationandApplicationForms

AmericanAssociationforCancerResearchPublicLedgerBuilding620ChestnutStreet,Suite816Philadelphia,PA19106-3483(215) 440-9300 (215) 440-9313 (FAX)

THE AMERICAN ASSOCIATION FOR CANCER RESEARCH PRESENTS

An Important Educational Opportunity forPredoctoral and Postdoctoral Fellows

^ - Contemplating Careers in Basic Cancer Research

^^ HISTOPATHOBIOLOGY OF NEOPLASIA

The Edward A. Smuckler Memorial WorkshopSupported by a Generous Grant from the National Cancer Institute

Keystone Conference CenterKeystone, Colorado

June 20-June 27, 1993

•¿�Intensive training in the histopathology and biology of neoplasia.

•¿�Twenty-eight hours of hands-on laboratory exercises directed by distinguishedpathologists.

•¿�An outstanding series of lectures on rapidly developing areas of cancer research bylaboratory directors and other prominent investigators.

•¿�Extensive written course materials that will serve as valuable references in the future.

•¿�Full funding of participants' lodging and subsistence expenses during the workshop.

LABORATORY AND LECTURING FACULTY

John H. Lehman*, Albany College of Medicine,

Albany, NY, Course DirectorStephen Baird", VA Medical Center, San Diego,

CAHelen Feiner, New York University School of

Medicine, New York, NYMichael W. Lleberman*, Baylor College of

Medicine, Houston, TXRobert Low, University of Colorado School of

Medicine, Denver, COGary Miller*, University of Colorado School of

Medicine, Denver, COHarold L. Moses, Vanderbilt University School of

Medicine, Nashville, TN

Sharon B. Murphy, Children's Hospital, Chicago, IL

Garth L. Nicolson, UT-M. D. Anderson Cancer Ctr.,

Houston, TXG. Barry Pierce, University of Colorado School of

Medicine, Denver, CO.Michael Prystowsky, University of Pennsylvania

School of Medicine, Philadelphia, PAStewart Sell, University of Texas Medical School,

Houston, TXSaraswati Sukumar, The Salk Institute, La Jolla, CAFrederick Waldman, University of California, San

Francisco, CASandra R. Wolman*, Harper Hospital, Detroit, Ml

Additional Faculty to be Announced

"Member of the Workshop Executive Committee

Further Information: American Association for Cancer Research •¿�Public Ledger Building620 Chestnut Street •¿�Suite 816 •¿�Philadelphia, PA 19106-3483Telephone: (215) 440-9300 •¿�FAX: (215)440-9313

AACR SPECIAL CONFERENCE IN CANCER RESEARCH

CellDeathin CancerandDevelopment

October17-21,1993ChathamBarsInn,Chatham(CapeCod),Massachusetts

CONFERENCE CHAIRPERSON

Alan R. Eastman/ Hanover,NH

PROGRAM COMMITTEE

Nathan A. Berger / Cleveland,OHH. Robert Horvitz / Boston,MAJohn T. Isaacs / Baltimore,MD

Stanley J. Korsmeyer / St. Louis,MOThomas R. Tritton / Burlington,VTAndrew H. Wyllie / Edinburgh,Scotland

SCIENTIFIC PROGRAM

KeynoteAddressAndrewH.Wyllie/ Edinburgh,Scotland

CellDeathand DevelopmentMartinC.Raff/ London,EnglandH.RobertHorvitz/ Boston,MALawrenceSchwartz/ Amherst,MAHermannSteller/ Cambridge,MA

CellDeathinthePathogenesisof CancerJohnT. Isaacs/ Baltimore,MDRolfSchulte-Hermann/ Vienna,AustriaDavidP.Lane/ Dundee,Scotland

Suppressionof Cell DeathStanleyJ. Korsmeyer/ St.Louis,MOEileenWhite/ Piscataway,NJWilliamSugden/ Madison,WlRuthCraig/ Hanover,NH

Enzyrnology of Cell DeathJohnA.Cidlowski/ ChapelHill,NCAlanR.Eastman/ Hanover,NHPeterJ.A.Davies/ Houston,TX

Application Deadline: June 28, 1993

CellDeathin the ImmuneSystemPeterH.Krammer/ Heidelberg,GermanyDouglasR.Green/ LaJolla,CAJonathanD.Ashwell/ Bethesda,MDArnoldH.Greenberg/ Winnipeg,Manitoba,Canada

GeneticEventsAssociatedwithCellDeathJ.JohnCohen/ Denver,COBarbaraOsborne/ Amherst,MARalphE.Buttyan/ NewYork,NYRobertSchlegel/ Boston,MA

Cell Death in Cancer ChemotherapyNathanA.Berger/ Cleveland,OHYvesG.Pommier/ Bethesda,MDNancyL Oleinick/ Cleveland,OHCarlosJ. Carrera/ SanDiego,CA

Applicants are encouraged to submit abstractsfor poster presentation.

InformationandApplicationForms

American Association for Cancer ResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483

215-440-9300 215-440-9313 (FAX)

COVER LEGEND.

CancerResearch

The recipients of the 1993 Awards granted by the AmericanAssociation for Cancer Research (AACR) are featured on thisissue's cover. The awards, which will be presented at the 84th

Annual Meeting of the Association, being held in Orlando,Florida, from May 19 to May 22, cover a wide range ofinvestigations. Two of the awards are being given to investigators who are in the early stages of their careers. The Seventeenth Richard and Hinda Rosenthal Foundation Award,which recognizes unusual advances in clinical cancer researchby a person who is under 51 years of age, is being awarded toWaun Ki Hong (upper left), Chief of Head and Neck Oncologyat the University of Texas M. D. Anderson Cancer Center,Houston, Texas. Dr. Hong is being honored for his work indeveloping effective strategies for the treatment and prevention of epithelial aerodigestive neoplasms, including alternatives to laryngectomy and the use of 13-m-retinoic acid as atherapeutic agent. He has published 140 original papers and70 reviews and book chapters. He serves on many advisoryboards, committees, and editorial boards, including an appointment on the Editorial Board of Cancer Research. Hereceived the Milken Family Foundation Award in 1990 anda Presidential Citation from the American Society for Headand Neck Surgery in 1991.

The second award dedicated to a young investigator is theTwelfth Annual Cornelius P. Rhoads Memorial Award, presented to a person who is under 41 years of age. This awardwas established by an anonymous donor in memory of apioneer in cancer therapy and founder of the Sloan-KetteringInstitute in New York. This year's recipient is Tom Curran

(upper right), Head of the Department of Molecular Oncologyand Virology and Associate Director of the Roche Institute,Nutley, New Jersey. Dr. Curran has a distinguished record inmolecular oncology and is being honored for his discovery ofthe fos oncogene and the subsequent uncovering of its interaction with they*/«oncogene and their encoded proteins. Heis author or coauthor of 100 original articles and reviews andhas served on many study sections, committees, and editorialboards. He has presented lectures at meetings and participatedin the activities of the AACR, including membership on the

AACR Special Conferences Committee and the EditorialBoard of the AACR's journal on the molecular biology of

cancer, Cell Growth & Differentiation. In 1992, Dr. Curranreceived the Passano Foundation Young Scientist Award andthe First Glasgow University Tenovus Scotland Medal. Hehas also been a recipient of the Rota Levi Montalcini AwardLectureship and the Fidia Research Foundation Lectureship.

The Thirty-third Annual G. H. A. Clowes Memorial Award,established by the Eli Lilly Company to honor a formerResearch Director of the firm and one of the founders of theAACR, is being given to Stuart H. Yuspa (upper center), Chiefof the Laboratory of Cellular Carcinogenesis and TumorPromotion, National Cancer Institute, Bethesda, Maryland.He is being honored for his use of the mouse skin model todefine cellular and molecular mechanisms of tumor promotion and to place this stage of cancer development within theperspective of the accumulation of successive genetic lesions.His work has been particularly notable in fostering a deeperunderstanding of the biology of the skin. He has been activein various cancer organizations, serving on many committeesand editorial boards. He was a member of the AACR Boardof Directors from 1988 to 1991 and is currently serving asCo-Chairperson to the Carcinogenesis Subcommittee of the1992-1993 AACR Program Committee. He also holds anappointment on the AACR Ad Hoc Committee for ScienceEducation. In addition, he is an Associate Editor of CancerResearch. Prior awards include the Elizabeth Miller MemorialLectureship and the Lila Gruber Memorial Cancer ResearchAward.

Excellence in therapeutic research is recognized by thepresentation of the Twelfth Annual Bruce F. Cain MemorialAward to Victor Ling (lower right). Head of the Division ofMolecular and Structural Biology, Ontario Cancer Center,Toronto, Ontario, Canada. This award was established by theWarner-Lambert Company in memory of one of its distinguished scientists who contributed to the design, synthesis,and evaluation of potential antitumor drugs. Dr. Ling is beinghonored for his seminal contributions to the mechanisms ofdrug resistance, particularly with regard to the role of P-glycoproteins. He joined the Ontario Cancer Institute in 1971and is now Professor of Medical Biophysics at the Universityof Toronto. He is currently a member of the Board of Directors of the AACR. He serves on numerous committees, studysections, and editorial boards, including Cancer Research. Hehas received many awards, such as the Gairtner Award, 1990;the General Motors Cancer Research Foundation KetteringPrize, 1991; and the Courvoisier Leadership Award, 1992.

The Second Annual American Cancer Society Award, theAACR's newest award, will be presented to Joseph F. Frau-meni, Jr. (lower left). Director of the Epidemiology and Bio-Statistics Program, National Cancer Institute, Bethesda, Maryland. One of the most distinguished world authorities in thefields of epidemiology and biostatistics, Dr. Fraumeni is aproductive and influential contributor to our knowledge ofhuman tumor etiology. His dedication to cancer etiologyresearch covers a span of about 30 years in which he has madeseminal contributions to our understanding of the causes ofcancer, while at the same time guiding, inspiring, and helpingother epidemiologists throughout the world to conduct productive research. In 1969, together with Fred Li, he identifieda familial aggregation of cancers of different sites, especiallychildhood sarcomas and breast cancer, known today as theLi-Fraumeni syndrome. He has also served on many committees and editorial boards, including his current posts asAssociate Editor for both Cancer Research and Cancer Epidemiology, Biomarkers & Prevention.