Cancer Nanobiotechnology
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Transcript of Cancer Nanobiotechnology
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Outline
• Why nanotechnology is promising in cancer control?
• How can it help?
• “Today” what does nanotechnology do to amaze us?
• Bright points aside/ Dark points aside...
• Biotechnologists! Any ideas?
• References
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Why Nanotechnology is promising in cancer
control?
1. Limitations of Macromedicine:
• Microscopic residual
• Functional damage to organs
• Resistance in cancer cells
• Side effects of therapies
2. Novelty of “nano” and its uncovered potentials
• It is promising in other fields
• It has shown unique properties
ATTENTION: We now know some nano limitations also!
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How can it help?
Detection/
diagnosis
Drug
delivery
Targeted
therapy
Imaging
Biomarker
mapping
Gene
Delivery
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Today what does nanotechnology do
to amaze us?!
1. Nanotheranostics
2. Fighting with Cancer Stem Cells
3. Novel nanodevices
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Today what does
nanotechnology
do to amaze us?!
1. Nanotheranostics
2. Fighting with
Cancer Stem
Cells
3. Novel
nanodevices
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Today what does
nanotechnology
do to amaze us?! • Therapeutics + Diagnostics
• Application of nanotechnology in preparation of
dual-purpose nanomaterials used for
simultaneous diagnosis and therapy.
• A combined technique will result in an
improved disease management, reduced risks
and reduced cost.
• Suitable theranostic approaches are expected
for all diseases, especially cancer, in the future,
although this will take some time.
1. Nanotheranostics
2. Fighting with
Cancer Stem
Cells
3. Novel
nanodevices
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Today what does
nanotechnology
do to amaze us?!
1. Nanotheranostics
2. Fighting with
Cancer Stem
Cells
3. Novel
nanodevices
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Today what does
nanotechnology
do to amaze us?!
1. Nanotheranostics
2. Fighting with
Cancer Stem
Cells
3. Novel
nanodevices
• Case study 1:
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Yang, Hee-Man, et al. "Multifunctional poly (aspartic acid) nanoparticles containing iron oxide
nanocrystals and doxorubicin for simultaneous cancer diagnosis and therapy." Colloids and Surfaces A:
Physicochemical and Engineering Aspects 391.1 (2011): 208-215.
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Today what does
nanotechnology
do to amaze us?!
1. Nanotheranostics
2. Fighting with
Cancer Stem
Cells
3. Novel
nanodevices
• Case study 2:
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Yang, Kai, et al. "Multimodal imaging guided photothermal therapy using functionalized graphene
nanosheets anchored with magnetic nanoparticles."Advanced materials 24.14 (2012): 1868-1872.
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Today what does
nanotechnology
do to amaze us?!
1. Nanotheranostics
2. Fighting with
Cancer Stem
Cells
3. Novel
nanodevices
• CSCs are functionally and phenotypically distinct
from other tumor cells.
• Nanotechnology for the targeting of CSCs can
provide us with a solution to cure cancer before a
tumor forms
• curcumin shows anti-CSC activity, but its efficacy
is limited by its poor bioavailability. Compared with
free curcumin, curcumin-loaded nanomedicine
showed enhanced stability, bioavailability and
antitumor effects (Mimeault and Batra 2011)
• SWNTs conjugated with CD133 antibodies
developed by Wang et al. and many other such
studies.
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Today what does
nanotechnology
do to amaze us?!
1. Nanotheranostics
2. Fighting with
Cancer Stem
Cells
3. Novel
nanodevices
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Today what does
nanotechnology
do to amaze us?!
1. Nanotheranostics
2. Fighting with
Cancer Stem
Cells
3. Novel
nanodevices
Plasmonic Nanobubbles
• When exposed to intense and short laser pulses,
plasmon resonant nanoparticles may reach high
temperatures and heat or even evaporate the
surrounding space.
• The plasmonic nanobubble expands to its maximal
diameter, then collapses back to the nanoparticle.
• PNBs show different optical efficacy.
• Plasmonic nanobubble can be 100-1000 times
brighter than gold NPs.
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Lukianova-Hleb, Ekaterina Y., and Dmitri O. Lapotko. "Plasmonic Nanobubbles for Cancer
Theranostics." Engineering in Translational Medicine. Springer London, 2014. 879-926.
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Today what does
nanotechnology
do to amaze us?!
1. Nanotheranostics
2. Fighting with
Cancer Stem
Cells
3. Novel
nanodevices
Plasmonic Nanobubbles
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Lukianova-Hleb, Ekaterina Y., and Dmitri O. Lapotko. "Plasmonic Nanobubbles for Cancer
Theranostics." Engineering in Translational Medicine. Springer London, 2014. 879-926.
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Bright points aside/ Dark points aside...
• Toxicity/Biocompatibility studies
Should be further investigated
• Costs
Sometimes high
• Research output
Let’s see in the next slides...
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Nanomedicine publication profiles over time
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Venditto, Vincent J., and Francis C. Szoka Jr. "Cancer nanomedicines: so many papers and so few drugs!." Advanced drug delivery
reviews 65.1 (2013): 80-88.
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Nanomedicine innovation and approval timeline
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Venditto, Vincent J., and Francis C. Szoka Jr. "Cancer nanomedicines: so many papers and so few drugs!." Advanced drug delivery
reviews 65.1 (2013): 80-88.
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BIOTECHNOLOGISTS!
Any Ideas?
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References to Dig Deeper
• Venditto, Vincent J., and Francis C. Szoka Jr. "Cancer nanomedicines: so many papers
and so few drugs!." Advanced drug delivery reviews 65.1 (2013): 80-88.
• Ahmed, Naveed, Hatem Fessi, and Abdelhamid Elaissari. "Theranostic applications of
nanoparticles in cancer." Drug Discovery Today 17.17 (2012): 928-934.
• Lukianova-Hleb, Ekaterina Y., and Dmitri O. Lapotko. "Plasmonic Nanobubbles for
Cancer Theranostics." Engineering in Translational Medicine. Springer London, 2014.
879-926.
• Janát-Amsbury, Margit M., and You Han Bae. "Nanotechnology in Cancer." Handbook
of Anticancer Pharmacokinetics and Pharmacodynamics. Springer New York, 2014.
703-730.
• Sanna, Vanna, Nicolino Pala, and Mario Sechi. "Targeted therapy using
nanotechnology: focus on cancer." International journal of nanomedicine 9 (2014): 467.
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THANK YOU
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