BYI 02960 Presentation to DPC 2009-11-17ir4.rutgers.edu/FoodUse/FUWorkshop/Industry...
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2010-09-15 • BYI 02960 Introduction IR-4 FUW • Slide 1 BYI 02960 Matching Future Requirements with a New Molecule
Transcript of BYI 02960 Presentation to DPC 2009-11-17ir4.rutgers.edu/FoodUse/FUWorkshop/Industry...
2010-09-15 • BYI 02960 Introduction IR-4 FUW • Slide 1
BYI 02960Matching Future Requirements with a New Molecule
2010-09-15 • BYI 02960 Introduction IR-4 FUW • Slide 2
BYI 02960 – Brief Profile
Target Site: Nicotinic Acetylcholine Receptor Agonist
Major pests: Sucking Insects – Aphid, Leafhopper, Whitefly
Applications: Foliar, Soil, Seed
Systemicity: Xylem Limited
Global Joint Review Submission: Planned for mid-2012
Matching Future Requirements – with a New Molecule
2010-09-15 • BYI 02960 Introduction IR-4 FUW • Slide 3
BYI 02960 – Research Code
KEY MESSAGES
Bee safety
Control of neonic resistant pests
Management of vectored diseases
Matching Future Requirements – with a New Molecule
2010-09-15 • BYI 02960 Introduction IR-4 FUW • Slide 4
Significant resources committed to demonstrating pollinator safety
BYI 02960 – Pollinator Safety
Lab Toxicity Studieso Technical, metabolites and formulationso Acute, chronic and mechanistico Honeybees, bumblebees and other pollinators
Semi-field and Field Studieso Residues in pollen and nectar of representative cropso Effect trials
• Mortality, foraging behavior and hive health• EUP planned to allow larger scale studies
Lab and semi-field studies completed to date demonstrate that BYI 02960 is safe to bees
Positive pollinator safety profile
2010-09-15 • BYI 02960 Introduction IR-4 FUW • Slide 5
Average of field data 2007-2009
Spectrum extension: mealybugs, flea beetles, certain thrips, Citricola scale, BBM, etc.
BYI 02960 – Profile – Foliar & SoilBYI 02960 Imidacloprid
Foliar
Soil
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Aphids
Hoppers
Whiteflies
Aphis sp.
Myzus sp.
Dysaphis plantaginea.
Empoasca sp.
Nilaparvata lugens (BPH)
Rice hoppers (GLH, WBPH).
Bemisia sp.
Trialeurodes vaporariorum
Aphids
Hoppers
Whiteflies
e.g. Aphis sp., Myzus sp
e.g. BPH, SBPH, WBPH
e.g. Bemisia sp.
Confirming activity against key pests
2009-12-06 • Slide 6
BYI 02960 – SL200 – Foliar
Rosy Apple Aphid count 5/22/09
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00
0 0 00
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Control Calypso 480 SC4oz/a
BY1029603.42oz/a
BY1029606.84oz/a
BY10296010.26oz/a
Calypso SC2507.7oz/a
Ave
rage
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A o
n a
0-5
scal
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Highest number of aphids counted for ten colonies per tree with 4 trees per treatment. Aphids on a 0-5 scale where 0 = no ahids; 1 = 1-3 aphids; 2= 4-10 aphids; 3 = 11-30 aphids; 4 = 31-100; 5 =>100 aphids
Apple – Dysaphis plantaginae (Pre- bloom, Early pink) Trial ID: ID09NARA6M-UTY1, Jim Steffel, New Smithfield, PA – A = 2009-04-29
BYI 02960 plus NO SURFACTANT
23 DAA
2009-12-06 • Slide 7
Citrus – Coccus pseudomagnoliarum (Nymphs) – Citricola scaleTrial ID: ID10NARA6T-USQ1, Sam Wells, Fresno, CA – A = 2010-06-22 – 1075 liters/Ha
BYI 02960 – SL200 – Foliar
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2 DAA 8 DAA 15 DAA 22 DAA 59 DAA
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BYI 02960 SL200 21884 - 100 BYI 02960 SL200 21884 - 150 BYI 02960 SL200 21884 - 200
PROVADO 192SC 100 UNTREATED
Effect (% Abbott) No Nymphs/Leaf
rate g ai/ha3.4 meter trees
No PTXProtocol ID10NARA6T
All Treatments plus Dyne-Amic @ 0.25% v/v Means followed by same letter do not significantly differ (P=.05, Student-Newman-Keuls)
b bb b
a
b b b b
a
bb b
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a
b bb
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2009-12-06 • Slide 8
BYI 02960 – Citrus – Citricola Scale DamageCitrus – Coccus pseudomagnoliarum (Honeydew) – Citricola scaleTrial ID: ID10NARA6T-USQ1, Sam Wells, Fresno, CA – A = 2010-06-22 – 1075 liters/Ha
BYI 02960 (150 gms A/HA)Untreated
Protocol ID10NARA6T
2010-08-20 • Slide 9
BYI 02960 – SL200 – Foliar
0
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3 DAA 5 DAA 7 DAA 14 DAA
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BYI 02960 21884 – 25 BYI 02960 21884 – 50
BYI 02960 21884 – 100 BYI 02960 21884 – 50 + Agral 90 0.5% v/v
Admire 2F – 42 Untreated Check
Effect (% Abbott) No of insects / marked branch
rate g ai/ha
No PTXProtocol ID09NARADL
Blueberry – Fimbriaphis fimbriata (Mixed) – Blueberry aphid Trial ID: ID09NARADL-JAD3, Andrew Dornan (McMillan, ICMS - BC), Abbotsford, BC – A = 2009-07-10 – 500 lts/Ha
Means followed by same letter do not significantly differ (P=.05, Student-Newman-Keuls.)
a
b
bb b
b
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bb
b b b
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bb b b b
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b b b b
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2010-03-19 • Slide 10
Cantaloupe – CYSDV – Cucurbit Yellow Stunting Disorder Virus Trial ID: ID09NARA6C-UMW1, Dr. John Palumbo, Yuma, AZ – A = 2009-06-01, B = 2009-06-15 - 191.7 lts/Ha
BYI 02960 – SL200 – Foliar
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14 DAB / 28 DAA 19 DAB / 33 DAA
UNTREATED BYI 02960 SL200-21884 - 100 BYI 02960 SL200-21884 - 150
BYI 02960 SL200-21884 - 200 Venom 70SG - 196 MOVENTO SC240 - 88
Fulfill 50WDG - 96 Fulfill 50WDG - 96 + ActiGard Assail 30SG - 112
Effect – Leaves YIVC*/row-ft
rate g ai/ha
No PTXProtocol ID09NARA6C
All Treatments plus Dyne-Amic @ 0.25% v/v
*YIVC = Yellows, interveinal chlorosis
a
cdd d
cd
ab abbc bc
a
bcc c
bc
abab
bc bc
Means followed by same letter do not significantly differ (P=.05, Student-Newman-Keuls)
2010-09-15 • BYI 02960 Introduction IR-4 FUW • Slide 11
BYI 02960 – nAChR Resistance
Cross-Resistance to Neonicotinoids
NN resistance is primarily metabolic
NN resistance not target-site
BYI 02960 not degraded through equivalent pathway
2010-09-08 • Slide 12
Squash – Bemisia tabaci (Silverleafing) – Sweetpotato whitefly Trial ID: ID10NARA6H-UJU2, John Curtis, Dover, FL – A = 2010-08-09 (soil, drip)
BYI 02960 – SL200 – Soil
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7 DAA 14 DAA 18 DAA 21 DAA 25 DAA 29 DAA
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BYI 02960 SL200 21884 - 200 BYI 02960 SL200 21884 - 300 BYI 02960 SL200 21884 - 400
ADMIRE PRO 550SC - 424.6 VENOM 70WG - 400 UNTREATED
Effect (% Abbott) Number “Silvered” Leaves/10 Plants
rate g ai/ha
No PTXProtocol ID10NARA6H
b b b b b
a
Means followed by same letter do not significantly differ (P=.05, Student-Newman-Keuls)
b b b b b
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9/23/2010ID10NARA6HUJU2 (BEMIAR/DRIP/SQUASH): Silverleafing in BYI 02960 @ 400 G A/HA (A, 89.2% control), compared with the untreated buffer (B) at 29 DAA.
AB
2010-09-15 • BYI 02960 Introduction IR-4 FUW • Slide 14
Tool for resistance management programs
BYI 02960 – NN-resistant PopulationsBYI 02960 Imidacloprid
BPH, 2006BPH, 2007BPH, 2008BPH, 2009
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NN-resistant Hoppers
NN-resistant Whiteflies
Bemisia argentifolii, BrazilBemisia tabaci, SpainBemisia tabaci Q, JapanBemisia tabaci B, US
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2010-09-15 • BYI 02960 Introduction IR-4 FUW • Slide 15
Thank You!
