By. Mike Carrier. Carl and Gerty Cori were born and lived in Prague Czechoslovakia and they both...
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Transcript of By. Mike Carrier. Carl and Gerty Cori were born and lived in Prague Czechoslovakia and they both...
By. Mike Carrier
Carl and Gerty Cori were born and lived in Prague Czechoslovakia and they both studied at the German University of Prague
Background
Glycogen is a polymer of glucose
Glycogen is used by many living organisms to store energy
Glycogen is found in the liver
Converted into lactic acid
Prior Knowledge
Discovered that the formation of glucose-1-phosphate is linked to glycogen
Glucose-1-phosphate is used to transport glucose to muscle cells from the liver
When the muscle cells use the glucose, they produce lactic acid
The lactic acid is then transported back to the liver and is used to reform glycogen
Cori cycle
Glucose-1-Phosphate
The Coris succeeded in purifying the glucose-1-phosphate
The main problem faced when purifying and enzyme, many enzyme-catalyzed reactions are reversible
The Coris had to wisely choose the enzyme inhibitors, to isolate the enzymes carrying out the reactions
Cori Ester
Carl and Gerty Cori’s discovery helped further knowledge in cardohydrate metabolic processes and the discovery of the Cori cycle greatly helped improve the treatment of diabetes later on.
In 1947 the Coris won the Nobel prize for psychology or medicine
Later on
Cori, Carl and Gerty, Robert K. Griffith,
http://www.chemistryexplained.com/Co-Di/Cori-Carl-and-Gerty.html
Carl Ferdinand Cori and Gerty Theresa Cori, Chemical Heritage Foundation,
http://www.chemheritage.org/discover/chemistry-in-history/themes/biomolecules/proteins-and-sugars/cori-and-cori.aspx
Gerty Cori, http://en.wikipedia.org/wiki/Gerty_Cori
The Nobel Prize in Physiology or Medicine 1947, Carl Cori, Gerty Cori, Bernardo Houssay, The Official Web Site of the Nobel Prize,
http://nobelprize.org/nobel_prizes/medicine/laureates/1947/cori-cf-bio.html
Bibliography