Buck Institute for Age Research

Review of the Nathan Shock Center of Excellence in Basic Biology of Aging

at the

Buck Institute for Age Research

What are Nathan Shock Centers?

First RFA -- 1999 Support Admin core, 2 or more research resource cores,

research development coreEnhance basic biology of aging research; establish regional/national

resources; enhance aging research environment for junior/other investigators

Second RFA -- 2004 Fund research and training related to the basic biology of aging

Intended for institutions with substantial investment in/commitment to aging research

Not intended to support clinical research

Third RFA -- 2009 Applications due early May, 2009

1999 -- four centers funded (U Michigan, U Rochester, U Texas San Antonio, U Washington)

Buck Institute applied (same yr Buck opened)

2004 -- five centers funded (Buck Institute, Jackson Labs, U Michigan,

U Texas San Antonio, U Washington)

2009 -- # to be funded unknown (Buck's competitive renewal)

Buck Institute's Nathan Shock Center(organization)

Director and PI -- Dale Bredesen (Buck CEO)Transferred to Campisi July, 2008

Administrative Core (Bredesen/Campisi)

Four research Cores:Animal/transgenic (Kerby/McDonald, Zhang)

Genomics (Melov)Proteomics (Gibson)

Imaging (Nicholls/Brand)

Research & Development Core (Greenberg)

Buck Institute's Nathan Shock Center(resource allocation)

Awarded Requested

Total award (yr 1): $383 K 633 K

Administrative core: $52 K 86 KAnimal/transgenic core: $60 K 100 KGenomics core: $60 K 101 KProteomics core: $61 K 102 KImaging core: $51 K 85 KResearch/development core: $99 K 157 K

Buck Institute's Nathan Shock Center(activities)

Annual Buck symposium (partial)

Special courses (2-3/yr)

Weekly seminar series (6/yr)

High school internships (2/yr)

Pilot projects (2/yr)

Core activities

Buck Institute's Nathan Shock Center(future plans)

Continue support for:

Research and Development Core

(Annual symposium -- partial Seminars -- 4-6 Courses -- 2-3

Pilot projects -- at least 2)

Buck Institute's Nathan Shock Center(future plans)

Continue support for:

Animal core

(Reduced emphasis on transgenicsExpand with small animal imaging)

Buck Institute's Nathan Shock Center(future plans)

Continue support for:

Genomics core

(Incorporate SOLID sequencingLunyak as co-director)

Buck Institute's Nathan Shock Center(future plans)

Continue support for:

Proteomics core

(Biomolecular Mass Spectrometry CoreExpand to include lipid, carbohydrate analyses)

Buck Institute's Nathan Shock Center(future plans)

Continue support for:

Imaging core

(Bioenergetics and Imaging CoreExpand to include Seahorse analyses)

Buck Institute's Nathan Shock Center(future plans)

Continue support for:

Imaging core

(Bioenergetics and Imaging CoreExpand to include Seahorse analyses)

Buck Institute's Nathan Shock Center(future plans)

Establish new core:

Small molecule screening core

(Bob HughesTools for drug discovery

Tools for animal model testingTools for pathway identification)