BTISNET- BIOTECHNOLOGY INFORMATION SYSTEM NETWORK

Bindhu SreekeshScientist –D

NICCELLDepartment of Biotechnology,

New Delhi

What is Bioinformatics

Bioinformatics is a “scientific discipline that compasses all aspects of biological information acquisition, processing, storage, distribution, analysis and interpretation”.

It is a multi disciplinary subject which combines

the tools of Biology, Chemistry, Mathematics,

Statistics and Computer Science to understand

Life & its processes.

Bioinformatics in India1983• Formation of Task Group on Bioinformatics by

Dr. S. Ramachandran

19861986Department of Biotechnology established

19871987• Biotechnology Information System Network Biotechnology Information System Network

(BTISnet) (BTISnet) • 1st grant of Rs.13.38 crores by DBT towards

setting up of National Infrastructural Facility on Bioinformatics

1988

• Establishment of the first 9 DICs in India

1989 onwards….

• Establishment of DIC sub-centers

Current Status

DICs 10

Sub-DICs 48

Center of Excellence 6

• Enormous growth of Biological data size & information

• Recognized the importance of IT for advanced research

• Transfer and exchange of information, scientific knowledge, technology packages

•To provide a national bioinformatics network designed to bridge the inter disciplinary gaps on biotechnology information and establish link among scientists in organizations involved in R&D and manufacturing activities in the country.

•To build up information resources, prepare databases on biotechnology and to develop relevant information handling tools and techniques.

•To continuously assess information requirements, organize creation of necessary infrastructure and to provide information and computer support services to the national community of users working in biotechnology and allied areas.  

 

OBJECTIVES

•To coordinate efforts to access Biotechnology information world wide including establishing linkages with some of the international resources of Biotechnology information (e.g. Databanks on genetic materials, published literature, patents, and other information of scientific and commercial value.

•Perform research into advanced methods of computer based information processing for analyzing the structure and function of biologically important molecules.  

•To evolve and implement programmes on education of users and training of information scientists responsible for handling of biotechnology information and its applications to biotechnology research and development.

•To promote international collaboration towards exchange of scientific information in biotechnology through the development of appropriate network arrangements.

CENTRES OF EXCELLENCE (CoEs)

To undertake advanced research in frontier areas in Bioinformatics and computational biology and act as national hubs in bioinformatics for creating a platform for biotechnology development, technology transfer and commercialization.

1. Bose Institute2. Indian Institute of Science3. Jawaharlal Nehru University4. Madurai Kamaraj University5. University of Pune

RESEARCH ACTIVITIES PROPOSED TO BE UNDERTAKEN BY THE COEs       

(i) Bose Institute, Calcutta

• Modelling of protein structures • Molecular interactions and docking • Drug design • Chromosomal dynamics • Stress biology of plants • Functional genomics • Host-pathogen interaction

(ii) Indian Institute of Science, Bangalore

• Analysis of protein structures, motifs and recognition • Peptide design • Protein folding studies • Structural biology of lectins, xylanase, phycocyanins,

phospholipase etc • Structural genomics • Annotation and functional analysis of genomes • Microarray informatics

(iii) Jawaharlal Nehru University, New Delhi

• Building gene models • Improved algorithms for first and last exon predictions • Genome evolution • Virtual screening and drug design • Prediction of ligand binding site of proteins

(iv) University of Pune, Pune

• Comparative and structural genomics • Comparative structural genomics • Metabolic pathway engineering • Proteomics

 (v) Madurai Kamraj University, Madurai

•Genomics, proteomics and structural bioinformatics of selected regulatory systems in Streptomyces, Salmonella etc •Validation and annotation of databases of selected organisms •Computational and experimental analysis of selected systems    

Priority Areas of the proposed Centres

    Institution Priority Area

Bose Institute Molecular Modeling & Genetic Engineering

Indian Institute of Science Structural Biology & Bioinformatics

Jawaharlal Nehru University Computational Genomics

Madurai Kamraj University Genetic Engineering & Structural Bioinformatics

University of Pune

Computational Biology & Genomics

Sub DICs upgraded to DICs

– Anna University– Kerala Agricultural University– M.S. University, Baroda– University of Calcutta– Pondicherry University

NEW BIOINFORMATICS CENTRES

1. Central Agricultural Research Institute, Port Blair

2. College of Engineering, Raipur

3. T.M.bahalpur University, Bahalpur

4. Birla Institute of Technology, Ranchi

DISTRIBUTED INFORMATION CENTRES (DICs)

1.Anna University2.CCMB3.IARI4.IMT5.KAU6.MSU, Baroda7.NBRC8.NII9.Pondicherry University10.University of Calcutta

DISTRIBUTED INFORMATION SUB CENTRES (SDICs)

1. ACTREC2. Aligarh Muslim University3. AIIMS4. AAU5. BHU6. Barkatullah University7. Banasthali Vidyapith8. Bharathidasan University9. Birla Institute of Scientific Research10.Birla Institute of Technology11.Biotech Consortium Indian Ltd.12.Biotech Park in Biotechnology City13.CARI14.HPU15.NEHU16.CDRI17.IICB

DISTRIBUTED INFORMATION SUB CENTRES (SDICs) (Contd..)

• PAU• CIFA• IISR• RGCB• CIMAP• IIT, Delhi• RRL, Jammu• CPCRI• IIT, Kharagpur• SCST for Sikkim• CSRTI• IVRI• T. M. Bhagalpur University• CSKKV• Institute of Life Sciences• TNAU• Dr. Y.S. Parmar Univeristy• MGIMS

36.TNVASU37.DAVV38.MSSRF39.TBGRI40.Engineering College41.NBRI42.University of Agricultural Sc.43.G. B. PantNagar Univer.44.NDRI45.University of Delhi46.GNDU47.NIO48.University of Kashmir

DISTRIBUTED INFORMATION SUB CENTRES (SDICs) (Contd..)

Educational Activities of India in Bioinformatics

Short-Term Training

•Nationwide trainings and workshops•Presently around 100 organised per year in different areas•More than 17000 trained so far

Long-Term Training

Advanced Diploma Courses in five UniversitiesM.Sc., M.Tech., Ph.D. courses in Bioinformatics

1. Advanced Diploma Courses 1.MKU, Madurai2.University of Pune3.University of Calcutta4.JNU, New Delhi5.Pondichery University

2. Post-graduate Courses (M.Sc, M.Tech, Ph.D)

1.JNU, New Delhi2.University of Pune3.Bose Institute4.Anna University5.National Brain Research Centre

3. Traineeship/ Studentship

4. Short-term Training and Workshop Programmes

Developmental Activities

• Database development

• Software Development

• R & D Activities in Bioinformatics

BIOGRID INDIA

• ENOURMOUS GROWTH OF INFORMATION • Dissemination of Biotechnology information to

researchers in the country • Human Resource Development • R&D activities in Bioinformatics • Database sharing • Course material sharing

BIOGRID INDIA

Service Providers VPN Network

MK Univ., Madurai

IISc, Bangalore

NBRC, Gurgaon

IMT, Chandigarh

CDFD, Hyderabad

Univ. of Pune

Deptt. Of Biotecdhnology, Delhi

JNU, Delhi

NII, Delhi

IGIB, DelhiSouth Campus, DU, Delhi

Internet

Router

IIT, , Delhi

22nd September, 2005 23

INSTITUTIONS IN BIOGRID INDIA

1. JNU Bioinformatics Center, JNU 2. University of Delhi South Campus. 3. Madurai Kamraj University, Madurai. 4. Indian Institute of Science 5. National Institute of Immunology. 6. Institute of Microbial Technology 7. Department of Biotechnology 8. University of Pune9. Institute of Genomics & Integrative Biology, Delhi

University Campus, Mall Road near Jubilee Hall Delhi. 10.National Brain Research Centre 11.Centre for DNA Fingerprinting and Diagnostics,

Hyderabad. 12.Indian Institute of Technology, New Delhi.

INTEGRATION OF BIOTECHNOLOGY DATABASES ON BTISNET

Medical Biotechnology

Agricultural Biotechnology

Medicinal or Aromatic Plants

Animal Biotechnology

Aquaculture & Marine Biotechnology

Biodiversity Databases

Mirror Sites on Major Databases

BioGrid Nodes/ Server [High Speed Network]

BTISNet Software package

Molecular Biology

Emphasis on infrastructure creation and human Emphasis on infrastructure creation and human resource development resource development

Biotechnology in India has greatly benefited Biotechnology in India has greatly benefited from the capacity building in Bioinformaticsfrom the capacity building in Bioinformatics

Dedicated virtual private network connecting the Dedicated virtual private network connecting the major centres – sharing of data as well as major centres – sharing of data as well as computing resourcescomputing resourcesBiogrid India (VPN)Centres of Excellence in Bioinformatics

Achievements

DBT INFRASTRUCTURE

Local Area Network – LAN

Website : http://www.dbtindia.nic.in: http://www.btisnet.nic.in

List servers : btis.dbt@lsmgr.nic.in noticeboard.dbt@lsmgr.nic.in

Library FTSNAS

•Extension of high speed and large bandwidth network connectivity to other BTISnet centers and DBT institutions. •Augmentation of infrastructure at the BTISnet centers to cope up with enhanced IT applications in Biotechnology. •Mirroring of more biological databases, useful to the researchers.

Future plans

• Cataloging of BTISnet products to promote sharing of information resources over the network.

• Support to R&D projects in Bioinformatics as well as projects aimed at creating bioinformatics resources on net.

• Publication of Bioinformatics textbooks and monographs.

• Setting up of a Digital/Electronic Library for effective delivery of information to the end users.

• Establishing a video conferencing facility