BRIAN G. T · S2013 Lect 3 100 5 3.0/5 CHGN 428 Introductory Biochemistry I F2013 Lect 1 100 56...

BRIAN G. TREWYN

1

CURRICULUM VITAE

152 Coolbaugh Hall Phone: (303) 384-2224 (office) Department of Chemistry Phone: (515) 520-9217 (cell) Material Science Program FAX: (303) 273-3629 Colorado School of Mines Email: [email protected] Golden, CO 80401 EDUCATION

Iowa State University, Ames, IA • Ph.D. Chemistry (Spring 2006) – Inorganic Chemistry

• Dissertation: Biological applications and transmission electron microscopy investigation of

mesoporous silica nanoparticles *Top Research Award 2006

Research Advisor: Professor Victor S.-Y. Lin (Deceased 04 May 2010)

University of Wisconsin – La Crosse • B.S. Chemistry and Microbiology (2000)

EXPERIENCE

Assistant Professor of Chemistry (August 2012 – Present)

Department of Chemistry

Colorado School of Mines

Golden, CO 80401

• Directly responsible for education and thesis development of graduate students under my

supervision

• Manage and direct a state-of-the-art chemistry research laboratory of 6 graduate students and 8

undergraduate students

• Direct the synthesis and characterization of novel porous materials for catalytic, adsorbent,

biomedical, and plant science applications

• Design, synthesize, and test new organic and inorganic high surface area, porous conductive

nanoparticles for electrochemical and electrocatalytic reactions

• Lead research efforts on new energy sources including the selective conversion of synthesis gas to

ethanol, microalgae oil conversion to biodiesel and highly stable and selective C-H bond

activation and inexpensive hydrodeoxygenation heterogeneous catalysis

• Author and review grant proposals and peer-reviewed research publications

• Instructor of Biochemistry and Microbiology for undergraduate students

• Instructor of Heterogeneous Catalysis graduate course

• Instructor for Inorganic Field Session Summer course

• Instructor of Chemistry and Biochemistry of Pharmaceuticals

Adjunct Professor (May 2010 – July 2012)


Iowa State University

Ames, IA 50011

• Directly responsible for education and thesis development of graduate students under my

supervision

• Manage and direct a state-of-the-art chemistry research laboratory of 14+ graduate students,

undergraduate students, and post-doctoral researchers

BRIAN G. TREWYN

2

• Direct the synthesis and characterization of novel porous materials for catalytic, adsorbent,

biomedical, and plant science applications

• Design, synthesize, and test new adsorbent materials for metal, nitrate, and organophosphate

contaminations from aqueous sources

• Lead research efforts on new energy sources including the selective conversion of synthesis gas to

ethanol, microalgae oil conversion to biodiesel and highly stable and selective C-H bond

activation and inexpensive hydrodeoxygenation heterogeneous catalysis

• Plan and oversee experiments on nanoparticle endocytosis and controlled release into biological

cellular systems


Associate Director—Center for Catalysis (June 2007— July 2012)

Institute of Physical Research and Technology

Associate Scientist II (June 2010— July 2012)

Assistant Scientist III (June 2006—June 2010)


Iowa State University

Ames, IA

http://www.iprt.ameslab.gov/ccat/

• Devise and optimize highly efficient and selective catalysts that convert green feedstocks into

value-added products

• Development of process flow diagrams, technoeconomic analyses, and life cycle assessments of

the novel high-value sequestration technology designed and produced in the research laboratory

• Design new methods to optimize FCC zeolite catalyst lifetime and recyclability

• Oversee a biological research facility for the growth, maintenance, and application of various

animal and plant cell cultures

• Foster collaborative research between different departments and colleges at ISU


Adjunct Faculty – Chemistry Lecturer (August 2009 – May 2010)

Des Moines Area Community College

Des Moines, IA

Chem 122 – Introduction to General Chemistry (evening course)

• Taught assigned night course in accordance with course competencies and syllabi

• Developed a variety of instructional strategies, techniques and delivery methods designed to meet

the individual learning styles of students

Graduate Research Assistant


Iowa State University (September 2000—April 2006)

• Designed and synthesized novel porous nanomaterials for various catalysis, biomedical and

biotechnological applications

• Designed and developed nanomaterials with optimal particle size, morphology, pore size and

volume, and surface structure and area for tailored synthetic systems

• Fully characterized and purified nanomaterials and their surface functional groups,

• Maintained various animal and plant cell cultures for the development of site-selective controlled

release vehicles and controlled chemical and DNA delivery materials

Research Advisor – Professor Victor S.-Y. Lin

BRIAN G. TREWYN

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Graduate Teaching Assistant *Excellence in Teaching Award


Iowa State University (September 2000—December 2003)

• Teaching assistant for General Chemistry lecture and laboratory, teaching assistant for Organic

and Inorganic Chemistry Laboratories

• Substitute lecturer for General Chemistry, Bioinorganic Chemistry, and Physical Inorganic

Chemistry

Undergraduate Internship

United States Department of Interior – Fish and Wildlife Service

La Crosse Fish Health Center April 1999—August 2000

• Assistant scientist in fish virology, bacteriology, and histology laboratories

• Developed PCR techniques for fish parasitic and bacterial diseases

Advisor – Dr. Becky Lasee

AWARDS AND HONORS

• Outstanding Faculty Award, Colorado School of Mines, Department of Chemistry May, 2016

• Outstanding Faculty Award, Colorado School of Mines, Department of Chemistry May, 2015

• Ames Laboratory Inventor Incentive Award for Fiscal Year 2015, March 2015



• Sole-nomination for 2006 CGS/University Microfilms International Distinguished Dissertation

Award by ISU

• Zaffarano Research Award, Iowa State University, March 2006

• Procter & Gamble Travel Award, March 2005

• Iowa State University Department of Chemistry Excellence in Teaching Award, May 2001

SKILLS

• Strong management and supervising skills with good interpersonal communication and effective

listening skills obtained as the principal investigator of a large research laboratory

• Experienced at balancing budgets and dividing monies among personnel expenses, instrument

maintenance costs, and consumable purchases for a successful chemical and catalytic research

center

• Highly experienced in the development of new nanomaterial chemistries, including synthesis,

characterization, and applications in bioenergy, catalytic, and biomedical investigations

• Advanced knowledge of wet laboratory techniques for the synthesis, purification, and

characterization of organic, polymer, and inorganic compounds

• Understanding of heterogeneous catalysis fundamentals and experienced at research surrounding

biofuel upgrading, FCC, synthesis gas conversion, fine chemical syntheses, and other pressurized

catalytic reactions

• Skilled in the characterization of zeolite catalysts and porous structures with electron microscopy

(STEM, SEM, and TEM) and spectroscopy (EDX and EELS), chemisorption and nitrogen

physisorption, powder X-ray diffraction, FTIR and DR-UV spectroscopy, and zeta potential

• Proficient with additional analytical techniques and computer software including GC, HPLC, GC-

MS, 1D and 2D NMR, MS Office suite and various scientific software including ChemDraw and

ChemDoodle

• Practiced at writing, reviewing, and reporting federal and state funded research grants and peer

reviewed scientific publications

BRIAN G. TREWYN

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• Skilled in biochemistry fundamentals and biological techniques including aseptic laboratory

technique, fluorescence confocal microscopy, flow cytometry, biological electron microscopy,

prokaryote, eukaryote, and microalgae cell-line maintenance, nucleic acid purification and PCR

techniques, and DNA, RNA, and protein electrophoresis

TEACHING AT CSM

Course Summary

Course

Number

Course Title Term

(F, S,

SI, SII)

& Year

Type

(Lab,

Lect,

Rec,

Ind

Study)

Credit

Hours

%

Responsible

Number

of

Students

Student

Survey

Response to

“Overall

Instructor

Effectiveness”

CHGN

462

Microbiology &

the

Environment

S2013 Lect 3 100 60 3.2/5

CHGN

562

Microbiology &

the

Environment

S2013 Lect 3 100 5 3.0/5

CHGN

428

Introductory

Biochemistry I

F2013 Lect 1 100 56 2.8/5

CHGN

462

Microbiology S2014 Lect 3 100 50 3.95/5

CHGN

490

Summer Field

Session

SI2014 Lect

& Lab

6 15 15 --

CHGN

428

Introductory

Biochemistry I

F2014 Lect 3 100 55 3.6/5

CHGN

462


CHGN

490

Summer Field

Session

SI2015 Lect

& Lab

6 15 25 --

CHGN

428

Introductory

Biochemistry I

F2015 Lect 3 100 61 3.6/5

CHGN

428


BRIAN G. TREWYN

5

CHGN

490

Summer Field

Session

SI2016 Lect

& Lab

6 15 16 --

CHGN

428

Introductory

Biochemistry I

F2016 Lect 3 100 75 4.2/5

CHGN

584

Fundamentals

of Catalysis

F2016 Lect 3 100 10 4.25/5

CHGN

462


CHGN

490

Summer Field

Session

SI2017 Lect

& Lab

6 15 19 --

CHGN

462

Microbiology S2018 Lect 3 100 88

CHGN

498

Chemistry and

Biochemistry of

Pharmaceuticals

S2018 Lect 3 100 25

OUTREACH ACTIVITIES

• Lead writer of semiannual Chemistry Department Newsletter and Departmental Webmaster (2017

to present)

• High School Student mentor, Jefferson County School District – January 2014 to present

• Programming director of Nanoscience division of the American Chemical Society – January 2016

to present

• Participant in discussion hosted by the CSM research office with new faculty on working with the

Office of Research Administration – September 2016

• Organization committee for the North American Catalysis Society International Meeting in

Denver, CO in June 2017

• Symposia Co-organizer and Moderator – 250th ACS National Meeting – 2015 Boston ENFL

Division

• Symposium Moderator – 249th ACS National Meeting – 2015 Denver Nanoscience Division

• Symposia Co-organizer and Moderator – 247th ACS National Meeting – 2014 Dallas ENFL

Division

• Abstract reviewer and Poster judge - Symposium for Thermal and Catalytic Sciences for Biofuels

and Biobased Products – 2014, Denver, CO

• Symposium Moderator – 245th ACS National Meeting – 2013 New Orleans, Nanoscience Division

• Peer-reviewer for ACS Advanced Materials and Interfaces, ACS Biomaterials Science &

Engineering, ACS Catalysis, ACS Nano, Acta Biomaterialia, Advanced Functional Materials,

Advanced Healthcare Materials, Advanced Materials, Advanced Powder Technology, Algal

Research, Angewandte Chemie, Applied Catalysis A, Applied Catalysis B, Applied Organometallic

Chemistry, Applied Surface Science, Bioengineering, Biomacromolecules, Biomaterials,

BRIAN G. TREWYN

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Biotechnology Journal, ChemCatChem, Chemical Engineering Journal, Chemical Engineering

Science, Chemical Reviews, Chemical Society Reviews, Chemistry - A European Journal,

Chemistry of Materials, ChemistrySelect, ChemPlusChem, ChemSusChem, Colloids and Surfaces

A: Physicochemical and Engineering Aspects, Environmental Science and Technology, European

Biophysics Journal, Expert Opinion in Drug Delivery, Expert Opinion On Therapeutic Patents,

Industrial & Engineering Chemistry Research, Inorganic Chemistry, Journal of Material

Chemistry B, Journal of Molecular Structure, Journal of Nanostructure in Chemistry, Journal of

Natural Gas Science & Engineering, Journal of the American Chemistry Society, Journal of

Visualized Experiments, Langmuir, Material Letters, Microporous and Mesoporous Materials,

Molecular Pharmaceutics, MRS Advances, Nano Letters, Nanomedicine, Nanoscale, Nanoscale,

Nature, Research Letters, Nature Communications, Organometallics, Plant Cell Reports, RSC

Advances, Scientific Reports, Small, Soft Matter, Theranostics, Therapeutic Delivery, Thin Solid

Films, and Topics in Catalysis.

COMMITTEES AND ORGANIZATIONS

• Member of the American Vacuum Society, 2016 to present

• Member of the Royal Society of Chemistry, 2016 to present

• Elected member of the Professional & Scientific Committee Council, June 2007 – June 2009

• Sigma Xi, Scientific Research Society, April 2006 to present

• Member of the American Chemical Society, January 2002 to present

• Member of the Student-Faculty Liaison Committee, ISU January 2004-May 2006

• Mentor for undergraduate–graduate student mentoring program, ISU, Spring 2005

• Member of Student Faculty Search Committee, Iowa State University (Fall 2003 & 2005)

PEER-REVIEWED PUBLICATIONS h-index = 35 as of February 2018

1. Ashley E. Augspurger, Xiaoxing Sun, Brian G. Trewyn, Ning Fang,* Anthony S. Stender*

Monitoring the Stimulated Uncapping Process of Gold-Capped Mesoporous Silica

Nanoparticles, Analytical Chemistry, 2018, ASAP.

2. Gauri V. Deodhar, Marisa L. Adams, Sutapa Joardar, Madhura Joglekar, Malcolm Davidson,

William C. Smith, Madelyn Mettler, Sydney A. Toler, Fiona Davies, S. Kim R. Williams and

Brian G. Trewyn* Reassociation of Concanavalin A Subunits Released from Mesoporous

Silica Nanoparticles with Conserved Enzymatic Activity, Langmuir, 2018, 34(1) 228-233.

*Includes two high school student coauthors (MM & SAT).

3. Marrone, B. L., Lacey, R. E., Anderson, D. B., Bonner, J., Coons, J., Dale, T., Downes, C. M.,

Fernando, S., Fuller, C., Goodall, B. Holladay, J. E., Kadam, K., Liu, W., Mott, J. B., Nikolov,

Z., Ogden, K. I., Sayre, R. T., Trewyn, B. G., Olivares, J.* Review of the harvesting and

extraction program within the National Alliance for Advanced Biofuels and Bioproducts.

Algal Research, 2017, ASAP.

4. Megan M. Moyer, Canan Karakaya, Robert J. Kee, and Brian G. Trewyn*, In Situ Formation

of Metal Carbide Catalysts, ChemCatChem, 2017, 9, 3090-3101.

5. Mengze Xu, Calvin Mukarakate, Kristiina Iisa, Sridhar Budhi, Martin Menart, Malcolm

Davidson, David J. Robichaud, Mark R. Nimlos, Brian G. Trewyn, and Ryan M. Richards,

Deactivation of Multilayered MFI Nanosheet Zeolite during Upgrading of Biomass Pyrolysis

Vapors, ACS Sustainable Chem. Eng. 2017, 5, 5477−5484.

6. Liqiu Yang, Brett W. McNichols, Malcolm Davidson, Ben Schweitzer, Diego A. Gomez-

Gualdron, Brian G. Trewyn, Alan Sellinger, and Moises A. Carreon, Noble Metal-free

Catalytic Decarboxylation of Oleic Acid to n-Heptadecane on Nickel-based Metal-Organic

Frameworks (MOFs), Catal. Sci. Tech., 2017, 7, 3027-3035.

BRIAN G. TREWYN

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7. Chih-Hsiang Tsai, Mengze Xu, Pranaw Kunal, and Brian G. Trewyn*, Aerobic Oxidative

Esterification of Primary Alcohols over Pd-Au Bimetallic Catalysts Supported on Mesoporous

Silica Nanoparticles, Cat. Today, 2017, http://dx.doi.org/10.1016/j.cattod.2017.01.046.

8. Gauri Deodhar, Marisa Adams, and Brian G. Trewyn*, Controlled Release and Intracellular

Protein Delivery from Mesoporous Silica Nanoparticles, Biotech. J., 2017, 12.

9. Dominik Munz, Daoyong Wang, Megan M. Moyer, Michael S. Webster-Gardiner, Pranaw

Kunal, David Watts, Brian G. Trewyn*, Andrei N. Vedernikov*, and T. Brent Gunnoe*,

Aerobic Epoxidation of Olefine by Platinum Catalysts Supported on Mesoporous Silica

Nanoparticles, ACS Catalysis, 2016, 7, 4584-4593.

10. Sam H. Gage, Brian G. Trewyn, Cristian V. Ciobanu, Svitlana Pylypenko, and Ryan M.

Richards, Synthetic Advancements and Catalytic Applications of Nickel Nitride, Catal. Sci.

Tech., 2016, 6, 4059-4076.

11. Madhura Joglekar, Vinh Nguyen, Svitlana Pylypenko, Chilan Ngo, Quanning Li, Matthew E.

O’Reilly, Tristan S. Gray, William A. Hubbard, T. Brent Gunnoe, Andrew M. Herring, and

Brian G. Trewyn*, Organometallic Complexes Anchored to Conductive Carbon for

Electrocatalytic Oxidation of Methane at Low Temperature J. Am. Chem. Soc., 2016, 138,

116-125. *Highlighted in Chemical and Engineering News – 02 November 2015 issue,

*Awarded Cover Art

12. Mengze Xu, Calvin Mukarakate, David J. Robichaud, Mark R. Nimlos, Ryan M. Richards, and

Brian G. Trewyn*, Elucidating Zeolite Deactivation Mechanisms During Biomass Catalytic

Fast Pyrolysis from Model Reactions and Zeolite Syntheses, Top. Catal., 2016, 59, 73-85.

*Invited contribution

13. Sridhar Budhi, Calvin Mukarakate, Kristiina Iisa, Svitlana Pylypenko, Peter, N. Ciesielski,

Matthew M. Yung, Bryon S. Donohoe, Rui Katahira, Mark R. Nimlos, and Brian G.

Trewyn*, Molybdenum Incorporated Mesoporous Silica Catalyst for Production of Biofuels

and Value-added Chemicals via Catalytic Fast Pyrolysis, Green Chem., 2015, 17, 3035.

14. Madhura Joglekar, Svitlana Pylypenko, Megan M. Otting, Justin S. Valenstein, Brian G.

Trewyn*, A Universal and Versatile Route for Selective Covalent Tethering of Single-Site

Catalysts and Functional Groups on the Surface of Ordered Mesoporous Carbons, Chem.

Mater., 2014, 26, 2873-2882.

15. Sridhar Budhi, Svitlana Pylypenko, Chorthip Peeraphatdit, Vy Nguyen, Emily Smith, Brian

G. Trewyn*, Enhanced Metal Loading in SBA-15-type Catalysts Facilitated by Salt Addition:

Synthesis, Characterization and Catalytic Activity of Molybdenum Incorporated Porous Silica

Appl. Catal.-A., 2014, 475, 469-475.

16. Robert A. Roggers, Madhura Joglekar, Justin S. Valenstein, Brian G. Trewyn*, Mimicking

Red Blood Cell Lipid Membrane to Enhance the Hemocompatibility of Large-Pore

Mesoporous Silica, ACS Appl. Mater. Interf., 2014, 6, 1675-1681.

17. Susana Martin-Ortigosa, David J. Peterson, Justin S. Valenstein, Victor S.-Y. Lin, Brian G.

Trewyn, L. Alexander Lyznik, and Kan Wang, Mesoporous Silica Nanoparticle Mediated

Intracellular Cre Protein Delivery for Maize Genome Editing via loxP Sites Excision, Plant

Phys., 2014, 164, 537-547.

18. Madhura Joglekar and Brian G. Trewyn*, “Polymer-based Stimuli-responsive Nanosystems

for Biomedical Applications, Biotech. J., 2013, 8, 931-945.

19. Madhura Joglekar, Robert A. Roggers, Yannan Zhao, and Brian G. Trewyn*, Morphology

Effects of Mesoporous Silica Nanoparticles on Human Erythrocytes, RSC Adv., 2013, 3, 2454-

2461.

BRIAN G. TREWYN

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20. Kapil Kandel, Stacey M. Althaus, Chorthip Peeraphatdit, Takeshi Kobayashi, Brian G.

Trewyn, Marek Pruski, Igor I. Slowing, Solvent-Induced Reversal of Activities between Two

Closely Related Heterogeneous Catalysts in the Aldol Reaction. ACS Catal., 2013, 2, 265-271.

At ISU

21. Young Jin Lee, Rachael C. Leverence, Erica A. Smith, Justin S. Valenstein, Kapil Kandel,

Brian G. Trewyn, High-Throughput Analysis of Algal Crude Oils Using High Resolution

Mass Spectrometry Lipids, 2013, 48, 297-305.

22. Robert A. Roggers, Victor S.-Y. Lin, and Brian G. Trewyn,* Chemically Reducible Lipid

Bilayer Coated Mesoporous Silica Nanoparticles Demonstrating Controlled Release and HeLa

and Normal Mouse Liver Cell Biocompatibility and Cellular Internalization, Molecular

Pharm., 2012, 9, 2770-2777.

23. Susana Martin-Ortigosa, Justin S. Valenstein, Brian G. Trewyn,* and Kan Wang,*

Mesoporous Silica Nanoparticle Mediated Protein and DNA Codelivery to Plant Cells via

Biolistic Method Adv. Funct. Mater., 2012, 17, 3576-3586. *Awarded Cover Art

24. I-Ju Fang, Igor I. Slowing, Chia-Wen Wu, Victor S.-Y. Lin, and Brian G. Trewyn,* Ligand

Conformation Dictates Membrane and Endosomal Trafficking of Arginine-Glycine-Aspartate

(RGD)-functionalized Mesoporous Silica Nanoparticles, Chemistry – A European Journal,

2012, 18, 7787-7792.

25. Justin S. Valenstein, Kapil Kandel, Forrest Melcher, Igor I. Slowing, Victor S.-Y. Lin, and

Brian G. Trewyn,* Functional Mesoporous Silica Nanoparticles for the Selective

Sequestration of Free Fatty Acids from Microalgal Oil, ACS Appl. Mater. Interf., 2012, 4,

1003-1009.

26. Kapil Kandel; Stacey M Althaus, Chorthip Peeraphatdit, Takeshi Kobayash, Brian G Trewyn,

Marek Pruski, Igor Slowing,* Substrate Inhibition in the Heterogeneous Catalyzed Aldol

Condensation: A Mechanistic Study of Supported Organocatalysts. J. Catal., 2012, 291, 63-

68.

27. Susana Martin-Ortigosa, Justin S. Valenstein, Wei Sun, Lorena Moeller, Ning Fang, Brian G.

Trewyn, Victor S.-Y. Lin, and Kan Wang,* Parameters Affecting the Efficient Delivery of

Mesoporous Silica Nanoparticle Materials and Gold Nanorods into Plant Tissues by the

Biolistic Method. Small, 2012, 8(3), 413-422.

28. Yulin Huang, Weihua Deng, Enruo Guo, Po-Wen Chung, Senniang Chen, Brian G. Trewyn,

Robert C. Brown, and Victor S.-Y. Lin, Mesoporous Silica Nanoparticle-Stabilized and

Manganese-Modified Rhodium Nanoparticles as Catalysts for Highly Selective Synthesis of

Ethanol and Acetaldehyde from Syngas, ChemCatChem, 2012, 4, 674-680.

29. Xiaoxing Sun, Yannan Zhao, Victor S.-Y. Lin, Igor I. Slowing, Brian G. Trewyn,*

Luciferase and Luciferin Co-immobilized Mesoporous Silica Nanoparticle Materials for

Intracellular Biocatalysis, J. Am. Chem. Soc., 2011, 113, 18554-18557.

30. “Nikola Z. Knezevic, Brian G. Trewyn, Victor S.-Y. Lin Functionalized Mesoporous Silica

Nanoparticle-based Visible Light Responsive Controlled Release Delivery System, Chem.

Commun., (Cambridge, UK) 2011, 47(10), 2817-2819.

31. Nikola Z. Knezevic, Brian G. Trewyn, Victor S.-Y. Lin, Light- and pH-Responsive Release

of Doxorubicin from a Mesoporous Silica-Based Nanocarrier, Chemistry – A European

Journal, 2011, 17(12), 3338-3342.

32. Yannan Zhao, Xiaoxing Sun, Guannan Zhang, Brian G. Trewyn,* Igor I. Slowing,* Victor

S.-Y. Lin, Interaction of Mesoporous Silica Nanoparticles with Red Blood Cell Membranes:

Size and Surface Effects, ACS Nano, 2011, 5, 1366-1375.

33. Igor I. Slowing,* Juan L. Vivero-Escoto, Yannan Zhao, Kapil Kandel, Chorthip Peeraphatdit,

Brian G. Trewyn,* Victor S.-Y. Lin, Exocytosis of Mesoporous Silica Nanoparticles from

BRIAN G. TREWYN

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Mammalian Cells: From Asymmetric Cell-to-Cell Transfer to Protein Harvesting, Small, 2011,

7, 1526-1532.

34. Chih-Hsiang Tsai, Juan L. Vivero-Escoto,* Igor I. Slowing, I-Ju Fang, Brian G. Trewyn,*

Victor S.-Y. Lin, Surfactant-assisted Controlled Release of Hydrophobic Drugs Using Anionic

Surfactant Templated Mesoporous Silica Nanoparticles, Biomaterials, 2011, 32, 6234-6244.

35. Jing Tang, Igor I. Slowing, Yulin Huang, Brian G. Trewyn,* Jun Hu, Honglai Liu,* and

Victor S.-Y. Lin,” Poly(lactic acid)-coated Mesoporous Silica Nanosphere for Controlled

Release of Venlafaxine, J. Colloid Interf. Sci., 2011, 360, 488-496.

36. Tanay Kesharwani, Justin S. Valenstein, Brian G. Trewyn, Fengkui Li, Victor S.-Y. Lin,

Richard C. Larock,* Synthesis of Nanotubes via Cationic Polymerization of Styrene and

Divinylbenzene, Polymer Chem. 2010, 1(9), 1427-1429.

37. Hung-Ting Chen, Brian G. Trewyn, Jerzy W. Wiench, Marek Pruski, and Victor S.-Y. Lin,*

Urea and Thiourea-Functionalized Mesoporous Silica Nanoparticle Catalysts with Enhanced

Catalytic Activity for Diels-Alder Reaction, Top. Catal., 2010, 53(3-4), 187-191.

38. Juan L. Vivero-Escoto, Brian G. Trewyn, and Victor S.-Y. Lin,* Mesoporous Silica

Nanoparticles: Synthesis and Applications, Annual Review of Nano Research, 2010, 3, 191-

231.

39. Yannan Zhao, Juan L. Vivero-Escoto, Igor I. Slowing,* Brian G. Trewyn,* and Victor S.-Y.

Lin, Capped Mesoporous Silica Nanoparticles as Stimuli-Responsive Controlled Release

Systems for Intracellular Drug/Gene Delivery, Expert Opinion on Drug Delivery, 2010, 7(9),

1013-1029.

40. Igor I. Slowing,* Juan L. Vivero-Escoto, Brian G. Trewyn,* Victor S-Y. Lin, Mesoporous

Silica Nanoparticles: Structural Design and Applications, J. Mater. Chem., 2010, 20(37)

7924-7937. *Awarded Cover Art

41. Juan L. Vivero-Escoto,* Igor I. Slowing, Brian G. Trewyn,* Victor S.-Y. Lin, Mesoporous

Silica Nanoparticles for Intracellular Controlled Drug Delivery, Small, 2010, 6(18) 1952-1967.

*Most accessed article from 11/2010-10/2011

42. Erin M. Rockafellow, Xiaowen Fang, Brian G. Trewyn, Klaus Schmidt-Rohr,* and William

S. Jenks,* Solid-State 13C NMR Characterization of Carbon-Modified TiO2,” Chem. Mater.,

2009, 21(7), 1187-1197.

43. Yibo Zhou, Brian G. Trewyn, Robert J. Angelici,* and L. Keith Woo,* Catalytic Reactions of

Carbene Precursors on Bulk Gold Metal, J. Am. Chem. Soc., 2009, 131(33), 11734-11743.

44. Yannan Zhao, Brian G. Trewyn, Igor I. Slowing, and Victor S.-Y. Lin,* “Mesoporous Silica

Nanoparticle-Based Double Drug Delivery System for Glucose-Responsive Controlled

Release of Insulin and Cyclic AMP,” J. Am. Chem. Soc., 2009, 131(24), 8398-8400.

45. Wei Sun, Ning Fang, Brian G. Trewyn, Makoto Tsunoda, Igor I. Slowing, Victor S.-Y. Lin,

and Edward S. Yeung,* Endocytosis of a Single Mesoporous Silica Nanoparticle into a Human

Lung Cancer Cell Observed by Differential Interference Contrast Microscopy, Analytical and

Bioanalytical Chemistry, 2008, 391(6), 2119-2125.

46. Yulin Huang, Brian G. Trewyn, Hung-Ting Chen, and Victor S.-Y. Lin,* One-Pot Reaction

Cascades Catalyzed by Base- and Acid-Functionalized Mesoporous Silica Nanoparticles, New

J. Chem., 2008, 32(8), 1311-1313.

47. Bolin Zhu, Mihaela Lazar, Brian G. Trewyn, and Robert J. Angelici,* Aerobic Oxidation of

Amines to Imines Catalyzed by Bulk Gold Powder and By Alumina-Supported Gold, J. Catal.,

2008, 260(1), 1-6.

48. Brian G. Trewyn, Jennifer A. Nieweg, Yannan Zhao and Victor S.-Y. Lin,* Biocompatible

Mesoporous Silica Nanoparticles with Different Morphologies for Animal Cell Membrane

Penetration, Chem. Eng. J. (Amsterdam, Netherlands), 2008, 137(1), 23-29.

BRIAN G. TREWYN

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49. Cheng-Yu Lai, Chia-Wen Wu, Daniela Radu, Brian Trewyn, and Victor S.-Y. Lin,*

Reversible Binding and Fluorescence Energy Transfer Between Surface-Derivatized CdS

Nanoparticles and Multi-Functionalized Fluorescent Mesoporous Silica Nanospheres, Studies

in Surface Science and Catalysis, 2007, 170B (From Zeolites to Porous MOF Materials),

1827-1835.

50. Brian G. Trewyn, Igor I. Slowing, Supratim Giri, and Victor S.-Y. Lin,* Synthesis and

Functionalization of a Mesoporous Silica Nanoparticle Based on the Sol-Gel Process and

Applications in Controlled Release, Acc. Chem. Res., 2007, 40, 846-853.

51. Igor I. Slowing, Brian G. Trewyn, Supratim Giri, and Victor S.-Y. Lin,* Mesoporous Silica

Nanoparticles for Drug Delivery and Biosensing Applications, Adv. Funct. Mater., 2007, 17,

1225-1236.

52. Brian G. Trewyn, Igor I. Slowing, Supratim Giri, and Victor S.-Y. Lin,* Mesoporous Silica

Nanoparticle-Based Controlled Release, Drug Delivery, and Biosensor Systems, Chem.

Commun., 2007, 31, 3236-3245. *Top 10 Article published in 2007 contribution to the

2008 ChemComm impact factor

53. Francois Torney, Brian G. Trewyn, Victor S.-Y. Lin,* and Kan Wang,* Mesoporous Silica

Nanoparticles Deliver DNA and Chemicals into Plants, Nature Nanotech., 2007, 2, 295-300.

54. Supratim Giri, Brian G. Trewyn, and Victor S.-Y. Lin,* Mesoporous Silica Nanomaterial-

based Biotechnological and Biomedical Delivery Systems, Nanomedicine, 2007, 2, 99-111.

55. Igor I. Slowing, Brian G. Trewyn, and Victor S.-Y. Lin,* Mesoporous Silica Nanoparticles

for Intracellular Delivery of Membrane-Impermeable Proteins, J. Am. Chem. Soc., 2007, 129,

8845-8849.

56. Yang Cai, Rajeev Kumar, Wei Huang, Brian G. Trewyn, Jerzy W. Wiench, Marek Pruski,

and Victor S.-Y. Lin,* Mesoporous Aluminum Silicate Catalyst with Single-Type Active

Sites: Characterization by Solid-State NMR and Studies of Reactivity for Claisen

Rearrangement Reactions, J. Phys. Chem. C, 2007, 111, 1480-1486.

57. Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the

Endocytosis by Human Cancer Cells, Igor I. Slowing, Brian G. Trewyn, and Victor S.-Y.

Lin,* J. Am. Chem. Soc., 2006, 128, 14792-14793.

58. Jennifer A. Nieweg, Kelemu Lemma, Brian G. Trewyn, Victor S.-Y. Lin,* and Andreja

Bakac,* Mesoporous Silica-Supported Uranyl: Synthesis and Photoreactivity, Inorg. Chem.,

2005, 44, 5641-5648.

59. Supratim Giri, Brian G. Trewyn, Michael P. Stellmaker, and Victor S.-Y. Lin,* Magnetic

Nanoparticle-Capped Mesoporous Silica Nanorod-Based Stimuli-Responsive Controlled

Release Delivery System, Angew. Chem. – Int. Ed., 2005, 44, 5038-5044.

60. Brian G. Trewyn, Chad M. Whitman, and Victor S.-Y. Lin,* Morphological Control of

Room-Temperature Ionic Liquid Templated Mesoporous Silica Nanoparticles for Controlled

Release of Antibacterial Agents, Nano Letters, 2004, 4, 2139-2143.

61. Amy S. Determan, Brian G. Trewyn, Victor S.-Y. Lin, Marit Nilsen-Hamilton, and Balaji

Narasimhan,* Encapsulation, Stabilization, and Release of BSA-FITC from Polyanhydride

Microspheres, J. Control. Rel., 2004, 100, 97-109.

62. Seong Huh, Jerzy W. Wiench, Brian G. Trewyn, Seahn Song, Marek Pruski, and Victor S.-Y.

Lin,* Tuning of Particle Morphology and Pore Properties in Mesoporous Silicas with Multiple

Organic Functional Groups, Chem. Commun. (Cambridge, U.K.), 2003, 18, 2364-2365.

63. Cheng-Yu Lai, Brian G. Trewyn, Dusan M. Jeftinija, Ksenija Jeftinija, Shu Xu, Srdija

Jeftinija, and Victor S.-Y. Lin,* A Mesoporous Silica Nanosphere-Based Carrier System with

Chemically Removable CdS Nanoparticle Caps for Stimuli Responsive Controlled Release of

Neurotransmitters and Drug Molecules, J. Am. Chem. Soc., 2003, 125, 4451-4459.

BRIAN G. TREWYN

11

Book Chapters

At CSM

64. Susana Martin Ortigosa, Brian G. Trewyn, and Kan Wang, Nanoparticle-mediated

recombinase delivery into maize, in Site-Specific Recombinases. Ed. Nikolai Eroshenko,

Springer, 2017.

65. Pranaw Kunal and Brian G. Trewyn Mesoporous silica supported single-site catalysis, in

Heterogeneous Catalysis for Today’s Challenges. Ed. Brian G. Trewyn, Royal Society of

Chemistry, Cambridge, UK, 2015.

66. Brian G. Trewyn and Jack A. Mohr, Recent advances in biotherapeutic delivery and cellular

interactions of mesoporous silica nanoparticle materials, in Nanoparticles for Biotherapeutic

Delivery, Vol 2. Ed. Joshua D. Ramsey and M. Laird Forrest, Future Medicine, LLC, 2015.

67. Megan M. Otting, Yazhou Ji, Ryan M. Richards, and Brian G. Trewyn, Chemistry in

confined pore domains in Pore Scale Phenomena, Ed. John Poate, Tissa Illangasekara, Hossein

Kazemi, and Robert Kee, World Scientific: Hackensack, NJ, 2015.

68. Xiaoxing Sun and Brian G. Trewyn, Porous silica nanoparticles for drug delivery and

controlled release in Nanotechnology and Drug Delivery, Ed. Jose L. Arias, CRC Press,

Taylor and Francis Group: Boca Raton, 2015.

69. Brian G. Trewyn, Surface-functionalized nanoporous catalysts towards biofuel applications

in Nanotechnology for the Energy Challenge, 2nd edition, Javier Garcia-Martinez, John Wiley

& Sons, Ltd: United Kingdom, 2013.

At ISU

70. I-Ju Fang and Brian G. Trewyn, Application of mesoporous silica nanoparticles in

intracellular delivery of molecules and proteins in Methods in Enzymology, Nejat Düzgünes,

Elsevier B.V., Inc: United Kingdom, 2012.

71. Hung-Ting Chen, Brian G. Trewyn, and Victor S.-Y. Lin, Surface-functionalized nanoporous

catalysts towards biofuel applications in Nanotechnology for the Energy Challenge, Javier

Garcia-Martinez, John Wiley & Sons, Ltd: United Kingdom, 2011.

72. Igor I. Slowing, Brian G. Trewyn, and Victor S.-Y. Lin, Nanogated mesoporous silica

materials in The Supramolecular Chemistry of Organic-Inorganic Hybrid Materials, Knut

Rurack and Ramon Martinez-Manez, John Wiley & Sons, Ltd: United Kingdom, 2010.

73. Brian G. Trewyn, Hung-Ting Chen, and Victor S.-Y. Lin, Surface-functionalized nanoporous

catalysts for renewable chemistry in Recoverable and Recyclable Catalysts, Maurizio

Benaglia, John Wiley & Sons, Ltd: United Kingdom, 2009.

PATENTS AUTHORED

U.S. Patent Application Serial Number: 10/945,545

Title: ANTIMICROBIAL MESOPOROUS SILICA NANOPARTICLES


Title: METHODS OF USING CAPPED MESOPOROUS SILICATES


Title: SEQUESTRATION OF COMPOUNDS FROM MICROORGANISMS

U.S. Patent Application – Pending

Title: NANOPARTICLE TECHNOLOGY FOR BIOREFINERY OF NON-FOOD SOURCE

FEEDSTOCKS

U.S. Patent Application – Pending

BRIAN G. TREWYN

12

Title: SELECTIVE ADSORPTION OF TOCOPHEROL BY PENTAFLUOROPHENYL

FUNCTIONALIZED MESOPOROUS SILICA NANOPARTICLES


Title: METHODS FOR THE CO-DELIVERY OF PROTEIN AND DNA INTO PLANT CELLS USING

MESOPOROUS SILICA NANOPARTICLE

POSTER PRESENTATIONS

• 55th Pittsburgh Conference, Chicago, IL, March 2004

ORAL PRESENTATIONS

• 229th American Chemical Society Conference, San Diego, CA, March 2005

• 231st American Chemical Society Conference, Atlanta, GA, March 2006

• 233rd American Chemical Society Conference, Chicago, IL, March 2007

• DOE/ITP Nanomanufacturing Meeting, DOE Headquarters, Washington, D.C., Sept. 2008 and

2009

• Inorganic Seminar Series, Iowa State University, Ames, IA October 2008

• 239th American Chemical Society Conference, San Francisco, CA, March 2010

• 241st American Chemical Society Conference, Anaheim, CA, March 2011

INVITED PRESENTATIONS

• 46th Rocky Mountain Conference on Analytical Chemistry, Denver, CO, August 2004

• Truman State University, Kirksville, MO, April 2011 “Research with Mesoporous Nanoparticles

for Solutions to the Environment, Energy, and Biomedical Challenges of Today and Tomorrow”

• 242nd American Chemical Society Conference, Denver, CO, August 2011 “Research with

Mesoporous Nanoparticles for Solutions to the Environment, Energy, and Biomedical Challenges

of Today and Tomorrow”

• St. Cloud State University, St. Cloud, MN, October 2011 “Tackling the Environment, Energy,

and Biomedical Challenges of Tomorrow with Mesoporous Nanoparticle Technology Today”

• University of Northern Iowa, Cedar Falls, IA, October 2011 “Tackling the Environment, Energy,

and Biomedical Challenges of Tomorrow with Mesoporous Nanoparticle Technology Today”

• Colorado School of Mines, Golden, CO, March 2012 “Tackling the Environment, Energy, and

Biomedical Challenges of Tomorrow with Mesoporous Nanoparticle Technology Today”

• American Association of Pharmaceutical Sciences (AAPS), October 2012 “Discovery, Synthesis,

and Functionalization of Mesoporous Silica Nanoparticles”

• Rocky Mountain Regional Meeting, American Chemical Society Conference, Westminster, CO,

October 2012 “Tackling the Bioenergy Challenges of Tomorrow with Mesoporous Nanoparticle

Technology Today”

• Anschutz Medical Campus-University of Colorado, Denver, CO, November 2012 “Tackling a

Variety of Biomedical Challenges of Tomorrow with Mesoporous Nanoparticle Technology

Today”

• Southwest Forestry University, Kunming, Yunnan, P.R.C., November 2012 “New Developments

in the Utilization of Mesoporous Nanoparticle Materials in Viable Plant and Microorganism

Systems and as Advanced Catalysts for Biofuel Upgrading”

• 245th American Chemical Society Conference, New Orleans, LA, April 2013

• Colorado Center for Biorefinery and Biofuels, Boulder CO, April 2013 “Tackling the

Environmental and Bioenergy Challenges of Tomorrow with Mesoporous Nanoparticle

Technology Today”

BRIAN G. TREWYN

13

• 250th American Chemical Society Conference – Catalysis division, Boston, MA, August 2015

“Tackling the Environment and Energy Challenges of Tomorrow with Mesoporous Nanoparticle

Technology Today”

• Metro State University of Denver, Department of Chemistry, Denver, CO, April 2016 “Exploring

Energy, Environmental, and Biological Challenges with Mesoporous Nanoparticle Technology”

• The 11th International Symposium of the Romanian Catalysis Society – RomCat 2016, Timisoara,

Romania, June 7, 2016, Keynote address: “Exploring Biocatalytic, Thermocatalytic and

Electrocatalytic Systems Integrated with Unique Organic and Inorganic Porous Materials”

• Max Planck Institute of Colloids and Interfaces – Potsdam, Germany, June 10, 2016 “Exploring


• University of Bordeaux, Institut de Chimie de la Matière Condensée de Bordeaux CNRS - UPR

9048 – Bordeaux, France, June 13, 2016 “Exploring Energy, Environmental, and Biological

Challenges with Mesoporous Nanoparticle Catalysts and Delivery Technology”

• Ecole Nationale Supérieure de Chimie de Paris, Chimie ParisTech, Paris, France, June 15, 2016

“Exploring Energy, Environmental, and Biological Challenges with Mesoporous Nanoparticle

Technology”

• Department of Chemistry, University of Houston, Houston, TX, October 18, 2016. “Exploring

Energy, Environmental, and Biological Challenges with Mesoporous Nanoparticle Catalysts and

Delivery Technology”

• Royal Society of Chemistry, Challenges in Nanoscience, Tsinghua University, Beijing, China,

November 12, 2016. Plenary Lecture: “Exploring Energy, Environmental, and Biological

Challenges with Mesoporous Nanoparticle Technology”

• Department of Chemistry, University of North Carolina – Charlotte, January 23, 2017.

“Exploring Energy, Environmental, and Biological Challenges with Mesoporous Nanoparticle

Technology”

• Department of Chemistry, University of Missouri – Columbia, February 10, 2017. “Exploring


• Rocky Mountain Regional Meeting – American Chemical Society, Loveland, CO, October 26,

2017. “Reassociation of Multisubunit Proteins Released from Mesoporous Silica Nanoparticles

with Conserved Enzymatic Activity”

• Department of Chemistry, University of Southern California, November 7, 2017. “Exploring


• Department of Chemistry, University of Texas – Austin, November 29, 2017. “Exploring Energy,

Environmental, and Biological Challenges with Mesoporous Nanoparticle Technology”

BRIAN G. T · S2013 Lect 3 100 5 3.0/5 CHGN 428 Introductory Biochemistry I F2013 Lect 1 100 56...

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Transcript of BRIAN G. T · S2013 Lect 3 100 5 3.0/5 CHGN 428 Introductory Biochemistry I F2013 Lect 1 100 56...