Breeding progress through data acquisition and data analysis Bachmann Neu i… · Introduction of...

Breeding progress through data acquisition and data analysis

Schweizer Sennenhund-Verein für Deutschland e.V.

Dr. Norbert Bachmann

SSV breeding strategies

Execution of breeding in the SSV according to phase program: Phase I

In case „problems“ occur increasingly within the population,data will be collected.

“Problems” can be aberration of health as well as deviations in the exterior.

Dr. Norbert BachmannSchweizer Sennenhund-Verein für Deutschland e.V.


Execution of breeding in the SSV according to phase program: Phase II

Evaluation of the data collected in phase I.

Creation of a breeding program involving the club membersas well as scientific support.

Dr. Norbert BachmannSchweizer Sennenhund-Verein für Deutschland e.V. Dr. Norbert Bachmann

Verification of the breeding success(population analysis)

• continue the breeding program

• modificate the breeding program

• stop the breeding program.


Execution of breeding in the SSV according to phase program: Phase III


health / high life span

FCI standard for Bernese Mountain Dogs

• movement (functional properties)

• behavior (functional properties)

• exterior


Breeding goals-priority list


health / high life span• increase the average• life span -> 9-10 years

fighting cancerfighting hip dysplasiafighting elbow dysplasia


Breeding goals-priority list


Movement (functional properties)

“GAIT / MOVEMENT :Sound and balanced movement in all gaits covering a lot of ground; free stride reaching well out in front, with good drive from behind; at the trot, coming and going, legs moving forward in a straight line. “


Breeding goals-priority list FCI standard for Bernese Mountain Dogs:


important for quality of life!

„BEHAVIOUR / TEMPERAMENT:

Self-confident, attentive, vigilant, fearless in every day situations; good-naturedanddevoted to his own people, self-assured and placid towards strangers ; of medium ; of medium temperament, docile.


Breeding goals-priority list FCI standard for Bernese Mountain Dogs:


important for quality of life !!!important for quality of life!


Breeding strategies since 1978 until 2012


Data capturingData storage

Data maintenanceTransparency of data (understandable for

every breeder)

Breeding withphenotypicinformation

Blood sample collectionBlood sample processing

Blood sample warehousingDNA-extraction

Since 1996

Data capturingData storage

Data maintenance

Blood sample collectionBlood sample processing

Blood sample warehousingDNA-extraction Breeding with

phenotypicinformation

Breeding withgenomic breeding

values

until 2012

from 2012 on


Promotion of data density / data transparency


Voluntary measures (examples) • questionnaire activities • reward of transparency • annual publication of the reporting rates of live and death

Non Voluntary Breeding regulations (examples) • responsibility to genome testing from the third litter..." • "10 out of 14 ancestors must have death or life reports • publication of data in database


Phase III - Breeding success review (population analysis)Example: life span


102,62 102,98103,53

101,7

97,22

93,41

100,4

98,77

92,2792,82

91,45

96,27

91,14 91,05 90,64

97,51 97,58

80

85

90

95

100

105

1986-1989/6

17 Mel

d.

1990/196 M

eld.

1991/230 M

eld.

1992/222 M

eld.

1993/268 M

eld.

1994/316 M

eld.

1995/306 M

eld.

1996/351 M

eld.

1997/483 M

eld.

1998/388 M

eld.

1999/372 M

eld.

2000/319 M

eld.

2001/438 M

eld.

2002/492 M

eld.

2003/401 M

eld.

2004/335 M

eld.

2005/289 M

eld.

ave

rag

eli

fee

xpa

ncy

of

Be

rne

se

Mo

un

tain

do

gs,

in

mo

nth

s, S

SV

Year of birth Bernes Mountain dogs,SSV

SSV breeding strategiesPhase III - Breeding success review (population analysis)Example: life span


1990 1991 1992 1993 1994 1996 1997 1998 1999 2000 Formulare „Totmeld-ungen“

Blutabnahme bei Zuchthunden für eine "Blutbank" Dr. Terill Eckart referiert zum Malignen Histio- zytose bei dem SSV-Zucht- in Hohenroda

„Lebenserwartung beim Berner Sennenhund“ wird zum zentralen Thema

ca. 550 Todmeldungen

2001 2002

Fragebögen "Tod-/Lebendmeldung" Meldeverpflichtung Lebend-/Todmeldung

2. internationales Gesundheitssymposium in der Schweiz, der SSV stellt zum erstmalig seine Zuchtstrategien zu Langlebigkeit und Gesundheit vor. C.Fechler/ Dr. N. Bachmann

Altersfrischewettbewerbe Einführung SSV-Kurier als neues Medium Informationsartikel zum Lebensalter durch Arbeitskreis Berner 1. internationales Gesundheitssymposium in der Schweiz,

K.Klaiber Präsident C. Fechler Zuchtleiter u. Zuchtbuchführer

2003 2004 2005 Gesundheitssymposium

Hohenroda Zuchtplan Berner Sennenhunde: "Lebenserwartung Berner

Sennenhunde" zentrales Thema

Deckrüdenbeschränkung/-

umverteilung Höhere Lebenserwartung in SSV-

Chronik als Zuchtziel durch

Arbeitskreis Berner formuliert

"10 von 14 Regel, Lebend-

/Todmeldung" Anerkennung der Frühsterblichkeit

als "genetisches Problem"

Randomisierung

Röntgenkandidaten

Dr. N. Bachmann, Präsident

C. Fechler Zuchtleitung

Satzungsreform: Zuchtentscheidung: Zuchtausschuss u. Mitgliederversammlung

Introduction of the genome test on a voluntary basis: 2012• 1000 dogs tested genomically• 917 registered in Dogbase• 364 are dead

Publication of results for life expectancy, hip dysplasia and elbow dysplasia

SSV pretest (histiocytic sarcoma, MH)

SSV breeding strategiesPhase III - Breeding success review (population analysis)Example: life expectancy and genomic breeding values



Phase III - Breeding success review (population analysis)Example: life expectancy and genomic breeding values


1 2 3 4 5mittlere Lebenserwartung in Monaten 152 132,3 107,8 82,5 54,3mittlerer genomischer Zuchtwert

"Langlebigkeit" 121,4 112 102,3 89,7 80,1

152

132,3

107,8

82,5

54,3

121,4112

102,3

89,780,1

0

20

40

60

80

100

120

140

160

Life ecpectancy corelatingwith the genomic

breedingvalue for longevity

347 genomically tested dogs,reported dead

(07/2018)

mittlere Lebenserwartung inMonaten

mittlerer genomischer Zuchtwert"Langlebigkeit"

Lineair (mittlerer genomischerZuchtwert "Langlebigkeit")

Gr. 2:120- 143 Mo Gr. 4: 72- 95 MoGr. 3: 96- 142 Mo Gr. 5:< 72 MoGr. 1: > 143 Mo

42 dogs 74 dogs 85 dogs 79 dogs 76 dogs

average life expectancies in months

average genomic breeding value“longevity“

Linear (average genomicbreeding value “longevity“)


average genomic breeding value“longevity“

We can draw the following conclusions:A high age means a high genomic life value.

In case the curve runs similarly linear in the next 3 to 5 years when a majority of the test candidates will be dead, we can for sure claim the genomic breeding value for age a suitable breeding instrument to increase the life expectancy.”







1 2 3 4 5mittlere Lebenserwartung in Monaten 152 132,3 107,8 82,5 54,3mittlerer genomischer Zuchtwert "Histiozytäres

Sarkom" 90,6 91,4 101,7 117,7 107,6

152

132,3

107,8

82,5

54,3

90,6 91,4101,7

117,7107,6

0

20

40

60

80

100

120

140

160

Life expectancy in relation toto the genomic breeding

value for "Histiocytic sarcoma"

(07/2018)

mittlere Lebenserwartung in Monaten mittlerer genomischer Zuchtwert "Histiozytäres Sarkom"

Gr. 2:120- 143 Mo

Gr. 4:72- 95 MoGr. 3: 96- 120 Mo

Gr. 5:< 72 Mo

Gr. 1: > 143 Mo

42 dogs 74 dogs 85 dogs 79 dogs 76 dogs

average genomic breeding value „Histiocytic sarcoma“


average genomic breeding value„Histiocytic sarcoma“


Conclusio: For reaching a very high age> 10 years the SSV-pretest alone is not meaningfulThe results of the SSV-pretest within the group 10 years and older (reached age) as well as within the group „died under the age of 8” are on a similar level.Therefore a simultaneous consideration of the genomic breeding value for age is essential for the breeding progress.





Phase III - Breeding success review (population analysis)Example: X-ray rate


0

10

20

30

40

50

60

70

%

1983 1985 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 2007 2009 2011 2013 2015 2017


Phase III - Breeding success review (population analysis)Example: hip-dysplasie


BERNER SENNENHUND

0%

20%

40%

60%

80%

100%

1983

1985

1987

1989

1991

1993

1995

1997

1999

2001

2003

2005

2007

2009

2011

2013

2015

2017

Geburtsjahrgang

HD-frei HD-Verdacht HD-leicht HD-mittel HD-schwer


Phase III - Breeding success review (population analysis)Example: ellbow-dysplasie


0%

20%

40%

60%

80%

100%

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

2013

2014

2015

2016

2017

Geburtsjahrgang

ED-frei ED-Grad I ED-Grad II ED-Grad III

• Collection and record of data• Data density• Data quality• Blood sample collection• Constant evaluation and verification of the development of

breeding progress


The long way to healthy, suitable and standard-conformantdogs


Thank you for your attention!


Breeding progress through data acquisition and data analysis Bachmann Neu i… · Introduction of...

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