Bovine Viral Diarrhoea (BVD) - BVD vaccines and … AR, et al. Financial-economic analysis of Bovine...
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milk Reduced milk production Poor reproductive performance Growth retardation Increased susceptibility to other diseases Early culling and increased mortality among young stock BVD is the most prevalent infectious disease in cattle and causes a significant negative economic impact. The mechanism of disease is complex, with different clinical manifestations for transient and persistent infections. Diagnostic tools, using specific antibody and virus detection techniques, are available to assess the BVD status of herds. Bovine Viral Diarrhoea (BVD) Economic impact of BVD 3,5 u Peterhans E, Bachofen C, Stalder H, et al. Cytopathic bovine viral diarrhea viruses (BVDV): emerging pestiviruses doomed to extinction. Vet Res. 2010;41(6):44. v Lanyon SR, Hill FI, Reichel MP,et al. Bovine viral diarrhoea: Pathogenesis and diagnosis. Vet J. 2014;199(2):201–9. w EU Thematic network on control of bovine viral diarrhoea virus (BVDV). BVDV Control QLRT – 2001-01573 Position paper. x Lindberg A, Brownlie J, Gunn GJ, et al. The control of bovine viral diarrhoea virus in Europe: today and in the future. Rev Sci Tech. 2006;25(3):961-79. y Saatkamp HW, Beek PMJC, Moen AR, et al. Financial-economic analysis of Bovine Viral Diarrhoea Virus control in Dutch dairy herds. Proceedings of the 12th International Symposium on Veterinary Epidemiology and Economics, Durban, South Africa, 2009. References BVD infection can have a negative economic impact through: Mechanism of disease 1,2 ncp/cp biotypes Transient infection Reproductive dysfunction Respiratory complications Diarrhoea cp Abortion, malformation Persistently infected animal Persistent infection Immunotolerance Fatal haemorrhagic disease Mucosal disease Rare mutation within same viral strain I n s e m i n a t i o n B i r t h PI day 30–110 ncp biotype E U R O P E A N U N I O N EU N O R T H A M E R I C A 50% 50% 2 2 1 1 BVD farm status: means of diagnosis 3 Herd level seroprevalence in the EU 3 Prevalence of BVD type 1 and 2 3,4 milk B u l k m i l k 1 V i r u s d e t e c t i o n B u l k m i l k 2 Identifies herds with recent infection Identifies herds with active infection V i r u s d e t e c t i o n I n d i v i d u a l b l o o d s a m p l e 3 Identifies transiently infected/PI animals milk P o o l e d y o u n g s t o c k b l o o d 4 Detects recent reinfection of cleared herds or missed PI 2 % Prevalence A n t i b o d y d e t e c t i o n A n t i b o d y d e t e c t i o n BVD Virus 1 Spikes Cover Protein Shell Genome Taxonomy: Genotypes: Biotypes: BVD type 1 and BVD type 2 Cytopathogenic (cp) and non-cytopathogenic (ncp) <10% >90% 60 80 Flaviviridae pestivirus ncp
Transcript of Bovine Viral Diarrhoea (BVD) - BVD vaccines and … AR, et al. Financial-economic analysis of Bovine...
milk Reducedmilk production
Poor reproductive performance
Growthretardation
Increased susceptibility
to other diseases
Early culling and increased mortality among young stock
BVD is the most prevalent infectious disease in cattle and
causes a significant negative economic impact. The
mechanism of disease is complex, with different clinical
manifestations for transient and persistent infections. Diagnostic
tools, using specific antibody and virus detection techniques, are available to assess the BVD
status of herds.
Bovine Viral Diarrhoea(BVD)
Economic impact of BVD3,5
u Peterhans E, Bachofen C, Stalder H, et al. Cytopathic bovine viral diarrhea viruses (BVDV): emerging pestiviruses
doomed to extinction. Vet Res. 2010;41(6):44. v Lanyon SR, Hill FI, Reichel MP,et al. Bovine viral diarrhoea: Pathogenesis
and diagnosis. Vet J. 2014;199(2):201–9. w EU Thematic network on control of bovine viral diarrhoea virus (BVDV).
BVDV Control QLRT – 2001-01573 Position paper. x Lindberg A, Brownlie J, Gunn GJ, et al. The control of bovine viral
diarrhoea virus in Europe: today and in the future. Rev Sci Tech. 2006;25(3):961-79. y Saatkamp HW, Beek PMJC,
Moen AR, et al. Financial-economic analysis of Bovine Viral Diarrhoea Virus control in Dutch dairy herds. Proceedings of
the 12th International Symposium on Veterinary Epidemiology and Economics, Durban, South Africa, 2009.
References
BVD infection can have a negativeeconomic impact through:
Mechanism of disease1,2
ncp/cp biotypes
Transient infectionReproductive dysfunction
Respiratory complications
Diarrhoea
cp
Abortion,malformation
Persistently infected animal
Persistentinfection
Imm
un
oto
lera
nce
Fatal haemorrhagic disease
Mucosal disease
Rare mutation within same viral strain
Inse
min
ation Birth
PI
day 30–110
ncp biotype
EU
ROPEAN UNION
EU
NO
RTH AMERIC
A
50%
50%
22
11
BVD farm status: means of diagnosis3
Herd level seroprevalence in the EU3
Prevalence of BVD type 1 and 23,4
milkBulk milk
1
Virus detection
Bulk milk
2
Identifiesherds with
recent infection
Identifies herds with
activeinfection
Virus detection
Ind
ividual blood sample
3
Identifiestransientlyinfected/PI
animals
milk
Po
oled
young stock blood
4Detects recent
reinfectionof cleared herds or missed PI
2
%
Prevalence
Antibody detection
Antibody detection
BVD Virus1
Spikes
Cover
Protein Shell
Genome
Taxonomy:
Genotypes:
Biotypes:
BVD type 1 and BVD type 2
Cytopathogenic (cp) and non-cytopathogenic (ncp)
<10%
>90%
60 80
Flaviviridae pestivirus
ncp
