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Brazilian National Cancer Institute (INCA) – Rio de Janeiro - BrazilDepartment of Gynecologic Oncology

BORDERLINE SEROUS AND MUCINOUS OVARIAN TUMORS: EXPERIENCE OF 10 YEARS

Reis, J.; Patury, P.; Santos, L.; Barakat, M.; Derchain, S.; Silva, I.F.; Mathias, L.

Borderline ovarian tumor account for 15% to 20% of epithelial ovarian cancers and occurs in women in the reproductive age group.

Retrospective study of borderline ovarian tumors treated at Gynecologic Oncologic Department at Brazilian National Cancer Institute (INCA) between January 1997 and October 2007.

There were 122 cases selected by histopathology. The mean age was 49 (17-83) years. Thirty two patients (26,2%) had Ca 125 > 35 U/ml, with mean of 172 (36,3–1182) U/ml. Histological origin was as follows: 59 cases of mucinous (48,3%), 57 (46,7%) serous and 6 (5%) seromucinous. Majority of the cases (95%) were stage I (Ia,76,2%; Ib, 9,8%; Ic, 9%). Two patients (1,6%) had stage II (IIa/IIc); one (0,9%) had stage IIIa; and three (2,5%) were stage IIIb. There was not stage IV.

Borderline Serous Tumor

Surgical specimen

Microscopy

The surgical staging of borderline tumors must be meticulous, although had been not consensus about adjuvant therapy. These tumors appear favorable behavior than carcinomas, with lower recurrence and the fertility-sparing surgery is a safe procedure.

Sixty seven women (55%) underwent primary surgical procedure at INCA. Of 55 patients (45%) operated in others hospitals, 38 had complete surgery in our institution. There were changing of stage in 7 cases (18,4%): 5 Ia became Ib(3) and Ic(2); and 2 Ib to IIIc. In 28 cases (23%) had fertility-sparing surgery. Adjuvant chemotherapy was administered in 3 patients (2,5%). The mean follow-up was 56,8 months, with 2 (1,6%) recurrences. There were four deaths (3,3%), not due to neoplasm.

Borderline Mucinous Tumor

Surgical specimen

Microscopy