BONITmatrix® Bone regeneration - as perfect as nature

Biomaterials

medical implant solutions

CompositionBONITmatrix®

60 : 40

13 %87 %

HA ß-TCP

ß-TCP

HA

SiO2

SiO2

90 nm 400 nm Nano-porousmatrix

Composition & Properties BONITmatrix® consists of the nanocrys-talline calcium phosphates HA and ß-TCP in the proven ratio of 60/40. A specific feature is the incorporation of biological active silicon in form of a silicon dioxide xerogel. The material is characterized by an interconnecting pore system in the nano- and micrometer range. The high capillarity and the adsorptive capacity of the surface allow for the dif-fusion of biological fluids. The surface binding of important growth

Biomaterials

The goal of all treatment methods for bone regeneration is the „Restitutio ad integrum“. To achieve this, bone graft substitutes have to be completely integ-rated into natural processes. In the ideal case the material should thus have os-teogenic, osteoconductive and osteoin-

More Safety with resorbable Bone graft materials

Efficiency BONITmatrix® is a synthetic bone graft material for filling and reconstruction of bone defects. Through the constant and complete resorption the material acts as place holder for new bone tissue and integrates optimal into the physiological healing process.

ductive properties. So far a good bone graft substitute should allow physiolo-gical activities at a cellular level, should be resorbed in a controlled manner and at least should support simultaneously the formation of new bone.

Clinical results show already 4 months after sinus floor elevation formation of a compact implant bed which enables the insertion of enossal implants with a sufficient primary stability.

Furthermore the biomaterial shows very good osseointegration, combined with a multi-centric bone regeneration.

factors present in the blood supports os-teogenesis.

For accurate functionality of BONITmatrix® a direct contact with vital bone tissue is absolutely necessary. Therefore the implantation of BONITmatrix ® may take place only in cleaned and vitalized defects.

Advantages at a glance

Application

Biomaterials

• Accelerated bone regeneration • Completely resorbable• Synthetic (no potential risk of disease transmission)• High biocompatibility• No foreign body reaction• Interconnecting pore system with pores in the nano-and micrometer range• Simple and safe handling (moldable,retained in the defect)• Verified by clinical trials

For accurate functionality of BONITmatrix® a direct contact with vital bone tissue is absolutely necessary. Therefore the implantation of BONITmatrix ® may take place only in cleaned and vitalized defects.

• Defects following extractions• Defects after Apical Resection• Sinus floor elevation• Peri implant defects• Defects following removal of bone cysts• Residual defects following osteotomy• Other polymural alveolar defetcs• Periodontal defects, also in combination with membranes• Extraction defects in preparation for implant therapy• Defects after harvesting autologous bone

Application

1. Pre-operative surgical planning

2. Opening end debridement of the defect area (Removal of granulation

tissue and connective tissue)

3. Mixing of BONITmatrix with autologous blood

1 2 3

4 5 6

4. Filling of the defect with the BONITmatrix®/blood mixture

5. Placement of a membrane or peri-osteum over the augmented site

6. Wound closure

F-BM

-061

115-

EN

Article Overview

Biomaterials

BONITmatrix® is gamma-sterilized and is intended for single use. Resterilisation is not possible. Products supplied sterile

Other References

Article No. Content Granulate Size

BM01.06.40.0025 0,25 g (≈0,5 cm³) 0,6 x 4,0 mm

BM01.06.40.005 0,5 g (≈1,0 cm³) 0,6 x 4,0 mm

BM01.06.40.010 1,0 g (≈2,0 cm³) 0,6 x 4,0 mm

BM01.06.03.0025 0,25 g (≈0,5 cm³) 0,6 x 0,3 mm

1. Krischkovsky G (2009) Maximaler Knochenerhalt nach Zahnverlust unter Verkürzung der Regenerati-onszeit. Implantologie Journal 4: 46-50.

2. Mertens C, Kosmehl H, Frankmann-Pricoli J, Ste-veling HG (2008) Histologische Evaluation bei Si-nusbodenelevation mit nanokristallinem Knochen-ersatzmaterial. Poster: 22. Kongress der Deutschen Gesellschaft für Implantologie im Zahn-Mund-Kieferbereich

3. Kalitzki P (2008) Anwenderstudie: Ein Vergleich xenogener und alloplastischer Knochenersatz- bzw. Knochenaufbaumaterialien. ZMK 24(9): 578-588

4. Mertens C, Kosmehl H, Frankmann-Pricoli J, Steve-ling HG (2008) Immunohistochemical observations after sinus floor elevation with a reduced healing period. Poster: 17th Annual Scientific Meeting Eu-ropean Association for Osseointegration

5. Mertens C, Kosmehl H, Steveling HG (2008) Use of nanoporous biphasic grafting material in sinus floor elevation. Poster: XIX. congress of the European As-sociation for Cranio-Maxillo-Facial Surgery

6. Gabbour G, Schildt E, Burkhardt L (2007) Gesteuerte Gewebe- und Knochenregeneration (GTR und GBR) - Fallpräsentation eines Patienten mit fortgeschrit-tener chronischer marginaler Parodontitis. Dent Im-plantol 11(1): 22-24

7. Mertens C, Kosmehl H, Steveling HG (2007) Ver-kürzte Einheilzeit nach Sinusbodenelevation mit Knochenersatzmaterial auf Kalziumphosphatbasis. Poster: 4. Gemeinschaftstagung der ÖGOCI, DGI und SGI

8. Krischkovsky G (2006) Erfolgreiche Knochenregene-ration durch synthetisches Silizium-Kalziumphos-phat-Komposit. Dental Tribune German Edition 22

9. Bulnheim U, Müller P, Klinkenberg ED, Neumann HG, Rychly J (2006) In vitro studies of mesenchymal stem cells on the calcium phosphate xerogel com-posite BONITmatrix. Biomaterialien 7(1)

10. Teller M, Gopp U, Neumann HG, Kühn KD (2006) Release of Gentamycin from bone regenerative materials. An in vitro study. Journal of Biomedical Research Part B: Applied Biomaterials.pp.23-29

11. Klinkenberg ED, Neumann HG, Bulnheim U, Rychly J (2006) The new art of bone graft substitute design. Biomaterialien 7 (S1)

12. Henkel KO, Dietrich W, Bienengräber V (2005) Ein neuartiges Knochenersatzmaterial auf Kalzium-phosphatbasis. Therapeutische Anwendungen bei Defekten im Ober- und Unterkiefer. Dens1/2005:20-22. (Mitteilunsgblatt der Zahnärztekammer und der Kassenzahnärztlichen Vereinigung Mecklenburg- Vorpommern).

13. Hopp M, Rogaschewski S, Krahl T, Biffar R (2005) Klinische Erfahrungen und materialkundliche As-pekte bei der Anwendung eines neuen xerogenen Augmentationsmaterials. Implantologie 13(3): 301-305

14. Becker P, Teller M, Lüthen F, Nebe B., Bulnheim U., Rychly J., Neumann HG (2004) BONITmatrix - Kno-chenregenerationsmaterial für die dentale Applika-tion. Biomaterialien 5(S1)

15. BONITmatrix als optimaler Knochenersatz - Ein Fall aus der Praxis. 16 Industry Report Dental Tribune German Edition Nr. 19/2004. 24. September 2004.

Literature

must not be reapplied or applied repea-tedly since functionality and sterility can then no longer be guaranteed.

DOT GmbHA Member of the Eifeler-HoldingCharles-Darwin-Ring 1a18059 RostockGermany

Tel: +49(0)381-4 03 35-0Fax: +49(0)381-4 03 35-99info@dot-coating.dewww.dot-coating.de

DOT is one of Europe’s leading providers of medical coating solutions for orthopaedic and dental implants and instruments and also their cleanroom packaging.

We also develop and manufacture products for regenerative medicine for dental and orthopaedic applications.

Our comprehensive supply chain concept makes us an ideal medical technology partner. Our activities help restore the health of patients worldwide and thus make a major contribution to the improvement of their quality of life.

medical implant solutions