BONE TUMORS. Bone tumors Bone tumors are classified into: Primary bone tumors Secondary bone...
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Transcript of BONE TUMORS. Bone tumors Bone tumors are classified into: Primary bone tumors Secondary bone...
Bone tumorsBone tumors
Bone tumors are classified into: Primary bone tumors Secondary bone tumors ( Metastasis)
Most are classified according to the normal normal cell of origincell of origin and apparent pattern of differentiation
Bone tumorsBone tumors
Bone-forming tumors Cartilage-forming tumors Miscellaneous tumors Hematopoietic tumors Fibrous tumors
Primary Bone TumorsPrimary Bone Tumors
Bone-Forming tumorsBone-Forming tumors Osteoma Osteoid osteoma and
osteoblastoma Osteosarcoma
Cartilage-Forming tumorsCartilage-Forming tumors Chondroma
(Enchondroma) Osteochondroma Chondrosarcoma
Miscellaneous tumorsMiscellaneous tumors− Ewing’s sarcoma Giant cell tumor of
bone
OsteomaOsteoma
OsteomaOsteoma are benign lesions of bone that in many cases represent developmental aberrations or reactive growths
rather than true neoplasms. Site;Site; Age;Age; Gross:Gross: Histology:Histology:
Osteosarcoma
Osteosarcoma is a bone-producing Osteosarcoma is a bone-producing malignant mesenchymal tumormalignant mesenchymal tumor . .
Bone-Forming tumors;Tumor TypeTumor Type LocationsLocations AgeAge MorphologyMorphology
BENIGNBENIGN Osteoma Facial bones, skull 40-50 Exophytic growths
attached to bone surface; histologically resemble normal bon
Osteoid osteoma Metaphysis of femur and tibia
10-20 Cortical tumors, characterized by
pain; histologically interlacing trabeculae
of woven bone
Osteoblastoma Vertebral column 10-20 vertebral processes; histologically similar to osteoid osteoma
MALIGNANTMALIGNANT Primary
osteosarcoma Metaphysis of distal femur, proximal tibia,
and humerus
10-20 Grow outward, lifting periosteum, and
inward to the medullary cavity; microscopically
malignant cells form osteoid.
Secondary
osteosarcoma Femur, humerus,
pelvis >40 Complications of
polyostotic Paget disease;
histologically similar to primary
osteosarcoma
Osteochondroma Osteochondroma Morphology
•Osteochondromas are mushroom shaped and range in size from 1 to 20 cm. •The outer layerouter layer of the head of the osteochondroma is composed of benign hyaline cartilage varying in thickness•Newly formed bone forms the inner portioninner portion of the head and stalk, with the stalk cortex merging with the cortex of the host bone.
Osteochondroma (exostosis)Microscopic
The cap is benign hyaline cartilage, resembling disorganized growth plate undergoing endochondral ossification. Newly formed bone forms the inner portion of the head and stalk
ChondrosarcomaChondrosarcoma
Chondrosarcomas comprise a Chondrosarcomas comprise a variety of tumors sharing the ability variety of tumors sharing the ability to produce neoplastic cartilageto produce neoplastic cartilage
ChondrosarcomaChondrosarcomaGross features
SITE;SITE; pelvis, shoulder, ribs. rarely involve the distal extremities.
ChondrosarcomaChondrosarcomaMicroscopic
These tumors are composed of lobules of cartilage with anaplastic chondrocytes in the lacunae and with focal enchondral ossification and calcification.
Cartilage-forming Tumors;Tumor Type Locations Age Morphology
BENIGN Osteochondroma Metaphysis of long tubular bones
10-30 Bony excrescences with a cartilaginous cap; may be solitary
or multiple and hereditary
Chondroma Small bones of hands and feet
30-50 Well-circumscribed single tumors resembling normal
cartilage; arise with medullary cavity of bone; uncommonly multiple and
hereditary
MALIGNANTChondrosarcoma Bones of shoulder,
pelvis, proximal femur, and ribs
40-60 Arise within medullary cavity and
erode cortex; microscopically well
differentiated cartilage-like or
anaplastic
Giant Cell Tumor
This is a neoplasm that contains large numbers of osteoclast like giant cells admixed with mononuclear cells.
These tumors are slightly more common in females.
METASTATIC BONE METASTATIC BONE TUMORSTUMORS
Metastatic tumors are the most common malignant tumor of bone.
Pathways of spread:Pathways of spread:
Origin:Origin: The radiologic appearance of metastasesThe radiologic appearance of metastases