Body cavities and respiratory
system development
Wiesława Klimek-Piotrowska MD, PhD
DEVELOPMENT OF BODY CAVITIES
At approximately 11 weeks, after return of intestines to the abdomen.
DEVELOPMENT OF DIAPHRAGM
Approximately 25 days
Aproximately 32 days
Congenital diaphragmatic hernia
Accesory diaphragm
Congenital hiatal hernia
RESPIRATORY SYSTEM DEVELOPMENT
Succesive stages in development of the respiratory diverticulum.
Various types of esophageal atresia and/or tracheoesophageal fistula.
90% 4% 4%
1% 1%
Esophageal atresia with esophageotracheal fistula.
Expansion of the lung buds into the
pericardioperitoneal canals.
Stages in development of the trachea and lungs.
5 weeks 6 weeks
8 weeks
Phases of the lung development
Phases of lung development
The pseudoglandular phase
The canalicular phase
The saccular phase
In terminal sac period
• Premature fetuses born between week 25
and week 28 can survive with intensive
care; this is the earliest period at which
fetuses can survive.
The blood-air barrier in the lung
The alveolar phase
At birth
• Approximately 150 million primordial
alveoli, one half of the adult number, are
present in the lungs of a full-term newborn
infant.
• The lungs are approximately half-filled with
fluid derived from the amniotic cavity,
lungs and tracheal glands.
Fetal breathing movements
• Fetal breathing movements occur before
birth and are essential for normal lungs
development.
• The pattern of FBMs is widely used in the
diagnosis of labor and as a predictor of
fetal outcome in a preterm delivery.
The alveolar phase
Approximately 95%of mature alveoli develop postnatally.
The wall construction
„White lungs” IRDS
Lobe of azygos vein
Pulmonary aplasia.
Biyyam D R et al. Radiographics 2010;30:1721-1738
©2010 by Radiological Society of North America
Congenital lung cyst
Thank You for attention.